-
公开(公告)号：US5618715A
公开(公告)日：1997-04-08
申请号：US75199
申请日：1993-06-10
申请人： Mohammed Shoyab , Joyce M. Zarling , Hans Marquardt , Marcia B. Hanson , Najma Malik , Peter S. Linsley , Timothy M. Rose , Anthony F. Purchio
发明人： Mohammed Shoyab , Joyce M. Zarling , Hans Marquardt , Marcia B. Hanson , Najma Malik , Peter S. Linsley , Timothy M. Rose , Anthony F. Purchio
IPC分类号： A61K38/00 , C07K14/07 , C07K14/475 , C07K14/495 , C07K14/52 , C07K16/22 , C07K16/24 , C12N15/62 , C12N15/73 , C12N5/00 , C07H17/00 , C12N15/00 , C12P21/06
CPC分类号： C07K14/005 , A61K38/191 , A61K38/204 , C07K14/475 , C07K14/495 , C07K14/52 , C07K14/522 , C07K16/22 , C07K16/24 , C12N15/625 , C12N15/73 , C07K2319/00 , C07K2319/02 , C07K2319/50 , C07K2319/75 , C12N2710/24122
摘要： Novel compositions comprising Oncostatin M and congeners thereof, as well as methods for their preparation and methods for their use are provided. The compositions may be prepared by isolation from natural sources, or by recombinant means in either prokaryotic or eukaryotic host cells. In addition, the DNA and polypeptide sequences for Oncostatin M are disclosed. The compositions find use in modulating growth of cells, in particular inhibition of tumor cell proliferation, and stimulation of normal cell growth, especially cells involved in hematopoiesis. Cell growth inhibition compositions may additionally include an adjunctive agent comprising at least one of a transforming growth factor, tumor necrosis factor, or an interferon. Receptors having high affinity for Oncostatin M may additionally be used to screen polypeptides for Oncostatin M-like activity. Methods for use of antibodies to the compositions and probes specific for Oncostatin M mRNA as a means for detecting tumor cells are also provided.
摘要翻译： 提供了包含制瘤素M及其同源物的新型组合物，以及其制备方法及其使用方法。 组合物可以通过从天然来源或通过重组方法在原核或真核宿主细胞中分离来制备。 此外，公开了制瘤素M的DNA和多肽序列。 该组合物可用于调节细胞的生长，特别是抑制肿瘤细胞增殖，刺激正常的细胞生长，特别是涉及造血的细胞。 细胞生长抑制组合物可另外包括包含转化生长因子，肿瘤坏死因子或干扰素中的至少一种的辅助剂。 对制瘤素M具有高亲和力的受体可以另外用于筛选多肽用于制瘤素M样活性。 还提供了使用针对制瘤素M mRNA特异性的组合物和探针的抗体作为肿瘤细胞检测手段的方法。
-
公开(公告)号：US5451506A
公开(公告)日：1995-09-19
申请号：US78707
申请日：1993-06-16
IPC分类号： A61K38/00 , C07K14/07 , C07K14/475 , C07K14/495 , C07K14/52 , C07K16/22 , C07K16/24 , C12N15/62 , C12N15/73 , G01N33/74 , G01N33/60 , G01N33/68 , C07K13/00
CPC分类号： C07K14/005 , A61K38/204 , C07K14/475 , C07K14/495 , C07K14/522 , C07K16/22 , C07K16/24 , C12N15/625 , C12N15/73 , C07K2319/00 , C07K2319/02 , C07K2319/50 , C07K2319/75 , C12N2710/24122 , Y10S435/96
摘要： Novel compositions comprising Oncostatin M and congeners thereof, as well as methods for their preparation and methods for their use are provided. The compositions may be prepared by isolation from natural sources, or by recombinant means in either prokaryotic or eukaryotic host cells. In addition, the DNA and polypeptide sequences for Oncostatin M are disclosed. The compositions find use in modulating growth of cells, in particular inhibition of tumor cell proliferation, and stimulation of normal cell growth, especially cells involved in hematopoiesis. Cell growth inhibition compositions may additionally include an adjunctive agent comprising at least one of a transforming growth factor, tumor necrosis factor, or an interferon. Receptors having high affinity for Oncostatin M may additionally be used to screen polypeptides for Oncostatin M-like activity. Methods for use of antibodies to the compositions and probes specific for Oncostatin M mRNA as a means for detecting tumor cells are also provided.
摘要翻译： 提供了包含制瘤素M及其同源物的新型组合物，以及其制备方法及其使用方法。 组合物可以通过从天然来源或通过重组方法在原核或真核宿主细胞中分离来制备。 此外，公开了制瘤素M的DNA和多肽序列。 该组合物可用于调节细胞的生长，特别是抑制肿瘤细胞增殖，刺激正常的细胞生长，特别是涉及造血的细胞。 细胞生长抑制组合物可另外包括包含转化生长因子，肿瘤坏死因子或干扰素中的至少一种的辅助剂。 对制瘤素M具有高亲和力的受体可以另外用于筛选多肽用于制瘤素M样活性。 还提供了使用针对制瘤素M mRNA特异性的组合物和探针的抗体作为肿瘤细胞检测手段的方法。
-
公开(公告)号：US5428012A
公开(公告)日：1995-06-27
申请号：US85279
申请日：1993-07-01
IPC分类号： A61K38/00 , C07K14/07 , C07K14/475 , C07K14/495 , C07K14/52 , C07K16/22 , C07K16/24 , C12N15/62 , C12N15/73 , C12P21/02 , C12N15/00
CPC分类号： C07K14/005 , A61K38/191 , A61K38/204 , C07K14/475 , C07K14/495 , C07K14/52 , C07K14/522 , C07K16/22 , C07K16/24 , C12N15/625 , C12N15/73 , C07K2319/00 , C07K2319/02 , C07K2319/50 , C07K2319/75 , C12N2710/24122
摘要： Novel compositions comprising Oncostatin M and congeners thereof, as well as methods for their preparation and methods for their use are provided. The compositions may be prepared by isolation from natural sources, or by recombinant means in either prokaryotic or eukaryotic host cells. In addition, the DNA and polypeptide sequences for Oncostatin M are disclosed. The compositions find use in modulating growth of cells, in particular inhibition of tumor cell proliferation, and stimulation of normal cell growth, especially cells involved in hematopoiesis. Cell growth inhibition compositions may additionally include an adjunctive agent comprising at least one of a transforming growth factor, tumor necrosis factor, or an interferon. Receptors having high affinity for Oncostatin M may additionally be used to screen polypeptides for Oncostatin M-like activity. Methods for use of antibodies to the compositions and probes specific for Oncostatin M mRNA as a means for detecting tumor cells are also provided.
-
公开(公告)号：US5120535A
公开(公告)日：1992-06-09
申请号：US46846
申请日：1987-05-04
申请人： Hans Marquardt , Joyce M. Zarling , Mohammed Shoyab , Marcia B. Hanson , Mario N. Lioubin , Thomas J. Brown , Tatsuhiko Ikeda
发明人： Hans Marquardt , Joyce M. Zarling , Mohammed Shoyab , Marcia B. Hanson , Mario N. Lioubin , Thomas J. Brown , Tatsuhiko Ikeda
IPC分类号： A61K38/00 , C07K14/495 , C07K14/52 , C07K16/22 , C07K16/24
CPC分类号： C07K14/52 , A61K38/204 , A61K38/217 , C07K14/495 , C07K16/22 , C07K16/24 , A61K38/00 , C07K2319/75
摘要： Novel compositions are provided for modulating growth, particularly of tumor cells, which compositions are combinations of Oncostatin M, and one or both of transforming growth factors or .gamma.-interferons, or analogs thereof. In addition, a novel transforming growth factor is provided, designated TGF-.beta.2, as well as methods for its preparation.
摘要翻译： 提供新的组合物用于调节生长，特别是肿瘤细胞的生长，该组合物是制瘤素M以及转化生长因子或γ-干扰素之一或两者或其类似物的组合。 此外，提供了一种新的转化生长因子，称为TGF-β2，以及其制备方法。
-
公开(公告)号：US5907033A
公开(公告)日：1999-05-25
申请号：US678922
申请日：1996-07-12
CPC分类号： C07K16/24 , C07K2317/34 , C07K2319/75 , Y10S530/866
摘要： The present invention relates to monoclonal antibodies that define Oncostatin M, a novel cytokine. The monoclonal antibodies of the invention are capable of binding to Oncostatin M, inhibiting Oncostatin M receptor binding, and/or inhibiting Oncostatin M bioactivity. Such antibodies may be used to detect the presence at Oncostatin M and/or to modulate Oncostatin M bioactivities in an in vivo or in vitro system.
摘要翻译： 本发明涉及定义制瘤素M（一种新型细胞因子）的单克隆抗体。 本发明的单克隆抗体能够结合制瘤素M，抑制制瘤素M受体结合和/或抑制制瘤素M生物活性。 这样的抗体可用于检测制瘤素M中的存在和/或在体内或体外系统中调节制瘤素M生物活性。
-
公开(公告)号：US5681930A
公开(公告)日：1997-10-28
申请号：US943387
申请日：1992-09-10
CPC分类号： C07K16/24 , C07K2317/34 , C07K2319/75 , Y10S530/866
摘要： The present invention relates to monoclonal antibodies that define Oncostatin M, a novel cytokine. The monoclonal antibodies of the invention are capable of binding to Oncostatin M, inhibiting Oncostatin M receptor binding, and/or inhibiting Oncostatin M bioactivity. Such antibodies may be used to detect the presence at Oncostatin M and/or to modulate Oncostatin M bioactivities in an in vivo or in vitro system.
摘要翻译： 本发明涉及定义制瘤素M（一种新型细胞因子）的单克隆抗体。 本发明的单克隆抗体能够结合制瘤素M，抑制制瘤素M受体结合和/或抑制制瘤素M生物活性。 这样的抗体可用于检测制瘤素M中的存在和/或在体内或体外系统中调节制瘤素M生物活性。
-
公开(公告)号：US4714683A
公开(公告)日：1987-12-22
申请号：US694712
申请日：1985-01-25
IPC分类号： A61K38/00 , C07K14/47 , C07K16/18 , G01N33/53 , G01N33/534 , G01N33/577 , G01N33/68
CPC分类号： C07K14/4703 , C07K16/18 , A61K38/00 , Y10S436/804 , Y10S930/12
摘要： Polypeptides, polynucleotide sequences, DNA constructs and compositions are provided for the preparation and use of polypeptides associated with naturally occurring polypeptides found in brains. The small molecular weight polypeptides are growth inhibitors for neoplastic cells without inhibiting normal cells. The polypeptides comprise specific regions which are highly conserved, separated by less conserved regions. The polypeptides find use in inhibiting neoplastic growth and detecting receptors for the polypeptides. Antibodies are provided in conjunction with the polypeptides, which may be used together or separately for detecting the presence of the neoplastic cell retarding polypeptides.
摘要翻译： 提供多肽，多核苷酸序列，DNA构建体和组合物用于制备和使用与脑中发现的天然存在的多肽相关的多肽。 小分子量多肽是不抑制正常细胞的肿瘤细胞的生长抑制剂。 多肽包含高度保守的特定区域，由较不保守的区域分开。 多肽可用于抑制肿瘤生长并检测多肽的受体。 结合多肽提供抗体，其可以一起使用或分开用于检测肿瘤细胞阻滞多肽的存在。
-
公开(公告)号：US4806492A
公开(公告)日：1989-02-21
申请号：US766864
申请日：1985-08-15
IPC分类号： C12P21/08 , A61K38/00 , A61K39/395 , A61P9/00 , A61P25/20 , A61P25/26 , A61P35/00 , A61P37/00 , A61P43/00 , C07C43/23 , C07C323/16 , C07C323/20 , C07D323/00 , C07D405/12 , C07H21/04 , C07K1/14 , C07K1/20 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/005 , C07K14/195 , C07K14/435 , C07K14/47 , C07K14/705 , C07K16/00 , C07K16/18 , C12N15/00 , C12N15/09 , C12P21/00 , C12P21/02 , C12R1/19 , C12R1/91 , G01N33/50 , G01N33/53 , G01N33/531 , G01N33/534
CPC分类号： C07D405/12 , C07C323/16 , C07C323/20 , C07C43/23 , C07D323/00 , C07K14/4703 , C07K16/18 , A61K38/00 , Y10S436/804 , Y10S436/813 , Y10S530/828 , Y10S530/839
摘要： Novel polypeptides, polynucleotide sequences, DNA constructs and compositions are provided for the preparation and use of polypeptides associated with naturally occurring polypeptides found in brains. The small molecular weight polypeptides are growth inhibitors for neoplastic cells without inhibiting normal cells. The polypeptides comprise specific regions which are highly conserved, separated by less conserved regions. The polypeptides find use in inhibiting neoplastic growth and detecting receptors for the polypeptides. Antibodies are provided in conjunction with the polypeptides, which may be used together or separately for detecting the presence of the neoplastic cell retarding polypeptides.
-
公开(公告)号：US5011777A
公开(公告)日：1991-04-30
申请号：US546248
申请日：1990-06-29
CPC分类号： C07K14/4703 , C07K16/18 , A61K38/00
摘要： Novel polypeptides, polynucleotide sequences, DNA constructs and compositions are provided for the preparation and use of polypeptides associated with naturally occurring polypeptides found in brains. The low molecular weight polypeptides either are growth inhibitors for neoplastic cells without inhibiting normal cells or affect GABA-ergic transmission. The polypeptides find use in inhibiting neoplastic growth, modulating diazepam receptor response, and detecting receptors for the polypeptides. Antibodies are provided in conjunction with the polypeptides, which may be used together or separately for detecting the presence of the polypeptides.
摘要翻译： 提供新颖的多肽，多核苷酸序列，DNA构建体和组合物用于制备和使用与脑中发现的天然存在的多肽相关的多肽。 低分子量多肽或者是肿瘤细胞的生长抑制剂，而不抑制正常细胞或影响GABA能传递。 多肽可用于抑制肿瘤生长，调节地西泮受体应答，并检测多肽的受体。 结合多肽提供抗体，其可一起使用或分开用于检测多肽的存在。
-
公开(公告)号：US4963485A
公开(公告)日：1990-10-16
申请号：US823159
申请日：1986-01-27
CPC分类号： C07K16/18 , C07K14/4703 , A61K38/00 , Y10S436/815
摘要： Novel polypeptides, polynucleotide sequences, DNA constructs and compositions are provided for the preparation and use of polypeptides associated with naturally occurring polypeptides found in brains. The low molecular weight polypeptides either are growth inhibitors for neoplastic cells without inhibiting normal cells or affect GABA-ergic transmission. The polypeptides find use in inhibiting neoplastic growth, modulating diazepam receptor response, and detecting receptors for the polypeptides. Antibodies are provided in conjunction with the polypeptides, which may be used together or separately for detecting the presence of the polypeptides.
摘要翻译： 提供新颖的多肽，多核苷酸序列，DNA构建体和组合物用于制备和使用与脑中发现的天然存在的多肽相关的多肽。 低分子量多肽或者是肿瘤细胞的生长抑制剂，而不抑制正常细胞或影响GABA能传递。 多肽可用于抑制肿瘤生长，调节地西泮受体应答，并检测多肽的受体。 结合多肽提供抗体，其可一起使用或分开用于检测多肽的存在。
-
-
-
-
-
-
-
-
-
搜索结果
20 条记录 (耗时 0.03 秒)
