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16 条记录 (耗时 0.022 秒)

    Visual voicemail unavailability solution
    4.
    发明授权
    Visual voicemail unavailability solution 有权
    可视语音邮件不可用性解决方案

    公开(公告)号：US08199889B2

    公开(公告)日：2012-06-12

    申请号：US12635233

    申请日：2009-12-10

    申请人： Alison Raphael ,  David Ingram ,  Dionne Pignatiello

    发明人： Alison Raphael ,  David Ingram ,  Dionne Pignatiello

    IPC分类号： H04M1/64

    CPC分类号： H04W4/12 ,  H04L29/08108 ,  H04L51/24 ,  H04L51/38 ,  H04L67/04 ,  H04M3/53333 ,  H04M2203/2072 ,  H04M2242/15

    摘要： A solution for notifying a user of alternate means of accessing voicemail data utilize a timer that can be set on a user device upon receipt of a message waiting indicator. When the timer expires, if no data communications connection has been established between the user device and a voicemail server, the user device can present alternate voicemail access instructions to the user. These instructions may be obtained from the message waiting indicator or may be stored on the user device. In another embodiment, a voicemail server sets a timer after sending a message waiting indicator to a user device. The voicemail server sends a message containing alternate voicemail access instructions if no connection has been established between the voicemail server and the user device upon expiration of the timer.

    摘要翻译： 用于通知用户访问语音邮件数据的替代方式的解决方案利用可以在接收到消息等待指示符时在用户设备上设置的定时器。 当定时器到期时，如果在用户设备和语音邮件服务器之间没有建立数据通信连接，则用户设备可以向用户提供备用语音邮件访问指令。 这些指令可以从消息等待指示符获得，或者可以存储在用户设备上。 在另一个实施例中，语音邮件服务器在向用户设备发送消息等待指示符之后设置定时器。 语音邮件服务器发送包含备用语音邮件访问指令的消息，如果在计时器到期后，如果在语音邮件服务器和用户设备之间没有建立连接。

    Isolation, expansion and use of clonogenic endothelial progenitor cells
    7.
    发明申请
    Isolation, expansion and use of clonogenic endothelial progenitor cells 审中-公开
    克隆型内皮祖细胞的分离，扩增和使用

    公开(公告)号：US20050266556A1

    公开(公告)日：2005-12-01

    申请号：US11055182

    申请日：2005-02-09

    申请人： Mervin Yoder ,  David Ingram

    发明人： Mervin Yoder ,  David Ingram

    IPC分类号： A61K35/12 ,  C12N5/074 ,  C12N5/0789 ,  C12N5/08

    CPC分类号： C12N5/0068 ,  A61K2035/124 ,  C12N5/0647 ,  C12N5/0692 ,  C12N2501/125 ,  C12N2501/145 ,  C12N2501/22 ,  C12N2501/26 ,  C12N2502/28 ,  C12N2533/54 ,  C12N2533/90 ,  G01N33/5005 ,  G01N33/56966 ,  G01N2333/70589 ,  G01N2333/70596

    摘要： A hierarchy of endothelial colony forming cells (EPCs) was identified from mammalian cord blood, umbilical vein and aorta. A newly isolated cell named high proliferative potential—endothelial colony forming cell (HPP-ECFC) was isolated and characterized. Single cell assays were developed that test the proliferative and clonogenic potential of endothelial cells derived from cord blood, or from HUVECs and HAECs. EPCs were found to reside in vessel walls. Use of a feeder layer of cells derived from high proliferative potential-endothelial colony forming cells (HPP-ECPCS) from human umbilical cord blood, stimulates growth and survival of repopulating hematopoietic stem and progenitor cells. Stimulation of growth and survival was determined by increased numbers of progenitor cells in in vitro cultures and increased levels of human cell engraftment in the NOD/SCID immunodeficient mouse transplant system.

    摘要翻译： 从哺乳动物脐带血，脐静脉和主动脉鉴定了内皮细胞集落形成细胞（EPCs）的层次。 分离并鉴定了称为高增殖潜力 - 内皮细胞集落形成细胞（HPP-ECFC）的新分离的细胞。 开发了单细胞测定法，其测试来自脐带血或来自HUVEC和HAEC的内皮细胞的增殖和克隆潜能。 发现EPCs存在血管壁。 使用源自人类脐带血的来自高增殖潜能 - 内皮细胞集落形成细胞（HPP-ECPCS）的细胞饲养层，刺激再造血造血干细胞和祖细胞的生长和存活。 通过在体外培养物中增加祖细胞数量和NOD / SCID免疫小鼠移植系统中人细胞移植水平的增加来确定刺激生长和存活。

    Materials and methods for suppressing and/or treating neurofibroma and related tumors
    8.
    发明授权
    Materials and methods for suppressing and/or treating neurofibroma and related tumors 有权
    用于抑制和/或治疗神经纤维瘤和相关肿瘤的材料和方法

    公开(公告)号：US08933082B2

    公开(公告)日：2015-01-13

    申请号：US14032994

    申请日：2013-09-20

    申请人： D Wade Clapp ,  David Ingram ,  Feng-Chun Yang

    发明人： D Wade Clapp ,  David Ingram ,  Feng-Chun Yang

    IPC分类号： A61K31/4965

    CPC分类号： A61K31/506 ,  A61K31/505 ,  C07D401/14

    摘要： Germline mutations in the NF1 tumor suppressor gene cause Von Recklinghausen's neurofibromatosis type 1 (NF1), a common genetic disorder of the nervous system characterized by plexiform neurofibroma development. Using adoptive transfer of hematopoietic cells, we establish that NF1 heterozygosity of bone marrow derived cells in the tumor microenvironment is sufficient to allow neurofibroma progression in the context of Schwann cell nullizygosity. Further, genetic or pharmacologic attenuation of the c-kit signaling pathway in hematopoietic cells greatly diminishes neurofibroma initiation and progression. These studies identify haploinsufficient hematopoietic cells and the c-kit receptor as therapeutic targets for preventing plexiform neurofibromas and implicate mast cells as critical mediators of tumor initiation. Administering therapeutically effective doses of a tyrosine kinase inhibitor such as the compound imatinib mesylate to a patient in need thereof to treat tumors in a human patient afflicted with plexiform neurofibroma.

    摘要翻译： NF1肿瘤抑制基因中的种系突变导致Von Recklinghausen的神经纤维瘤病1型（NF1），其是以丛状神经纤维瘤发育为特征的神经系统的常见遗传疾病。 使用造血细胞的过继转移，我们确定了在肿瘤微环境中的骨髓衍生细胞的NF1杂合性足以允许神经纤维瘤在施万细胞无效的情况下进展。 此外，造血细胞中c-kit信号通路的遗传或药理学减弱大大减少了神经纤维瘤的起始和进展。 这些研究将单倍体造血细胞和c-kit受体鉴定为预防丛状神经纤维瘤和牵连肥大细胞作为肿瘤起始的关键介质的治疗靶点。 将治疗有效剂量的酪氨酸激酶抑制剂如化合物甲磺酸伊马替尼施用于有需要的患者以治疗患有丛状神经纤维瘤的人类患者中的肿瘤。

    MATERIALS AND METHODS FOR SUPPRESSING AND/OR TREATING NEUROFIBROMA AND RELATED TUMORS
    9.
    发明申请
    MATERIALS AND METHODS FOR SUPPRESSING AND/OR TREATING NEUROFIBROMA AND RELATED TUMORS 审中-公开
    用于抑制和/或治疗神经变性和相关肿瘤的材料和方法

    公开(公告)号：US20140121214A1

    公开(公告)日：2014-05-01

    申请号：US14032994

    申请日：2013-09-20

    申请人： D. Wade Clapp ,  David Ingram ,  Feng-Chun Yang

    发明人： D. Wade Clapp ,  David Ingram ,  Feng-Chun Yang

    IPC分类号： C07D401/14

    CPC分类号： A61K31/506 ,  A61K31/505 ,  C07D401/14

    摘要： Germline mutations in the NF1 tumor suppressor gene cause Von Recklinghausen's neurofibromatosis type 1 (NF1), a common genetic disorder of the nervous system characterized by plexiform neurofibroma development. Using adoptive transfer of hematopoietic cells, we establish that NF1 heterozygosity of bone marrow derived cells in the tumor microenvironment is sufficient to allow neurofibroma progression in the context of Schwann cell nullizygosity. Further, genetic or pharmacologic attenuation of the c-kit signaling pathway in hematopoietic cells greatly diminishes neurofibroma initiation and progression. These studies identify haploinsufficient hematopoietic cells and the c-kit receptor as therapeutic targets for preventing plexiform neurofibromas and implicate mast cells as critical mediators of tumor initiation. Administering therapeutically effective doses of a tyrosine kinase inhibitor such as the compound imatinib mesylate to a patient in need thereof to treat tumors in a human patient afflicted with plexiform neurofibroma.

    摘要翻译： NF1肿瘤抑制基因中的种系突变导致Von Recklinghausen的神经纤维瘤病1型（NF1），其是以丛状神经纤维瘤发育为特征的神经系统的常见遗传疾病。 使用造血细胞的过继转移，我们确定了在肿瘤微环境中的骨髓衍生细胞的NF1杂合性足以允许神经纤维瘤在施万细胞无效的情况下进展。 此外，造血细胞中c-kit信号通路的遗传或药理学减弱大大减少了神经纤维瘤的起始和进展。 这些研究将单倍体造血细胞和c-kit受体鉴定为预防丛状神经纤维瘤和牵连肥大细胞作为肿瘤起始的关键介质的治疗靶点。 将治疗有效剂量的酪氨酸激酶抑制剂如化合物甲磺酸伊马替尼施用于有需要的患者以治疗患有丛状神经纤维瘤的人类患者中的肿瘤。

    Visual voicemail unavailability solution
    10.
    发明授权
    Visual voicemail unavailability solution 有权
    可视语音邮件不可用性解决方案

    公开(公告)号：US08526920B2

    公开(公告)日：2013-09-03

    申请号：US13482308

    申请日：2012-05-29

    申请人： Alison Raphael ,  David Ingram ,  Dionne Pignatiello

    发明人： Alison Raphael ,  David Ingram ,  Dionne Pignatiello

    IPC分类号： H04L12/58 ,  H04M1/725 ,  H04M11/10 ,  H04W4/12 ,  H04L29/08

    CPC分类号： H04W4/12 ,  H04L29/08108 ,  H04L51/24 ,  H04L51/38 ,  H04L67/04 ,  H04M3/53333 ,  H04M2203/2072 ,  H04M2242/15

    摘要： A solution for notifying a user of alternate means of accessing voicemail data utilize a timer that can be set on a user device upon receipt of a message waiting indicator. When the timer expires, if no data communications connection has been established between the user device and a voicemail server, the user device can present alternate voicemail access instructions to the user. These instructions may be obtained from the message waiting indicator or may be stored on the user device. In another embodiment, a voicemail server sets a timer after sending a message waiting indicator to a user device. The voicemail server sends a message containing alternate voicemail access instructions if no connection has been established between the voicemail server and the user device upon expiration of the timer.

    摘要翻译： 用于通知用户访问语音邮件数据的替代方式的解决方案利用可以在接收到消息等待指示符时在用户设备上设置的定时器。 当定时器到期时，如果在用户设备和语音邮件服务器之间没有建立数据通信连接，则用户设备可以向用户提供备用语音邮件访问指令。 这些指令可以从消息等待指示符获得，或者可以存储在用户设备上。 在另一个实施例中，语音邮件服务器在向用户设备发送消息等待指示符之后设置定时器。 语音邮件服务器发送包含备用语音邮件访问指令的消息，如果在计时器到期后，如果在语音邮件服务器和用户设备之间没有建立连接。