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1.发明授权Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof 有权糖皮质激素模拟物，其制备方法，药物组合物及其用途公开(公告)号：US07553966B2
公开(公告)日：2009-06-30
申请号：US10944615
申请日：2004-09-17
申请人： Rajashehar Betageri , Thomas A. Gilmore , Christian Hanke Justus Joachim Harcken , Daniel Kuzmich , Hossein Razavi , Doris Riether , David S. Thomson , Ji Wang
发明人： Rajashehar Betageri , Thomas A. Gilmore , Christian Hanke Justus Joachim Harcken , Daniel Kuzmich , Hossein Razavi , Doris Riether , David S. Thomson , Ji Wang
IPC分类号： C07D215/38
CPC分类号： C07D209/12 , C07D213/30 , C07D215/14 , C07D217/16 , C07D231/12 , C07D233/64 , C07D235/12 , C07D237/08 , C07D239/26 , C07D241/12 , C07D261/18 , C07D263/32 , C07D263/56 , C07D277/24 , C07D277/64 , C07D307/80 , C07D333/16 , C07D401/06 , C07D405/06 , C07D471/04
摘要： Compounds of Formula (IA) and Formula (IB) wherein R1, R2, R3, R4, R5, and R6 are as defined herein for Formula (IA) or Formula (IB), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译： 式（IA）和式（IB）的化合物，其中R1，R2，R3，R4，R5和R6如本文对式（IA）或式（IB）所定义，或其互变异构体，前药，溶剂化物或其盐 ; 含有这些化合物的药物组合物，以及调节糖皮质激素受体功能的方法和治疗由糖皮质激素受体功能介导的疾病状态或病症的方法，或其特征在于使用这些化合物的患者的炎症，过敏或增殖过程。
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2.发明授权Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and thereof 有权糖皮质激素模拟物，其制备方法，药物组合物及其制备方法公开(公告)号：US08212040B2
公开(公告)日：2012-07-03
申请号：US11410408
申请日：2006-04-25
申请人： Younes Bekkali , Rajashehar Betageri , Mario G. Cardozo , Thomas A. Gilmore , Christian Hanke Justus Joachim Harcken , Thomas Martin Kirrane , Daniel Kuzmich , John Robert Proudfoot , Doris Riether , Hidenori Takahashi , David S. Thomson , Ji Wang , Renee M. Zindell , Hossein Razavi
发明人： Younes Bekkali , Rajashehar Betageri , Mario G. Cardozo , Thomas A. Gilmore , Christian Hanke Justus Joachim Harcken , Thomas Martin Kirrane , Daniel Kuzmich , John Robert Proudfoot , Doris Riether , Hidenori Takahashi , David S. Thomson , Ji Wang , Renee M. Zindell , Hossein Razavi
IPC分类号： C07D471/02 , A61K31/44
CPC分类号： C07D209/12 , C07D213/30 , C07D215/14 , C07D217/16 , C07D231/12 , C07D233/64 , C07D235/12 , C07D237/08 , C07D239/26 , C07D241/12 , C07D261/18 , C07D263/32 , C07D263/56 , C07D277/24 , C07D277/64 , C07D307/80 , C07D333/16 , C07D401/06 , C07D405/06 , C07D471/04
摘要： Compounds of Formula (IA) wherein R1, R2, R3, R4 and R5 are as defined herein for Formula (IA), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译： 式（IA）的化合物，其中R 1，R 2，R 3，R 4和R 5如本文对式（IA）所定义，或其互变异构体，前药，溶剂合物或其盐; 含有这些化合物的药物组合物，以及调节糖皮质激素受体功能的方法和治疗由糖皮质激素受体功能介导的疾病状态或病症的方法，或其特征在于使用这些化合物的患者的炎症，过敏或增殖过程。
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3.发明授权Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof 有权糖皮质激素模拟物，其制备方法，药物组合物及其用途公开(公告)号：US06903215B2
公开(公告)日：2005-06-07
申请号：US10394303
申请日：2003-03-21
申请人： Rajashehar Betageri , Thomas A. Gilmore , Christian Hanke Justus Joachim Harcken , Daniel Kuzmich , Doris Riether , David S. Thomson , Ji Wang , Hossein Razavi
发明人： Rajashehar Betageri , Thomas A. Gilmore , Christian Hanke Justus Joachim Harcken , Daniel Kuzmich , Doris Riether , David S. Thomson , Ji Wang , Hossein Razavi
IPC分类号： A61K31/343 , A61K31/404 , A61K31/405 , A61K31/4184 , A61K31/423 , A61K31/437 , A61K31/44 , A61K31/4402 , A61K31/4439 , A61P1/00 , A61P1/16 , A61P3/04 , A61P3/10 , A61P5/00 , A61P9/00 , A61P9/10 , A61P9/12 , A61P17/00 , A61P19/02 , A61P25/00 , A61P25/04 , A61P27/02 , A61P27/06 , A61P27/16 , A61P29/00 , A61P35/00 , A61P37/06 , A61P37/08 , C07C49/255 , C07C49/577 , C07D209/12 , C07D209/30 , C07D213/30 , C07D213/61 , C07D215/14 , C07D217/16 , C07D231/12 , C07D233/54 , C07D235/12 , C07D237/08 , C07D239/26 , C07D241/12 , C07D261/18 , C07D263/32 , C07D263/56 , C07D277/24 , C07D277/64 , C07D307/80 , C07D333/16 , C07D401/06 , C07D405/06 , C07D471/04 , C07D471/02 , A61K31/47
CPC分类号： C07D209/12 , C07D213/30 , C07D215/14 , C07D217/16 , C07D231/12 , C07D233/64 , C07D235/12 , C07D237/08 , C07D239/26 , C07D241/12 , C07D261/18 , C07D263/32 , C07D263/56 , C07D277/24 , C07D277/64 , C07D307/80 , C07D333/16 , C07D401/06 , C07D405/06 , C07D471/04
摘要： Compounds of Formula (IA) and Formula (IB) wherein R1, R2, R3, R4, R5, and R6 are as defined herein for Formula (IA) or Formula (IB), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译： 式（IA）和式（IB）的化合物，其中R 1，R 2，R 3，R 4， >，R 5和R 6如本文对式（IA）或式（IB）所定义，或其互变异构体，前药，溶剂合物或其盐; 含有这些化合物的药物组合物，以及调节糖皮质激素受体功能的方法和治疗由糖皮质激素受体功能介导的疾病状态或病症的方法，或其特征在于使用这些化合物的患者的炎症，过敏或增殖过程。
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4.发明授权Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof 有权糖皮质激素模拟物，其制备方法，药物组合物及其用途公开(公告)号：US08741897B2
公开(公告)日：2014-06-03
申请号：US10947420
申请日：2004-09-22
申请人： Younes Bekkali , Rajashekhar Betageri , Michel J. Emmanuel , Abdelhakim Hammach , Christian Hanke Justus Joachim Harcken , Thomas Martin Kirrane, Jr. , Daniel Kuzmich , Thomas Wai-Ho Lee , Pingrong Liu , Usha R. Patel , John Robert Proudfoot , Hossein Razavi , Doris Riether , Hidenori Takahashi , David S. Thomson , Ji Wang , Renee Zindell
发明人： Younes Bekkali , Rajashekhar Betageri , Michel J. Emmanuel , Abdelhakim Hammach , Christian Hanke Justus Joachim Harcken , Thomas Martin Kirrane, Jr. , Daniel Kuzmich , Thomas Wai-Ho Lee , Pingrong Liu , Usha R. Patel , John Robert Proudfoot , Hossein Razavi , Doris Riether , Hidenori Takahashi , David S. Thomson , Ji Wang , Renee Zindell
IPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , A61K31/4355 , A61K31/5025 , A61P25/28 , A61P9/00 , A61P35/00 , A61K31/4402 , A61K31/4409 , A61K31/4418 , A61K31/4406 , A61K31/497 , A61K31/506 , A61K31/4184 , A61K31/404 , A61K31/416 , A61K31/47
CPC分类号： C07D213/75 , A61K31/4745 , A61K31/52 , C07D209/08 , C07D209/12 , C07D213/30 , C07D215/14 , C07D231/12 , C07D231/56 , C07D237/20 , C07D239/42 , C07D307/79 , C07D319/06 , C07D319/08 , C07D333/56 , C07D403/10 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04
摘要： Compounds of Formula (IA), (IB), (IC), and (ID) wherein R1, R2, R3, R4, R5, and R6 are as respectively defined herein for Formula (IA), (IB), (IC), and (ID), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译： 式（IA），（IB），（IC）和（ID）的化合物，其中R 1，R 2，R 3，R 4，R 5和R 6如本文中对于式（IA），（IB） ，和（ID），或互变异构体，前药，溶剂合物或其盐; 含有这些化合物的药物组合物，以及调节糖皮质激素受体功能的方法和治疗由糖皮质激素受体功能介导的疾病状态或病症的方法，或其特征在于使用这些化合物的患者的炎症，过敏或增殖过程。
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5.发明授权Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof 有权糖皮质激素模拟物，其制备方法，药物组合物及其用途公开(公告)号：US07268152B2
公开(公告)日：2007-09-11
申请号：US10394157
申请日：2003-03-21
申请人： Younes Bekkali , Mario G. Cardozo , Christian Hanke Justus Joachim Harcken , Thomas M. Kirrane , Daniel Kuzmich , John Robert Proudfoot , Hossein Razavi , Hidenori Takahashi , David S. Thomson , Ji Wang , Renee Zindell
发明人： Younes Bekkali , Mario G. Cardozo , Christian Hanke Justus Joachim Harcken , Thomas M. Kirrane , Daniel Kuzmich , John Robert Proudfoot , Hossein Razavi , Hidenori Takahashi , David S. Thomson , Ji Wang , Renee Zindell
IPC分类号： C07D213/57 , A61K31/44
CPC分类号： C07C323/18 , C07C37/055 , C07C39/367 , C07C39/373 , C07C43/23 , C07C45/004 , C07C45/30 , C07C45/44 , C07C45/45 , C07C45/63 , C07C45/673 , C07C45/68 , C07C45/69 , C07C47/575 , C07C49/233 , C07C49/255 , C07C49/577 , C07C49/83 , C07C49/84 , C07C59/56 , C07C65/24 , C07C235/42 , C07C251/48 , C07C255/53 , C07C255/54 , C07C317/22 , C07C2601/02
摘要： Compounds of Formula (IA) and Formula (IB) wherein R1, R2, R3, R4, R5, and R6 are as defined herein for Formula (IA) or Formula (IB), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译： 式（IA）和式（IB）的化合物，其中R 1，R 2，R 3，R 4， >，R 5和R 6如本文对式（IA）或式（IB）所定义，或其互变异构体，前药，溶剂合物或其盐; 含有这些化合物的药物组合物，以及调节糖皮质激素受体功能的方法和治疗由糖皮质激素受体功能介导的疾病状态或病症的方法，或其特征在于使用这些化合物的患者的炎症，过敏或增殖过程。
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6.发明申请Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof 有权糖皮质激素模拟物，其制备方法，药物组合物及其用途公开(公告)号：US20050059714A1
公开(公告)日：2005-03-17
申请号：US10944615
申请日：2004-09-17
申请人： Rajashehar Betageri , Thomas Gilmore , Christian Hanke Harcken , Daniel Kuzmich , Hossein Razavi , Doris Riether , David Thomson , Ji Wang
发明人： Rajashehar Betageri , Thomas Gilmore , Christian Hanke Harcken , Daniel Kuzmich , Hossein Razavi , Doris Riether , David Thomson , Ji Wang
IPC分类号： A61K31/343 , A61K31/404 , A61K31/405 , A61K31/4184 , A61K31/423 , A61K31/437 , A61K31/44 , A61K31/4402 , A61K31/4439 , A61P1/00 , A61P1/16 , A61P3/04 , A61P3/10 , A61P5/00 , A61P9/00 , A61P9/10 , A61P9/12 , A61P17/00 , A61P19/02 , A61P25/00 , A61P25/04 , A61P27/02 , A61P27/06 , A61P27/16 , A61P29/00 , A61P35/00 , A61P37/06 , A61P37/08 , C07C49/255 , C07C49/577 , C07D209/12 , C07D209/30 , C07D213/30 , C07D213/61 , C07D215/14 , C07D217/16 , C07D231/12 , C07D233/54 , C07D235/12 , C07D237/08 , C07D239/26 , C07D241/12 , C07D261/18 , C07D263/32 , C07D263/56 , C07D277/24 , C07D277/64 , C07D307/80 , C07D333/16 , C07D401/06 , C07D405/06 , C07D471/04 , C07D213/26 , A61K31/138 , A61K31/195 , A61K31/277
CPC分类号： C07D209/12 , C07D213/30 , C07D215/14 , C07D217/16 , C07D231/12 , C07D233/64 , C07D235/12 , C07D237/08 , C07D239/26 , C07D241/12 , C07D261/18 , C07D263/32 , C07D263/56 , C07D277/24 , C07D277/64 , C07D307/80 , C07D333/16 , C07D401/06 , C07D405/06 , C07D471/04
摘要： Compounds of Formula (IA) and Formula (IB) wherein R1, R2, R3, R4, R5, and R6 are as defined herein for Formula (IA) or Formula (IB), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译： 式（IA）和式（IB）的化合物，其中R 1，R 2，R 3，R 4，R 5和R 6如本文中对式 ）或式（IB）或其互变异构体前药，溶剂合物或其盐; 含有这些化合物的药物组合物，以及调节糖皮质激素受体功能的方法和治疗由糖皮质激素受体功能介导的疾病状态或病症的方法，或其特征在于使用这些化合物的患者的炎症，过敏或增殖过程。
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7.发明申请Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof 有权糖皮质激素模拟物，其制备方法，药物组合物及其用途公开(公告)号：US20050176706A1
公开(公告)日：2005-08-11
申请号：US10947420
申请日：2004-09-22
申请人： Younes Bekkali , Rajashekhar Betageri , Michel Emmanuel , Abdelhakim Hammach , Christian Joachim Harcken , Thomas Kirrane , Daniel Kuzmich , Thomas Lee , Pingrong Liu , Usha Patel , John Proudfoot , Hossein Razavi , Doris Riether , Hidenori Takahashi , David Thomson , Ji Wang , Renee Zindell
发明人： Younes Bekkali , Rajashekhar Betageri , Michel Emmanuel , Abdelhakim Hammach , Christian Joachim Harcken , Thomas Kirrane , Daniel Kuzmich , Thomas Lee , Pingrong Liu , Usha Patel , John Proudfoot , Hossein Razavi , Doris Riether , Hidenori Takahashi , David Thomson , Ji Wang , Renee Zindell
IPC分类号： A61K31/4745 , A61K31/52 , A61K31/5377 , A61P5/44 , A61P5/46 , C07D209/08 , C07D213/75 , C07D237/20 , C07D239/42 , C07D307/79 , C07D319/06 , C07D319/08 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D471/02 , C07D471/04 , C07D487/04 , C07D491/02 , C07D491/04 , C07D495/04 , C07D498/02
CPC分类号： C07D213/75 , A61K31/4745 , A61K31/52 , C07D209/08 , C07D209/12 , C07D213/30 , C07D215/14 , C07D231/12 , C07D231/56 , C07D237/20 , C07D239/42 , C07D307/79 , C07D319/06 , C07D319/08 , C07D333/56 , C07D403/10 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04
摘要： Compounds of Formula (IA), (IB), (IC), and (ID) wherein R1, R2, R3, R4, R5, and R6 are as respectively defined herein for Formula (IA), (IB), (IC), and (ID), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译： 式（IA），（IB），（IC）和（ID）的化合物，其中R 1，R 2，R 3， R 4，R 5和R 6分别如式（IA），（IB），（IC）和 （ID）或其互变异构体前药，溶剂化物或盐; 含有这些化合物的药物组合物，以及调节糖皮质激素受体功能的方法和治疗由糖皮质激素受体功能介导的疾病状态或病症的方法，或其特征在于使用这些化合物的患者的炎症，过敏或增殖过程。
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8.发明申请Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and thereof 有权糖皮质激素模拟物，其制备方法，药物组合物及其制备方法公开(公告)号：US20060189647A1
公开(公告)日：2006-08-24
申请号：US11410408
申请日：2006-04-25
申请人： Younes Bekkali , Rajashehar Betageri , David Thomson , Doris Riether , Christian Hanke Justus Harcken , Daniel Kuzmich , John Proudfoot
发明人： Younes Bekkali , Rajashehar Betageri , David Thomson , Doris Riether , Christian Hanke Justus Harcken , Daniel Kuzmich , John Proudfoot
IPC分类号： A61K31/4745 , C07D471/02
CPC分类号： C07D209/12 , C07D213/30 , C07D215/14 , C07D217/16 , C07D231/12 , C07D233/64 , C07D235/12 , C07D237/08 , C07D239/26 , C07D241/12 , C07D261/18 , C07D263/32 , C07D263/56 , C07D277/24 , C07D277/64 , C07D307/80 , C07D333/16 , C07D401/06 , C07D405/06 , C07D471/04
摘要： Compounds of Formula (IA) wherein R1, R2, R3, R4 and R5 are as defined herein for Formula (IA), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译： 其中R 1，R 2，R 3，R 4和R 4的式（IA）化合物 式（IA）的定义如本文所定义，或其互变异构体，前药，溶剂合物或其盐; 含有这些化合物的药物组合物，以及调节糖皮质激素受体功能的方法和治疗由糖皮质激素受体功能介导的疾病状态或病症的方法，或其特征在于使用这些化合物的患者的炎症，过敏或增殖过程。
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9.发明授权Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof 有权糖皮质激素模拟物，其制备方法，药物组合物及其用途公开(公告)号：US07932392B2
公开(公告)日：2011-04-26
申请号：US11185349
申请日：2005-07-20
申请人： Rajashekhar Betageri , Thomas A. Gilmore , Daniel Kuzmich , John Robert Proudfoot , David S. Thomson
发明人： Rajashekhar Betageri , Thomas A. Gilmore , Daniel Kuzmich , John Robert Proudfoot , David S. Thomson
IPC分类号： C07D215/38
CPC分类号： C07D209/12 , C07D213/30 , C07D215/14 , C07D217/16 , C07D231/12 , C07D233/64 , C07D235/12 , C07D237/08 , C07D239/26 , C07D241/12 , C07D261/18 , C07D263/32 , C07D263/56 , C07D277/24 , C07D277/64 , C07D307/80 , C07D333/16 , C07D401/06 , C07D405/06 , C07D471/04
摘要： Compounds of Formula (IA) wherein R1, R2, R3, R4 and R5 are as defined herein for Formula (IA), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译： 式（IA）的化合物，其中R 1，R 2，R 3，R 4和R 5如本文对式（IA）所定义，或其互变异构体，前药，溶剂合物或其盐; 含有这些化合物的药物组合物，以及调节糖皮质激素受体功能的方法和治疗由糖皮质激素受体功能介导的疾病状态或病症的方法，或其特征在于使用这些化合物的患者的炎症，过敏或增殖过程。
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10.发明申请Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof 有权糖皮质激素模拟物，其制备方法，药物组合物及其用途公开(公告)号：US20050282881A1
公开(公告)日：2005-12-22
申请号：US11185349
申请日：2005-07-20
申请人： Younes Bekkali , Rajashehar Betageri , Mario Cardozo , Thomas Gilmore , Thomas Kirrane , Daniel Kuzmich , John Proudfoot , Hidenori Takahashi , David Thomson , Renee Zindell
发明人： Younes Bekkali , Rajashehar Betageri , Mario Cardozo , Thomas Gilmore , Thomas Kirrane , Daniel Kuzmich , John Proudfoot , Hidenori Takahashi , David Thomson , Renee Zindell
IPC分类号： A61K31/343 , A61K31/404 , A61K31/405 , A61K31/4184 , A61K31/423 , A61K31/437 , A61K31/44 , A61K31/4402 , A61K31/4439 , A61P1/00 , A61P1/16 , A61P3/04 , A61P3/10 , A61P5/00 , A61P9/00 , A61P9/10 , A61P9/12 , A61P17/00 , A61P19/02 , A61P25/00 , A61P25/04 , A61P27/02 , A61P27/06 , A61P27/16 , A61P29/00 , A61P35/00 , A61P37/06 , A61P37/08 , C07C49/255 , C07C49/577 , C07D209/12 , C07D209/30 , C07D213/30 , C07D213/61 , C07D215/14 , C07D217/16 , C07D231/12 , C07D233/54 , C07D235/12 , C07D237/08 , C07D239/26 , C07D241/12 , C07D261/18 , C07D263/32 , C07D263/56 , C07D277/24 , C07D277/64 , C07D307/80 , C07D333/16 , C07D401/06 , C07D405/06 , C07D471/04 , C07D45/02
CPC分类号： C07D209/12 , C07D213/30 , C07D215/14 , C07D217/16 , C07D231/12 , C07D233/64 , C07D235/12 , C07D237/08 , C07D239/26 , C07D241/12 , C07D261/18 , C07D263/32 , C07D263/56 , C07D277/24 , C07D277/64 , C07D307/80 , C07D333/16 , C07D401/06 , C07D405/06 , C07D471/04
摘要： Compounds of Formula (IA) wherein R1, R2, R3, R4 and R5 are as defined herein for Formula (IA), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译： 其中R 1，R 2，R 3，R 4和R 4的式（IA）化合物 式（IA）的定义如本文所定义，或其互变异构体，前药，溶剂合物或其盐; 含有这些化合物的药物组合物，以及调节糖皮质激素受体功能的方法和治疗由糖皮质激素受体功能介导的疾病状态或病症的方法，或其特征在于使用这些化合物的患者的炎症，过敏或增殖过程。
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