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1.发明授权
公开(公告)号：US5521086A
公开(公告)日：1996-05-28
申请号：US122889
申请日：1993-09-16
IPC分类号： C12N15/09 , C07K14/39 , C07K14/65 , C07K19/00 , C12N1/11 , C12N1/19 , C12N9/16 , C12N15/81 , C12P21/02 , C12R1/645 , C12N1/21 , C12N15/62
CPC分类号： C12N15/81 , C07K14/65 , C07K2319/00 , C07K2319/02
摘要： The invention generally features a novel recombinant DNA molecule useful for producing a heterologous protein, e.g., insulin-like growth factor-I, in yeast. The DNA molecule includes the following sequences joined in frame and in the following 5' to 3' progression: a sequence encoding a signal peptide of a yeast secreted protein; a sequence encoding at least 5 amino acids of the N-terminal region of a mature acid phosphatase protein, a sequence encoding a heterologous protein. Preferably the DNA molecule also encodes a spacer element that includes a proteolytic cleavage site.
摘要翻译： 本发明通常具有用于在酵母中产生异源蛋白质（例如胰岛素样生长因子-I）的新型重组DNA分子。 DNA分子包括以下框架连接的以下5'至3'进程的序列：编码酵母分泌蛋白质的信号肽的序列; 编码成熟酸性磷酸酶蛋白质N末端区域至少5个氨基酸的序列，编码异源蛋白质的序列。 优选地，DNA分子还编码包含蛋白水解切割位点的间隔元件。
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公开(公告)号：US07888486B2
公开(公告)日：2011-02-15
申请号：US11503062
申请日：2006-08-14
申请人： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , William Kelley, legal representative , Xiang-Yang Tan , Seung Poon Kwak , Menelas N. Pangalos
发明人： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , Xiang-Yang Tan , Seung Poon Kwak , Menelas N. Pangalos
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/24 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N33/74 , G01N2333/475 , G01N2800/2835 , G01N2800/50 , G01N2800/52
摘要： The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
摘要翻译： 本公开提供了与生长和分化因子-8（GDF-8）特别是小鼠和人源化抗体以及抗体片段相关的新分子，包括在体外和/或体内抑制GDF-8活性和信号传导的抗体片段。 本公开还提供了用于诊断，治疗，改善，预防，预后或监测肌肉，骨骼和胰岛素代谢等的退行性顺序，特别是肌萎缩性侧索硬化（ALS）的方法。 此外，本公开提供了通过使用本发明的抗体，多肽，多核苷酸和载体来治疗这种病症的药物组合物。
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3.发明授权Antagonist antibodies against GDF-8 and uses in treatment of ALS and other GDF-8 associated disorders 有权抗GDF-8抗体抗体，用于治疗ALS和其他GDF-8相关疾病公开(公告)号：US07910107B2
公开(公告)日：2011-03-22
申请号：US12508618
申请日：2009-07-24
申请人： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Erika L. F. Holzbaur-Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , William Kelley, legal representative , Xiang-Yang Tan , Seung Poon Kwak , Karen Wallace , Nicholas Weber , Menelas N. Pangalos
发明人： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Erika L. F. Holzbaur-Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , Xiang-Yang Tan , Seung Poon Kwak , Karen Wallace , Nicholas Weber , Menelas N. Pangalos
IPC分类号： A61K39/395
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/24 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N33/74 , G01N2333/475 , G01N2800/2835 , G01N2800/50 , G01N2800/52
摘要： The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
摘要翻译： 本公开提供了与生长和分化因子-8（GDF-8）特别是小鼠和人源化抗体以及抗体片段相关的新分子，包括在体外和/或体内抑制GDF-8活性和信号传导的抗体片段。 本公开还提供了用于诊断，治疗，改善，预防，预后或监测肌肉，骨骼和胰岛素代谢等的退行性顺序，特别是肌萎缩性侧索硬化（ALS）的方法。 此外，本公开提供了通过使用本发明的抗体，多肽，多核苷酸和载体来治疗这种病症的药物组合物。
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4.发明申请MOLECULAR TARGETS AND COMPOUNDS, AND METHODS TO IDENTIFY THE SAME, USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISEASES 审中-公开分子靶向和化合物及其鉴别方法，有助于治疗神经病变性疾病公开(公告)号：US20110077283A1
公开(公告)日：2011-03-31
申请号：US12865281
申请日：2009-02-03
申请人： David Frederik Fischer , Richard Antonius Jozef Janssen , Remko De Pril , Desiré Maria Petronella Catharina Van Steenhoven , Seung Kwak , David S. Howland , Ethan Signer
发明人： David Frederik Fischer , Richard Antonius Jozef Janssen , Remko De Pril , Desiré Maria Petronella Catharina Van Steenhoven , Seung Kwak , David S. Howland , Ethan Signer
IPC分类号： A61K31/713 , G01N33/53 , C40B30/04 , C07H21/02 , A61P25/00
CPC分类号： G01N33/6896 , C12N15/86 , C12N2710/10343 , G01N2500/04 , G01N2500/10 , G01N2800/2835
摘要： The present invention relates to methods and assays for identifying agents capable of inhibiting the mutant huntingtin protein, inhibiting or reducing polyglutamine-induced protein aggregation, and/or altering huntingtin protein conformation, which inhibition is useful in the prevention, amelioration and/or treatment of neurodegenerative diseases, and protein aggregation diseases more generally. In particular, the present invention provides methods and assays for identifying agents for use in the prevention and/or treatment of Huntington's disease. The invention provides polypeptide and nucleic acid TARGETs and siRNA sequences based on these
摘要翻译： 本发明涉及用于鉴定能够抑制突变型亨廷蛋白蛋白，抑制或降低多聚谷氨酰胺诱导的蛋白质聚集和/或改变亨廷顿蛋白质构象的试剂的方法和测定法，该抑制可用于预防，改善和/或治疗 神经变性疾病和蛋白质聚集疾病。 特别地，本发明提供用于鉴定用于预防和/或治疗亨廷顿氏病的药剂的方法和测定。 本发明提供了基于这些的多肽和核酸TARGET和siRNA序列
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公开(公告)号：US07262336B2
公开(公告)日：2007-08-28
申请号：US10258561
申请日：2001-04-24
申请人： Kathleen Young , David S. Howland , Karen L. Marquis , Sharon Rosenzweig-Lipson , Mark Ian Cockett
发明人： Kathleen Young , David S. Howland , Karen L. Marquis , Sharon Rosenzweig-Lipson , Mark Ian Cockett
IPC分类号： G01N33/00 , A01K67/027 , C12N15/00
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0356 , C07K14/4722 , C12N2830/008 , C12N2830/85
摘要： A transgenic rat containing in its genome a nucleotide sequence encoding a Ga subunit protein, which Ga protein subunit is uncoupled from regulation by Regulators of G-Protein Signaling (RGS) proteins, which Gx subunit protein is eventually the dominant-negative G188S mutant of Gax9, which nucleotide sequence is operatively associated with a neuron-specific expression control sequence, wherein the transgenic rat expresses the GA subunit protein in neural cells resulting in extended D-protein coupled receptor signaling mediated by the Ga subunit protein.
摘要翻译： 在其基因组中含有编码Ga亚基蛋白的核苷酸序列的转基因大鼠，其Ga蛋白亚基与G蛋白信号传导（RGS）蛋白调节因子的调节脱配，其中Gx亚基蛋白最终是Gax9的显性阴性G188S突变体 该核苷酸序列可操作地与神经元特异性表达控制序列相关，其中转基因大鼠在神经细胞中表达GA亚基蛋白，导致由Ga亚基蛋白介导的扩展的D蛋白偶联受体信号传导。
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6.发明授权Method for treating muscular dystrophy using antagonist antibodies against GDF-8 有权使用针对GDF-8的拮抗剂抗体治疗肌营养不良的方法公开(公告)号：US08349327B2
公开(公告)日：2013-01-08
申请号：US13030978
申请日：2011-02-18
申请人： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , William Kelley, legal representative , Xiang-Yang Tan , Seung Poon Kwak , Menelas N. Pangalos
发明人： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , Xiang-Yang Tan , Seung Poon Kwak , Menelas N. Pangalos
IPC分类号： A61K39/395
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/24 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N33/74 , G01N2333/475 , G01N2800/2835 , G01N2800/50 , G01N2800/52
摘要： The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
摘要翻译： 本公开提供了与生长和分化因子-8（GDF-8）特别是小鼠和人源化抗体以及抗体片段相关的新分子，包括在体外和/或体内抑制GDF-8活性和信号传导的抗体片段。 本公开还提供了用于诊断，治疗，改善，预防，预后或监测肌肉，骨骼和胰岛素代谢等的退行性顺序，特别是肌萎缩性侧索硬化（ALS）的方法。 此外，本公开提供了通过使用本发明的抗体，多肽，多核苷酸和载体来治疗这种病症的药物组合物。
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7.发明申请TARGET SEQUENCES AND METHODS TO IDENTIFY THE SAME, USEFUL IN TREATMENT OF NEURODEGENERATIVE DISEASES 审中-公开目标序列及其鉴定方法，有助于治疗神经损伤性疾病公开(公告)号：US20110105587A1
公开(公告)日：2011-05-05
申请号：US12865295
申请日：2009-02-03
申请人： David Frederik Fishcher , Richard Antonius Janssen , Remko De Pril , Desiré Maria Petronella Catharina Van Steenhoven , Seung Kwak , David S. Howland , Ethan Signer
发明人： David Frederik Fishcher , Richard Antonius Janssen , Remko De Pril , Desiré Maria Petronella Catharina Van Steenhoven , Seung Kwak , David S. Howland , Ethan Signer
IPC分类号： A61K31/713 , G01N33/68 , C40B30/04 , C07H21/02 , C07H21/00 , C12N15/85 , C12N15/861 , C12N15/86 , C12N15/869 , C12N15/867 , C12N5/071 , A61K31/7088 , A61P25/28 , A61P25/16 , A61P25/00
CPC分类号： G01N33/5023 , G01N2500/04 , G01N2800/2835
摘要： The present invention relates to methods and assays for identifying agents capable of inhibiting the mutant huntingtin protein, inhibiting or reducing cell death, in particular cell death associated with polyglutamine-induced protein aggregation, which inhibition is useful in the prevention, amelioration and/or treatment of neurodegenerative diseases, and Huntington's disease more generally. In particular, the present invention provides methods and assays for identifying agents for use in the prevention and/or treatment of Huntingtons disease. The invention provides polypeptide and nucleic acid TARGETs and siRNA sequences based on these TARGETS.
摘要翻译： 本发明涉及用于鉴定能够抑制突变型亨廷蛋白蛋白，抑制或减少细胞死亡，特别是与多聚谷氨酰胺诱导的蛋白质聚集相关的细胞死亡的试剂的方法和测定法，该抑制可用于预防，改善和/或治疗 的神经变性疾病，亨廷顿病更普遍。 特别地，本发明提供用于鉴定用于预防和/或治疗亨廷格病的药剂的方法和测定。 本发明提供了基于这些目标物的多肽和核酸TARGETs和siRNA序列。
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公开(公告)号：US08372625B2
公开(公告)日：2013-02-12
申请号：US13038954
申请日：2011-03-02
申请人： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Lioudmila Tchistiakova , Riyez Karim , Xiang-Yang Tan , Seung Poon Kwak , Menelas N. Pangalos , William Kelley
发明人： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , Xiang-Yang Tan , Seung Poon Kwak , Menelas N. Pangalos
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/24 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N33/74 , G01N2333/475 , G01N2800/2835 , G01N2800/50 , G01N2800/52
摘要： The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
摘要翻译： 本公开提供了与生长和分化因子-8（GDF-8）特别是小鼠和人源化抗体以及抗体片段相关的新分子，包括在体外和/或体内抑制GDF-8活性和信号传导的抗体片段。 本公开还提供了用于诊断，治疗，改善，预防，预后或监测肌肉，骨骼和胰岛素代谢等的退行性顺序，特别是肌萎缩性侧索硬化（ALS）的方法。 此外，本公开提供了通过使用本发明的抗体，多肽，多核苷酸和载体来治疗这种病症的药物组合物。
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9.发明申请ANTAGONIST ANTIBODIES AGAINST GDF-8 AND USES IN TREATMENT OF ALS AND OTHER GDF-8 ASSOCIATED DISORDERS 有权针对GDF-8的拮抗剂抗体和用于治疗ALS和其他GDF-8相关疾病的用途公开(公告)号：US20120016106A1
公开(公告)日：2012-01-19
申请号：US13038954
申请日：2011-03-02
申请人： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Erika L.F. Holzbaur-Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , William Kelley , Xiang-Yang Tan , Seung Poon Kwak , Karen Wallace , Nicholas Weber , Menelas N. Pangalos
发明人： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Erika L.F. Holzbaur-Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , William Kelley , Xiang-Yang Tan , Seung Poon Kwak , Karen Wallace , Nicholas Weber , Menelas N. Pangalos
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/24 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N33/74 , G01N2333/475 , G01N2800/2835 , G01N2800/50 , G01N2800/52
摘要： The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
摘要翻译： 本公开提供了与生长和分化因子-8（GDF-8）特别是小鼠和人源化抗体以及抗体片段相关的新分子，包括在体外和/或体内抑制GDF-8活性和信号传导的抗体片段。 本公开还提供了用于诊断，治疗，改善，预防，预后或监测肌肉，骨骼和胰岛素代谢等的退行性顺序，特别是肌萎缩性侧索硬化（ALS）的方法。 此外，本公开提供了通过使用本发明的抗体，多肽，多核苷酸和载体来治疗这种病症的药物组合物。
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10.发明申请ANTAGONIST ANTIBODIES AGAINST GDF-8 AND USES IN TREATMENT OF ALS AND OTHER GDF-8 ASSOCIATED DISORDERS 有权针对GDF-8的拮抗剂抗体和用于治疗ALS和其他GDF-8相关疾病的用途公开(公告)号：US20090285827A1
公开(公告)日：2009-11-19
申请号：US12508618
申请日：2009-07-24
申请人： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Erika L. F. Holzbaur-Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , William Kelley , Xiang-Yang Tan , Seung Poon Kwak , Karen Wallace , Nicholas Weber , Menelas N. Pangalos
发明人： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Erika L. F. Holzbaur-Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , William Kelley , Xiang-Yang Tan , Seung Poon Kwak , Karen Wallace , Nicholas Weber , Menelas N. Pangalos
IPC分类号： A61K39/395 , G01N33/53
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/24 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N33/74 , G01N2333/475 , G01N2800/2835 , G01N2800/50 , G01N2800/52
摘要： The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
摘要翻译： 本公开提供了与生长和分化因子-8（GDF-8）特别是小鼠和人源化抗体以及抗体片段相关的新分子，包括在体外和/或体内抑制GDF-8活性和信号传导的抗体片段。 本公开还提供了用于诊断，治疗，改善，预防，预后或监测肌肉，骨骼和胰岛素代谢等的退行性顺序，特别是肌萎缩性侧索硬化（ALS）的方法。 此外，本公开提供了通过使用本发明的抗体，多肽，多核苷酸和载体来治疗这种病症的药物组合物。
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