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    DETECTION OF RNA IN TISSUE SAMPLES
    3.
    发明申请
    DETECTION OF RNA IN TISSUE SAMPLES 有权
    检测组织样品中的RNA

    公开(公告)号：US20100034453A1

    公开(公告)日：2010-02-11

    申请号：US12537342

    申请日：2009-08-07

    申请人： David Lynch

    发明人： David Lynch

    IPC分类号： G06T7/00

    CPC分类号： G06T7/0012 ,  G06K9/00127 ,  G06T2207/10064 ,  G06T2207/30024

    摘要： Methods of identifying microRNA labeled with a fluorescent probe in a biological sample are disclosed. The methods include obtaining a plurality of fluorescence images of the sample and forming an image stack based on the plurality of fluorescence images, decomposing the image stack to obtain a component image that corresponds to the labeled microRNA, and identifying the microRNA based on the component image.

    摘要翻译： 公开了在生物样品中鉴定用荧光探针标记的微小RNA的方法。 所述方法包括获得样品的多个荧光图像并基于多个荧光图像形成图像堆叠，分解图像堆叠以获得与标记的微小RNA相对应的分量图像，并且基于分量图像识别微RNA 。

    VIBRATING MASS GYROSCOPE AND METHOD FOR MINIMIZING BIAS ERRORS THEREIN
    4.
    发明申请
    VIBRATING MASS GYROSCOPE AND METHOD FOR MINIMIZING BIAS ERRORS THEREIN 有权
    振动质量陀螺仪和最小化偏差的方法

    公开(公告)号：US20070028686A1

    公开(公告)日：2007-02-08

    申请号：US11364318

    申请日：2006-02-28

    申请人： Stanley Wyse ,  David Lynch

    发明人： Stanley Wyse ,  David Lynch

    IPC分类号： G01P15/08

    CPC分类号： G01C19/5719

    摘要： An exemplary vibrating mass gyroscope uses a mass disposed for movement along an x-axis and y-axis. First and second electrodes are disposed adjacent surfaces of the mass along an x-axis and y-axis. Circuitry, coupled to the first and second electrodes, provides during a first mode a dither driving voltage on one of the first and second electrodes causing vibrating displacement of the mass along the one of the x-axis and y-axis. The measurement voltage is sensed on the other of the first and second electrodes where the measurement voltage represents a first angular rate value. During a second mode, the circuitry provides a dither driving voltage on the other of the first and second electrodes causing vibrating displacement of the mass along the other of the x-axis and y-axis and measurement voltage is sensed on the one of the first and second electrodes where the measurement voltage represents a second angular rate value. A combiner coupled to the circuitry receives the first and second angular rate values, and generates a resulting angular rate value based on both the first and second angular rate values wherein common bias errors are canceled. The common bias errors cancel because the pickoff sensing axis is coincident with the forcing axis when the same electrode is used for both the forcing and for the pickoff.

    摘要翻译： 示例性振动质量陀螺仪使用设置为沿着x轴和y轴移动的质量。 第一和第二电极沿着x轴和y轴设置在质量块的相邻表面。 耦合到第一和第二电极的电路在第一模式期间提供在第一和第二电极之一上的抖动驱动电压，引起质量沿x轴和y轴中的一个的振动位移。 在测量电压表示第一角速度值的第一和第二电极中的另一个电极上检测测量电压。 在第二模式期间，电路在第一和第二电极的另一个上提供抖动驱动电压，引起质量沿x轴和y轴的另一个的振动位移，并且在第一和第二电极之一上检测测量电压 以及测量电压表示第二角速度值的第二电极。 耦合到电路的组合器接收第一和第二角速度值，并且基于消除常见偏差误差的第一和第二角速度值产生最终的角速度值。 当相同的电极用于强制和拾取时，传感偏差误差取消，因为传感轴与强制轴一致。

    Methods for analyzing inter-cellular phenomena
    5.
    发明申请
    Methods for analyzing inter-cellular phenomena 有权
    分析细胞间现象的方法

    公开(公告)号：US20060068371A1

    公开(公告)日：2006-03-30

    申请号：US11123610

    申请日：2005-05-04

    申请人： William Ortyn ,  David Basiji ,  David Lynch

    发明人： William Ortyn ,  David Basiji ,  David Lynch

    IPC分类号： C12Q1/00 ,  G01N21/25

    CPC分类号： G01N33/505 ,  G01J3/2889 ,  G01J3/36 ,  G01J3/4406 ,  G01N15/1429 ,  G01N15/147 ,  G01N15/1475 ,  G01N21/53 ,  G01N21/6428 ,  G01N21/6456 ,  G01N21/6458 ,  G01N33/5005 ,  G01N2015/1006 ,  G01N2015/1497 ,  G01N2021/6421 ,  G01N2021/6441 ,  G06K9/00127

    摘要： Aspects of the present invention encompass the collection of multispectral images from a population of objects, and the analysis of the collected images to measure at least characteristic of the population, using photometric and/or morphometric features identifiable in the collection of images. In an exemplary application, the objects are biological cells. In a particularly preferred, but not limiting implementation, the plurality of images for each individual object are collected simultaneously. In an empirical study the characteristic being measured involves the synapse between conjugated cells. The conjugated cells may represent a subpopulation of the overall population of objects that were imaged. In a particularly preferred, yet not limiting embodiment, the present invention enables the quantization of the redistribution of cellular molecules due to the conjugation of different biological cells. Significantly, such quantization is not feasible with standard microscopy and flow cytometry.

    摘要翻译： 本发明的方面包括从对象群体收集多光谱图像，以及使用在图像集合中可识别的光度和/或形态测量特征，对所收集的图像的分析至少测量群体的特征。 在示例性应用中，对象是生物细胞。 在特别优选但不是限制的实现中，用于每个单独对象的多个图像被同时收集。 在经验研究中，被测量的特征涉及共轭细胞之间的突触。 共轭细胞可以代表成像对象的总体群体的亚群。 在特别优选的但不是限制性的实施方案中，本发明使得由于不同生物细胞的共轭而能够量化细胞分子的再分布。 值得注意的是，这种量化在标准显微镜和流式细胞术中是不可行的。

    Materials and methods for the prevention or treatment of apoptosis and apoptosis-related diseases and conditions
    6.
    发明申请
    Materials and methods for the prevention or treatment of apoptosis and apoptosis-related diseases and conditions 审中-公开
    用于预防或治疗凋亡和凋亡相关疾病和病症的材料和方法

    公开(公告)号：US20050020580A1

    公开(公告)日：2005-01-27

    申请号：US10741493

    申请日：2003-12-19

    申请人： Andrew Badley ,  David Lynch

    发明人： Andrew Badley ,  David Lynch

    IPC分类号： A61K31/522 ,  A61K31/551

    CPC分类号： A61K31/522 ,  A61K31/551

    摘要： Compositions, kits and methods for reducing or inhibiting apoptosis in a cell or tissue and for treating or preventing an apoptosis-related disease or condition in a mammal that is not infected with HIV are disclosed. The methods involve administering to said mammal a therapeutically effective amount of one or more HIV protease inhibitors, and/or reducing mitochondrial adenine nucleotide translocator (ANT) dependent permeability transition pore complex (PTPC) opening and/or mitochondrial cytochrome c release in target cells or tissues.

    摘要翻译： 公开了用于减少或抑制细胞或组织中细胞凋亡并用于治疗或预防未被HIV感染的哺乳动物中凋亡相关疾病或病症的组合物，试剂盒和方法。 所述方法包括向所述哺乳动物施用治疗有效量的一种或多种HIV蛋白酶抑制剂和/或减少靶细胞中线粒体腺嘌呤核苷酸转运蛋白（ANT）依赖性通透性转换孔复合物（PTPC）开放和/或线粒体细胞色素c释放或 组织。

    Cap for a vehicle load box
    7.
    发明授权
    Cap for a vehicle load box 失效
    车载车箱盖

    公开(公告)号：US06705666B2

    公开(公告)日：2004-03-16

    申请号：US09682447

    申请日：2001-09-04

    申请人： David Lynch ,  Jerome Farrell ,  Leslie Ann Hersh ,  Stephen Lewis Bruford

    发明人： David Lynch ,  Jerome Farrell ,  Leslie Ann Hersh ,  Stephen Lewis Bruford

    IPC分类号： B60P3345

    CPC分类号： B60J7/10 ,  B60J7/106

    摘要： A cap (10) is provided for the load box (16) of a vehicle, like a pickup truck (12), including a box-like structure sized and adapted to fit on the load box to form an enclosed area for the storage of personal items, camping equipment, tools, parts or the like. On the forwardmost corner of the cap there is included a door (40) in the form of three-sided box (53, 58, 60), i.e., a door that wraps both around the forward corner of the cap and into the roof. Hinges (50) are provided at the cutline with the roof so that the door opens upwardly. In the preferred embodiment, closable and latchable steps (28) are structurally integrated into the a side of a load box at its forwardmost end and the door of the cap is aligned with the steps forming a doorway for improved ingress and egress to the enclosed area under the cap.

    摘要翻译： 为车辆的装载箱（16）提供盖（10），如皮卡车（12），其包括尺寸适合于装配在装载箱上的箱状结构，以形成用于存储 个人物品，野营设备，工具，零件等。 在盖的最前角处包括一个三边形盒（53,58,60）形式的门（40），即一个将盖子围绕盖的前角包围并进入屋顶的门。 铰链（50）在带有屋顶的切割线处设置，使得门向上打开。 在优选实施例中，可关闭和可闩锁的台阶（28）在其最前端结构地集成到装载箱的一侧，并且盖的门与形成门口的台阶对准，以改善进入和封闭区域的入口 在帽下。

    INITIATION FIXTURE AND AN INITIATOR ASSEMBLY INCLUDING THE SAME
    10.
    发明申请
    INITIATION FIXTURE AND AN INITIATOR ASSEMBLY INCLUDING THE SAME 有权

    公开(公告)号：US20080047452A1

    公开(公告)日：2008-02-28

    申请号：US11925220

    申请日：2007-10-26

    申请人： David Lynch ,  Ronald Dufrane ,  Jeffrey Kezerian ,  Jack Cotner

    发明人： David Lynch ,  Ronald Dufrane ,  Jeffrey Kezerian ,  Jack Cotner

    IPC分类号： C06C5/06

    CPC分类号： F42D1/04 ,  F42C7/12

    摘要： An initiator assembly (38) is factory-pre-assembled and comprises an initiation fixture (10) secured to a triggering device (40). The initiation fixture (10) comprises a unitary body, i.e., one without moving parts, and includes a bushing groove (18) to receive as an accessory an O-ring (64) to seal the device within the barrel (42) of the triggering device (40). A fuse/fixture sub-assembly (34) includes an initiation charge (30) disposed at the firing face (13a) and a signal-transmission fuse (22). The initiation fixture (110) may be a “universal” fixture having thereon optional external threads (36) and being otherwise dimensioned and configured to be received within either an internally threaded barrel (42) of a triggering device (40) or the barrel (42) of a triggering device which utilizes a fuse-holder cap (56). The initiator assembly (38) may include a spool (66) on which the signal-transmission tube (22) is wound.