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公开(公告)号：US20110076681A1
公开(公告)日：2011-03-31
申请号：US12798247
申请日：2010-03-31
申请人： Peter Michael Waterhouse , Linda Jane Lockett , Ming-Bo Wang , Timothy James Doran , Robert John Moore , Gerald Wayne Both
发明人： Peter Michael Waterhouse , Linda Jane Lockett , Ming-Bo Wang , Timothy James Doran , Robert John Moore , Gerald Wayne Both
CPC分类号： C12N15/113 , A01K2217/05 , A01K2217/058 , C12N15/11 , C12N15/1131 , C12N2310/11 , C12N2310/111 , C12N2310/3519 , C12N2310/53 , C12N2799/027
摘要： Methods and means for efficiently downregulating the expression of a target gene of interest in cell from an organism that is an animal, fungus, and protest. The invention provides chimeric nucleic acid molecules for downregulating target genes. The invention also provides modified cells and organisms comprising the chimeric nucleic acid molecules and compositions comprising the chimeric molecules.
摘要翻译： 用于从动物，真菌和抗原的生物体中有效地下调细胞中目标靶基因的表达的方法和装置。 本发明提供用于下调靶基因的嵌合核酸分子。 本发明还提供了修饰的细胞和生物体，其包含嵌合核酸分子和包含嵌合分子的组合物。
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公开(公告)号：US20080044906A1
公开(公告)日：2008-02-21
申请号：US10571384
申请日：2004-09-10
申请人： Peter Michael Waterhouse , Linda Jane Lockett , Ming-Bo Wang , Timothy James Doran , Robert John Moore , Gerald Wayne Both
发明人： Peter Michael Waterhouse , Linda Jane Lockett , Ming-Bo Wang , Timothy James Doran , Robert John Moore , Gerald Wayne Both
CPC分类号： C12N15/113 , A01K2217/05 , A01K2217/058 , C12N15/11 , C12N15/1131 , C12N2310/11 , C12N2310/111 , C12N2310/3519 , C12N2310/53 , C12N2799/027
摘要： Methods and means for efficiently downregulating the expression of a target gene of interest in cell from an organism that is an animal, fungus and protist. The invention provides chimeric nucleic acid molecules for downregulating target genes. The invention also provides modified cells and organisms comprising the chimeric nucleic acid molecules and compositions comprising the chimeric molecules.
摘要翻译： 用于从动物，真菌和原生生物的生物体中有效地下调目标基因在细胞中的表达的方法和手段。 本发明提供用于下调靶基因的嵌合核酸分子。 本发明还提供了修饰的细胞和生物体，其包含嵌合核酸分子和包含嵌合分子的组合物。
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公开(公告)号：US06759516B2
公开(公告)日：2004-07-06
申请号：US09861451
申请日：2001-05-21
IPC分类号： C07K100
CPC分类号： C12N15/1086 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/30 , C07K2319/21 , C07K2319/41 , C07K2319/42 , C07K2319/43 , Y10S530/82 , Y10S530/825
摘要： The present invention relates to method of identifying gene sequences of potential vaccine antigens. Also included are gene sequences and the polypeptides encoded by the gene sequences as well as the use of such sequences to induce a protective immune response in animals. Particularly, the invention relates to identifying potential antigen gene sequences of Mycoplasma, preferably Mycoplasma hyopneumoniae. In one aspect of the present invention there is provided a method of identifying expression proteins translated from a nucleotide sequence in an expression vector, said method comprising the use of a marker co-expressed with a protein translated from the nucleotide sequence. In a further aspect of the present invention there is provided a method of identifying a therapeutic antigenic gene sequence encoding a therapeutic antigenic protein of a disease, from a sample of nucleotide sequences. Preferably the marker is a polyHis tag.
摘要翻译： 本发明涉及鉴定潜在疫苗抗原基因序列的方法。 还包括基因序列和由基因序列编码的多肽以及这些序列在动物中诱导保护性免疫应答的用途。 特别地，本发明涉及鉴定支原体，优选猪肺炎支原体的潜在的抗原基因序列。 在本发明的一个方面，提供了鉴定从表达载体中的核苷酸序列翻译的表达蛋白质的方法，所述方法包括使用与从核苷酸序列翻译的蛋白质共表达的标记物。 在本发明的另一方面，提供了从核苷酸序列的样品鉴定编码疾病的治疗性抗原性蛋白质的治疗性抗原基因序列的方法。 优选地，标记是polyHis标签。
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公开(公告)号：US20110209231A1
公开(公告)日：2011-08-25
申请号：US12451540
申请日：2008-05-16
申请人： Timothy James Doran , James Climie McKay , Robert John Moore , John William Lowenthal , Scott Geoffrey Tyack
发明人： Timothy James Doran , James Climie McKay , Robert John Moore , John William Lowenthal , Scott Geoffrey Tyack
CPC分类号： C12N15/85 , A01K2217/058 , A01K2227/105 , A01K2227/30 , A01K2267/0337 , C12N15/1131 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/11 , C12N2760/16111 , C12N2800/90 , C12N2830/38 , C12N2830/90
摘要： The present invention relates to nucleic acid molecules comprising a double-stranded region, and nucleic acid constructs encoding therfor, that are useful for the treatment and/or prevention of influenza. In particular, the present invention relates to nucleic acid constructs encoding a double stranded RNA molecule(s) that can be used to produce transgenic poultry, for example chickens, such that they are at least less susceptible to an avian influenza infection. Also provided are nucleic acid molecules comprising a double-stranded region that can be used as a therapeutic to treat and/or prevent, for example, avian influenza in poultry.
摘要翻译： 本发明涉及包含双链区域的核酸分子和编码其的核酸构建体，其可用于治疗和/或预防流感。 特别地，本发明涉及编码可用于产生转基因家禽（例如鸡）的双链RNA分子的核酸构建体，使得它们至少不易受禽流感感染的影响。 还提供了包含双链区域的核酸分子，其可以用作治疗和/或预防家禽禽流感的治疗剂。
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公开(公告)号：US20100306869A1
公开(公告)日：2010-12-02
申请号：US12664097
申请日：2008-06-12
IPC分类号： A01K67/027 , C12N15/00 , C07H21/02 , C12N15/63 , C12N5/07
CPC分类号： C12N15/8509 , A01K2217/058 , A01K2227/30 , A01K2267/02 , C12N15/111 , C12N15/113 , C12N15/1136 , C12N2310/14 , C12N2320/32
摘要： The present invention relates to methods of modulating traits, particularly production traits, in avians such as chickens. In particular, the invention relates to the in ovo delivery of a dsRNA molecule, especially siRNAs, to modify production traits in commercially important birds.
摘要翻译： 本发明涉及在禽类如鸡中调节特性，特别是生产性状的方法。 特别地，本发明涉及dsRNA分子，特别是siRNAs的ovo递送，以改变商业上重要的鸟类的生产性状。
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公开(公告)号：US20120227119A1
公开(公告)日：2012-09-06
申请号：US13139163
申请日：2009-12-16
申请人： Timothy James Doran , Robert John Moore , John William Lowenthal , Craig Smith , Andrew Henrik Sinclair
发明人： Timothy James Doran , Robert John Moore , John William Lowenthal , Craig Smith , Andrew Henrik Sinclair
IPC分类号： A01K67/027 , A61K31/713
CPC分类号： C12N15/111 , A01K67/027 , A01K2207/05 , A01K2227/30 , A01K2267/02 , C07K14/4702 , C12N15/113 , C12N2310/14 , C12N2320/32
摘要： The present invention relates to nucleic acids and methods for modulating the sex of avians. In particular, the invention relates to the in ovo delivery of a dsRNA molecule, especially siRNAs, to increase the production of female birds.
摘要翻译： 本发明涉及调节禽类性别的核酸和方法。 特别地，本发明涉及dsRNA分子，特别是siRNAs的卵内递送，以增加雌性鸟的产生。
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公开(公告)号：US20120084873A1
公开(公告)日：2012-04-05
申请号：US13147856
申请日：2010-02-08
申请人： Andrew Sinclair , Craig Smith , Timothy James Doran , Robert John Moore , John William Lowenthal
发明人： Andrew Sinclair , Craig Smith , Timothy James Doran , Robert John Moore , John William Lowenthal
IPC分类号： A01K67/027 , G06Q90/00 , C07H21/02 , A61K31/7088 , C12N15/85
CPC分类号： A01K67/02 , A01K67/0275 , A01K2217/00 , A01K2217/058 , A01K2227/30 , A01K2267/02 , C07K14/465 , C12N15/8509 , C12N2799/027 , G06Q99/00
摘要： The present invention relates generally to the field of sex determination of animals. Provided are methods and agents to manipulate sex determination, particularly in avian animals such as chickens, through a male chromosome-linked testis (sex) regulatory gene. Expression or activity of the DMRT1 gene or protein is modulated to produce animals with displaying a phenotype sex that differs from their genotype.
摘要翻译： 本发明一般涉及动物的性别决定领域。 提供了通过雄性染色体连锁的睾丸（性别）调节基因来操作性别测定的方法和试剂，特别是在禽类动物如鸡中。 DMRT1基因或蛋白质的表达或活性被调节以产生具有不同于其基因型的表型性别的动物。
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公开(公告)号：US08066987B2
公开(公告)日：2011-11-29
申请号：US12064947
申请日：2006-08-29
IPC分类号： A01N63/00
CPC分类号： A61K39/0258 , A61K39/0275 , A61K2039/522 , A61K2039/523 , A61K2039/542 , A61K2039/552 , Y02A50/474 , Y02A50/482
摘要： The present invention relates to methods for the delivery of biologically active polypeptides to a subject by colonizing non-pathogenic Gram negative bacteria. Also provided by this invention are methods of treating or preventing diseases by administering colonizing Gram negative bacteria that express one or more biologically active polypeptides. The colonizing non-pathogenic Gram negative bacteria may be administered in pharmaceutical formulations.
摘要翻译： 本发明涉及通过定植非致病性革兰氏阴性细菌将生物活性多肽递送给受试者的方法。 本发明还提供了通过施用表达一种或多种生物活性多肽的定植革兰氏阴性细菌来治疗或预防疾病的方法。 定植的非致病性革兰氏阴性细菌可以以药物制剂施用。
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公开(公告)号：US20100291131A1
公开(公告)日：2010-11-18
申请号：US12663215
申请日：2008-06-06
IPC分类号： A61K39/08 , C12Q1/68 , G01N33/53 , C12Q1/02 , C12P21/06 , C12N1/36 , C12N1/20 , C12N15/63 , G01N33/00 , C07K14/33 , C07K16/12 , C07H21/04 , A01K67/00
CPC分类号： C12N1/36 , A61K39/00 , A61K2039/505 , A61K2039/517 , A61K2039/522 , A61K2039/523 , A61K2039/53 , C07K14/33
摘要： The present invention relates to a polypeptide based toxin that originates from Clostridium perfringens. The invention further relates to immunogenic compositions comprising the toxin and methods to vaccinate animals, for example chickens, such that they are less susceptible to clostridial diseases. Methods to determine whether an animal has been exposed to the toxin, polynucleotides encoding the toxin and attenuated bacteria that express a reduced or less active form of the toxin are also disclosed.
摘要翻译： 本发明涉及源自产气荚膜梭菌的基于多肽的毒素。 本发明进一步涉及包含毒素的免疫原性组合物和接种动物（例如鸡）的方法，使得它们对梭菌性疾病较不敏感。 还公开了确定动物是否暴露于毒素的方法，编码毒素的多核苷酸和表达减毒活性形式或毒素的减毒细菌的方法。
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公开(公告)号：US20090022691A1
公开(公告)日：2009-01-22
申请号：US12064947
申请日：2006-08-29
CPC分类号： A61K39/0258 , A61K39/0275 , A61K2039/522 , A61K2039/523 , A61K2039/542 , A61K2039/552 , Y02A50/474 , Y02A50/482
摘要： The present invention relates to methods for the delivery of biologically active polypeptides to a subject by colonising non-pathogenic Gram negative bacteria. Also provided by this invention are methods of treating or preventing diseases by administering colonising Gram negative bacteria that express one or more biologically active polypeptides. The colonising non-pathogenic Gram negative bacteria may be administered in pharmaceutical formulations.
摘要翻译： 本发明涉及通过定植非致病性革兰氏阴性细菌将生物活性多肽递送给受试者的方法。 本发明还提供了通过施用表达一种或多种生物活性多肽的定植革兰氏阴性细菌来治疗或预防疾病的方法。 定植的非致病性革兰氏阴性细菌可以以药物制剂施用。
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