公开(公告)号：US08337700B1

公开(公告)日：2012-12-25

申请号：US11360129

申请日：2006-02-23

Applicant: Peter Zuk, Jr.

Inventor： Peter Zuk, Jr.

IPC: B01D11/00 ,  B01D37/00 ,  A61B19/00

CPC classification number: A61M1/3621 ,  A61M1/3633

Abstract: A biological fluid filtration device, system, and method, for filtering a biological fluid, the device comprising a housing having an inlet, a first outlet and a second outlet, with a first fluid flow path defined between the inlet and the first outlet, with a second fluid flow path defined between the inlet and the second outlet, with a first biological fluid filtration media interposed between the inlet and the first outlet and across the first fluid flow path, with a second biological fluid filtration media interposed between the inlet and the second outlet and across the second fluid flow path, the housing essentially lacking a solid partition wall between the first biological fluid filtration media and the second biological fluid filtration media, a first flow restriction may be added downstream of the first biological fluid filtration media, and a second flow restriction may be added downstream of the second biological fluid filtration media, in another embodiment, the device comprises a housing having an inlet an outlet with a flow path defined between the inlet and the outlet, with a biological fluid filtration media interposed between the inlet and the outlet and across the fluid flow path, the device further including a flow restriction downstream of the biological fluid filtration media.

Abstract translation: 一种用于过滤生物流体的生物流体过滤装置，系统和方法，所述装置包括具有入口，第一出口和第二出口的壳体，所述第一流体流动路径限定在所述入口和所述第一出口之间， 限定在所述入口和所述第二出口之间的第二流体流动路径，其中介于所述入口和所述第一出口之间并跨过所述第一流体流动路径的第一生物流体过滤介质，第二生物流体过滤介质介于所述入口和所述第二出口之间， 第二出口并跨越第二流体流动路径，壳体基本上在第一生物流体过滤介质和第二生物流体过滤介质之间缺少固体分隔壁，第一流动限制可以被添加到第一生物流体过滤介质的下游，以及 在另一个实施方案中，第二生物流体过滤介质的下游可以添加第二流量限制 将具有入口的入口设置为具有限定在入口和出口之间的流动路径的外壳的壳体，其中插入在入口和出口之间并跨越流体流动路径的生物流体过滤介质，该装置还包括在 生物流体过滤介质。

公开(公告)号：US06951762B2

公开(公告)日：2005-10-04

申请号：US10107075

申请日：2002-03-27

Applicant: Peter Zuk, Jr.

Inventor： Peter Zuk, Jr.

IPC: B01F1/00 ,  B01F13/08 ,  B01F13/10 ,  B01F15/06 ,  B01J14/00 ,  B01J19/00 ,  C40B60/14 ,  G01N13/00 ,  G01N33/15 ,  G01N35/00 ,  G01N1/10 ,  B01L3/00 ,  B01L3/02 ,  G01N1/00 ,  G01N1/18

CPC classification number: B01F13/1013 ,  B01F1/00 ,  B01F13/0818 ,  B01F2015/062 ,  B01J14/00 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00306 ,  B01J2219/00346 ,  B01J2219/00351 ,  B01J2219/00481 ,  B01J2219/00585 ,  C40B60/14 ,  G01N13/00 ,  G01N33/15 ,  G01N2013/006 ,  G01N2035/00485 ,  G01N2035/00534 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/255 ,  Y10T436/2575

Abstract: An apparatus and method for mixing a solvent with a solute to form a solution, and for separating said solution from excess solute so that a sample of solution less excess solute can be obtained, and for synthesizing drug compounds.

Abstract translation: 将溶剂与溶质混合以形成溶液的装置和方法，并将所述溶液与过量溶质分离，从而可以获得溶液少于过量溶质的样品，并用于合成药物化合物。

公开(公告)号：US5779902A

公开(公告)日：1998-07-14

申请号：US903271

申请日：1997-07-25

Applicant: Peter Zuk, Jr.

Inventor： Peter Zuk, Jr.

IPC: A61M1/36 ,  B01D19/00 ,  B01D36/00 ,  B01D46/00 ,  B01D61/18 ,  B01D61/20 ,  B01D63/08 ,  B01D35/01

CPC classification number: B01D63/087 ,  A61M1/3627 ,  A61M1/3633 ,  A61M1/3643 ,  A61M1/3652 ,  B01D19/0031 ,  B01D36/001 ,  B01D46/0012 ,  B01D61/18 ,  B01D61/20 ,  B01D63/08 ,  A61M2202/0439 ,  A61M2205/7527 ,  A61M2205/7536

Abstract: A liquid filtration device useable for removing leukocytes from blood is disclosed. Located in-line on the upstream side of the filtration device is a vent device which is configured to allow liquid being filtered to flow therethrough and creates a pressure head sufficient to prevent air from entering the vent until the fluid flow therethrough stops and thereby allows air to automatically enter the vent to allow the air to drain liquid through the filtration device. The vent minimizes air entering the filtration system during the flow of liquid flow therethrough while automatically allowing air to enter the system and thereby drain the system when the flow of fluid stops.

Abstract translation: 公开了一种可用于从血液中除去白细胞的液体过滤装置。 位于过滤装置的上游侧的管线是排气装置，其构造成允许被过滤的液体流过其中并产生足以防止空气进入排气口的压力头，直到流体流过其中止，从而允许空气 自动进入排气口，使空气通过过滤装置排出液体。 排气口在流过液体流动过程中使进入过滤系统的空气最小化，同时自动允许空气进入系统，从而当流体流动停止时排出系统。

公开(公告)号：US07546925B1

公开(公告)日：2009-06-16

申请号：US11171724

申请日：2005-06-30

Applicant: Peter Zuk, Jr.

Inventor： Peter Zuk, Jr.

IPC: B01D29/05 ,  B01D63/08

CPC classification number: B01D63/087 ,  B01D61/18 ,  B01D63/081 ,  B01D2201/305 ,  B01D2201/34 ,  B01D2313/04 ,  B01D2313/23 ,  B01D2313/50 ,  B01L3/502 ,  B01L2300/042 ,  B01L2300/0681 ,  B01L2300/0832 ,  B01L2400/049 ,  G01N2001/4088

Abstract: A vacuum filtration apparatus (900) for detecting microorganisms and particulates in liquid samples. The apparatus includes a base (901), an absorbent pad (991), a filter (990), a funnel (930), and a lid (960). The funnel is releasably attached to the base, and may contain an integral flexible seal for releasably sealing the filter to the base. The outer wall of the lid may be segmented to make it flexible, this flexibility allows it to be releasably attached to the funnel or the base. The apparatus is designed so that any funnel will fit any base, and any lid will fit any base or any funnel when all parts are manufactured to normal tolerances. The apparatus may be configured to keep the filter wrinkle free in both the dry and wet states.

Abstract translation: 一种真空过滤装置（900），用于检测液体样品中的微生物和微粒。 该装置包括基座（901），吸收垫（991），过滤器（990），漏斗（930）和盖（960）。 漏斗可释放地附接到基座，并且可以包含用于将过滤器可释放地密封到基座的整体柔性密封件。 盖的外壁可以被分段以使其变得柔性，这种柔性允许其可释放地附接到漏斗或底座。 该设备的设计使得任何漏斗将适合任何底座，并且当所有零件制造成正常公差时，任何盖子都适合任何底座或任何漏斗。 该装置可以被配置成使干燥和潮湿状态下的滤纸皱纹保持不变。

公开(公告)号：US07270757B1

公开(公告)日：2007-09-18

申请号：US10693757

申请日：2003-10-24

Applicant: Peter Zuk, Jr.

Inventor： Peter Zuk, Jr.

IPC: B01D37/00 ,  B01D29/00

CPC classification number: A61M1/3633

Abstract: A high capacity gravity feed filter for filtering blood and blood products or the like includes a body having an inlet port, an outlet port, two filter wells, at least one filter element disposed in each of said filter wells, between the inlet port and outlet port so as to filter liquid which flows into the filtration device via the inlet port. The filter elements divide each of said filter wells into a first chamber and a second chamber. The device allows gases to vent the filtration device through the outlet port. The means may include a through slot located at the top of each of said second chambers. The filtration device allows air therein to be purged downstream into a receiving blood bag without the manipulation of the height of the filtration device or the receiving blood bag.

Abstract translation: 用于过滤血液和血液制品等的高容量重力进料过滤器包括具有入口，出口，两个过滤器孔，设置在每个所述过滤器孔中的至少一个过滤元件，入口和出口之间的主体 以便通过入口过滤流入过滤装置的液体。 过滤元件将每个所述过滤器孔分成第一室和第二室。 该装置允许气体通过出口端口排出过滤装置。 该装置可以包括位于每个所述第二室的顶部的通槽。 过滤装置允许其中的空气在下游被吹扫到接收血液袋中，而不用操纵过滤装置或接收血袋的高度。

公开(公告)号：US06913152B2

公开(公告)日：2005-07-05

申请号：US10263838

申请日：2002-10-03

Applicant: Peter Zuk, Jr.

Inventor： Peter Zuk, Jr.

IPC: B01D29/05 ,  B01D61/18 ,  B01D63/08 ,  B01L3/00 ,  G01N1/28 ,  G01N1/40 ,  B01D29/085

CPC classification number: B01D29/05 ,  B01D29/085 ,  B01D61/18 ,  B01D63/081 ,  B01D63/087 ,  B01D2201/305 ,  B01D2201/34 ,  B01L3/502 ,  B01L2300/042 ,  B01L2300/0681 ,  B01L2300/0832 ,  B01L2400/049 ,  G01N1/40 ,  G01N1/4077

Abstract: A vacuum filtration apparatus (900) for detecting microorganisms and particulates in liquid samples. The apparatus includes a base (901), an absorbent pad (991), a filter (990), a funnel (930), and a lid (960). The funnel is releasably attached to the base, and may contain an integral flexible seal for releasably sealing the filter to the base. The outer wall of the lid may be segmented to make it flexible, this flexibility allows it to be releasably attached to the funnel or the base. The apparatus is designed so that any funnel will fit any base, and any lid will fit any base or any funnel when all parts are manufactured to normal tolerances. The apparatus may be configured to to keep the filter wrinkle free in both the dry and wet states.

Abstract translation: 一种真空过滤装置（900），用于检测液体样品中的微生物和微粒。 该装置包括基座（901），吸收垫（991），过滤器（990），漏斗（930）和盖（960）。 漏斗可释放地附接到基座，并且可以包含用于将过滤器可释放地密封到基座的整体柔性密封件。 盖的外壁可以被分段以使其变得柔性，这种柔性允许其可释放地附接到漏斗或底座。 该设备的设计使得任何漏斗将适合任何底座，并且当所有零件制造成正常公差时，任何盖子都适合任何底座或任何漏斗。 该装置可以被配置成在干燥和潮湿状态下保持过滤器的皱纹自由。

公开(公告)号：US6010633A

公开(公告)日：2000-01-04

申请号：US812717

申请日：1997-03-06

Applicant: Peter Zuk, Jr. ,  Jonathan C. Alt

Inventor： Peter Zuk, Jr. ,  Jonathan C. Alt

IPC: A61K35/14 ,  A61K35/16 ,  A61M1/02 ,  A61M1/36 ,  B01D24/02 ,  B01D29/00 ,  B01D29/01 ,  B01D35/02 ,  B01D61/18 ,  B01D61/20 ,  B01D63/00 ,  B01D63/08 ,  B01D37/00 ,  B01D24/24

CPC classification number: B01D63/08 ,  A61M1/0209 ,  A61M1/0218 ,  A61M1/0231 ,  A61M1/3633 ,  B01D61/18 ,  B01D61/20

Abstract: An in-line gravity filtration device for biological fluids such as blood or blood products is disclosed. The device includes a series of channels formed downstream of filtration elements. The channels are defined in cross sectional area by the distance between the filtration elements and their bottoms. The channels are configured to form flow paths to an outlet port so that air within the channels is forced downstream through the outlet port thereby minimizing air being trapped on the downstream side of the device. For optimum performance, the cross section area of a single continuous channel, or the sum of the cross sectional area of parallel channels, leading to a single outlet port, should not exceed the cross sectional area of the outlet port.

Abstract translation: 公开了一种生物流体如血液或血液制品的在线重力过滤装置。 该装置包括在过滤元件下游形成的一系列通道。 通道以横截面积限定过滤元件与其底部之间的距离。 通道被配置成形成到出口的流动路径，使得通道内的空气被迫通过出口端口下游，从而最小化被捕获在设备的下游侧的空气。 为获得最佳性能，单个连续通道的横截面面积或通向单个出口的平行通道的横截面积之和应不超过出口的横截面面积。

公开(公告)号：US5798041A

公开(公告)日：1998-08-25

申请号：US524049

申请日：1995-09-06

Applicant: Peter Zuk, Jr.

Inventor： Peter Zuk, Jr.

IPC: A61M1/02 ,  A61M1/36 ,  B01D19/00 ,  B01D29/00 ,  B01D29/01 ,  B01D29/92 ,  B01D35/02 ,  B01D36/00 ,  B01D61/18 ,  B01D61/20 ,  B01D63/08 ,  B01D65/00 ,  B01D29/05

CPC classification number: A61M1/3633 ,  A61M1/3627 ,  A61M1/3643 ,  A61M1/3652 ,  B01D19/0031 ,  B01D29/012 ,  B01D36/001 ,  B01D61/18 ,  B01D61/20 ,  B01D63/08 ,  B01D63/087 ,  B01D65/00 ,  A61M2202/0439 ,  A61M2205/7527 ,  A61M2206/12

Abstract: An in-line liquid filtration device useable for filtration of blood, blood products or the like includes a housing having an inlet port, an outlet port, at least one filter element disposed in the housing between the inlet port and outlet port so as to filter liquid which flows into the filtration device via the inlet port. The filter element divides the housing into a first chamber and a second chamber. The device allows gases to vent the filtration device through the outlet port. The means may include a flow deflector within the first chamber and/or the second chamber. The means may also include a channel, preferably spiral, within either the first chamber and/or second chamber. The filtration device allows air therein to be purged downstream into either an air collecting bag or into the blood receiving bag without the manipulation of the height of the filtration device or the blood receiving bag.

公开(公告)号：US08361320B2

公开(公告)日：2013-01-29

申请号：US12842579

申请日：2010-07-23

Applicant: Peter Zuk, Jr.

Inventor： Peter Zuk, Jr.

IPC: B01D35/28 ,  B01D37/00 ,  B01D61/00 ,  B01D35/00

CPC classification number: A61M1/0209 ,  A61M1/0218 ,  A61M1/0231 ,  A61M1/3633 ,  B01D69/06 ,  B01D69/10

Abstract: Biological fluid filtration systems including biological fluid filtration devices capable of filtering blood or blood products, including the removal of leukocytes from the blood or blood product. Each system includes a means to automatically drain the biological fluid upstream of the biological fluid filtration media disposed in the biological fluid filtration device. Both single sided and double sided biological fluid filtration devices are disclosed, including double sided biological fluid filtration devices with a solid partition wall with a first independent fluid flow path on one side of the partition wall, and a second independent fluid flow path on the other side of the partition wall. Draining means include vent filtration devices, diaphragm draining devices, and biological fluid filtration devices that include an integral diaphragm. The biological fluid filtration devices include low hold-up volume filter underdrains that purge in excess of 95% of the initial air in the device before liquid begins to flow from the outlet, thereby allowing the devices to be used in bed side applications. Variable surface area biological fluid filtration devices are disclosed that further reduce hold-up volume.

Abstract translation: 生物流体过滤系统包括能够过滤血液或血液制品的生物流体过滤装置，包括从血液或血液制品中除去白细胞。 每个系统包括自动排出生物流体过滤装置中设置的生物流体过滤介质上游的生物流体的装置。 公开了单面和双面生物流体过滤装置，包括双面生物流体过滤装置，其具有在分隔壁的一侧上具有第一独立流体流动路径的固体分隔壁和在另一侧上的第二独立流体流动路径 侧壁的隔墙。 排水装置包括排气过滤装置，隔膜排放装置和包括整体隔膜的生物流体过滤装置。 生物流体过滤装置包括低滞留容积的过滤器排水，在液体从出口开始流动之前，该装置能够清除装置中初始空气的95％以上，从而允许这些装置用于床侧应用。 公开了可变表面积的生物流体过滤装置，其进一步减少滞留体积。

公开(公告)号：US6015500A

公开(公告)日：2000-01-18

申请号：US119292

申请日：1998-07-20

Applicant: Peter Zuk, Jr.

Inventor： Peter Zuk, Jr.

IPC: A61M1/36 ,  B01D19/00 ,  B01D36/00 ,  B01D46/00 ,  B01D61/18 ,  B01D61/20 ,  B01D63/08 ,  B01D37/00 ,  B01D35/01

CPC classification number: B01D63/087 ,  A61M1/3627 ,  A61M1/3633 ,  A61M1/3643 ,  A61M1/3652 ,  B01D19/0031 ,  B01D36/001 ,  B01D46/0012 ,  B01D61/18 ,  B01D61/20 ,  B01D63/08 ,  A61M2202/0439 ,  A61M2205/7527 ,  A61M2205/7536

Abstract: A liquid filtration device useable for removing leukocytes from blood contains a first chamber which is in fluid flow relationship with a second chamber. Filtration elements separate the first chamber from the second chamber so that liquid flowing from the first chamber is filtered thereby prior to entry into the second chamber. A passage leads from the second chamber into the first chamber and a hydrophobic filter may be used to prevent liquid from the first chamber from flowing through the passage into the second chamber while allowing air to flow therethrough. An outlet is located in the second chamber, preferably at the bottom thereof. A second outlet may be located within the second chamber and may be placed in fluid flow relationship therewith by a conduit or the like.

Abstract translation: 可用于从血液中除去白细胞的液体过滤装置包含与第二腔流体流动关系的第一腔室。 过滤元件将第一室与第二室分开，使得从第一室流出的液体在进入第二室之前被过滤。 通道从第二室引入第一室，并且可以使用疏水过滤器来防止来自第一室的液体流过通道进入第二室，同时允许空气流过其中。 出口位于第二室中，优选位于其底部。 第二出口可以位于第二室内并且可以通过管道等与流体流动关系地放置。