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1.发明申请PRODUCTION OF FATTY ALCOHOLS WITH FATTY ALCOHOL FORMING ACYL-COA REDUCTASES (FAR) 有权生产脂肪醇与脂肪醇形成ACYA-COA还原剂（FAR）公开(公告)号：US20130040352A1
公开(公告)日：2013-02-14
申请号：US13494709
申请日：2012-06-12
摘要： The disclosure relates to methods of producing fatty alcohols from recombinant host cells comprising genes encoding heterologous fatty acyl-CoA reductase (FAR) enzymes. The disclosure further relates to FAR enzymes and functional fragments thereof derived from marine bacterium and particularly marine gamma proteobacterium such as Marinobacter and Oceanobacter; polynucleotides encoding the FAR enzymes and vectors and host cells comprising the same.
摘要翻译： 本公开涉及从包含编码异源脂肪酰辅酶A还原酶（FAR）酶的基因的重组宿主细胞产生脂肪醇的方法。 本公开还涉及来自海洋细菌，特别是海洋γ蛋白杆菌如马里他杆菌和海洋杆菌的FAR酶及其功能片段; 编码FAR酶的多核苷酸和载体以及包含其的宿主细胞。
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2.发明授权Production of fatty alcohols with fatty alcohol forming acyl-CoA reductases (FAR) 有权用脂肪醇形成酰基辅酶A还原酶（FAR）生产脂肪醇公开(公告)号：US08216815B2
公开(公告)日：2012-07-10
申请号：US12825939
申请日：2010-06-29
IPC分类号： C12P7/42 , C12P21/06 , C12P21/04 , C12Q1/68 , C12Q1/26 , C12N9/02 , C12N1/20 , C12N15/00 , C07H21/04
摘要： The disclosure relates to methods of producing fatty alcohols from recombinant host cells comprising genes encoding heterologous fatty acyl-CoA reductase (FAR) enzymes. The disclosure further relates to FAR enzymes and functional fragments thereof derived from marine bacterium and particularly marine gamma proteobacterium such as Marinobacter and Oceanobacter; polynucleotides encoding the FAR enzymes and vectors and host cells comprising the same.
摘要翻译： 本公开涉及从包含编码异源脂肪酰辅酶A还原酶（FAR）酶的基因的重组宿主细胞产生脂肪醇的方法。 本公开还涉及来自海洋细菌，特别是海洋γ蛋白杆菌如马里他杆菌和海洋杆菌的FAR酶及其功能片段; 编码FAR酶的多核苷酸和载体以及包含其的宿主细胞。
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3.发明申请PRODUCTION OF FATTY ALCOHOLS WITH FATTY ALCOHOL FORMING ACYL-COA REDUCTASES (FAR) 有权生产脂肪醇与脂肪醇形成ACYA-COA还原剂（FAR）公开(公告)号：US20110000125A1
公开(公告)日：2011-01-06
申请号：US12825939
申请日：2010-06-29
IPC分类号： C10L1/19 , C12P7/64 , C07H21/00 , C12N15/63 , C12N1/21 , C12N1/19 , C12N9/02 , C12P5/00 , C07C9/00 , C09K3/00
摘要： The disclosure relates to methods of producing fatty alcohols from recombinant host cells comprising genes encoding heterologous fatty acyl-CoA reductase (FAR) enzymes. The disclosure further relates to FAR enzymes and functional fragments thereof derived from marine bacterium and particularly marine gamma proteobacterium such as Marinobacter and Oceanobacter; polynucleotides encoding the FAR enzymes and vectors and host cells comprising the same.
摘要翻译： 本公开涉及从包含编码异源脂肪酰辅酶A还原酶（FAR）酶的基因的重组宿主细胞产生脂肪醇的方法。 本公开还涉及来自海洋细菌，特别是海洋γ蛋白杆菌如马里他杆菌和海洋杆菌的FAR酶及其功能片段; 编码FAR酶的多核苷酸和载体以及包含其的宿主细胞。
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4.发明授权Production of fatty alcohols with fatty alcohol forming acyl-CoA reductases (FAR) 有权用脂肪醇形成酰基辅酶A还原酶（FAR）生产脂肪醇公开(公告)号：US08574877B2
公开(公告)日：2013-11-05
申请号：US13494709
申请日：2012-06-12
IPC分类号： C12P7/42 , C12P21/06 , C12P21/04 , C12Q1/68 , C12Q1/26 , C12N9/02 , C12N1/20 , C12N15/00 , C07H21/04
摘要： The disclosure relates to methods of producing fatty alcohols from recombinant host cells comprising genes encoding heterologous fatty acyl-CoA reductase (FAR) enzymes. The disclosure further relates to FAR enzymes and functional fragments thereof derived from marine bacterium and particularly marine gamma proteobacterium such as Marinobacter and Oceanobacter; polynucleotides encoding the FAR enzymes and vectors and host cells comprising the same.
摘要翻译： 本公开涉及从包含编码异源脂肪酰辅酶A还原酶（FAR）酶的基因的重组宿主细胞产生脂肪醇的方法。 本公开还涉及来自海洋细菌，特别是海洋γ蛋白杆菌如马里他杆菌和海洋杆菌的FAR酶及其功能片段; 编码FAR酶的多核苷酸和载体以及包含其的宿主细胞。
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公开(公告)号：US20100298612A1
公开(公告)日：2010-11-25
申请号：US12784770
申请日：2010-05-21
申请人： Behnaz Behrouzian , Robert McDaniel , Xiyun Zhang , Louis Clark
发明人： Behnaz Behrouzian , Robert McDaniel , Xiyun Zhang , Louis Clark
CPC分类号： C12P7/04 , C12N9/0008 , C12N9/1288
摘要： The present disclosure provides a process for the production of long chain fatty alcohols by recombinant host cells expressing one or more heterologous carboxylic acid reductase enzymes useful for the conversion of fatty acids, and derivatives thereof, to long chain fatty alcohols.
摘要翻译： 本公开提供了通过表达用于将脂肪酸及其衍生物转化成长链脂肪醇的一种或多种异源羧酸还原酶的重组宿主细胞生产长链脂肪醇的方法。
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6.发明申请公开(公告)号：US20120009640A1
公开(公告)日：2012-01-12
申请号：US13171138
申请日：2011-06-28
申请人： Behnaz Behrouzian , Louis Clark , Yihui Zhu , Michael Clay , Kristian Karlshoej
发明人： Behnaz Behrouzian , Louis Clark , Yihui Zhu , Michael Clay , Kristian Karlshoej
IPC分类号： C12P7/04 , C12N1/19 , C12N1/21 , C11D3/386 , C07C1/22 , C12P5/02 , C07C31/125 , C07C69/003 , C11D3/22 , C11D3/60 , C12N9/06 , C07C67/00
CPC分类号： C12N9/0008 , C07C1/22 , C07K2319/00 , C07K2319/036 , C10G3/00 , C10G3/40 , C10G2300/1011 , C10G2400/04 , C11D3/2003 , C11D3/2013 , C11D3/2031 , C12N9/0006 , C12P7/04 , Y02P30/20
摘要： The present disclosure provides methods useful for producing fatty alcohol compositions from recombinant host cells. The disclosure further provides variant fatty acyl-CoA reductase (FAR) enzymes, polynucleotides encoding the variant FAR enzymes, and vectors and host cells comprising the same.
摘要翻译： 本公开内容提供了用于从重组宿主细胞产生脂肪醇组合物的方法。 本公开进一步提供变体脂肪酰基-CoA还原酶（FAR）酶，编码变体FAR酶的多核苷酸，以及载体和包含其的宿主细胞。
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公开(公告)号：US08574878B2
公开(公告)日：2013-11-05
申请号：US13171138
申请日：2011-06-28
申请人： Behnaz Behrouzian , Louis Clark , Yihui Zhu , Michael Clay , Kristian Karlshoej
发明人： Behnaz Behrouzian , Louis Clark , Yihui Zhu , Michael Clay , Kristian Karlshoej
IPC分类号： C12P7/04 , C12P5/02 , C12P7/42 , C12P21/06 , C12N9/02 , C12N1/20 , C12N1/00 , C11D3/00 , C07C51/00 , C07C53/00 , C07C1/00 , C07C29/00
CPC分类号： C12N9/0008 , C07C1/22 , C07K2319/00 , C07K2319/036 , C10G3/00 , C10G3/40 , C10G2300/1011 , C10G2400/04 , C11D3/2003 , C11D3/2013 , C11D3/2031 , C12N9/0006 , C12P7/04 , Y02P30/20
摘要： The present disclosure provides methods useful for producing fatty alcohol compositions from recombinant host cells. The disclosure further provides variant fatty acyl-CoA reductase (FAR) enzymes, polynucleotides encoding the variant FAR enzymes, and vectors and host cells comprising the same.
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公开(公告)号：US07879585B2
公开(公告)日：2011-02-01
申请号：US11865696
申请日：2007-10-01
申请人： Lorraine Joan Giver , Lisa Marie Newman , Emily Mundorff , Gjalt W. Huisman , Stephane J. Jenne , Jun Zhu , Behnaz Behrouzian , John H. Grate , James Lalonde
发明人： Lorraine Joan Giver , Lisa Marie Newman , Emily Mundorff , Gjalt W. Huisman , Stephane J. Jenne , Jun Zhu , Behnaz Behrouzian , John H. Grate , James Lalonde
CPC分类号： C12P13/002 , C07C253/30 , C12N9/0008 , C12P7/42 , C12P7/62 , C07C255/20
摘要： The present disclosure provides ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, method of using the engineered ketoreductase enzymes to synthesize a variety of chirally pure compounds, and the chirally pure compounds prepared therewith.
摘要翻译： 本公开提供与天然存在的野生型酮还原酶相比具有改善的性质的酮还原酶。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，使用工程化酮还原酶合成各种手性纯化合物的方法，以及用其制备的手性纯化合物。
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公开(公告)号：US08247192B2
公开(公告)日：2012-08-21
申请号：US12615139
申请日：2009-11-09
申请人： Behnaz Behrouzian , Anke Krebber , Emily Mundorff
发明人： Behnaz Behrouzian , Anke Krebber , Emily Mundorff
CPC分类号： C12N9/84 , C12P7/22 , C12P37/06 , C12P41/004
摘要： The present disclosure relates to engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.
摘要翻译： 本公开涉及具有改进性质的工程青霉素G酰基转移酶（PGA）酶，编码这些酶的多核苷酸，包含酶的组合物和使用酶的方法。
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公开(公告)号：US09040262B2
公开(公告)日：2015-05-26
申请号：US13695856
申请日：2011-05-04
申请人： Michael Crowe , Oscar Alvizo , Behnaz Behrouzian , Yong Koy Bong , Steven J. Collier , Anupam Gohel , Jagadeesh Mavinahalli , Naga Modukuru , Emily Mundorff , Derek Smith , Shiwei Song , Wan Lin Yeo
发明人： Michael Crowe , Oscar Alvizo , Behnaz Behrouzian , Yong Koy Bong , Steven J. Collier , Anupam Gohel , Jagadeesh Mavinahalli , Naga Modukuru , Emily Mundorff , Derek Smith , Shiwei Song , Wan Lin Yeo
CPC分类号： C12N9/0006 , A61K38/00 , C07K14/47 , C12P17/10 , C12P17/14 , C12Y101/00 , C12Y101/01184
摘要： The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
摘要翻译： 本公开涉及可用于制备依泽替米贝的非天然存在的多肽，编码多肽的多核苷酸以及使用多肽的方法。
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