公开(公告)号：US20230228755A1

公开(公告)日：2023-07-20

申请号：US18102088

申请日：2023-01-27

Applicant: Savicell Diagnostic Ltd. ,  Ramot at Tel-Aviv University Ltd.

Inventor： Giora DAVIDOVITS ,  Fernando PATOLSKY ,  David Eyal DAVIDOVITS ,  Irit ARBEL ,  Shoval TIRMAN ,  Aviv LUTATY ,  Tali SCIENMANN ,  Reuven TIROSH ,  Hagit PERETZ-SOROKA

IPC: G01N33/574 ,  G01N33/50

CPC classification number: G01N33/57423 ,  G01N33/5091 ,  A61K45/06

Abstract: A method of diagnosing lung cancer in a subject-in-need thereof is provided. The method comprises:



(a) providing a biological sample of the subject which comprises peripheral blood mononuclear cells (PBMCs);
(b) in vitro contacting the PBMCs with a stimulant selected from the group consisting of the stimulants listed in Tables 3 and 4; and
(c) measuring metabolic activity of the PBMCs having been contacted according to (b), wherein a statistically significant change in the metabolic activity of the PBMCs as compared to a control sample is indicative of lung cancer.

公开(公告)号：US20190200923A1

公开(公告)日：2019-07-04

申请号：US16060038

申请日：2016-12-08

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Fernando PATOLSKY ,  Vadim KRIVITSKY ,  Marina ZVERZHINETSKY

IPC: A61B5/00 ,  G01N27/414 ,  A61B5/1473 ,  H01L29/16 ,  H01L29/06

CPC classification number: A61B5/4866 ,  A61B5/1473 ,  A61B5/6833 ,  A61B5/6847 ,  B82Y15/00 ,  G01N27/4146 ,  G01N33/5005 ,  H01L23/532 ,  H01L29/06 ,  H01L29/0673 ,  H01L29/16 ,  H01L51/0049 ,  H01L51/0545 ,  H01L51/0558

Abstract: A sensing element comprises a transistor having a gate electrode, a source electrode, a gate electrode and a semiconductor nanostructure connecting between the source and the gate electrodes. The semiconductor nanostructure is modified by a functional moiety covalently attached thereto. A voltage source is connected to the gate electrode. A controller controls a gate voltage applied by the voltage source to the gate electrode such as to reverse a redox reaction occurring when the moiety contacts a redox reactive agent.

公开(公告)号：US20180372678A1

公开(公告)日：2018-12-27

申请号：US16060423

申请日：2016-12-08

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Fernando PATOLSKY ,  Vadim KRIVITSKY ,  Marina ZVERZHINETSKY

IPC: G01N27/414 ,  H01L23/532 ,  H01L29/06 ,  H01L51/00 ,  H01L51/05

Abstract: A method of detecting a presence and/or concentration of a marker, e.g., a marker, in a liquid, e.g., a liquid, is disclosed. The method comprises: contacting the liquid with a sensor having an immobilized affinity moiety interacting with the marker and being configured to generate a detectable signal responsively to the interaction. The method further comprises washing the liquid off the sensor, and detecting the presence and/or concentration of the marker based on a detectable signal received from the sensor within a time-window beginning a predetermined time period after a beginning time of the washing.

公开(公告)号：US20160204283A1

公开(公告)日：2016-07-14

申请号：US14912407

申请日：2014-08-11

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Fernando PATOLSKY ,  Alon KOSLOFF

IPC: H01L31/028 ,  H01L31/0224 ,  H01L31/18 ,  H01L31/0352 ,  H01L31/0745

CPC classification number: H01L31/028 ,  H01L21/0245 ,  H01L21/0251 ,  H01L21/02513 ,  H01L21/02532 ,  H01L21/02603 ,  H01L21/0262 ,  H01L21/02653 ,  H01L31/022425 ,  H01L31/035227 ,  H01L31/03529 ,  H01L31/0687 ,  H01L31/0725 ,  H01L31/0745 ,  H01L31/1812 ,  Y02E10/544

Abstract: A photovoltaic cell device is disclosed. The device comprises: an active region having a plurality of spaced-apart elongated nanostructures aligned vertically with respect to an electrically conductive substrate, wherein each elongated nanostructure has at least one p-n junction characterized by a bandgap within the electromagnetic spectrum, and is coated by an electrically conductive layer being electrically isolated from the substrate.

Abstract translation: 公开了一种光电池装置。 该器件包括：有源区，其具有相对于导电衬底垂直排列的多个间隔开的细长纳米结构，其中每个细长纳米结构具有至少一个pn结，其特征在于电磁光谱内的带隙，并且由 导电层与衬底电隔离。

公开(公告)号：US20210278362A1

公开(公告)日：2021-09-09

申请号：US17141296

申请日：2021-01-05

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Fernando PATOLSKY ,  Vadim KRIVITSKY ,  Boris FILANOVSKY

IPC: G01N27/404 ,  G01N33/00 ,  G01N27/30

Abstract: A carbon electrode having a functional moiety that forms a charge-transfer complex with a nitro-containing compound covalently attached to a surface of the electrode, and a process of preparing such an electrode are provided. Also provided are sensing systems integrating the carbon electrode and methods utilizing same for electrochemical detection of nitro-containing compounds.

公开(公告)号：US20170243911A1

公开(公告)日：2017-08-24

申请号：US15437897

申请日：2017-02-21

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Fernando PATOLSKY ,  Sharon LEFLER ,  Moria KWIAT ,  Ella DAVIDI ,  Omri HEIFLER

IPC: H01L27/146 ,  H03K17/78 ,  G01N21/64

CPC classification number: H01L27/14645

Abstract: A light sensor comprises a nanostructure connectable to a source electrode and a drain electrode, and light sensitive moiety covalently attached to a surface of the nanostructure. The light sensitive moiety comprises a light sensitive molecule having an absorbance spectrum in a visible range. The light sensitive molecule is selected such that upon irradiation of the light sensor by light having a central wavelength within the absorbance spectrum, the sensitive molecule transfers or extracts an electron to or from the surface of the nanostructure.

公开(公告)号：US20170062213A1

公开(公告)日：2017-03-02

申请号：US14849865

申请日：2015-09-10

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Fernando PATOLSKY ,  Guy DAVIDI ,  Alexander PEVZNER

IPC: H01L21/02 ,  H01L29/06 ,  H01L29/16 ,  H01L21/3065

CPC classification number: H01L21/02606 ,  H01L21/02532 ,  H01L21/02603 ,  H01L21/0262 ,  H01L21/02664 ,  H01L21/3065 ,  H01L29/0669 ,  H01L29/0673 ,  H01L29/068 ,  H01L29/16 ,  H01L29/775

Abstract: A method of fabricating a nanostructure, which comprises forming an elongated tubular nanostructure, and generating conditions for said tubular nanostructure to unwrap.

Abstract translation: 一种制造纳米结构的方法，其包括形成细长的管状纳米结构，并产生用于所述管状纳米结构展开的条件。

公开(公告)号：US20240361320A1

公开(公告)日：2024-10-31

申请号：US18768074

申请日：2024-07-10

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Ella BORBERG ,  Eran GRANOT ,  Fernando PATOLSKY

IPC: G01N33/569 ,  G01N27/327 ,  G01N33/543

CPC classification number: G01N33/56983 ,  G01N27/3271 ,  G01N33/5438 ,  G01N2469/10

Abstract: A functionalized electrode capable of selectively interacting with a viral biomarker, an electrochemical system comprising the electrode and methods utilizing same for, for example, determining a presence of a viral infection in a subject are provided.

公开(公告)号：US20200025684A1

公开(公告)日：2020-01-23

申请号：US16499285

申请日：2018-03-29

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Fernando PATOLSKY ,  Vadim KRIVITSKY

IPC: G01N21/64 ,  G01N21/33 ,  G01N21/49 ,  G01N33/58

Abstract: A system featuring a substrate and a multiplicity of nanostructures arranged on the substrate is provided. At least one portion of the nanostructures feature a capturing moiety covalently attached to a surface thereof and at least another portion of the nanostructures, which can be the same or different from the first portion, feature a light-activatable moiety covalently attached to a surface thereof. The capturing moiety is such that selectively interacts with an analyte, and the light-activatable moiety generates, upon exposure to light, a reactive moiety that interferes with an interaction of the capturing moiety and the analyte. Further provided are systems featuring a substrate and a multiplicity of nanostructures aligned generally vertically to the substrate, at least a portion of these nanostructures being branched nanostructures. Uses of the systems in extracting, and optionally identifying, the analyte from a sample are also provided.

公开(公告)号：US20190234900A1

公开(公告)日：2019-08-01

申请号：US16297665

申请日：2019-03-10

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Fernando PATOLSKY ,  Le-Chang HSIUNG ,  Vadim KRIVITSKY ,  Vladimir NADDAKA

IPC: G01N27/414 ,  C12Q1/00 ,  G01N27/327 ,  G01N33/50

CPC classification number: G01N27/4146 ,  B01L3/5027 ,  C12Q1/004 ,  G01N27/3278 ,  G01N33/50 ,  G01N2800/7066

Abstract: Systems and methods for sensing target molecules such as redox reactive agents, comprising a sample compartment and a sensing compartment being in fluid communication, are disclosed. A sensing compartment which comprises nanostructures to which a functional moiety is covalently attached and which is such that upon contacting a redox reactive agent a change in electrical property of the nanostructure occurs, and integration of such a sensing compartment with sensing systems as described herein are also disclosed. Methods of monitoring a metabolic activity of cells, and uses thereof, are also disclosed.