Device and method for testing sensitive elements on an electronic chip
    2.
    发明授权
    Device and method for testing sensitive elements on an electronic chip 失效
    用于测试电子芯片上敏感元件的装置和方法

    公开(公告)号:US06607929B1

    公开(公告)日:2003-08-19

    申请号:US09555136

    申请日:2000-07-10

    IPC分类号: H01L2166

    CPC分类号: G01R1/06783 G01R31/2829

    摘要: A method and device for testing an electronic chip (10) having on the surface a plurality of addressable electrically conductive sensitive elements (12) in which the sensitive elements on the chip are put in contact with a conductive solution (52), one or more sensitive elements (12) are addressed selectively in order to apply to each sensitive element addressed an electrical test signal referred to as an input signal, and a signal, referred to as the output signal, on an electrode (60, 60a) also in contact with the conductive solution, is measured.

    摘要翻译: 一种用于测试电子芯片(10)的方法和装置,所述电子芯片(10)在表面上具有多个寻址导电敏感元件(12),其中芯片上的敏感元件与导电溶液(52)接触,一个或多个 选择性地寻址敏感元件(12),以便将被称为输入信号的电测试信号的每个敏感元件和被称为输出信号的信号应用于也接触的电极(60,60a)上 与导电溶液进行测量。

    Device for receiving a fluid sample and applications thereof
    5.
    发明授权
    Device for receiving a fluid sample and applications thereof 有权
    用于接收流体样品的装置及其应用

    公开(公告)号:US08147665B2

    公开(公告)日:2012-04-03

    申请号:US10578318

    申请日:2004-11-15

    IPC分类号: G01N27/327

    摘要: The invention relates to a device for receiving a fluid sample, which is designed such as to form an electrode, such as a counter electrode or a working electrode, in an electrochemical cell. The inventive device comprises an end part having at least one cavity which opens to the exterior via an opening and which is equipped with a base. The invention is characterized in that the aforementioned end part comprises a first electrically-insulating hydrophobic zone which is adjacent to the cavity opening and a second electrically-conducting hydrophilic zone which is adjacent to the first zone and which at least partially covers the base of the cavity, such that, when the end part is immersed in the fluid and then removed therefrom, the cavity retains part of the fluid by means of capillary action.

    摘要翻译: 本发明涉及一种用于接收流体样品的装置,其被设计成在电化学电池中形成诸如对电极或工作电极之类的电极。 本发明的装置包括具有至少一个空腔的端部,所述至少一个空腔经由开口向外部开口并且具有底座。 本发明的特征在于,上述端部包括与腔开口相邻的第一电绝缘疏水区和邻近第一区的第二导电亲水区,并且至少部分地覆盖第一区的底部 使得当端部浸入流体中然后从其中移出时,空腔通过毛细管作用保持部分流体。

    Method for detecting specific nucleic acid sequences by amplification in
highly dilute solution
    6.
    发明授权
    Method for detecting specific nucleic acid sequences by amplification in highly dilute solution 失效
    通过在高度稀释溶液中扩增来检测特异性核酸序列的方法

    公开(公告)号:US5514540A

    公开(公告)日:1996-05-07

    申请号:US90436

    申请日:1993-07-06

    摘要: A method for detecting specific nucleic acid sequences (a single sequence and/or a mixture of nucleic acid sequences) which are present in a biological sample, comprising at least one enzymatic amplification. Detection is carried out, after placing the biological samples in a solution in order to extract the nucleic acid, by enrichment with target sequences by putting the biological samples into contact with at least one pair of appropriate triggers, followed by at least one appropriate dilution of the obtained enrichment amplifying solution, and by putting a fraction of this solution into contact with at least one pair of triggers, followed by the detection of the obtained double-strand target nucleic acid copies. Applications in the diagnosis of genetic, infectious and tumoral diseases, in checking biological samples and in cell typing etc.

    摘要翻译: 存在于生物样品中的特异性核酸序列(单序列和/或核酸序列的混合物)的方法,其包含至少一种酶促扩增。 在将生物样品置于溶液中以提取核酸之后,通过将生物样品与至少一对合适的触发剂接触,然后通过与靶序列的富集至少一次适当的稀释 获得的富集放大溶液,并将该溶液的一部分与至少一对触发剂接触,然后检测所获得的双链靶核酸拷贝。 诊断遗传,感染和肿瘤疾病,检查生物样品和细胞分型等方面的应用

    Method for fixing a protein on a pyrrole-based polymer and use thereof for making a sensor
    8.
    发明授权
    Method for fixing a protein on a pyrrole-based polymer and use thereof for making a sensor 有权
    将蛋白质固定在吡咯类聚合物上的方法及其制造传感器的用途

    公开(公告)号:US07998726B2

    公开(公告)日:2011-08-16

    申请号:US10533950

    申请日:2003-11-20

    摘要: The aim of the present invention is to provide a method for attaching a protein to a conductive polymer, that can be used in particular for producing a sensor or a multisensor, for example a biochip.This aim, and also others, are achieved, in accordance with the invention, by means of a method for attaching a protein to a pyrrole polymer, comprising the following steps: coupling of the protein to be attached with pyrrole so as to obtain a first solution of a protein-pyrrole coupling compound, preparation of a second solution of pyrrole not containing the protein, mixing of said first solution with said second solution so as to obtain an electropolymerization solution, electropolymerization of the pyrrole and of the protein coupled to the pyrrole on a conductive support using said electropolymerization solution.

    摘要翻译: 本发明的目的是提供一种将蛋白质连接到导电聚合物上的方法,其特别可用于生产传感器或多传感器,例如生物芯片。 根据本发明,通过将蛋白质与吡咯聚合物连接的方法,其目的以及其它目的以及其它目的,也包括以下步骤:将待连接的蛋白质与吡咯偶联以获得第一 蛋白质 - 吡咯偶联化合物的溶液,制备不含有蛋白质的吡咯的第二溶液,将所述第一溶液与所述第二溶液混合,得到电聚合溶液,吡咯和与吡咯偶联的蛋白质的电聚合 在使用所述电聚合溶液的导电载体上。

    Process for preparing double-stranded RNA, and its applications
    10.
    发明授权
    Process for preparing double-stranded RNA, and its applications 失效
    制备双链RNA的方法及其应用

    公开(公告)号:US5795715A

    公开(公告)日:1998-08-18

    申请号:US244722

    申请日:1994-06-17

    CPC分类号: C12P19/34 C12Q1/6865

    摘要: A method for preparing double stranded RNA, wherein the simultaneous transcription of two complementary DNA sequence strands in a single reaction mixture is preformed, and the two resulting transcripts are immediately hybridized. The double stranded RNA fragments may be used for detecting and/or assaying nucleic acid target sequences in a biological sample.

    摘要翻译: PCT No.PCT / FR92 / 01209 Sec。 371日期:1994年6月17日 102(e)日期1994年6月17日PCT提交1992年12月18日PCT公布。 公开号WO93 / 12229 日期1993年6月24日制备双链RNA的方法,其中在单个反应混合物中同时转录两个互补DNA序列链,并且立即将两个得到的转录物杂交。 双链RNA片段可用于检测和/或测定生物样品中的核酸靶序列。