摘要:
Phenylcarboxylic acid derivatives having a hetero ring in the substituent of the formula: ##STR1## wherein R.sup.1 is halogen, alkyl, cycloalkyl, hydroxy, alkoxy, phenoxy which has a substituent selected from halogen and alkyl, carboxyl, alkylsulfonyloxy, phenylsulfonyloxy optionally substituted by halogen, alkylsulfonyloxyalkoxy, amino, alkanoylamino, benzoylamino, alkenyloxy, phenylalkoxyalkoxy, hydroxyalkoxy, phenylalkoxy having optionally 1 to 3 substituents selected from halogen, alkyl and alkoxy, halogenoalkyl, cycloalkyloxy optionally substituted by hydroxy, alkoxy substituted by cycloalkyl having optionally hydroxy substituent, imidazolylalkyl or imidazolylalkoxy; k is 0 or 1 to 3; or (R.sup.1).sub.k is alkylenedioxy; A is alkylene or alkylenoxy; l is 0 or 1; B is methylene or carbonyl; m is 0 or 1; D is alkylene; E is alkylene or alkenylene; n is 0 or 1; and R.sup.2 is hydrogen or alkyl, or a salt thereof, which have fatty acid synthesis-inhibitory activity, cholesterol synthesis-inhibitory activity and are useful as antilipidemic agent, prophylactic and treating agent of arteriosclerosis, prophylactic and treating agent of obesity, antidiabetics.
摘要:
Phenylcarboxylic acid derivatives having the formula: ##STR1## wherein R.sup.1 and R.sup.2 are each H, halogen, alkyl, haloalkyl, alkanoyl, cycloalkyl, nitro, amino, --O--D--R.sup.5 (D is alkylene, R.sup.5 is H, amino, morpholino, carboxyl, phthalimido, phenyl, epoxy), substituted or unsubstituted phenoxy, substituted or unsubstituted phenylalkylamino, carboxylalkenyl, or both form alkylenedioxy; R.sup.3 is H, --E--R.sup.6 (E is alkylene, R.sup.6 is H, carboxyl, cyano, OH, phenylalkoxy, or halogen-substituted phenyl, or phenylcarbamoyl), --CO--G--R.sup.7 (G is alkylene, R.sup.7 is H, substituted or unsubstituted phenylcarbamoyl), substituted or unsubstituted benzoyl, alkenyl, carbamoyl, phenyl, or halophenyl; R.sup.4 is H or alkyl; A is alkylene, alkylene condensed with cycloalkyl ring, or alkenylene; B is alkylene or alkenylene; l is 0 or 1. Said compounds have fatty acid synthesis-inhibitory activity, cholesterol synthesis-inhibitory activity and are useful as antilipidemic agent, prophylactic and treating agent of artherosclerosis, prophylactic and treating agent of obesity, antidiabetics.
摘要:
An oxazolidine derivative represented by the formula (I) ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are H, optionally halogenated alkyl, optionally halogenated alkoxy, OH, halo, NO.sub.2, amino optionally having acetyl or alkyl, COOH, alkoxycarbonyl, CN, alkanoyl, 2-oxazolyl, or R.sup.1 and R.sup.2 may be combined with each other to represent --(CH.sub.2).sub.p -- or --O(CH.sub.2).sub.q O-- (p is 3-5, q is 1-3) to form a ring, m and n are each 0 or 1, R.sup.4 and R.sup.5 are H or alkyl, X is C or N, Y is CH.sub.2 OH, CHO or COOR.sup.6 (R.sup.6 is alkyl, benzyl or H), A is alkylene, carbonyl or sulfonyl, B is alkylene, E is alkylene which may be substituted with halo or is alkenylene, Z is O or S, except for a compound wherein n is 0, m is 1 and Y is CH.sub.2 OH, and except for a compound wherein n is 0, Y is COOR.sup.6 (R.sup.6 is alkyl), a salt thereof, a process for its preparation, anti-hyperlipidemic composition containing the derivative as an active ingredient and a method for treating hyperlipidemia comprising administering the derivative.
摘要:
An electrochemical sensor includes a base plate provided with a concave part formed on one of surfaces thereof, a fluid channel formed so that a bottom part of the concave part and the other one of the surfaces of the base plate are communicated with each other, a plurality of electrodes formed on the concave part; a reagent fixed on the electrodes, a cover which covers the concave part, and an air channel which causes the inside and outside of the concave part to be communicated with each other.
摘要:
There is disclosed an adapter ring for rotation of a photographing lens barrel, the adapter ring being fitted into an outer periphery of the photographing lens barrel, the adapter ring being rotated through engaging with a ratchet wheel having a plurality of pawls which ratchet wheel rotates in conjunction with a dial disposed in a waterproof protector. This adapter ring has: a plurality of first projecting portions arranged in a predetermined angle range around an optical axis in the outer periphery to engage with the pawls of the ratchet wheel; and a plurality of second projecting portions which are the same plurality of projecting portions as the plurality of first projecting portions, the second projecting portions being arranged in a predetermined angle range but out of the predetermined angle range of the plurality of the first projecting portions.
摘要:
A semiconductor device includes a device isolation insulating film which is buried in a semiconductor substrate, a gate insulation film which is provided on the semiconductor substrate, a gate electrode which is provided on the gate insulation film, a source region and a drain region which are provided in the semiconductor substrate and spaced apart from each other in a manner to sandwich the gate electrode, both end portions of each of the source region and the drain region being offset from the device isolation insulating film in a channel width direction by a predetermined distance, and first and second gate electrode extension portions which are provided in a manner to cover both end portions of each of the source region and the drain region in a channel length direction.
摘要:
Reagents which regulate human RC Kinase activity and reagents which bind to human RC Kinase gene products can be used to regulate this protein for therapeutic effects. Such regulation is particularly useful for treating chronic obstructive pulmonary disease, asthma, cancer, and diseases in which cell signaling is defective.
摘要:
A system includes a plurality of cameras and a waterproof housing. The plurality of cameras include a first camera including a first operating member, a second camera including a second operating member which is superposed to the position of the first operating member in the waterproof housing upon storing the second camera in the waterproof housing. The waterproof housing can store whichever one of the first camera and the second camera. The waterproof housing includes a third operating member and a fourth operating member. The third operating member operates the first operating member upon storing the first camera in the waterproof housing, and the fourth operating member operates the second operating member upon storing the second camera.
摘要:
The present invention provides a beam measuring device which can measure a beam current value with high accuracy in a non-destructive manner and, at the same time, can measure a position of a beam.A measuring device includes a magnetic shielding part for shielding an outer magnetic field, and a plurality of magnetic field sensors which are arranged in a shielding space which is formed by the magnetic shielding part, wherein the magnetic field sensor includes a plurality of magnetic field collection mechanisms which collect magnetic fields which the beam current to be measured generates, and the magnetic field collection mechanism is a cylindrical structural body which has at least a surface thereof formed of a superconductive body and includes a bridge portion which has only a portion thereof formed of a superconductive body on an outer peripheral portion thereof, and a magnetic field which the beam current to be measured generates is measured by the magnetic field sensors. Due to the arrangement of the plurality of magnetic field sensors, a beam position and a beam current can be detected.
摘要:
A device for DNA analysis includes: an imaging device having a plurality of pixel parts; and microarrays arranged and fixed on a surface on a side of light incidence of the imaging device, wherein each of the plurality of pixel parts includes plural kinds of photoelectric conversion parts stacked on a semiconductor substrate and each capable of detecting light with a different wavelength region from each other to generate a charge corresponding thereto; the plural kinds of photoelectric conversion parts are stacked such that they are able to receive light from the same subject; and the plural kinds of photoelectric conversion parts are each configured of at least one photoelectric conversion device having sensitivity to the light to be detected in the photoelectric conversion part and arranged on a same plane.