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公开(公告)号：US06280971B1
公开(公告)日：2001-08-28
申请号：US09227806
申请日：1999-01-11
申请人： Min Wang , Judith M Ward , Richard Lloyd Warren , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , David Justin Charles Knowles , Michael Arthur Lonetto , Jeffrey Mooney , Michael Terence Black , Martin Karl Russell Burnham , Christine Debouck , Jason Craig Fedon , John Edward Hodgson , Deborah Dee Jaworski , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Yi Y Zhong
发明人： Min Wang , Judith M Ward , Richard Lloyd Warren , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , David Justin Charles Knowles , Michael Arthur Lonetto , Jeffrey Mooney , Michael Terence Black , Martin Karl Russell Burnham , Christine Debouck , Jason Craig Fedon , John Edward Hodgson , Deborah Dee Jaworski , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Yi Y Zhong
IPC分类号： C12N1231
CPC分类号： C12Y305/04025 , C07K2319/00 , C12N9/78
摘要： The invention provides ribA polypeptides and polynucleotides encoding ribA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribA polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供ribA多肽和编码ribA多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribA多肽筛选抗菌化合物的方法。
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公开(公告)号：US5891672A
公开(公告)日：1999-04-06
申请号：US977554
申请日：1997-11-25
申请人： Min Wang , Judith M Ward , Richard Lloyd Warren , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , David Justin Charles Knowles , Michael Arthur Lonetto , Jeffrey Mooney , Michael Terence Black , Martin Karl Russell Burnham , Christine Debouck , Jason Craig Fedon , John Edward Hodgson , Deborah Dee Jaworski , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Yi Yi Zhong
发明人： Min Wang , Judith M Ward , Richard Lloyd Warren , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , David Justin Charles Knowles , Michael Arthur Lonetto , Jeffrey Mooney , Michael Terence Black , Martin Karl Russell Burnham , Christine Debouck , Jason Craig Fedon , John Edward Hodgson , Deborah Dee Jaworski , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Yi Yi Zhong
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K38/43 , A61K39/085 , A61K39/395 , A61K48/00 , A61P1/00 , A61P9/00 , A61P11/00 , A61P11/02 , A61P13/02 , A61P13/12 , A61P17/00 , A61P17/02 , A61P19/00 , A61P25/00 , A61P27/02 , A61P27/16 , A61P43/00 , C07H21/04 , C07K14/31 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/78 , C12N9/86 , C12N15/09 , C12N15/31 , C12P21/02 , C12R1/445 , C07H21/00 , C12N15/63
CPC分类号： C12Y305/04025 , C12N9/78 , C07K2319/00
摘要： The invention provides ribA polypeptides and polynucleotides encoding ribA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribA polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供ribA多肽和编码ribA多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribA多肽筛选抗菌化合物的方法。
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公开(公告)号：US07176299B2
公开(公告)日：2007-02-13
申请号：US11166905
申请日：2005-06-23
申请人： Michael Terence Black , Martin Karl Russell Burnham , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M. Pratt , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Judith M. Ward , Richard Lloyd Warren
发明人： Michael Terence Black , Martin Karl Russell Burnham , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M. Pratt , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Judith M. Ward , Richard Lloyd Warren
CPC分类号： C12N9/0036 , A61K38/00 , A61K39/00 , C07K14/31 , C07K16/1275 , C07K2319/00 , C12N9/78 , C12N15/52 , C12Q1/689 , C12Q2600/158 , C12Y105/0103 , C12Y305/04025
摘要： This invention relates to newly identified Staphylococcal polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.
摘要翻译： 本发明涉及新鉴定的葡萄球菌多核苷酸，由这种多核苷酸编码的多肽，这种多核苷酸和多肽的用途，以及这些多核苷酸和多肽的产生以及用多核苷酸转化的重组宿主细胞。 本发明还涉及抑制这些多核苷酸或多肽的生物合成或作用以及这种抑制剂在治疗中的用途。
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公开(公告)号：US6159949A
公开(公告)日：2000-12-12
申请号：US7476
申请日：1998-01-15
申请人： Michael Terence Black , Deborah Dee Jaworski , Anna Lisa Kosmatka , Christopher Michael Traini , Richard Warren , Min Wang
发明人： Michael Terence Black , Deborah Dee Jaworski , Anna Lisa Kosmatka , Christopher Michael Traini , Richard Warren , Min Wang
IPC分类号： C12N15/09 , A61K31/00 , A61K38/00 , A61K39/085 , A61K39/395 , A61K45/00 , A61K48/00 , A61P31/00 , C07K14/195 , C07K14/31 , C07K16/14 , C12N1/21 , C12N15/00 , C12N15/31 , C12P21/02 , C12P21/08 , C12R1/445 , G01N33/53 , G01N33/566 , C07H21/00 , C12N15/63
摘要： The invention provides ftsY polypeptides and polynucleotides encoding ftsY polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ftsY polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了编码ftsY多肽的ftsY多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ftsY多肽筛选抗菌化合物的方法。
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公开(公告)号：US06171598B2
公开(公告)日：2001-01-09
申请号：US09225967
申请日：1999-01-06
申请人： Min Wang , Judith M Ward , Richard Lloyd Warren , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , David Justin Charles Knowles , Michael Arthur Lonetto , Jeffrey Mooney , Michael Terence Black , Martin Karl Russell Burnham , Christine Debouck , Jason Craig Fedon , John Edward Hodgson , Deborah Dee Jaworski , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Yi Yi Zhong
发明人： Min Wang , Judith M Ward , Richard Lloyd Warren , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , David Justin Charles Knowles , Michael Arthur Lonetto , Jeffrey Mooney , Michael Terence Black , Martin Karl Russell Burnham , Christine Debouck , Jason Craig Fedon , John Edward Hodgson , Deborah Dee Jaworski , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Yi Yi Zhong
IPC分类号： A61K3850
CPC分类号： C12Y305/04025 , C07K2319/00 , C12N9/78
摘要： The invention provides ribA polypeptides and polynucleotides encoding ribA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribA polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供ribA多肽和编码ribA多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribA多肽筛选抗菌化合物的方法。
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公开(公告)号：US6072032A
公开(公告)日：2000-06-06
申请号：US7484
申请日：1998-01-15
申请人： Michael Terence Black , Deborah Dee Jaworski , Anna Lisa Kosmatka , Christopher Michael Traini , Min Wang , Richard Lloyd Warren, Jr.
发明人： Michael Terence Black , Deborah Dee Jaworski , Anna Lisa Kosmatka , Christopher Michael Traini , Min Wang , Richard Lloyd Warren, Jr.
IPC分类号： G01N33/50 , A61K31/00 , A61K38/00 , A61K39/09 , A61K39/395 , A61K45/00 , A61K48/00 , A61P11/00 , A61P25/00 , A61P27/00 , A61P27/02 , A61P27/16 , A61P29/00 , A61P31/00 , A61P31/04 , C07K14/315 , C07K14/705 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/31 , C12P21/02 , C12Q1/02 , C12R1/46 , G01N33/15 , G01N33/566 , G01N33/569 , G01N33/68 , C07K1/00
CPC分类号： C07K14/3156 , G01N33/56944 , A61K38/00
摘要： The invention provides ftsY polypeptides and polynucleotides encoding ftsY polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ftsY polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了编码ftsY多肽的ftsY多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ftsY多肽筛选抗菌化合物的方法。
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公开(公告)号：US06555338B1
公开(公告)日：2003-04-29
申请号：US09042775
申请日：1998-03-17
IPC分类号： C12P2106
摘要： The invention provides nrdF polynucleotides encoding nrdF polypeptides from Staphylococcus aureus and methods for producing such polypeptides by recombinant techniques. The invention also provides polynucleotides having high identity to the nrdF polynucleotides. Also provided are preferred methods for utilizing these polynucleotides and polypeptides as diagnostic reagents and in diagnostic assays to screen for microbial infections in organisms and materials.
摘要翻译： 本发明提供了编码来自金黄色葡萄球菌的nrdF多肽的nrdF多核苷酸以及通过重组技术产生此类多肽的方法。 本发明还提供了与nrdF多核苷酸具有高同一性的多核苷酸。 还提供了利用这些多核苷酸和多肽作为诊断试剂以及用于筛选生物体和材料中微生物感染的诊断测定法的优选方法。
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公开(公告)号：US06448036B1
公开(公告)日：2002-09-10
申请号：US08977866
申请日：1997-11-25
申请人： Michael Terence Black , Martin Karl Russell Burnham , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Judith M Ward , Richard Lloyd Warren
发明人： Michael Terence Black , Martin Karl Russell Burnham , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Judith M Ward , Richard Lloyd Warren
IPC分类号： C07H2104
CPC分类号： C12N9/1085 , A61K38/00 , A61K39/00 , C07K14/31 , C07K16/1275 , C12N9/78 , C12Y205/01009 , C12Y305/04025
摘要： The invention provides ribB polypeptides and polynucleotides encoding ribB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribB polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供ribB多肽和编码ribB多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribB多肽筛选抗菌化合物的方法。
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公开(公告)号：US06284878B1
公开(公告)日：2001-09-04
申请号：US08991023
申请日：1997-12-15
申请人： Michael Arthur Lonetto , Deborah Dee Jaworski , Min Wang , Richard Lloyd Warren , Christopher Michael Traini , Anna Lisa Kosmatka , David Justin Charles Knowles , John Edward Hodgson , Michael Terence Black , David J. Holmes , Richard Oakley Nicholas , Robert King Stodola
发明人： Michael Arthur Lonetto , Deborah Dee Jaworski , Min Wang , Richard Lloyd Warren , Christopher Michael Traini , Anna Lisa Kosmatka , David Justin Charles Knowles , John Edward Hodgson , Michael Terence Black , David J. Holmes , Richard Oakley Nicholas , Robert King Stodola
IPC分类号： C07H2102
CPC分类号： C12N9/1205 , A61K38/00 , A61K39/00 , C07K14/3156 , C12N9/78 , C12N9/80 , C12Y207/01002
摘要： The invention provides def1 polypeptides and polynucleotides encoding def1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing def1 polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了def1多肽和编码def1多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用def1多肽筛选抗菌化合物的方法。
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公开(公告)号：US06280735B1
公开(公告)日：2001-08-28
申请号：US09369700
申请日：1999-08-06
申请人： Michael Terence Black , Martin Karl Russell Burnham , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Judith M Ward , Richard Lloyd Warren
发明人： Michael Terence Black , Martin Karl Russell Burnham , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Judith M Ward , Richard Lloyd Warren
IPC分类号： A61K3902
CPC分类号： C12N9/0036 , A61K38/00 , A61K39/00 , C07K14/31 , C07K16/1275 , C07K2319/00 , C12N9/78 , C12N15/52 , C12Q1/689 , C12Q2600/158 , C12Y105/0103 , C12Y305/04025
摘要： The invention provides ribG polypeptides and polynucleotides encoding ribG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribG polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供ribG多肽和编码ribG多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribG多肽筛选抗菌化合物的方法。
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