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1.发明申请COMPOSITION FOR PROMOTING REMYELINATION IN NERVE CELLS COMPRISING 2,5-DIHYDROXYBENZENESULFONIC ACID AND USE THEREOF 有权用于促进包含2,5-二羟基苯甲酸的神经细胞中的再诱导的组合物及其用途公开(公告)号：US20170049730A1
公开(公告)日：2017-02-23
申请号：US15202341
申请日：2016-07-05
发明人： Yunil Lee , Suhyun Kim , Haechul Park , Sangchul Park
IPC分类号： A61K31/185
CPC分类号： A61K31/185
摘要： A method of preventing or treating a disease associated with demyelination of a nerve cell in a mammal, a method of promoting remyelination or suppressing demyelination of a nerve cell in a mammal, and a method of reducing expression of PMP22 in a nerve cell of a mammal by administration of 2,5-dihydroxybenzenesulfonic acid or a pharmaceutically acceptable salt or solvate thereof.
摘要翻译： 一种预防或治疗与哺乳动物神经细胞脱髓鞘相关的疾病的方法，哺乳动物神经细胞脱髓鞘的促进再髓鞘化或抑制神经细胞的脱髓鞘化的方法，以及降低哺乳动物神经细胞中PMP22表达的方法 通过施用2,5-二羟基苯磺酸或其药学上可接受的盐或溶剂合物。
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公开(公告)号：US20190206867A1
公开(公告)日：2019-07-04
申请号：US16030224
申请日：2018-07-09
发明人： Jung Han LEE , Sungchul Park , Yunil Lee , Byoung-gi Kim , Yeongmin Jeon , Daewon Ha , Inchan Hwang , Jae Hyun Park , Woocheol Shin
IPC分类号： H01L27/092 , H01L29/423 , H01L27/02 , H01L29/08 , H01L21/8238 , H01L21/306 , H01L29/66 , H01L21/3213 , H01L21/02 , H01L29/78 , H01L29/165
CPC分类号： H01L27/0924 , H01L21/02529 , H01L21/02532 , H01L21/02636 , H01L21/30604 , H01L21/32139 , H01L21/823814 , H01L21/823821 , H01L21/823828 , H01L21/823864 , H01L21/823878 , H01L27/0207 , H01L29/0847 , H01L29/165 , H01L29/42372 , H01L29/6653 , H01L29/66545 , H01L29/66636 , H01L29/7848
摘要： A semiconductor substrate includes a plurality of gate electrodes crossing active patterns on a substrate and extending in a second direction, the gate electrodes spaced apart in the second direction from each other, a gate separation pattern having a major axis in the first direction and between two of the gate electrodes, the two of the gate electrodes adjacent to each other in the second direction, and a plurality of gate spacers covering sidewalls of respective ones of the gate electrodes, the gate spacers crossing the gate separation pattern and extending in the second direction. The gate separation pattern includes a lower portion extending in the first direction, an intermediate portion protruding from the lower portion and having a first width, and an upper portion between two adjacent gate spacers and protruding from the intermediate portion, the upper portion having a second width less than the first width.
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公开(公告)号：US20170095451A1
公开(公告)日：2017-04-06
申请号：US15284267
申请日：2016-10-03
发明人： Sungchun Cho , Jongsun Kang , Sangchul Park , Yunil Lee , Hyebeen Kim , Hyeyoung Lee
IPC分类号： A61K31/4035
CPC分类号： A61K31/4035
摘要： A method of increasing PGC-1α expression in a mammalian cell, the method comprising administering an effective amount of indoprofen, a pharmaceutically acceptable salt thereof, or a solvate thereof to the cell.
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公开(公告)号：US09820997B2
公开(公告)日：2017-11-21
申请号：US14933833
申请日：2015-11-05
发明人： Yunil Lee , Kiyoung Chang , Sangchul Park , Sungchun Cho
IPC分类号： A61K31/635 , A61K31/145 , A61K31/167 , A61K31/63
CPC分类号： A61K31/635 , A61K31/145 , A61K31/167 , A61K31/63
摘要： A method of accelerating remyelination or suppressing demyelination of neurons in a mammal, and a method of treating a disease associated with demyelination of neurons in a mammal.
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5.发明申请PHARMACEUTICAL COMPOSITION FOR TREATING DISEASE ASSOCIATED WITH DEMYELINATION OF NEURONS AND METHOD OF USING THE PHARMACEUTICAL COMPOSITION 有权用于治疗与神经元脱氨相关的疾病的药物组合物和使用药物组合物的方法公开(公告)号：US20160120884A1
公开(公告)日：2016-05-05
申请号：US14933833
申请日：2015-11-05
发明人： Yunil Lee , Kiyoung Chang , Sangchul Park , Sungchun Cho
IPC分类号： A61K31/635 , A61K31/167 , A61K31/63 , A61K31/145
CPC分类号： A61K31/635 , A61K31/145 , A61K31/167 , A61K31/63
摘要： A method of accelerating remyelination or suppressing demyelination of neurons in a mammal, and a method of treating a disease associated with demyelination of neurons in a mammal.
摘要翻译： 一种加速哺乳动物神经细胞再髓鞘化或抑制脱髓鞘化的方法，以及治疗哺乳动物神经元脱髓鞘疾病相关疾病的方法。
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公开(公告)号：US10256324B2
公开(公告)日：2019-04-09
申请号：US15664226
申请日：2017-07-31
发明人： Sungil Park , Changhee Kim , Yunil Lee , Mirco Cantoro , Junggun You , Donghun Lee
IPC分类号： H01L29/66 , H01L29/78 , H01L29/06 , H01L29/08 , H01L29/10 , H01L21/28 , H01L29/40 , H01L29/423
摘要： A semiconductor device includes an active pillar on a substrate. A first source/drain region is disposed at a top end of the active pillar and has a greater width than the active pillar. A first insulating layer is disposed on a sidewall of the active pillar and a second insulating layer is disposed on at least a bottom surface of the first source/drain region. A gate electrode is disposed on the first insulating layer and the second insulating layer. A second source/drain region is disposed in the substrate at a bottom end of the active pillar. Methods of fabrication are also described.
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公开(公告)号：US20170157145A1
公开(公告)日：2017-06-08
申请号：US15332306
申请日：2016-10-24
发明人： Yunil Lee , Yunjong Lee , Sangwoo Ham , Sangchul Park , Jooho Shin
IPC分类号： A61K31/573 , G01N33/50 , C12N9/00 , A61K31/4196 , A61K31/407
CPC分类号： A61K31/573 , A61K31/407 , A61K31/4196 , C12N9/93 , C12Y603/02 , G01N33/5023 , G01N33/5058 , G01N33/6896 , G01N2333/9015 , G01N2800/2814 , G01N2800/2835
摘要： A method of inducing Parkin expression; inhibiting oxidative stress; and inhibiting cell death of cells by administering deferasirox, hydrocortisone, ketorolac, dexamethasone, and prednisone, a pharmaceutically acceptable salt, stereoisomer, derivative, or solvate thereof to the cell, optionally in a subject, as well as a method of preventing or treating neurodegenerative disease in the subject.
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公开(公告)号：US10559673B2
公开(公告)日：2020-02-11
申请号：US16284843
申请日：2019-02-25
发明人： Sungil Park , Changhee Kim , Yunil Lee , Mirco Cantoro , Junggun You , Donghun Lee
IPC分类号： H01L29/66 , H01L29/78 , H01L29/06 , H01L29/08 , H01L29/10 , H01L21/28 , H01L29/40 , H01L29/423 , H01L29/786 , H01L29/417
摘要： A semiconductor device includes an active pillar on a substrate. A first source/drain region is disposed at a top end of the active pillar and has a greater width than the active pillar. A first insulating layer is disposed on a sidewall of the active pillar and a second insulating layer is disposed on at least a bottom surface of the first source/drain region. A gate electrode is disposed on the first insulating layer and the second insulating layer. A second source/drain region is disposed in the substrate at a bottom end of the active pillar. Methods of fabrication are also described.
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公开(公告)号：US20180248018A1
公开(公告)日：2018-08-30
申请号：US15664226
申请日：2017-07-31
发明人： Sungil Park , Changhee Kim , Yunil Lee , Mirco Cantoro , Junggun You , Donghun Lee
CPC分类号： H01L29/66666 , H01L21/28114 , H01L29/0653 , H01L29/0847 , H01L29/1033 , H01L29/401 , H01L29/4238 , H01L29/66553 , H01L29/7827
摘要： A semiconductor device includes an active pillar on a substrate. A first source/drain region is disposed at a top end of the active pillar and has a greater width than the active pillar. A first insulating layer is disposed on a sidewall of the active pillar and a second insulating layer is disposed on at least a bottom surface of the first source/drain region. A gate electrode is disposed on the first insulating layer and the second insulating layer. A second source/drain region is disposed in the substrate at a bottom end of the active pillar. Methods of fabrication are also described.
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公开(公告)号：US09782371B2
公开(公告)日：2017-10-10
申请号：US15202341
申请日：2016-07-05
发明人： Yunil Lee , Suhyun Kim , Haechul Park , Sangchul Park
IPC分类号： A61K31/635 , A61K31/145 , A61K31/167 , A61K31/185
CPC分类号： A61K31/185
摘要： A method of preventing or treating a disease associated with demyelination of a nerve cell in a mammal, a method of promoting remyelination or suppressing demyelination of a nerve cell in a mammal, and a method of reducing expression of PMP22 in a nerve cell of a mammal by administration of 2,5-dihydroxybenzenesulfonic acid or a pharmaceutically acceptable salt or solvate thereof.
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