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    Condition management callback system and method of operation thereof
    1.
    发明申请
    Condition management callback system and method of operation thereof 有权
    条件管理回调系统及其操作方法

    公开(公告)号：US20050188140A1

    公开(公告)日：2005-08-25

    申请号：US10782080

    申请日：2004-02-19

    申请人： Russell Hitchcock ,  Michael Holmes ,  Keith Kahn ,  Gerald Williams

    发明人： Russell Hitchcock ,  Michael Holmes ,  Keith Kahn ,  Gerald Williams

    IPC分类号： G06F13/24

    CPC分类号： G06F13/24

    摘要： A condition management callback system and method for use with a processor employing a hierarchical register consolidation structure. In one embodiment, the system includes: (1) a condition management structure, (2) a callback abstraction subsystem configured to register a callback for at least one element object in the condition management structure and store logically abstracted data associated with the callback and (3) an abstraction retrieval subsystem configured to employ the condition management structure to determine a condition of at least one status indicator in the condition management structure by traversing the hierarchical register consolidation structure, initiate the callback based on the condition and pass the logically abstracted data if the element object representing the status indicator has the callback registered.

    摘要翻译： 一种条件管理回调系统和方法，用于与使用分层寄存器整合结构的处理器。 在一个实施例中，系统包括：（1）条件管理结构，（2）回调抽象子系统，配置为在条件管理结构中注册至少一个元素对象的回调，并存储与回调相关联的逻辑抽象数据， 3）一种抽象检索子系统，被配置为使用条件管理结构来通过遍历分层寄存器合并结构来确定条件管理结构中的至少一个状态指示符的条件，基于条件启动回调，并且通过逻辑抽象数据，如果 表示状态指示器的元素对象具有已注册的回调。

    System and method for automatically generating a hierarchical register consolidation structure
    2.
    发明申请
    System and method for automatically generating a hierarchical register consolidation structure 有权
    自动生成分层寄存器整合结构的系统和方法

    公开(公告)号：US20050015755A1

    公开(公告)日：2005-01-20

    申请号：US10801792

    申请日：2004-03-16

    申请人： Michael Holmes ,  Gerald Williams

    发明人： Michael Holmes ,  Gerald Williams

    IPC分类号： G06F9/45

    CPC分类号： G06F17/5045

    摘要： A system for, and method of, automatically generating a hierarchical register consolidation structure. In one embodiment, the system includes: (1) a graph generator that parses a High-level Design Language (HDL) file to generate an intermediate graph containing definitions of microprocessor-accessible registers, node interrelationships and summary bits and masks associated with alarm registers, (2) a graph converter, associated with the graph generator, that selectively adds virtual elements and nodes to the intermediate graph to transform the intermediate graph into a mathematical tree and (3) a description generator, associated with the graph converter, that employs the mathematical tree to generate a static tree description in a programming language suitable for use by a device-independent condition management structure.

    摘要翻译： 一种自动生成分层寄存器整合结构的系统和方法。 在一个实施例中，系统包括：（1）图形生成器，其解析高级设计语言（HDL）文件以生成包含微处理器可访问寄存器，节点相互关系和与报警寄存器相关联的摘要位和掩码的定义的中间图 ，（2）与图形生成器相关联的图形转换器，其选择性地将虚拟元素和节点添加到中间图，以将中间图变换成数学树;以及（3）与图形转换器相关联的描述生成器，其使用 数学树在适合于与设备无关的条件管理结构使用的编程语言中生成静态树描述。

    Condition management system and a method of operation thereof
    3.
    发明申请
    Condition management system and a method of operation thereof 失效
    条件管理系统及其操作方法

    公开(公告)号：US20050005089A1

    公开(公告)日：2005-01-06

    申请号：US10612097

    申请日：2003-07-02

    申请人： Jason Eckhart ,  Michael Holmes ,  Chang Li ,  Gerald Williams

    发明人： Jason Eckhart ,  Michael Holmes ,  Chang Li ,  Gerald Williams

    IPC分类号： G06F9/48 ,  G06F15/00

    CPC分类号： G06F9/4812

    摘要： For use with a processor employing a hierarchical register consolidation structure (HRCS), a condition management system and method of operation thereof. In one embodiment, the system includes a condition management structure (CMS) that abstracts groups of status indicators associated with the HRCS into a tree of hierarchical container objects and element objects. Each of the container objects is associated with at least one of the element objects and linked to a single parent object, and each of the element objects configured to represent at least one of the status indicators and linked to a single child object. The system further includes an abstraction retrieval subsystem that employs the CMS to traverse the HRCS to determine a condition of at least one of the status indicators, and an abstraction management subsystem that employs the CMS to control a propagation of selected ones of the status indicators through the HRCS.

    摘要翻译： 用于与采用分级寄存器合并结构（HRCS）的处理器，条件管理系统及其操作方法。 在一个实施例中，系统包括条件管理结构（CMS），其将与HRCS相关联的状态指示符组抽象为分层容器对象和元素对象的树。 每个容器对象与至少一个元素对象相关联并链接到单个父对象，并且每个元素对象被配置为表示至少一个状态指示符并链接到单个子对象。 该系统还包括抽象检索子系统，其利用CMS遍历HRCS以确定至少一个状态指示符的状况，以及抽象管理子系统，其使用CMS来控制所选择的状态指示符的传播 HRCS。

    METHOD AND APPARATUS FOR MONITORING ANESTHESIA DRUG DOSAGES, CONCENTRATIONS, AND EFFECTS USING N-DIMENSIONAL REPRESENTATIONS OF CRITICAL FUNCTIONS
    6.
    发明申请
    METHOD AND APPARATUS FOR MONITORING ANESTHESIA DRUG DOSAGES, CONCENTRATIONS, AND EFFECTS USING N-DIMENSIONAL REPRESENTATIONS OF CRITICAL FUNCTIONS 审中-公开
    用于监测麻醉药物剂量，浓度和效果的方法和装置，使用关键功能的三维表示

    公开(公告)号：US20080033661A1

    公开(公告)日：2008-02-07

    申请号：US11843524

    申请日：2007-08-22

    申请人： Noah Syroid ,  Dwayne Westenskow ,  Julio Bermudez ,  James Agutter ,  David Strayer ,  Robert Albert ,  Michael Holmes ,  Frank Drews ,  Haunke Prenzel

    发明人： Noah Syroid ,  Dwayne Westenskow ,  Julio Bermudez ,  James Agutter ,  David Strayer ,  Robert Albert ,  Michael Holmes ,  Frank Drews ,  Haunke Prenzel

    IPC分类号： G06F19/00

    CPC分类号： G09B23/28 ,  A61B5/00 ,  A61M5/142 ,  A61M16/021 ,  A61M2202/048 ,  A61M2205/3576 ,  A61M2205/6072 ,  G06F19/3456 ,  G16H50/50

    摘要： A method, system and apparatus for the monitoring, diagnosis and evaluation of the state of a dynamic system is disclosed. This method and system provides the processing means for receiving sensed and/or simulated data, converting such data into a displayable object format and displaying such objects in a manner such that the interrelationships between the respective variables can be correlated and identified by a user. This invention provides for the rapid cognitive grasp of the overall state of a critical function with respect to a dynamic system. The system provides for displayed objects, which change in real-time to show the changes of the functions of the system. It is a highly flexible system which works with a wide variety of applications, including biological systems, environmental systems, engineering systems, economic systems, mechanical systems, chemical systems and the like. In particular, this invention is directed to the processing and display of drug data for the use of doctors in the process of monitoring or administering drugs to patients.

    摘要翻译： 公开了一种用于动态系统状态的监视，诊断和评估的方法，系统和装置。 该方法和系统提供了用于接收感测和/或模拟数据的处理装置，将这些数据转换成可显示对象格式，并以这样一种方式显示这些对象，使得各个变量之间的相互关系可以由用户相关和识别。 本发明提供了关于动态系统的关键功能的总体状态的快速认知掌握。 系统提供显示对象，实时更改以显示系统功能的更改。 它是一个高度灵活的系统，适用于各种应用，包括生物系统，环境系统，工程系统，经济系统，机械系统，化学系统等。 特别地，本发明涉及在向患者监测或给予药物的过程中使用医生的药物数据的处理和显示。

    Methods and compositions for targeted cleavage and recombination
    8.
    发明申请
    Methods and compositions for targeted cleavage and recombination 有权
    用于靶向切割和重组的方法和组合物

    公开(公告)号：US20050064474A1

    公开(公告)日：2005-03-24

    申请号：US10912932

    申请日：2004-08-06

    申请人： Fyodor Urnov ,  Michael Holmes ,  Jeffrey Miller ,  Carl Pabo

    发明人： Fyodor Urnov ,  Michael Holmes ,  Jeffrey Miller ,  Carl Pabo

    IPC分类号： C07K14/435 ,  C07K14/47 ,  C07K14/715 ,  C12N9/14 ,  C12N9/22 ,  C12N15/62 ,  C12P19/34 ,  C12Q1/68

    CPC分类号： A61K35/12 ,  C07K14/43595 ,  C07K14/4717 ,  C07K14/715 ,  C07K2319/00 ,  C07K2319/09 ,  C07K2319/81 ,  C12N9/14 ,  C12N9/22 ,  C12N15/62 ,  C12N15/85 ,  C12N2800/80

    摘要： Disclosed herein are methods and compositions for targeted cleavage of a genomic sequence, targeted alteration of a genomic sequence, and targeted recombination between a genomic region and an exogenous polynucleotide homologous to the genomic region. The compositions include fusion proteins comprising a cleavage domain (or cleavage half-domain) and an engineered zinc finger domain and polynucleotides encoding same. Methods for targeted cleavage include introduction of such fusion proteins, or polynucleotides encoding same, into a cell. Methods for targeted recombination additionally include introduction of an exogenous polynucleotide homologous to a genomic region into cells comprising the disclosed fusion proteins.

    摘要翻译： 本文公开了用于基因组序列的靶向切割，基因组序列的靶向改变以及基因组区域和与该基因组区域同源的外源多核苷酸之间的靶向重组的方法和组合物。 组合物包括包含切割结构域（或切割半结构域）和工程化锌指结构域的融合蛋白和编码它们的多核苷酸。 用于靶向切割的方法包括将这种融合蛋白或其编码的多核苷酸引入细胞。 用于靶向重组的方法另外包括将与基因组区域同源的外源多核苷酸引入包含所公开的融合蛋白的细胞中。