公开(公告)号：US20060093646A1

公开(公告)日：2006-05-04

申请号：US11262413

申请日：2005-10-28

申请人： Michael Cima ,  John Santini ,  Mark Staples ,  Charles Hutchinson

发明人： Michael Cima ,  John Santini ,  Mark Staples ,  Charles Hutchinson

IPC分类号： A61F2/28 ,  A61F2/02

CPC分类号： A61F2/30771 ,  A61B17/0642 ,  A61B17/80 ,  A61B17/86 ,  A61B17/8625 ,  A61B2017/0648 ,  A61C8/0012 ,  A61C8/0016 ,  A61C19/063 ,  A61F2/30744 ,  A61F2/30767 ,  A61F2/36 ,  A61F2/3662 ,  A61F2/367 ,  A61F2/3676 ,  A61F2/38 ,  A61F2/3804 ,  A61F2/3859 ,  A61F2/389 ,  A61F2/40 ,  A61F2/4425 ,  A61F2/446 ,  A61F2002/2817 ,  A61F2002/30013 ,  A61F2002/30032 ,  A61F2002/30036 ,  A61F2002/30062 ,  A61F2002/30064 ,  A61F2002/30075 ,  A61F2002/30224 ,  A61F2002/30324 ,  A61F2002/30326 ,  A61F2002/30677 ,  A61F2002/3068 ,  A61F2002/30787 ,  A61F2002/30808 ,  A61F2002/3081 ,  A61F2002/30838 ,  A61F2002/30878 ,  A61F2002/30929 ,  A61F2002/30971 ,  A61F2002/3611 ,  A61F2002/3625 ,  A61F2002/3631 ,  A61F2002/4631 ,  A61F2210/0004 ,  A61F2210/0061 ,  A61F2230/0069 ,  A61F2250/0024 ,  A61F2250/003 ,  A61F2250/0035 ,  A61F2250/0036 ,  A61F2250/0037 ,  A61F2250/0068 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00131 ,  A61F2310/00179 ,  A61L27/54 ,  A61L2300/406 ,  A61L2300/414 ,  A61L2300/604 ,  A61N1/30

摘要： Implantable prosthetic devices are provided for controlled drug delivery, for orthopedic and dental applications. The device may include a prosthetic device body having at least one outer surface area; two or more discrete reservoirs located in spaced apart positions across at least a portion of the outer surface area, the reservoirs formed with an opening at the surface of the device body and extending into the device body; and a release system disposed in the reservoirs which comprises at least one therapeutic or prophylactic agent, wherein following implantation into a patient the therapeutic or prophylactic agent is released in a controlled manner from the reservoirs. The prosthetic device body preferably is a joint prosthesis or part thereof, such as a hip prosthesis, a knee prosthesis, a vertebral or spinal disc prosthesis, or part thereof. Optional reservoir caps may further control release kinetics.

摘要翻译： 提供可植入的假体装置用于受控的药物递送，用于矫形和牙科应用。 该装置可以包括具有至少一个外表面区域的假体装置主体; 两个或更多个离散的储存器位于跨过外表面区域的至少一部分的间隔位置，储存器在装置主体的表面处形成并延伸到装置主体中的开口; 以及设置在储存器中的释放系统，其包括至少一种治疗或预​​防剂，其中在植入患者体内后，以受控的方式从所述储存器释放所述治疗剂或预防剂。 修复装置本体优选地是关节假体或其部分，例如髋关节假体，膝假体，椎骨或脊椎椎间盘假体或其一部分。 可选的储存瓶盖可进一步控制释放动力学。

公开(公告)号：US20080015494A1

公开(公告)日：2008-01-17

申请号：US11776351

申请日：2007-07-11

申请人： John Santini ,  Michael Cima ,  Jonathan Coppeta ,  James Prescott ,  Zouhair Sbiaa ,  Mark Staples

发明人： John Santini ,  Michael Cima ,  Jonathan Coppeta ,  James Prescott ,  Zouhair Sbiaa ,  Mark Staples

IPC分类号： A61M31/00

CPC分类号： A61M37/0015 ,  A61M5/1409 ,  A61M5/14248 ,  A61M5/1452 ,  A61M5/14526 ,  A61M2005/14204 ,  A61M2005/14268 ,  A61M2037/0023

摘要： A pump patch device is provided for drug delivery. The device may include a substrate having a plurality of discrete reservoirs, each reservoir having a reservoir opening; a drug disposed in the reservoirs; a pump for delivering a carrier fluid through or adjacent to the reservoir openings; a flow channel for receiving and combining the carrier fluid from the pump with the drug from the reservoirs to form a fluidized drug; and a needle for delivering the fluidized drug into the skin or another biological tissue of a patient. A device is provided for use in dialysis that includes a non-disposable module including a pump or pressure generator; and a disposable cassette operably connected to the pump or pressure generator and including a plurality of discrete reservoirs containing drug and sensors. A fluidics connection device is provided that includes a compression cold weld seal for a microfluidic via.

摘要翻译： 提供泵补丁装置用于药物递送。 该装置可以包括具有多个分立储存器的基板，每个储存器具有储存器开口; 贮存在药物中的药物; 用于将载体流体输送通过或邻近储存器开口的泵; 流动通道，用于接收和组合来自泵的载体流体与来自储存器的药物以形成流化药物; 以及用于将流化药物输送到患者的皮肤或另一生物组织中的针。 提供用于透析的装置，其包括非一次性模块，其包括泵或压力发生器; 以及可操作地连接到泵或压力发生器并且包括多个包含药物和传感器的离散储存器的一次性盒。 提供一种流体连接装置，其包括用于微流体通孔的压缩冷焊缝。

公开(公告)号：US20070088442A1

公开(公告)日：2007-04-19

申请号：US11549831

申请日：2006-10-16

申请人： Michael Cima ,  John Santini ,  Kurt Shelton ,  James Prescott ,  Mark Staples ,  Jonathan Coppeta

发明人： Michael Cima ,  John Santini ,  Kurt Shelton ,  James Prescott ,  Mark Staples ,  Jonathan Coppeta

IPC分类号： A61F2/30 ,  A61F2/28 ,  A61B6/12

CPC分类号： A61B5/055 ,  A61B5/4514 ,  A61B5/4528 ,  A61B6/037 ,  A61B6/481 ,  A61B8/481 ,  A61F2/32 ,  A61F2/34 ,  A61F2/36 ,  A61F2/38 ,  A61F2/3804 ,  A61F2/3859 ,  A61F2/389 ,  A61F2/40 ,  A61F2/4425 ,  A61F2/4657 ,  A61F2002/2817 ,  A61F2002/30004 ,  A61F2002/30062 ,  A61F2002/30075 ,  A61F2002/30113 ,  A61F2002/30154 ,  A61F2002/30156 ,  A61F2002/30326 ,  A61F2002/30673 ,  A61F2002/30677 ,  A61F2002/30682 ,  A61F2002/30733 ,  A61F2002/30787 ,  A61F2002/3081 ,  A61F2002/30838 ,  A61F2002/30878 ,  A61F2002/30884 ,  A61F2002/30904 ,  A61F2002/30971 ,  A61F2002/3401 ,  A61F2002/3456 ,  A61F2002/3469 ,  A61F2002/3495 ,  A61F2002/3611 ,  A61F2002/3625 ,  A61F2002/4662 ,  A61F2002/488 ,  A61F2210/0004 ,  A61F2210/0061 ,  A61F2230/0006 ,  A61F2230/0021 ,  A61F2230/0023 ,  A61F2250/0014 ,  A61F2250/0037 ,  A61F2310/00011 ,  A61F2310/00179 ,  A61L27/50

摘要： A method is provided for non-invasively detecting mechanical wear of a prosthetic device implanted in a patient, the method comprises using a non-invasive imaging technique to image the prosthetic device that includes a wear indicating composition; and detecting whether the wear indicating composition has been released from the prosthetic device, and, if so, the location, type, and/or amount thereof. The implant device includes a prosthetic device body having at least one outer surface area; at least one reservoir (e.g., a plurality of discretely spaced micro-reservoirs) in the device body; a wear indicator composition disposed in said at least one reservoir, wherein mechanical wear of the at least one outer surface area of the device body in vivo causes release of at least part of the wear indicator composition. The prosthetic device body may be one for replacement of a hip, a knee, a shoulder, an elbow, or a vertebra.

摘要翻译： 提供了一种用于非侵入性地检测植入患者体内的假体装置的机械磨损的方法，所述方法包括使用非侵入性成像技术对包括磨损指示组合物的假体装置进行成像; 以及检测磨损指示组合物是否已经从假体装置释放，以及如果是，则其位置，类型和/或数量。 植入装置包括具有至少一个外表面区域的假体装置主体; 设备主体中的至少一个储存器（例如，多个离散间隔的微储器）; 布置在所述至少一个储存器中的磨损指示剂组合物，其中所述装置主体的所述至少一个外表面区域的体内机械磨损导致所述磨损指示剂组合物的至少一部分的释放。 假体装置主体可以是用于替换髋部，膝盖，肩部，肘部或椎骨的人造体。

公开(公告)号：US20050267440A1

公开(公告)日：2005-12-01

申请号：US11142629

申请日：2005-06-01

申请人： Stephen Herman ,  Timothy Kreiger ,  John Santini ,  James Prescott ,  Mark Staples ,  Sara Lipka

发明人： Stephen Herman ,  Timothy Kreiger ,  John Santini ,  James Prescott ,  Mark Staples ,  Sara Lipka

IPC分类号： A61B5/00 ,  A61B5/03 ,  A61B5/042 ,  A61B5/07 ,  A61M31/00 ,  A61M37/00 ,  A61N1/05 ,  A61N1/30

CPC分类号： A61K9/0009 ,  A61B5/03 ,  A61B5/04001 ,  A61B5/042 ,  A61B5/076 ,  A61B5/14528 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1486 ,  A61B5/686 ,  A61K9/0024 ,  A61K9/0097 ,  A61M37/00 ,  A61N1/05 ,  A61N1/30 ,  A61N1/306

摘要： Methods and devices are provided for enhancing mass transport through any fibrous tissue capsule that may form around an implanted medical device following implantation. Methods and devices are also provided to enhance vascularization around the implanted device, which also will aid in mass transport to/from the device. The device preferably comprises multiple reservoirs containing (i) a drug formulation for short- or long-term, controlled drug delivery, (ii) sensors for sensing an analyte in the patient, or (iii) a combination thereof.

摘要翻译： 提供的方法和装置用于增强通过植入后可能在植入的医疗装置周围形成的任何纤维组织胶囊的质量传递。 还提供了方法和装置以增强植入装置周围的血管化，这也有助于大量运输到装置。 装置优选地包括多个储存器，其包含（i）用于短期或长期，受控药物递送的药物制剂，（ii）用于感测患者中的分析物的传感器，或（iii）其组合。

公开(公告)号：US20060024358A1

公开(公告)日：2006-02-02

申请号：US11194157

申请日：2005-08-01

申请人： John Santini ,  Mark Staples ,  Stephen Herman

发明人： John Santini ,  Mark Staples ,  Stephen Herman

IPC分类号： A61F13/02 ,  A61L15/16

CPC分类号： A61K9/703 ,  A61F2013/00642 ,  A61K9/0009 ,  A61K9/0021 ,  A61K9/0097 ,  A61K9/7084 ,  A61K9/7092 ,  A61M37/0015 ,  A61M2037/0023 ,  A61N1/30

摘要： Devices and methods are provided for transdermal administration of a pharmaceutical agent to a patient in need thereof. The device includes a substrate, a plurality of discrete reservoirs in the substrate, one or more pharmaceutical agents stored in the reservoirs, discrete reservoir caps that prevent the pharmaceutical agent from passing out from the reservoirs until desired, control means for actuating release of the one or more pharmaceutical agents from one or more of the reservoirs by disintegrating or permeabilizing the reservoir caps, means for securing the device to the skin of the patient, and means for transporting the pharmaceutical agent to the skin following release from the one or more of the reservoirs. In another embodiment, the device is adapted for diagnostic sensing instead of or in addition to drug delivery.

公开(公告)号：US08722107B2

公开(公告)日：2014-05-13

申请号：US13400007

申请日：2012-02-17

申请人： Mark Staples ,  James Rolke

发明人： Mark Staples ,  James Rolke

IPC分类号： A01N65/00

CPC分类号： A61K31/732 ,  A61K36/00 ,  C08B37/0045 ,  C08B37/006 ,  C08L5/06 ,  C08L2203/02 ,  Y10T428/2982

摘要： The present invention provides compositions of modified pectin and methods for preparing and using them.

公开(公告)号：US20120123102A1

公开(公告)日：2012-05-17

申请号：US13357325

申请日：2012-01-24

申请人： Mark Staples ,  James Rolke

发明人： Mark Staples ,  James Rolke

IPC分类号： C08B37/06

CPC分类号： A61K31/732 ,  A61K36/00 ,  C08B37/0045 ,  C08B37/006 ,  C08L5/06 ,  C08L2203/02 ,  Y10T428/2982

摘要： The present invention provides compositions of modified pectin and methods for preparing and using them.

公开(公告)号：US20080050339A1

公开(公告)日：2008-02-28

申请号：US11975380

申请日：2007-10-18

申请人： Mary DiBiase ,  Wen-Li Chung ,  Mark Staples ,  Eric Scharin

发明人： Mary DiBiase ,  Wen-Li Chung ,  Mark Staples ,  Eric Scharin

IPC分类号： A61K38/21

CPC分类号： A61K38/215 ,  A61K9/0019 ,  A61K38/21 ,  A61K47/10 ,  A61K47/183 ,  C07K14/565

摘要： Liquid interferon compositions having a pH between 4.0 and 7.2 are described. The compositions comprise interferon-beta and a stabilizing agent at between about 0.3% and 5% by weight which is an amino acid selected from the group consisting of acidic amino acids, arginine and glycine. If needed, salt is added to provide sufficient ionic strength. The liquid composition has not been previously lyophilized or previously cavitated. The liquid is preferably contained within a vessel having at least one surface in contact with the liquid that is coated with a material inert to adsorption of interferon-beta. A kit for parenteral administration of a liquid interferon formulation and a method for stabilizing liquid interferon compositions are also described.

公开(公告)号：US20050250735A1

公开(公告)日：2005-11-10

申请号：US11093268

申请日：2005-03-28

申请人： Mark Staples ,  James Rolke

发明人： Mark Staples ,  James Rolke

IPC分类号： A61K31/732 ,  C08B37/00 ,  C08B37/06 ,  C08L5/06

CPC分类号： A61K31/732 ,  A61K36/00 ,  C08B37/0045 ,  C08B37/006 ,  C08L5/06 ,  C08L2203/02 ,  Y10T428/2982

摘要： The present invention provides compositions of modified pectin and for preparing and using them.

摘要翻译： 本发明提供了改性果胶的组合物及其制备和使用。

公开(公告)号：US08512691B2

公开(公告)日：2013-08-20

申请号：US11975379

申请日：2007-10-18

申请人： Mary D. DiBiase ,  Wen-Li Chung ,  Mark Staples ,  Eric Scharin

发明人： Mary D. DiBiase ,  Wen-Li Chung ,  Mark Staples ,  Eric Scharin

IPC分类号： A61K38/21 ,  A61K38/00 ,  C07K14/565

CPC分类号： A61K38/215 ,  A61K9/0019 ,  A61K38/21 ,  A61K47/10 ,  A61K47/183 ,  C07K14/565

摘要： Liquid interferon compositions having a pH between 4.0 and 7.2 are described. The compositions comprise interferon-beta and a stabilizing agent at between about 0.3% and 5% by weight which is an amino acid selected from the group consisting of acidic amino acids, arginine and glycine. If needed, salt is added to provide sufficient ionic strength. The liquid composition has not been previously lyophilized or previously cavitated. The liquid is preferably contained within a vessel having at least one surface in contact with the liquid that is coated with a material inert to adsorption of interferon-beta. A kit for parenteral administration of a liquid interferon formulation and a method for stabilizing liquid interferon compositions are also described.

摘要翻译： 描述pH在4.0和7.2之间的液体干扰素组合物。 所述组合物包含约0.3％至5％重量的干扰素-β和稳定剂，其为选自酸性氨基酸，精氨酸和甘氨酸的氨基酸。 如果需要，加入盐以提供足够的离子强度。 液体组合物以前没有冻干或先前被气蚀。 液体优选包含在具有至少一个表面与液体接触的容器中，该表面涂覆有对吸附干扰素-β无惰性的物质。 还描述了用于液体干扰素制剂的肠胃外给药的试剂盒和用于稳定液体干扰素组合物的方法。