公开(公告)号：US4877029A

公开(公告)日：1989-10-31

申请号：US32489

申请日：1987-03-30

Applicant: Robert F. Valentini ,  Patrick Aebischer ,  Pierre M. Galletti

Inventor： Robert F. Valentini ,  Patrick Aebischer ,  Pierre M. Galletti

IPC: A61B17/00 ,  A61B17/11 ,  A61B19/00 ,  A61F2/00 ,  A61L27/26

CPC classification number: A61B17/1128 ,  A61L27/26 ,  A61B17/00491 ,  A61B2017/00004 ,  A61F2002/30235 ,  A61F2230/0069 ,  A61L2430/32

Abstract: Medical devices employing semipermeable materials, such as acrylic copolymers, polyurethane isocyanate, and other biocompatible semipermeable polymers, are disclosed for use as guidance channels in regenerating nerves. The devices can be formed by tubular semipermeable conduits adapted to receive the ends of a severed or damaged nerve. The tubular conduits define lumens through which axons can regenerate to restore motor and/or sensory functions. The guidance materials are chosen such that they are capable of allowing the diffusion of nutrients and other metabolites to the regenerating nerve site while excluding fibroblasts and other scar-forming cells. In particular, tubular channels which have a smooth inner surface and longitudinally oriented trabeculae result in significantly larger regenerated nerve cables and higher numbers of regenerated myelinated axons.

公开(公告)号：US5092871A

公开(公告)日：1992-03-03

申请号：US600021

申请日：1990-11-30

Applicant: Patrick Aebischer ,  Paolo Dario ,  Angelo Sabatini ,  Robert F. Valentini

Inventor： Patrick Aebischer ,  Paolo Dario ,  Angelo Sabatini ,  Robert F. Valentini

IPC: A61B17/00 ,  A61B17/11 ,  A61F2/00 ,  A61L31/04 ,  A61L31/14

CPC classification number: A61L31/14 ,  A61B17/1128 ,  A61L31/04 ,  A61L31/048 ,  A61B17/00491 ,  A61B2017/00004 ,  A61F2002/30235 ,  A61F2230/0069 ,  A61L2430/32 ,  Y10S623/92 ,  Y10S977/908

Abstract: A medical device is disclosed for use in regenerating a severed nerve, including a tubular, biocompatible, electrically-charged membrane or guidance channel, having openings adapted to receive the ends of the severed nerve and defining a lumen through which the nerve can regenerate. The electrically-charged membrane can further include a polymeric electret material that is electrically poled. A method for repairing a severed nerve is also disclosed and includes placing severed nerve ends in proximity to each other within the lumen of the guidance channel of the present invention and securing the nerve ends to the device.

Abstract translation: 公开了用于再生切断的神经的医疗装置，其包括管状的，生物相容的，带电荷的膜或引导通道，其具有适于接收切断的神经的端部并限定神经可再生的内腔的开口。 带电膜可以进一步包括电极化的聚合物驻极体材料。 还公开了修复切断的神经的方法，并且包括在本发明的引导通道的内腔内彼此靠近地设置切断的神经末端并将神经末端固定到该装置。

公开(公告)号：US5030225A

公开(公告)日：1991-07-09

申请号：US621081

申请日：1990-11-30

Applicant: Patrick Aebischer ,  Robert F. Valentini

Inventor： Patrick Aebischer ,  Robert F. Valentini

IPC: A61B17/00 ,  A61B17/11 ,  A61F2/00 ,  A61L31/04 ,  A61L31/14

CPC classification number: A61L31/14 ,  A61B17/1128 ,  A61L31/04 ,  A61L31/048 ,  A61N1/0556 ,  A61N1/36103 ,  A61B17/00491 ,  A61B2017/00004 ,  A61F2002/30235 ,  A61F2230/0069 ,  A61L2430/32 ,  Y10S977/908

Abstract: A medical device is disclosed for use in regenerating a severed nerve. The device includes an implantable, tubular, electrically-charged membrane having openings adapted to receive the ends of the severed nerve and a lumen having a diameter ranging from about 0.5 millimeters to about 2.0 centimeters to permit regeneration of the nerve therethrough. The membrane is fabricated such that an electric charge is exhibited at the inner membrane surface to stimulate regeneration by axonal sprouting and process extension. Also disclosed are methods for repairing a severed nerve and for preparing a medical device for use in regeneration of a severed nerve.

Abstract translation: 公开了用于再生切断的神经的医疗装置。 该装置包括可植入的，管状带电的膜，其具有适于接纳切断的神经的端部的开口和具有约0.5毫米至约2.0厘米的直径的内腔，以允许神经通过其再生。 制造膜，使得在内膜表面显示电荷，以通过轴突发芽和加工延伸来刺激再生。 还公开了修复切断的神经和用于制备用于再次切断的神经的医疗装置的方法。

公开(公告)号：US4878913A

公开(公告)日：1989-11-07

申请号：US93371

申请日：1987-09-04

Applicant: Patrick Aebischer ,  Robert F. Valentini ,  Pierre M. Galletti

Inventor： Patrick Aebischer ,  Robert F. Valentini ,  Pierre M. Galletti

IPC: A61F2/72

CPC classification number: A61F2/72

Abstract: Devices and methods for transmitting neural signals from a proximal stump of a transected nerve to a prosthetic apparatus are disclosed employing microelectrodes, preferably conductive fiber networks, capable of sensing electrical signals from a nerve and transmitting such signals to a prosthetic apparatus; and a semipermeable guidance channel disposed about the microelectrodes. The channels include an opening adapted to receive the proximal stump of a transected nerve, such that the channel promotes the growth of the stump and the formation of an electrical connection between the transected nerve and the microelectrode.

公开(公告)号：US20070172454A1

公开(公告)日：2007-07-26

申请号：US11622284

申请日：2007-01-11

Applicant: Nicole Deglon ,  Patrick Aebischer ,  Jean-Charles Bensadoun

Inventor： Nicole Deglon ,  Patrick Aebischer ,  Jean-Charles Bensadoun

IPC: A61K48/00 ,  A61K38/20 ,  C12N15/867

CPC classification number: A61K38/204 ,  A61K48/00

Abstract: The invention relates to the use of an IL-6R/IL-6 chimera, a mutein, isoform, fused protein, functional derivative, active fraction or circularly permutated derivative or a salt thereof, for the manufacture of a medicament for the treatment and/or prevention of Huntington's disease.

Abstract translation: 本发明涉及IL-6R / IL-6嵌合体，突变蛋白，同种型，融合蛋白，功能衍生物，活性级分或环状置换衍生物或其盐在制备用于治疗和/ 或预防亨廷顿氏病。

公开(公告)号：US06800281B2

公开(公告)日：2004-10-05

申请号：US10008610

申请日：2001-11-08

Applicant: Patrick Aebischer ,  Susan Mary Kingsman ,  Stuart Naylor ,  Nicholas Mazarakis

Inventor： Patrick Aebischer ,  Susan Mary Kingsman ,  Stuart Naylor ,  Nicholas Mazarakis

IPC: A61K4800

CPC classification number: C12N15/86 ,  A61K48/00 ,  C07K14/4756 ,  C12N2740/15043

Abstract: Disclosed and claimed are methods for treating or preventing neurodegenerative diseases, conditions or maladies or symptoms or physiology associated therewith, such as treating or preventing Parkinson's disease or symptoms or physiology associated therewith such as motor deficits or nigrostriatal degeneration; or, for inducing nigrostriatal regeneration. Advantageously, the methods involve administering a lentiviral vector that expresses GDNF, such as human GDNF, or a variant, homolog, analog or derivative thereof.

Abstract translation: 公开并要求保护的是用于治疗或预防神经变性疾病，病症或疾病或症状或与之相关的生理学的方法，例如治疗或预防帕金森病或与之相关的症状或生理学，例如运动缺陷或黑质纹状体变性; 或用于诱导黑质纹状体再生。 有利地，所述方法包括施用表达GDNF的慢病毒载体，例如人GDNF，或其变体，同系物，类似物或衍生物。

公开(公告)号：US6083523A

公开(公告)日：2000-07-04

申请号：US148671

申请日：1998-09-04

Applicant: Keith E. Dionne ,  Dwaine F. Emerich ,  Diane Hoffman ,  Paul R. Sanberg ,  Lisa Christenson ,  Orion D. Hegre ,  David W. Scharp ,  Paul E. Lacy ,  Patrick Aebischer ,  Alfred V. Vasconcellos ,  Michael J. Lysaght ,  Frank T. Gentile

Inventor： Keith E. Dionne ,  Dwaine F. Emerich ,  Diane Hoffman ,  Paul R. Sanberg ,  Lisa Christenson ,  Orion D. Hegre ,  David W. Scharp ,  Paul E. Lacy ,  Patrick Aebischer ,  Alfred V. Vasconcellos ,  Michael J. Lysaght ,  Frank T. Gentile

IPC: A61F2/02 ,  A61K9/00 ,  A61K9/48 ,  A61K9/50 ,  A61K35/12 ,  A61K35/30 ,  A61K35/39 ,  A61K38/18 ,  A61K39/395 ,  A61K47/36 ,  A61K48/00 ,  A61L27/00 ,  C12N5/00 ,  C12N5/071 ,  C12N5/077

CPC classification number: A61K9/0092 ,  A61K35/12 ,  A61K35/30 ,  A61K35/39 ,  A61K38/185 ,  A61K48/00 ,  A61K9/0024 ,  A61K9/4816 ,  C12N5/0012 ,  C12N5/0062 ,  C12N5/0614 ,  C12N5/0656 ,  C12N5/0677 ,  A61K2035/126 ,  A61K2035/128 ,  C12N2510/02 ,  Y10S514/814 ,  Y10S514/866

Abstract: An immunoisolatory vehicle for the implantation into an individual of cells which produce a needed product or provide a needed metabolic function. The vehicle is comprised of a core region containing isolated cells and materials sufficient to maintain the cells, and a permselective, biocompatible, peripheral region free of the isolated cells, which immunoisolates the core yet provides for the delivery of the secreted product or metabolic function to the individual.

Abstract translation: 用于植入到产生所需产品或提供所需代谢功能的细胞个体中的免疫分析载体。 载体由含有分离的细胞和足以维持细胞的材料的核心区域组成，以及不含分离细胞的选择性选择性生物相容的外周区域，所述细胞免疫分离核心，但提供分泌产物或代谢功能的递送， 个人

公开(公告)号：US5554148A

公开(公告)日：1996-09-10

申请号：US453571

申请日：1995-05-26

Applicant: Patrick Aebischer ,  Paul C. DiCesare ,  Moses Goddard ,  Paul J. Mulhauser

Inventor： Patrick Aebischer ,  Paul C. DiCesare ,  Moses Goddard ,  Paul J. Mulhauser

IPC: A61F2/02 ,  A61K9/00 ,  A61K9/22 ,  A61K35/12 ,  A61K35/30 ,  A61M31/00 ,  B01J13/02 ,  C12N5/00 ,  C12N5/071 ,  C12N5/0793 ,  C12N11/04

CPC classification number: A61K9/0092 ,  A61F2/022 ,  A61K35/12 ,  A61K35/30 ,  A61K38/1825 ,  A61K9/0024 ,  A61K9/0085 ,  A61M31/002 ,  B01J13/02 ,  C12N11/04 ,  C12N5/0012 ,  C12N5/0614 ,  C12N5/0619 ,  C12N5/0676 ,  A61K2035/126 ,  A61M2210/0687 ,  A61M2210/0693 ,  C12N2533/30

Abstract: Refillable immunoisolatory neurological therapy devices for local and controlled delivery of a biologically active factor to the brain of a patient. The devices include a cell chamber adapted for infusion with nsecretory cells and having at least one semipermeable or permselective surface across which biologically active factors secreted by the cells can be delivered to the brain. The devices also include means for introducing secretory cells into the cell chamber, and means for renewing the cells or cell medium.

Abstract translation: 用于局部和控制地将生物活性因子递送到患者脑部的可补充的免疫隔离神经治疗装置。 所述装置包括适于与分泌细胞一起输注并具有至少一个半透性或选择性选择性表面的细胞室，细胞分泌的生物活性因子可以被输送到脑。 所述装置还包括用于将分泌细胞引入细胞室的装置和用于更新细胞或细胞培养基的装置。

公开(公告)号：US5389535A

公开(公告)日：1995-02-14

申请号：US169169

申请日：1993-12-17

Applicant: Patrick Aebischer ,  Lars Wahlberg

Inventor： Patrick Aebischer ,  Lars Wahlberg

IPC: A61F2/02 ,  A61K9/00 ,  A61K9/48 ,  A61K35/12 ,  A61M31/00 ,  B01J13/02 ,  B01J13/04 ,  C12N5/00 ,  C12N5/071 ,  C12N5/0793 ,  C12N11/04 ,  C12N11/08 ,  C12M1/40

CPC classification number: A61K9/0092 ,  A61F2/022 ,  A61K35/12 ,  A61K9/0024 ,  A61K9/0085 ,  A61K9/4816 ,  A61K9/4833 ,  A61M31/002 ,  B01J13/02 ,  B01J13/04 ,  C12N11/04 ,  C12N11/08 ,  C12N5/0012 ,  C12N5/0614 ,  C12N5/0619 ,  A61K2035/126 ,  A61K2035/128 ,  A61M2210/0687 ,  A61M2210/0693 ,  C12N2533/30

Abstract: Methods and systems are disclosed for encapsulating viable cells which produce biologically-active factors. The cells are encapsulated within a semipermeable, polymeric membrane by co-extruding an aqueous cell suspension and a polymeric solution through a common port to form a tubular extrudate having a polymeric outer coating which encapsulates the cell suspension. For example, the cell suspension and the polymeric solution can be extruded through a common extrusion port having at least two concentric bores, such that the cell suspension is extruded through the inner bore and the polymeric solution is extruded through the outer bore. The polymeric solution coagulates to form an outer coating. As the outer coating is formed, the ends of the tubular extrudate can be sealed to form a cell capsule. In one embodiment, the tubular extrudate is sealed at intervals to define separate cell compartments connected by polymeric links.

Abstract translation: 公开了用于包封产生生物活性因子的活细胞的方法和系统。 通过将水性细胞悬浮液和聚合物溶液共挤出通过共同的口以形成具有封装细胞悬浮液的聚合物外涂层的管状挤出物，将细胞包封在半透膜聚合物膜内。 例如，细胞悬浮液和聚合物溶液可以通过具有至少两个同心孔的共同挤出口挤出，使得细胞悬浮液通过内孔挤出并且聚合物溶液通过外孔挤出。 聚合物溶液凝结形成外涂层。 当形成外涂层时，管状挤出物的端部可被密封以形成电池盒。 在一个实施方案中，管状挤出物间隔密封以限定通过聚合物连接物连接的分离的细胞室。

公开(公告)号：US5158881A

公开(公告)日：1992-10-27

申请号：US461999

申请日：1990-01-08

Applicant: Patrick Aebischer ,  Lars Wahlberg

Inventor： Patrick Aebischer ,  Lars Wahlberg

IPC: A61J3/07 ,  A61F2/02 ,  A61K9/00 ,  A61K9/48 ,  A61K9/50 ,  A61K35/12 ,  A61K35/13 ,  A61M31/00 ,  B01J13/02 ,  B01J13/04 ,  C12N5/00 ,  C12N5/071 ,  C12N5/0793 ,  C12N11/04 ,  C12N11/08

CPC classification number: A61K9/0024 ,  A61F2/022 ,  A61K35/13 ,  A61K9/0085 ,  A61K9/0092 ,  A61K9/4816 ,  A61K9/4833 ,  A61M31/002 ,  B01J13/02 ,  B01J13/04 ,  C12N11/04 ,  C12N11/08 ,  C12N5/0012 ,  C12N5/0614 ,  C12N5/0619 ,  A61M2210/0687 ,  A61M2210/0693 ,  C12N2533/30

Abstract: Methods and systems are disclosed for encapsulating viable cells which produce biologically-active factors. The cells are encapsulated within a semipermeable, polymeric membrane by co-extruding an aqueous cell suspension and a polymeric solution through a common port to form a tubular extrudate having a polymeric outer coating which encapsulates the cell suspension. For example, the cell suspension and the polymeric solution can be extruded through a common extrusion port having at least two concentric bores, such that the cell suspension is extruded through the inner bore and the polymeric solution is extruded through the outer bore. The polymeric solution coagulates to form an outer coating. As the outer coating is formed, the ends of the tubular extrudate can be sealed to form a cell capsule. In one embodiment, the tubular extrudate is sealed at intervals to define separate cell compartments connected by polymeric links.

Abstract translation: 公开了用于包封产生生物活性因子的活细胞的方法和系统。 通过将水性细胞悬浮液和聚合物溶液共挤出通过共同的口以形成具有封装细胞悬浮液的聚合物外涂层的管状挤出物，将细胞包封在半透膜聚合物膜内。 例如，细胞悬浮液和聚合物溶液可以通过具有至少两个同心孔的共同挤出口挤出，使得细胞悬浮液通过内孔挤出并且聚合物溶液通过外孔挤出。 聚合物溶液凝结形成外涂层。 当形成外涂层时，管状挤出物的端部可被密封以形成电池盒。 在一个实施方案中，管状挤出物间隔密封以限定通过聚合物连接物连接的分离的细胞室。