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    ELECTROSPRAY DEVICES FOR MASS SPECTROMETRY
    4.
    发明申请
    ELECTROSPRAY DEVICES FOR MASS SPECTROMETRY 有权
    用于大量光谱的电子设备

    公开(公告)号：US20060097151A1

    公开(公告)日：2006-05-11

    申请号：US10982189

    申请日：2004-11-05

    申请人： Karen Seaward ,  Hongfeng Yin ,  Kevin Killeen ,  Daniel Sobek ,  Daniel Roitman

    发明人： Karen Seaward ,  Hongfeng Yin ,  Kevin Killeen ,  Daniel Sobek ,  Daniel Roitman

    IPC分类号： H01J49/04

    CPC分类号： H01J49/165

    摘要： An electrospray device for a mass spectrometry system is described. The electrospray device comprises a body portion and a tip portion extending from the body portion. The tip portion comprises a polymeric material. The electrospray device also comprises a hydrophobic coating substantially selectively covering the tip portion. The hydrophobic coating is electrically nonconductive.

    摘要翻译： 描述了用于质谱系统的电喷雾装置。 电喷雾装置包括主体部分和从主体部分延伸的尖端部分。 尖端部分包括聚合材料。 电喷雾装置还包括基本上选择性地覆盖尖端部分的疏水涂层。 疏水涂层是不导电的。

    Fluid-channel device with covalently bound hard and soft structural components
    5.
    发明申请
    Fluid-channel device with covalently bound hard and soft structural components 审中-公开
    具有共价结合的硬和软结构部件的流体通道装置

    公开(公告)号：US20050274456A1

    公开(公告)日：2005-12-15

    申请号：US10356020

    申请日：2003-02-03

    申请人： Daniel Roitman ,  Karla Robotti ,  Kevin Killeen

    发明人： Daniel Roitman ,  Karla Robotti ,  Kevin Killeen

    IPC分类号： B01L3/00 ,  B32B37/00 ,  B32B31/00

    CPC分类号： B32B37/00 ,  B01L3/5027 ,  B32B38/06 ,  B32B2315/08 ,  B32B2379/08

    摘要： A hybrid hard/soft microfluidic device is assembled by covalently bonding bard and soft materials. The channels are formed in a polyimide material, which is to be sandwiched between an integrated circuit and a glass cover. The glass covered is treated with an amino siloxane to form free amine groups. The polyimide is treated to form free carboxyl groups. The glass and polyimide are bonded through amidation. The remaining polyimide surface is treated with polyamines to form free amine groups, while silicon dioxide surfaces of the integrated surface are treated with isocyanate siloxane to form free isocyanate groups. The integrated circuit is then covalently bonded to the polyimide surface. The latter surface can be a thermoplastic coating that offers some compliance, more intimate contact, and more thorough bonding.

    摘要翻译： 混合硬/软微流体装置通过共价键合吟游诗人和软材料组装。 通道形成在被夹在集成电路和玻璃盖之间的聚酰亚胺材料中。 用氨基硅氧烷处理覆盖的玻璃以形成游离胺基团。 处理聚酰亚胺形成游离羧基。 玻璃和聚酰亚胺通过酰胺化键合。 剩余的聚酰亚胺表面用多胺处理以形成游离胺基，而整体表面的二氧化硅表面用异氰酸酯硅氧烷处理形成游离异氰酸酯基团。 然后将集成电路共价结合到聚酰亚胺表面。 后者表面可以是热塑性涂层，其提供一些顺应性，更紧密的接触和更彻底的粘合。

    Evanescent wave sensor containing nanostructures and methods of using the same
    6.
    发明申请
    Evanescent wave sensor containing nanostructures and methods of using the same 审中-公开
    含有纳米结构的Ev逝波传感器及其使用方法

    公开(公告)号：US20050265648A1

    公开(公告)日：2005-12-01

    申请号：US10858770

    申请日：2004-06-01

    申请人： Daniel Roitman ,  Kevin Killeen ,  Sungsoo Yi

    发明人： Daniel Roitman ,  Kevin Killeen ,  Sungsoo Yi

    IPC分类号： C01B31/02 ,  G01N21/55 ,  G01N33/53 ,  G02B6/26 ,  G02B6/10

    CPC分类号： G01N21/554 ,  B82Y20/00

    摘要： The invention provides an evanescent wave sensor containing a porous nanostructure layer. In general, a subject sensor contains a transparent substrate and a porous nanostructure layer bound to a surface of the substrate. Also provided by he invention are methods of using the subject sensors, e.g., in analyte detection, as well as kits and systems that include the subject sensors.

    摘要翻译： 本发明提供一种含有多孔纳米结构层的ev逝波传感器。 通常，被检体传感器包含与基底表面结合的透明基底和多孔纳米结构层。 本发明还提供了使用本发明的传感器，例如在分析物检测中的方法，以及包括对象传感器的试剂盒和系统。

    Evanescent wave sensor with attached ligand
    10.
    发明申请
    Evanescent wave sensor with attached ligand 审中-公开
    具有附着配体的渐逝波传感器

    公开(公告)号：US20070099180A1

    公开(公告)日：2007-05-03

    申请号：US11264808

    申请日：2005-10-31

    申请人： Karla Robotti ,  Daniel Roitman

    发明人： Karla Robotti ,  Daniel Roitman

    IPC分类号： C12Q1/70 ,  G01N33/554 ,  C12M1/34

    CPC分类号： G01N33/54373 ,  B82Y15/00 ,  B82Y30/00 ,  G01N21/553 ,  G01N33/54353

    摘要： The invention in particular embodiments provides an evanescent wave sensor which includes a ligand bound to a sensor substrate via a β-hydroxy-linker moiety, as defined herein. Methods of making the subject evanescent wave sensors are also provided which include contacting a first reactive moiety which has an epoxy-ring moiety with a second reactive moiety which has an amino moiety or a thiol moiety, as further described herein. Also provided by the invention are methods in which a subject evanescent wave sensor is contacted with a sample, and binding of analytes in the sample to the sensor is assessed by evanescent wave detection. The invention also provides kits and systems for performing the subject methods.

    摘要翻译： 本发明在具体实施方案中提供了一种ev逝波传感器，其包括通过本文定义的β-羟基 - 连接体部分与传感器底物结合的配体。 还提供了制备对象ev逝波传感器的方法，其包括使具有环氧环部分的第一反应性部分与具有氨基部分或硫醇部分的第二反应性部分接触，如本文进一步描述的。 本发明还提供了一种方法，其中对象ev逝波传感器与样品接触，并且通过ev逝波检测来评估样品中的分析物与传感器的结合。 本发明还提供用于执行主题方法的套件和系统。