公开(公告)号：US20060200981A1

公开(公告)日：2006-09-14

申请号：US11416491

申请日：2006-05-01

申请人： Raghbir Bhullar ,  Eric Diebold ,  Brian Hill ,  Nigel Surridge ,  P. Walling

发明人： Raghbir Bhullar ,  Eric Diebold ,  Brian Hill ,  Nigel Surridge ,  P. Walling

IPC分类号： H05K3/02 ,  B23K26/00

CPC分类号： G01N33/5438 ,  C12Q1/001 ,  G01N27/3272 ,  H05K1/0393 ,  H05K3/027 ,  Y10T29/49007 ,  Y10T29/49117 ,  Y10T29/49155 ,  Y10T29/49156

摘要： A method of making a biosensor is provided. The biosensor includes an electrically conductive material on a base and electrode patterns formed on the base, the patterns having different feature sizes. The conductive material is partially removed from the base using broad field laser ablation so that less than 90% of the conductive material remains on the base and that the electrode pattern has an edge extending between two points. A standard deviation of the edge from a line extending between two points is less than about 6 μm

摘要翻译： 提供制造生物传感器的方法。 生物传感器包括在基底上的导电材料和形成在基底上的电极图案，图案具有不同的特征尺寸。 使用宽场激光烧蚀部分地从基底去除导电材料，使得小于90％的导电材料保留在基底上，并且电极图案具有在两个点之间延伸的边缘。 边缘与两点之间延伸的线的标准偏差小于约6um

公开(公告)号：US20050103624A1

公开(公告)日：2005-05-19

申请号：US10871937

申请日：2004-06-18

申请人： Raghbir Bhullar ,  Eric Diebold ,  Brian Hill ,  Nigel Surridge ,  Paul Walling

发明人： Raghbir Bhullar ,  Eric Diebold ,  Brian Hill ,  Nigel Surridge ,  Paul Walling

IPC分类号： C12Q1/00 ,  G01N27/30 ,  G01N27/403 ,  G01N33/487 ,  G01N33/49 ,  G01N33/543 ,  H05K1/00 ,  H05K3/02 ,  G01N27/26

CPC分类号： C12Q1/001 ,  G01N27/3272 ,  G01N33/5438 ,  H05K1/0393 ,  H05K3/027 ,  Y10T29/49117 ,  Y10T29/49155 ,  Y10T29/49156

摘要： An electrochemical biosensor with electrode elements that possess smooth, high-quality edges. These smooth edges define gaps between electrodes, electrode traces and contact pads. Due to the remarkable edge smoothness achieved with the present invention, the gaps can be quite small, which provides marked advantages in terms of test accuracy, speed and the number of different functionalities that can be packed into a single biosensor. Further, the present invention provides a novel biosensor production method in which entire electrode patterns for the inventive biosensors can be formed all at one, in nanoseconds—without regard to the complexity of the electrode patterns or the amount of conductive material that must be ablated to form them.

摘要翻译： 具有电极元件的电化学生物传感器具有光滑，高质量的边缘。 这些光滑边缘限定电极，电极迹线和接触垫之间的间隙。 由于本发明实现了显着的边缘平滑度，所以间隙可以相当小，这在测试精度，速度和可以包装到单个生物传感器中的不同功能的数量方面提供显着的优点。 此外，本发明提供了一种新颖的生物传感器制造方法，其中可以以纳秒为单位形成本发明的生物传感器的整个电极图案，而不考虑电极图案的复杂性或必须烧蚀的导电材料的量 形成它们

公开(公告)号：US20060200982A1

公开(公告)日：2006-09-14

申请号：US11416497

申请日：2006-05-01

申请人： Raghbir Bhullar ,  Eric Diebold ,  Brian Hill ,  Nigel Surridge ,  P. Douglas Walling

发明人： Raghbir Bhullar ,  Eric Diebold ,  Brian Hill ,  Nigel Surridge ,  P. Douglas Walling

IPC分类号： H05K3/02 ,  B23K26/00

CPC分类号： G01N33/5438 ,  C12Q1/001 ,  G01N27/3272 ,  H05K1/0393 ,  H05K3/027 ,  Y10T29/49007 ,  Y10T29/49117 ,  Y10T29/49155 ,  Y10T29/49156

摘要： A method of making a biosensor is provided. The method includes providing an electrically conductive material on a base and partially removing the conductive material using laser ablation from the base so that less than 90% of the conductive material remains on the base and at least one electrode pattern is formed from the conductive material. The at least one electrode pattern has an edge extending between two points. A standard deviation of the edge from a line extending between two points is less than about 6 μm along the length of the edge.

摘要翻译： 提供制造生物传感器的方法。 该方法包括在基底上提供导电材料，并使用从基底的激光烧蚀部分地去除导电材料，使得小于90％的导电材料保留在基底上，并且由导电材料形成至少一个电极图案。 所述至少一个电极图案具有在两点之间延伸的边缘。 边缘与两点之间延伸的线的标准偏差沿着边缘的长度小于约6μm。

公开(公告)号：US20050023137A1

公开(公告)日：2005-02-03

申请号：US10871843

申请日：2004-06-18

申请人： Raghbir Bhullar ,  Harvey Buck ,  Brian Hill ,  Paul Walling ,  Terry Beaty ,  David Burke ,  Eric Diebold

发明人： Raghbir Bhullar ,  Harvey Buck ,  Brian Hill ,  Paul Walling ,  Terry Beaty ,  David Burke ,  Eric Diebold

IPC分类号： B01L3/02 ,  C12Q1/00 ,  G01N1/00 ,  G01N27/00 ,  G01N27/30 ,  G01N33/487

CPC分类号： C12M1/00 ,  C12Q1/001 ,  G01N27/3272

摘要： A biosensor having multiple electrical functionalities located both within and outside of the measurement zone in which a fluid sample is interrogated. Incredibly small and complex electrical patterns with high quality edges provide electrical functionalities in the biosensor and also provide the electrical wiring for the various other electrical devices provided in the inventive biosensor. In addition to a measurement zone with multiple and various electrical functionalities, biosensors of the present invention may be provided with a user interface zone, a digital device zone and/or a power generation zone. The inventive biosensors offer improved ease of use and performance, and decrease the computational burden and associated cost of the instruments that read the biosensors by adding accurate yet cost-effective functionalities to the biosensors themselves.

摘要翻译： 具有位于测量区域内和外部的多个电功能的生物传感器，其中询问流体样品。 具有高质量边缘的难以置信的小且复杂的电气图案在生物传感器中提供电功能，并且还为本发明的生物传感器中提供的各种其它电气装置提供电线。 除了具有多个和各种电功能的测量区域之外，本发明的生物传感器可以设置有用户界面区域，数字设备区域和/或发电区域。 本发明的生物传感器提供了改进的易用性和性能，并且通过向生物传感器本身添加准确而成本有效的功能来降低读取生物传感器的仪器的计算负担和相关成本。

公开(公告)号：US08439201B2

公开(公告)日：2013-05-14

申请号：US12989833

申请日：2009-05-21

申请人： Eric Mazur ,  Eric Diebold

发明人： Eric Mazur ,  Eric Diebold

IPC分类号： B03B1/00

CPC分类号： B82B3/0071

摘要： The invention provides methods and systems for separating particles that exhibit different Raman characteristics. The method can include introducing nanoparticles, on which Raman-active molecules are adsorbed, into a photopolymerizable resin and exposing to excite Raman active vibrational modes of the molecules to generate Raman-shifted radiation suitable for polymerizing the resin such that the Raman-shifted radiation causes selective polymerization of a resin surrounding nanoparticles if the nanoparticles provide a Raman enhancement factor greater than a threshold. In addition, methods for electrically isolating nanoparticles, or selectively removing one type of nanoparticles from collections, are disclosed. These methods rely on generation of blue-shifted anti-Stokes photons to selectively expose portions of a photoresist covering the nanoparticles to those photons. Such exposure can cause a change in the exposed portions (e.g., polymerize or increase solubility to a developing agent), which can be employed to achieve isolation of the nanoparticles or their selective removal.

摘要翻译： 本发明提供了分离显示不同拉曼特性的颗粒的方法和系统。 该方法可以包括将其上吸附有拉曼活性分子的纳米颗粒引入可光聚合树脂中并暴露于分子的激发拉曼活性振动模式以产生适于聚合树脂的拉曼偏移辐射，使得拉曼位移辐射导致 如果纳米颗粒提供大于阈值的拉曼增强因子，则围绕纳米颗粒的树脂的选择性聚合。 此外，公开了用于电绝缘纳米颗粒或从集合中选择性地除去一种类型的纳米颗粒的方法。 这些方法依赖于产生蓝移的反斯托克斯光子，以选择性地将覆盖纳米颗粒的光刻胶的部分暴露于那些光子。 这种暴露可导致暴露部分的变化（例如，聚合或增加对显影剂的溶解度），其可用于实现纳米颗粒的分离或其选择性去除。

公开(公告)号：US08294891B2

公开(公告)日：2012-10-23

申请号：US12523567

申请日：2008-01-22

申请人： Eric Mazur ,  Eric Diebold

发明人： Eric Mazur ,  Eric Diebold

IPC分类号： G01N21/03 ,  G01J3/44

CPC分类号： G01N21/658 ,  B65D79/02 ,  B65D2203/02 ,  G01N33/02

摘要： In one aspect, a system for use in product packaging is disclosed that includes a polymeric sensing substrate coupled to a package such that a front sensing surface thereof is in contact with a portion of a product, e.g., a fungible product, stored in the package and a back surface thereof is accessible via an environment external to the package. The system further includes a radiation source adapted to direct radiation to the substrate's back surface such that the radiation would interact with one or more molecular species of the product that are in contact with the substrate's sensing surface. The system also includes a detector that is adapted to detect radiation returning from the substrate in response to its illumination by the radiation source. The front surface of the sensing substrate can comprise a plurality of micron-sized or submicron-sized ridges having a discontinuous or continuous metal coating, e.g., a metallic layer with a thickness in a range of about 10 nm to about 1000 nm (and preferably in a range of about 50 nm to about 120 nm), disposed thereon.

摘要翻译： 在一个方面，公开了一种用于产品包装的系统，其包括耦合到包装的聚合物感测衬底，使得其前感测表面与存储在包装中的产品（例如，可替代产品）的一部分接触 并且其后表面可通过包装外部的环境访问。 该系统还包括适于将辐射引导到衬底的背表面的辐射源，使得辐射将与与衬底的感测表面接触的产品的一种或多种分子种类相互作用。 该系统还包括检测器，其适于检测响应于其由辐射源照射的从衬底返回的辐射。 感测基板的前表面可以包括具有不连续或连续金属涂层的多个微米尺寸或亚微米尺寸的脊，例如厚度在约10nm至约1000nm范围内的金属层（优选地， 在约50nm至约120nm的范围内）。

公开(公告)号：US20090046283A1

公开(公告)日：2009-02-19

申请号：US12017720

申请日：2008-01-22

申请人： Eric Mazur ,  Eric Diebold ,  Steven M. Ebstein

发明人： Eric Mazur ,  Eric Diebold ,  Steven M. Ebstein

IPC分类号： G01J3/44 ,  H01L21/00

CPC分类号： B81B1/006 ,  B01L3/5023 ,  B01L3/5027 ,  B01L3/5088 ,  B01L2200/12 ,  B01L2300/165 ,  B81C1/00206 ,  B82Y15/00 ,  B82Y30/00 ,  G01N21/658

摘要： In one aspect, the present invention generally provides methods for fabricating substrates for use in a variety of analytical and/or diagnostic applications. Such a substrate can be generated by exposing a semiconductor surface (e.g., silicon surface) to a plurality of short laser pulses to generate micron-sized, and preferably submicron-sized, structures on the surface. The structured surface can then be coated with a thin metallic layer, e.g., one having a thickness in a range of about 10 nm to about 1000 nm.

摘要翻译： 一方面，本发明通常提供用于制造用于各种分析和/或诊断应用的基底的方法。 可以通过将半导体表面（例如，硅表面）暴露于多个短激光脉冲以在表面上产生微米尺寸且优选亚微米尺寸的结构来产生这种基板。 然后可以用薄金属层涂覆结构化表面，例如具有在约10nm至约1000nm范围内的厚度的金属层。

公开(公告)号：US20110178820A1

公开(公告)日：2011-07-21

申请号：US12818894

申请日：2010-06-18

申请人： Abhishek S. Soni ,  Paul J. Galley ,  Alan Greenburg ,  Steven Bousamra ,  Stefan Weinert ,  Eric Diebold

发明人： Abhishek S. Soni ,  Paul J. Galley ,  Alan Greenburg ,  Steven Bousamra ,  Stefan Weinert ,  Eric Diebold

IPC分类号： G06Q50/00

CPC分类号： G06F19/3456 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/4839 ,  A61B5/7275 ,  G06F19/3418 ,  G06F19/3468 ,  G06F19/3475 ,  G06F19/3481 ,  G06Q50/24 ,  G16H10/20 ,  G16H10/60 ,  G16H15/00

摘要： Embodiments related to a system and method managing the implementation, execution, data collection, data analysis and status reporting of a structured collection procedure running on a portable, hand-held collection device are disclosed. The collection device performing the structured collection procedure has program instructions that when executed by a processor cause the processor to initiate automatically a schedule of events of the structured collection procedure upon one or more entry criteria being met at some unknown time, store in memory patient data collected in accordance to the schedule of events, end automatically the structured collection procedure upon one or more exit criteria being met at some unknown time. Status reporting can be provided throughout the execution of the collection procedure.

摘要翻译： 公开了涉及在便携式手持收集装置上运行的结构化收集过程的实现，执行，数据收集，数据分析和状态报告的系统和方法的实施例。 执行结构化收集过程的收集装置具有当处理器执行时使得处理器在某个未知时间满足一个或多个入口标准时自动启动结构化收集过程的事件调度的程序指令，存储在存储器患者数据中 根据事件进度收集，在一些未知时间满足一个或多个退出条件时自动结束结算收集程序。 整个执行过程中可以提供状态报告。

公开(公告)号：US20110155649A1

公开(公告)日：2011-06-30

申请号：US12989833

申请日：2009-05-21

申请人： Eric Mazur ,  Eric Diebold

发明人： Eric Mazur ,  Eric Diebold

IPC分类号： B82B3/00 ,  B07B13/00 ,  B82Y40/00

CPC分类号： B82B3/0071

摘要： The invention provides methods and systems for separating particles that exhibit different Raman characteristics. The method can include introducing nanoparticles, on which Raman-active molecules are adsorbed, into a photopolymerizable resin and exposing to excite Raman active vibrational modes of the molecules to generate Raman-shifted radiation suitable for polymerizing the resin such that the Raman-shifted radiation causes selective polymerization of a resin surrounding nanoparticles if the nanoparticles provide a Raman enhancement factor greater than a threshold. In addition, methods for electrically isolating nanoparticles, or selectively removing one type of nanoparticles from collections, are disclosed. These methods rely on generation of blue-shifted anti-Stokes photons to selectively expose portions of a photoresist covering the nanoparticles to those photons. Such exposure can cause a change in the exposed portions (e.g., polymerize or increase solubility to a developing agent), which can be employed to achieve isolation of the nanoparticles or their selective removal.

摘要翻译： 本发明提供了分离显示不同拉曼特性的颗粒的方法和系统。 该方法可以包括将其上吸附有拉曼活性分子的纳米颗粒引入可光聚合的树脂中并暴露于分子的激发拉曼活性振动模式以产生适于聚合树脂的拉曼偏移辐射，使得拉曼位移辐射导致 如果纳米颗粒提供大于阈值的拉曼增强因子，则围绕纳米颗粒的树脂的选择性聚合。 此外，公开了用于电绝缘纳米颗粒或从集合中选择性地除去一种类型的纳米颗粒的方法。 这些方法依赖于产生蓝移的反斯托克斯光子，以选择性地将覆盖纳米颗粒的光刻胶的部分暴露于那些光子。 这种暴露可导致暴露部分的变化（例如，聚合或增加对显影剂的溶解度），其可用于实现纳米颗粒的分离或其选择性去除。

公开(公告)号：US20100171948A1

公开(公告)日：2010-07-08

申请号：US12481973

申请日：2009-06-10

申请人： Eric Mazur ,  Eric Diebold ,  Steven Ebstein

发明人： Eric Mazur ,  Eric Diebold ,  Steven Ebstein

IPC分类号： G01J3/44

CPC分类号： B82Y30/00 ,  B01L3/5023 ,  B01L3/5027 ,  B01L3/5088 ,  B01L2200/12 ,  B01L2300/165 ,  B81B1/006 ,  B81C1/00206 ,  B82Y15/00 ,  G01N21/658

摘要： In one aspect, the present invention generally provides methods for fabricating substrates for use in a variety of analytical and/or diagnostic applications. Such a substrate can be generated by exposing a semiconductor surface (e.g., silicon surface) to a plurality of short laser pulses to generate micron-sized, and preferably submicron-sized, structures on the surface. The structured surface can then be coated with a thin metallic layer, e.g., one having a thickness in a range of about 10 nm to about 1000 nm.

摘要翻译： 一方面，本发明通常提供用于制造用于各种分析和/或诊断应用的基底的方法。 可以通过将半导体表面（例如，硅表面）暴露于多个短激光脉冲以在表面上产生微米尺寸且优选亚微米尺寸的结构来产生这种基板。 然后可以用薄金属层涂覆结构化表面，例如具有在约10nm至约1000nm范围内的厚度的金属层。