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    Oxazolidine derivatives and pharmaceutically acceptable salts thereof
    2.
    发明授权
    Oxazolidine derivatives and pharmaceutically acceptable salts thereof 失效
    恶唑烷衍生物及其药学上可接受的盐

    公开(公告)号：US5480899A

    公开(公告)日：1996-01-02

    申请号：US167798

    申请日：1993-12-21

    申请人： Shingo Yano ,  Tomoyasu Ohno ,  Kazuo Ogawa ,  Haruo Yamada ,  Tetsuhiko Shirasaka ,  Hiroyuki Kawamura ,  Shinichi Watanabe

    发明人： Shingo Yano ,  Tomoyasu Ohno ,  Kazuo Ogawa ,  Haruo Yamada ,  Tetsuhiko Shirasaka ,  Hiroyuki Kawamura ,  Shinichi Watanabe

    IPC分类号： C07D263/16 ,  C07D263/24 ,  C07D263/26 ,  C07D263/32 ,  C07D413/04 ,  A61K31/42

    CPC分类号： C07D263/16 ,  C07D263/24 ,  C07D263/26 ,  C07D263/32 ,  C07D413/04

    摘要： An oxazolidine derivative represented by the formula (I) ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are H, optionally halogenated alkyl, optionally halogenated alkoxy, OH, halo, NO.sub.2, amino optionally having acetyl or alkyl, COOH, alkoxycarbonyl, CN, alkanoyl, 2-oxazolyl, or R.sup.1 and R.sup.2 may be combined with each other to represent --(CH.sub.2).sub.p -- or --O(CH.sub.2).sub.q O-- (p is 3-5, q is 1-3) to form a ring, m and n are each 0 or 1, R.sup.4 and R.sup.5 are H or alkyl, X is C or N, Y is CH.sub.2 OH, CHO or COOR.sup.6 (R.sup.6 is alkyl, benzyl or H), A is alkylene, carbonyl or sulfonyl, B is alkylene, E is alkylene which may be substituted with halo or is alkenylene, Z is O or S, except for a compound wherein n is 0, m is 1 and Y is CH.sub.2 OH, and except for a compound wherein n is 0, Y is COOR.sup.6 (R.sup.6 is alkyl), a salt thereof, a process for its preparation, anti-hyperlipidemic composition containing the derivative as an active ingredient and a method for treating hyperlipidemia comprising administering the derivative.

    摘要翻译： PCT No.PCT / JP93 / 00559 Sec。 371日期：1993年12月21日 102（e）日期1993年12月21日PCT提交1993年4月28日PCT公布。 出版物WO93 / 22298 （I）表示的恶唑烷衍生物其中R 1，R 2和R 3为H，任意卤代烷基，任选卤代烷氧基，OH，卤素，NO 2，任选具有乙酰基或烷基的氨基， COOH，烷氧基羰基，CN，烷酰基，2-恶唑基或R 1和R 2可以彼此结合以表示 - （CH 2）p - 或-O（CH 2）q O-（p为3-5，q为1-3 ）形成环，m和n各自为0或1，R4和R5为H或烷基，X为C或N，Y为CH2OH，CHO或COOR6（R6为烷基，苄基或H），A为亚烷基， 羰基或磺酰基，B是亚烷基，E是可以被卤素取代的亚烷基或亚烷基，Z是O或S，除了其中n是0，m是1且Y是CH 2 OH的化合物，除了其中 n为0，Y为COOR 6（R6为烷基），其盐，其制备方法，含有该衍生物作为活性成分的抗高血脂组合物和治疗高脂血症的方法，其包括给予该衍生物。

    Phenylcarboxylic acid derivatives
    3.
    发明授权
    Phenylcarboxylic acid derivatives 失效
    苯基羧酸衍生物

    公开(公告)号：US4999378A

    公开(公告)日：1991-03-12

    申请号：US372336

    申请日：1989-06-20

    申请人： Setsuro Fujii ,  Hiroyuki Kawamura ,  Shinichi Watanabe

    发明人： Setsuro Fujii ,  Hiroyuki Kawamura ,  Shinichi Watanabe

    IPC分类号： C07C217/22 ,  C07C217/44 ,  C07C217/46 ,  C07C217/84 ,  C07C217/86 ,  C07C217/90 ,  C07C225/22 ,  C07C229/18 ,  C07C233/17 ,  C07C233/18 ,  C07C233/69 ,  C07C233/78 ,  C07C255/25 ,  C07C275/30 ,  C07D295/092 ,  C07D303/22 ,  C07D317/58 ,  C07D319/18

    CPC分类号： C07D295/088 ,  C07C217/22 ,  C07C217/44 ,  C07C217/46 ,  C07C217/84 ,  C07C217/86 ,  C07C217/90 ,  C07C225/22 ,  C07C229/18 ,  C07C233/17 ,  C07C233/18 ,  C07C233/69 ,  C07C233/78 ,  C07C255/25 ,  C07C275/30 ,  C07D303/22 ,  C07D317/58 ,  C07D319/18 ,  C07C2101/08 ,  C07C2101/14

    摘要： Phenylcarboxylic acid derivatives having the formula: ##STR1## wherein R.sup.1 and R.sup.2 are each H, halogen, alkyl, haloalkyl, alkanoyl, cycloalkyl, nitro, amino, --O--D--R.sup.5 (D is alkylene, R.sup.5 is H, amino, morpholino, carboxyl, phthalimido, phenyl, epoxy), substituted or unsubstituted phenoxy, substituted or unsubstituted phenylalkylamino, carboxylalkenyl, or both form alkylenedioxy; R.sup.3 is H, --E--R.sup.6 (E is alkylene, R.sup.6 is H, carboxyl, cyano, OH, phenylalkoxy, or halogen-substituted phenyl, or phenylcarbamoyl), --CO--G--R.sup.7 (G is alkylene, R.sup.7 is H, substituted or unsubstituted phenylcarbamoyl), substituted or unsubstituted benzoyl, alkenyl, carbamoyl, phenyl, or halophenyl; R.sup.4 is H or alkyl; A is alkylene, alkylene condensed with cycloalkyl ring, or alkenylene; B is alkylene or alkenylene; l is 0 or 1. Said compounds have fatty acid synthesis-inhibitory activity, cholesterol synthesis-inhibitory activity and are useful as antilipidemic agent, prophylactic and treating agent of artherosclerosis, prophylactic and treating agent of obesity, antidiabetics.

    摘要翻译： 具有下式的苯基羧酸衍生物：其中R1和R2各自为H，卤素，烷基，卤代烷基，烷酰基，环烷基，硝基，氨基，-OD-R5（D为亚烷基，R5为H，氨基，吗啉代，羧基 苯二甲酰亚氨基，苯基，环氧基），取代或未取代的苯氧基，取代或未取代的苯基烷基氨基，羧基烯基或二者形成亚烷基二氧基; R3是H，-E-R6（E是亚烷基，R6是H，羧基，氰基，OH，苯基烷氧基或卤素取代的苯基或苯基氨基甲酰基），-CO-G-R7（G是亚烷基，R7是H， 取代或未取代的苯基氨基甲酰基），取代或未取代的苯甲酰基，烯基，氨基甲酰基，苯基或卤代苯基; R4是H或烷基; A是亚烷基，与环烷基环稠合的亚烷基或亚烯基; B是亚烷基或亚烯基; l是0或1.所述化合物具有脂肪酸合成抑制活性，胆固醇合成抑制活性，可用作抗血脂药物，动脉粥样硬化的预防和治疗剂，肥胖症的预防和治疗剂，抗糖尿病药。

    Die cushion controller
    4.
    发明授权
    Die cushion controller 有权
    模具缓冲控制器

    公开(公告)号：US07845205B2

    公开(公告)日：2010-12-07

    申请号：US11550330

    申请日：2006-10-17

    申请人： Yasusuke Iwashita ,  Tadashi Okita ,  Hiroyuki Kawamura ,  Satoshi Ikai

    发明人： Yasusuke Iwashita ,  Tadashi Okita ,  Hiroyuki Kawamura ,  Satoshi Ikai

    IPC分类号： B21J9/18 ,  B21J7/46

    CPC分类号： G05B19/19 ,  B21D24/02 ,  G05B2219/42087 ,  G05B2219/42123 ,  G05B2219/45143

    摘要： A die cushion controller, for driving a die cushion, disposed in opposition to a slide of a press machine, by controlling a servo motor, including: a pressure command portion which prepares a pressure command value for exerting a predetermined pressure to a press material disposed between the slide and the die cushion; a pressure detecting portion which detects an actual pressure exerted on the press material; a speed correction value preparing portion which prepares a speed correction value by multiplying a differential value of the pressure command value prepared by the pressure command portion by a coefficient; and a first speed command portion which prepares a speed command value to be instructed to the servo motor based on the pressure command value prepared by the pressure command portion, the actual pressure detected by the pressure detecting portion, and the speed correction value prepared by the speed correction value preparing portion.

    摘要翻译： 一种模具缓冲控制器，用于通过控制伺服电动机来驱动与冲压机的滑动相对设置的模具缓冲垫，包括：压力指令部分，其为制备的压力材料制备用于施加预定压力的压力指令值 滑块和模座之间; 压力检测部，其检测施加在所述挤压材料上的实际压力; 速度校正值准备部，其通过将由所述压力指令部准备的所述压力指令值的差分值乘以系数来准备速度校正值; 以及第一速度指令部，其基于由压力指令部准备的压力指令值，由压力检测部检测出的实际压力和由该压力指令部分准备的速度修正值，准备要指示给伺服电动机的速度指令值 速度校正值准备部。

    Controller
    6.
    发明授权
    Controller 有权
    控制器

    公开(公告)号：US07657356B2

    公开(公告)日：2010-02-02

    申请号：US11289319

    申请日：2005-11-30

    申请人： Yasusuke Iwashita ,  Tadashi Okita ,  Hiroyuki Kawamura ,  Satoshi Ikai

    发明人： Yasusuke Iwashita ,  Tadashi Okita ,  Hiroyuki Kawamura ,  Satoshi Ikai

    IPC分类号： G06F19/00

    CPC分类号： G05B19/416 ,  G05B2219/37388 ,  G05B2219/43058 ,  Y10T483/1702 ,  Y10T483/1733

    摘要： An acceleration detection unit for detecting acceleration is mounted on a driven body. When a previous block is a positioning command, the system waits till the detected value of acceleration detected by the acceleration detection unit becomes equal to or less than a set value αs after the distribution of the movement command of the positioning command is ended. If the detected value of acceleration becomes equal to or less than the set value αs, the distribution of the movement command of the next block is started. Because the cutting feed, etc., is started after the detected value of acceleration has become equal to or less than the set value αs and the vibrations stopped, machining can be conducted with high accuracy.

    摘要翻译： 用于检测加速度的加速度检测单元安装在被驱动体上。 当前一块是定位命令时，在定位命令的移动指令的分配结束之后，系统等待直到由加速度检测单元检测到的加速度的检测值变为等于或小于设定值αα。 如果检测到的加速度值等于或小于设定值ααα，则开始下一个程序段的移动指令的分配。 由于在加速度的检测值变得等于或小于设定值αα并且振动停止之后开始切削进给等，因此可以高精度地进行加工。

    Die cushion mechanism, and apparatus and method for controlling the same
    7.
    发明授权
    Die cushion mechanism, and apparatus and method for controlling the same 有权
    模具缓冲机构及其控制装置及方法

    公开(公告)号：US07631528B2

    公开(公告)日：2009-12-15

    申请号：US11265187

    申请日：2005-11-03

    申请人： Yasusuke Iwashita ,  Tadashi Okita ,  Hiroyuki Kawamura ,  Satoshi Ikai

    发明人： Yasusuke Iwashita ,  Tadashi Okita ,  Hiroyuki Kawamura ,  Satoshi Ikai

    IPC分类号： B21D55/00 ,  B21C51/00 ,  B21J9/18

    CPC分类号： G05B19/19 ,  B21D24/02 ,  G05B2219/42123 ,  G05B2219/42275

    摘要： A control apparatus for controlling a die cushion mechanism including a servo-motor as a drive source and producing a force adapted to be applied outside. The control apparatus includes a force commanding section for commanding a force to be produced by the die cushion mechanism; a force detecting section for detecting a force produced by the die cushion mechanism; a force controlling section for executing a force control on the servo-motor, based on a force command value commanded by the force commanding section and a force detected value detected by the force detecting section; and an abnormality preventing section for preventing, in association with a control state of the servo-motor, the die cushion mechanism from producing an abnormal force.

    摘要翻译： 一种用于控制模具缓冲机构的控制装置，其包括作为驱动源的伺服电动机，并产生适于施加到外部的力。 控制装置包括用于指示由模具缓冲机构产生的力的力指令部分; 用于检测由模具缓冲机构产生的力的力检测部分; 力控制部，其基于由所述力指令部所指示的力指令值和由所述力检测部检测到的力检测值，对所述伺服电动机进行力控制; 以及防止与伺服电动机的控制状态相关联的模具缓冲机构产生异常力的异常防止部。

    Process for Manufacturing Outer Ring Member for Constant-Velocity Joint
    9.
    发明申请
    Process for Manufacturing Outer Ring Member for Constant-Velocity Joint 失效
    制造用于恒速接头的外圈构件的制造方法

    公开(公告)号：US20090013746A1

    公开(公告)日：2009-01-15

    申请号：US12224330

    申请日：2007-01-18

    申请人： Satoru Ishizuna ,  Hiroaki Suzuki ,  Junji Yoshida ,  Hiroyuki Kawamura ,  Isao Nakata ,  Michie Hirane ,  Sadaichi Takamatsu ,  Jun Noguthi

    发明人： Satoru Ishizuna ,  Hiroaki Suzuki ,  Junji Yoshida ,  Hiroyuki Kawamura ,  Isao Nakata ,  Michie Hirane ,  Sadaichi Takamatsu ,  Jun Noguthi

    IPC分类号： B21C23/20

    CPC分类号： F16D3/2055 ,  B21K1/762 ,  F16D3/223 ,  F16D2250/00 ,  F16D2300/10 ,  Y10T29/49689

    摘要： First shaped item with shaft part is produced by forward extrusion forming of work, and further, upset forming thereof is carried out to thereby obtain second shaped item with large-diameter part. Subsequently, backward extrusion forming of the second shaped item is carried out to thereby obtain third shaped item having not only cup part provided with ball rolling grooves but also circular diameter expansion portion provided at the mouth area of the inside wall of the cup part along the circumferential direction in such a fashion that the diameter is gradually expanded from the bottom side toward the opening side. Outer ring member for constant-velocity joint is obtained by further subjecting the third shaped item to low-temperature annealing treatment, shot blast treatment and lubricating chemical coating treatment, and thereafter to ironing forming.

    摘要翻译： 具有轴部的第一成形品通过工件的正向挤压成形而进行，进一步进行镦锻成形，得到具有大直径部的第二成形品。 随后，进行第二成形物的向后挤压成形，从而获得不仅具有滚珠滚动槽的杯部的第三成形件，而且还具有设置在杯部的内壁的口部区域的圆形扩径部 圆周方向的直径从底侧向开口侧逐渐扩大。 通过进一步对第三形状物进行低温退火处理，喷丸处理和润滑化学涂布处理，然后进行熨烫成形，得到等速接头的外圈构件。

    METHOD FOR CHANGING FORCE CONTROL GAIN AND DIE CUSHION CONTROL APPARATUS
    10.
    发明申请
    METHOD FOR CHANGING FORCE CONTROL GAIN AND DIE CUSHION CONTROL APPARATUS 有权
    改变力控制增益和DIE嵌套控制装置的方法

    公开(公告)号：US20080066515A1

    公开(公告)日：2008-03-20

    申请号：US11857620

    申请日：2007-09-19

    申请人： Yasusuke Iwashita ,  Tadashi Okita ,  Hiroyuki Kawamura ,  Satoshi Ikai

    发明人： Yasusuke Iwashita ,  Tadashi Okita ,  Hiroyuki Kawamura ,  Satoshi Ikai

    IPC分类号： B21D22/00

    CPC分类号： B21D24/02 ,  G05B19/237 ,  G05B2219/41251 ,  G05B2219/45143

    摘要： A method for changing a force control gain expressed as a ratio of force error to velocity command value in a control circuit performing a force control of a servo motor driving a die cushion disposed opposite to a slide in a press machine. The method includes: obtaining a difference between a displacement of the slide and a displacement of the die cushion in a state in which the slide and the die cushion collide with and are exerting force on each other; detecting the force when the difference of the displacements is obtained; calculating a spring constant of a structural portion based on a proportionality between the difference of the displacements and the force, when regarding the structural portion including the slide and the die cushion as an elastic structure; and changing the force control gain based on the spring constant using a fixed proportionality that exists between the force control gain and a reciprocal of the spring constant.

    摘要翻译： 一种用于在执行对在压机中与滑块相对设置的模座的驱动伺服电动机的力控制的控制电路中，改变表示为力误差与速度指令值的比的力控制增益的方法。 该方法包括：在滑块和模座碰撞并且彼此施加力的状态下，获得滑块的位移和模具垫的位移之间的差异; 当获得位移的差异时检测力; 当关于包括滑动件和模具衬垫的结构部分作为弹性结构时，基于位移的差异和力之间的比例来计算结构部分的弹簧常数; 并且使用存在于力控制增益和弹簧常数的倒数之间的固定比例度，基于弹簧常数来改变力控制增益。