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    Multi-layered polymerizing hydrogels for tissue regeneration
    4.
    发明申请
    Multi-layered polymerizing hydrogels for tissue regeneration 审中-公开
    用于组织再生的多层聚合水凝胶

    公开(公告)号：US20050069572A1

    公开(公告)日：2005-03-31

    申请号：US10681753

    申请日：2003-10-09

    申请人： Christopher Williams ,  Blanka Sharma ,  Jennifer Elisseeff

    发明人： Christopher Williams ,  Blanka Sharma ,  Jennifer Elisseeff

    IPC分类号： A61K45/06 ,  A61L27/38 ,  A61L27/50 ,  A61L27/52 ,  C12N5/00 ,  C12N5/071 ,  C12N5/077 ,  A61K45/00

    CPC分类号： A61L27/3891 ,  A61K45/06 ,  A61L27/3817 ,  A61L27/3847 ,  A61L27/3852 ,  A61L27/3895 ,  A61L27/50 ,  A61L27/52 ,  C12N5/0062 ,  C12N5/0655 ,  C12N5/0697 ,  C12N2533/30

    摘要： A multi-layered tissue construct includes: a first layer comprising a first hydrogel; and a second layer comprising a second hydrogel, wherein the first layer is connected to the second layer at a first transition zone and wherein at least one of the first layer and the second layer further comprises a component selected from the group consisting of cells and a bioactive substance. Another multi-layered tissue construct includes: a first layer comprising a first hydrogel; a second layer comprising cells of a first type, wherein the second layer is disposed on the first layer; and a third layer comprising a second hydrogel and optionally cells of the first type encapsulated in the second hydrogel, wherein the third layer is disposed on the second layer. Methods for producing these multi-layered tissue constructs are also disclosed.

    摘要翻译： 多层组织构建体包括：包含第一水凝胶的第一层; 以及包含第二水凝胶的第二层，其中所述第一层在第一过渡区连接到所述第二层，并且其中所述第一层和所述第二层中的至少一个还包含选自以下的组分：细胞和 生物活性物质。 另一多层组织构建体包括：第一层，其包含第一水凝胶; 第二层，其包括第一类型的单元，其中所述第二层设置在所述第一层上; 以及第三层，其包含第二水凝胶和任选地包封在第二水凝胶中的第一类型的细胞，其中第三层设置在第二层上。 还公开了生产这些多层组织构建体的方法。

    Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering
    5.
    发明授权
    Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering 失效
    用于药物递送和组织工程的半互穿或互穿聚合物网络

    公开(公告)号：US07625580B1

    公开(公告)日：2009-12-01

    申请号：US09724382

    申请日：2000-11-28

    申请人： Robert S. Langer ,  Jennifer Elisseeff ,  Kristi Anseth ,  Derek Sims

    发明人： Robert S. Langer ,  Jennifer Elisseeff ,  Kristi Anseth ,  Derek Sims

    IPC分类号： A61K2/02

    CPC分类号： A61L27/50 ,  A61L27/38 ,  A61L27/3817 ,  A61L27/3852 ,  A61L27/52 ,  A61L2400/06 ,  A61L2430/06

    摘要： Compositions for tissue engineering and drug delivery have been developed based on solutions of two or more polymers which form semi-interpenetrating or interpenetrating polymer networks upon exposure to active species following injection at a site in a patient in need thereof. The polymers crosslink to themselves but not to each other; semi-interpenetrating networks are formed when only one of the polymers crosslink. The resulting viscous solutions retain the biologically active molecules or cells at the site of injection until release or tissue formation, respectfully, occurs.As a result of studies conducted with polymer-cell suspensions forming interpenetrating polymer networks, it has been determined that polymer solutions can be formulated wherein the active species is provided by exposure of the polymer solution to an exogenous source of active species, typically electromagnetic radiation, preferably light. Studies demonstrate that light will penetrate through skin, body fluids (such as synovial fluid) and membranes and polymerize the polymer solutions. The polymer solutions can be crosslinked ionically or covalently, to form a hydrogel, semi-interpenetrating polymer network or an interpenetrating polymer network.

    摘要翻译： 已经开发了用于组织工程和药物递送的组合物，其基于在需要其的患者的部位注射后暴露于活性物质时形成半互穿或互穿聚合物网络的两种或更多种聚合物的溶液。 聚合物自身交联而不是彼此交联; 当只有一种聚合物交联时，形成半互穿网络。 所得粘稠溶液将生物活性分子或细胞保留在注射部位，直到发生释放或组织形成。 作为通过形成互穿聚合物网络的聚合物 - 细胞悬浮液进行的研究的结果，已经确定可以配制聚合物溶液，其中通过将聚合物溶液暴露于外源性活性物质（通常是电磁辐射）来提供活性物质， 最好是光。 研究表明，光将穿透皮肤，体液（如滑液）和膜，并聚合聚合物溶液。 聚合物溶液可以离子交换或共价交联，以形成水凝胶，半互穿聚合物网络或互穿聚合物网络。

    Method and material for enhanced tissue-biomaterial integration
    7.
    发明授权
    Method and material for enhanced tissue-biomaterial integration 有权
    增强组织生物材料整合的方法和材料

    公开(公告)号：US07897165B2

    公开(公告)日：2011-03-01

    申请号：US11369578

    申请日：2006-03-07

    申请人： Jennifer Elisseeff ,  Dong-an Wang ,  Anthony Ratcliffe

    发明人： Jennifer Elisseeff ,  Dong-an Wang ,  Anthony Ratcliffe

    IPC分类号： A61K31/715 ,  A61K38/39

    CPC分类号： A61L24/0031 ,  A61K35/32 ,  A61K45/06 ,  A61L24/0005 ,  A61L27/3604 ,  A61L27/3616 ,  A61L27/3633 ,  A61L27/3683 ,  A61L27/3687 ,  A61L27/3691 ,  A61L27/38 ,  A61L27/50 ,  A61L27/52 ,  C12N5/0062 ,  C12N5/0655 ,  C12N5/0697 ,  C12N2533/30

    摘要： The present invention relates to the covalent binding of a hydrogel to an extracellular matrix (ECM). The integration of the hydrogel with the tissue is superior to that in previous techniques. Moreover, unlike previous techniques, the present invention does not require a photoinitiator. Potential therapeutic applications include tissue repair and delivery of drugs or cells.The ECM is first exposed, then treated with a priming agent. Then a polymerizable agent is added and crosslinked to the ECM.Two primary embodiments of methods are disclosed. In the first, the priming agent is an oxidizer which creates tyrosyl radicals in the ECM, which are then bound by acrylate groups in the polymerizable agent. In the second, the priming agent contains aldehydes which bind amino groups in the ECM.

    摘要翻译： 本发明涉及水凝胶与细胞外基质（ECM）的共价结合。 水凝胶与组织的整合优于以前的技术。 此外，与以前的技术不同，本发明不需要光引发剂。 潜在的治疗应用包括药物或细胞的组织修复和递送。 首先暴露ECM，然后用启动剂处理。 然后加入可聚合的试剂并与ECM交联。 公开了两种方法的主要实施方案。 首先，起动剂是在ECM中产生酪氨酰自由基的氧化剂，然后在可聚合试剂中由丙烯酸酯基团结合。 在第二种情况下，引发剂含有结合ECM中氨基的醛。