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    METHOD FOR DIFFERENTIATION OF STEM CELLS INTO VASCULAR CELLS AND THE INDUCTION OF ANGIOGENESIS USING THE SAME
    3.
    发明申请
    METHOD FOR DIFFERENTIATION OF STEM CELLS INTO VASCULAR CELLS AND THE INDUCTION OF ANGIOGENESIS USING THE SAME 有权
    将干细胞分化成血管细胞的方法和使用其的血管生成的诱导

    公开(公告)号：US20120134965A1

    公开(公告)日：2012-05-31

    申请号：US13259767

    申请日：2010-03-24

    申请人： Sang-Heon Kim ,  Soo Hyun Kim ,  In Su Park ,  Young Mee Jung

    发明人： Sang-Heon Kim ,  Soo Hyun Kim ,  In Su Park ,  Young Mee Jung

    IPC分类号： A61K35/12 ,  C12N5/077 ,  C12N5/0775 ,  C12N5/0797 ,  A61P25/00 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P9/04 ,  C12N5/071 ,  C12N5/0789

    CPC分类号： C12N5/069 ,  A61K35/28 ,  A61K35/30 ,  A61K35/44 ,  A61K35/51 ,  A61K35/545 ,  C12N2501/115 ,  C12N2506/1384 ,  C12N2513/00 ,  C12N2533/52 ,  C12N2533/54 ,  C12N2533/70

    摘要： The present invention relates to a method for differentiating stem cells into vascular cells by culturing them in the form of a three-dimensional cell cluster and the use of the three-dimensional cell cluster for angiogenesis. Specifically, the present invention teaches a method for differentiating stem cells into vascular cells comprising culturing stem cells by adhering them onto a culture plate with a surface having a hydrophobic property or a culture plate onto which a growth factor is immobilized, wherein the cultured stem cells are later detached from the culture plate as their density increases to form a three-dimensional cell cluster and grown in the form of a three-dimensional cell cluster while differentiating into vascular cells. Also disclosed is the use of a three-dimensional cell cluster composed of the vascular cells differentiated from stem cells by the above method as a cell therapy agent for angiogenesis.

    摘要翻译： 本发明涉及一种通过以三维细胞簇的形式培养它们并使用三维细胞簇进行血管发生来将干细胞分化为血管细胞的方法。 具体而言，本发明教导了将干细胞分化成血管细胞的方法，包括通过将干细胞粘附在具有疏水性的表面的培养板上或培养板上固定有生长因子培养干细胞，其中培养的干细胞 随着其密度增加而随培养板分离，形成三维细胞簇，并以三维细胞簇的形式生长，同时分化为血管细胞。 还公开了通过上述方法将由干细胞分化的血管细胞组成的三维细胞簇用作血管发生的细胞治疗剂。

    METHOD FOR PREPARING BIODEGRADABLE POLYMER STEREOCOMPLEXES USING A SUPERCRITICAL FLUID-ORGANIC SOLVENT SYSTEM AND STEREOCOMPLEXES PREPARED BY THE SAME
    4.
    发明申请
    METHOD FOR PREPARING BIODEGRADABLE POLYMER STEREOCOMPLEXES USING A SUPERCRITICAL FLUID-ORGANIC SOLVENT SYSTEM AND STEREOCOMPLEXES PREPARED BY THE SAME 有权
    使用超临界流体有机溶剂系统制备可生物降解的聚合物立体异构体的方法及其制备的立体异构体

    公开(公告)号：US20110201710A1

    公开(公告)日：2011-08-18

    申请号：US12948621

    申请日：2010-11-17

    申请人： Soo Hyun Kim ,  Young Mee Jung ,  Sang-Heon Kim ,  Purnama Purba

    发明人： Soo Hyun Kim ,  Young Mee Jung ,  Sang-Heon Kim ,  Purnama Purba

    IPC分类号： C08J9/00 ,  C08G63/08

    CPC分类号： C08J3/005 ,  C08J9/0061 ,  C08J2203/08 ,  C08J2300/12 ,  C08J2300/16 ,  C08J2367/04 ,  C08J2369/00 ,  C08J2373/02 ,  C08J2400/14 ,  C08J2467/00 ,  C08J2469/00 ,  C08J2473/00

    摘要： The present invention relates to methods for preparing biodegradable polymer stereocomplexes using a supercritical fluid-organic solvent system and polymer stereocomplexes prepared by such methods. The method of the present invention involves introducing two types of homopolymers having different stereostructures and a small amount of organic solvent into a reactor, adding a supercritical fluid thereto, followed by applying a specific temperature and pressure to form a polymer stereocomplex having a crystalline structure. According to the method of the present invention, biodegradable polymer stereocomplexes in the form of powder or porous foam having excellent thermal and mechanical stabilities can be prepared in a simple, economical and environmentally-friendly manner in a single process.

    摘要翻译： 本发明涉及使用超临界流体 - 有机溶剂体系制备可生物降解的聚合物立体络合物的方法和通过这些方法制备的聚合物立体络合物。 本发明的方法包括将具有不同立体结构和少量有机溶剂的两种均聚物引入反应器中，向其中加入超临界流体，然后施加特定的温度和压力以形成具有结晶结构的聚合物立体络合物。 根据本发明的方法，可以在单一方法中以简单，经济和环保的方式制备具有优异热稳定性和机械稳定性的粉末或多孔泡沫形式的可生物降解的聚合物立体络合物。

    HIGHLY RESILIENT COPOLYMER WITH SHAPE RECOVERY FORCE AND FLEXIBILITY AND THE USE THEREOF FOR THE REPAIR OF ARTICULAR CARTILAGE DEFECTS
    6.
    发明申请
    HIGHLY RESILIENT COPOLYMER WITH SHAPE RECOVERY FORCE AND FLEXIBILITY AND THE USE THEREOF FOR THE REPAIR OF ARTICULAR CARTILAGE DEFECTS 审中-公开
    具有形状恢复力和灵活性的高活性共聚物及其用于修复牙齿缺损的用途

    公开(公告)号：US20100124570A1

    公开(公告)日：2010-05-20

    申请号：US12614919

    申请日：2009-11-09

    申请人： Soo Hyun KIM ,  Young Mee Jung ,  Sang-Heon Kim

    发明人： Soo Hyun KIM ,  Young Mee Jung ,  Sang-Heon Kim

    IPC分类号： A61K9/14 ,  C08G63/08 ,  A61K35/32 ,  A61P19/00

    CPC分类号： C08G63/08 ,  A61L27/18 ,  A61L2430/06 ,  C08L67/04

    摘要： The present invention relates to a highly resilient (lactide/glycolide)/ε-caprolactone copolymer with good shape recovery force, flexibility, and biodegradability and a use of such copolymer for the repair of articular cartilage defects. The highly resilient (lactide/glycolide)/ε-caprolactone copolymer of the present invention is capable of rapidly and efficiently inducing cartilage regeneration, can be easily deformed and almost completely restored to its original form after deformation. Further, the highly resilient copolymer of the present invention can be safely and conveniently transplanted to a patient by using an arthroscope without causing economic, physical, and mental burden. Thus, the highly resilient copolymer of the present invention can be effectively used as a polymer scaffold for the repair of cartilage defects.

    摘要翻译： 本发明涉及具有良好形状恢复力，柔韧性和生物降解性的高弹性（丙交酯/乙交酯）/己内酯共聚物，以及这种共聚物用于修复关节软骨缺陷的用途。 本发明的高弹性（丙交酯/乙交酯）/己内酯共聚物能够快速有效地诱导软骨再生，在变形后能够容易地变形并几乎完全恢复到原来的形态。 此外，本发明的高弹性共聚物可以通过使用关节镜安全且方便地移植到患者，而不会造成经济，身体和精神负担。 因此，本发明的高弹性共聚物可以有效地用作修复软骨缺陷的聚合物支架。

    Method for the immobilization of biologically active polypeptides by using maltose binding protein
    8.
    发明授权
    Method for the immobilization of biologically active polypeptides by using maltose binding protein 有权
    通过使用麦芽糖结合蛋白固定生物活性多肽的方法

    公开(公告)号：US08669075B2

    公开(公告)日：2014-03-11

    申请号：US12258072

    申请日：2008-10-24

    申请人： Sang-Heon Kim ,  Soo Hyun Kim ,  Min Han

    发明人： Sang-Heon Kim ,  Soo Hyun Kim ,  Min Han

    IPC分类号： C12P25/00 ,  A23J1/00

    CPC分类号： C07K14/245 ,  C07K14/52 ,  C07K17/06 ,  C07K2319/24 ,  C12N11/06 ,  C12N11/08 ,  C12N11/14 ,  G01N33/54353

    摘要： The present invention relates to a method for immobilization of a biologically active polypeptide using maltose binding protein (MBP) and a biologically active solid substrate on which a biologically active polypeptide is immobilized by the above method. More particularly, the present invention relates to a method for immobilization of a biologically active polypeptide comprising the following steps; 1) preparing a fusion protein by linking a biologically active polypeptide to carboxyl terminal of maltose binding protein (MBP); and 2) immobilizing the fusion protein on the hydrophobic surface by physical adsorption of amino terminal containing hydrophobic domain exposed on the surface of maltose binding protein on the hydrophobic surface of a solid substrate, and a biologically active solid substrate on which a biologically active polypeptide is immobilized by the said method.

    摘要翻译： 本发明涉及使用麦芽糖结合蛋白（MBP）和通过上述方法固定生物活性多肽的生物活性固体底物固定生物活性多肽的方法。 更具体地说，本发明涉及一种固定生物活性多肽的方法，包括以下步骤： 1）通过将生物活性多肽与麦芽糖结合蛋白（MBP）的羧基末端连接来制备融合蛋白; 和2）通过物理吸附暴露于麦芽糖结合蛋白表面上的疏水结构域的氨基末端在固体底物的疏水性表面上以及生物活性的固体底物上固定所述融合蛋白于所述疏水性表面上， 通过所述方法固定。

    PREPARATION METHOD OF CLAY/POLYMER COMPOSITE USING SUPERCRITICAL FLUID-ORGANIC SOLVENT SYSTEM
    9.
    发明申请
    PREPARATION METHOD OF CLAY/POLYMER COMPOSITE USING SUPERCRITICAL FLUID-ORGANIC SOLVENT SYSTEM 审中-公开
    使用超临界流体有机溶剂系统制备粘土/聚合物复合材料的方法

    公开(公告)号：US20120289618A1

    公开(公告)日：2012-11-15

    申请号：US13276793

    申请日：2011-10-19

    申请人： Youngmee JUNG ,  Soo Hyun Kim ,  Sang-Heon Kim ,  Purba Purnama

    发明人： Youngmee JUNG ,  Soo Hyun Kim ,  Sang-Heon Kim ,  Purba Purnama

    IPC分类号： C08J9/35 ,  C08L81/00 ,  C08L67/04 ,  C08L69/00 ,  C08J3/205 ,  C08K3/34

    CPC分类号： C08J3/205 ,  C08J9/0066 ,  C08J9/12 ,  C08J9/30 ,  C08J2203/08 ,  C08J2367/04 ,  C08J2467/04 ,  Y02P20/544

    摘要： The present invention relates to a method for preparing a clay/polymer composite having a predetermined form such as powder or porous foam with an enhanced thermal and mechanical stability using a simple, economical and eco-friendly supercritical fluid-organic solvent system, and more particularly, to a method for preparing a clay/biodegradable polymer stereoisomeric nanocomposite and a clay/polymer composite prepared by the method thereof. The method of preparing a clay/polymer composite according to the present invention may include (a) introducing a clay, a biodegradable single-phase D-type/L-type stereoisomeric polymer and an organic solvent into a reactor, (b) introducing a supercritical fluid into the reactor to form a stereoisomeric composite, and forming a clay/polymer composite dispersed with the clay on the stereoisomeric composite, and (c) collecting the clay/polymer composite, and the clay/polymer composite of the present invention is a clay/polymer composite prepared by the preparation method.

    摘要翻译： 本发明涉及一种使用简单，经济和环保的超临界流体 - 有机溶剂系统制备具有预定形式的粘土/聚合物复合材料的方法，所述预定形式如粉末或多孔泡沫具有增强的热和机械稳定性，更具体地说 涉及一种制备粘土/可生物降解的聚合物立体异构体纳米复合材料的方法和通过其方法制备的粘土/聚合物复合材料。 根据本发明的制备粘土/聚合物复合材料的方法可以包括（a）将一种粘土，一种可生物降解的单相D型/ L型立体异构体聚合物和有机溶剂引入反应器中，（b）将 超临界流体进入反应器以形成立体异构复合材料，并且在立体异构体复合材料上形成分散有粘土的粘土/聚合物复合材料，和（c）收集粘土/聚合物复合材料，本发明的粘土/聚合物复合材料是 通过制备方法制备粘土/聚合物复合材料。

    Apparatus and method for efficiently operating fast feedback channel in wireless communication system
    10.
    发明授权
    Apparatus and method for efficiently operating fast feedback channel in wireless communication system 有权
    无线通信系统中有效运行快速反馈信道的装置和方法

    公开(公告)号：US09379867B2

    公开(公告)日：2016-06-28

    申请号：US12978986

    申请日：2010-12-27

    申请人： Sang-Heon Kim ,  David Mazzarese ,  Hee-Won Kang

    发明人： Sang-Heon Kim ,  David Mazzarese ,  Hee-Won Kang

    IPC分类号： H04W72/04 ,  H04L5/00

    CPC分类号： H04L5/0053 ,  H04L5/0023 ,  H04L5/0096

    摘要： An apparatus and method for efficiently operating a fast feedback channel in a wireless communication system are provided. A method for operating a feedback channel in a Base Station (BS) of a wireless communication system includes identifying feedback information types of one or more feedback channels intended to be deallocated among a plurality of existing allocated feedback channels for a Mobile Station (MS), activating a bit corresponding to the identified feedback information type in a ‘deallocation bitmap’ field within a DownLink (DL) control signal, and transmitting the DL control signal to the MS. Among the feedback information types of the plurality of existing allocated feedback channels, the feedback information type having the smallest value corresponds to the highest priority bit among bits within the ‘deallocation bitmap’ field.

    摘要翻译： 提供了一种用于在无线通信系统中有效地操作快速反馈信道的装置和方法。 一种用于在无线通信系统的基站（BS）中操作反馈信道的方法包括识别用于移动台（MS）的多个现有分配的反馈信道中旨在被释放的一个或多个反馈信道的反馈信息类型， 在DownLink（DL）控制信号中的“解除分配位图”字段中激活与所识别的反馈信息类型相对应的位，并将DL控制信号发送到MS。 在多个现有分配的反馈信道的反馈信息类型中，具有最小值的反馈信息类型对应于“取消分配位图”字段内的比特中的最高优先级位。