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    MULTICOMPONENT ANALYSIS SENSOR AND METHOD OF MEASURING MULTIPLE COMPONENTS
    1.
    发明申请
    MULTICOMPONENT ANALYSIS SENSOR AND METHOD OF MEASURING MULTIPLE COMPONENTS 审中-公开
    多功能分析传感器和测量多个组件的方法

    公开(公告)号：US20100096276A1

    公开(公告)日：2010-04-22

    申请号：US12444077

    申请日：2007-10-01

    申请人： Shinki Kojima ,  Tomohiro Yamamoto ,  Fumihisa Kitawaki ,  Tetsuo Yukimasa

    发明人： Shinki Kojima ,  Tomohiro Yamamoto ,  Fumihisa Kitawaki ,  Tetsuo Yukimasa

    IPC分类号： G01N27/26

    CPC分类号： G01N27/3272 ,  C12Q1/005 ,  C12Q1/006

    摘要： A multicomponent analysis sensor for measuring two or more kinds of the subjects to be measured by using redox reactions, which is a multicomponent analysis sensor comprising a liquid sample inlet from which a liquid sample containing two or more kinds of the subjects to be measured is introduced, a first measurement chamber, a second measurement chamber, a first channel connecting the above-described liquid sample inlet to the above-described first measurement chamber and a second channel connecting the above-described first measurement chamber to the second measurement chamber, wherein the above-described first measurement chamber and the above-described second measurement chamber respectively have a working electrode and a counter electrode. A first reagent layer containing an enzyme and an electron transfer substance is provided in the first channel or the first chamber, while another reagent layer containing an enzyme is provided in the second channel or the second chamber.

    摘要翻译： 一种多组分分析传感器，用于通过使用氧化还原反应来测量要测量的两种或更多种待测对象，所述氧化还原反应是包含液体样品入口的多组分分析传感器，其中引入含有两种或更多种待测对象的液体样品 第一测量室，第二测量室，将上述液体样品入口连接到上述第一测量室的第一通道和将上述第一测量室连接到第二测量室的第二通道，其中， 上述第一测量室和上述第二测量室分别具有工作电极和对电极。 在第一通道或第一室中设置含有酶和电子转移物质的第一试剂层，而在第二通道或第二室中设置含有酶的试剂层。

    Measuring chip
    3.
    发明授权
    Measuring chip 有权
    测量芯片

    公开(公告)号：US08329116B2

    公开(公告)日：2012-12-11

    申请号：US12741435

    申请日：2008-11-21

    申请人： Shuhei Tanaka ,  Tomohiro Yamamoto ,  Nobuhiko Ozaki ,  Shinki Kojima

    发明人： Shuhei Tanaka ,  Tomohiro Yamamoto ,  Nobuhiko Ozaki ,  Shinki Kojima

    IPC分类号： G01N15/06 ,  G01N33/00 ,  G01N33/48

    CPC分类号： G01N33/54366 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2300/0645 ,  B01L2300/0877 ,  B01L2300/0887 ,  B01L2400/0415 ,  Y10T436/11

    摘要： Provided is a measuring chip, which can spot a specimen liquid of a minute quantity for an immune agglutination easily and precisely to the measuring chip and which can prevent the flow of the specimen liquid and the contamination of the specimen. The measuring chip comprises at least two substrates, a spacer arranged between the substrates, at least one passage made of the substrates and the spacer into a hollow shape and having two open ends, counter electrodes for applying an electric field, and a specimen-spotted portion to be spotted with the specimen. The specimen-spotted portion has a structure made of a square, circular, elliptical or sector shape by that spacer. Moreover, the specimen-spotted portion has two open ends, one of which is connected to one open end of that passage.

    摘要翻译： 提供了一种测量芯片，其可以容易且准确地将测量芯片上的微量的微量样品液体点样，并且可以防止样品液体的流动和样品的污染。 测量芯片包括至少两个基板，布置在基板之间的间隔件，由基板和间隔件形成中空形状的至少一个通道，并具有两个开口端，用于施加电场的对电极和被检测点 用样品点样的部分。 样品点状部分具有由该间隔物形成的正方形，圆形，椭圆形或扇形的结构。 此外，样本点状部分具有两个开口端，其中一个连接到该通道的一个开口端。

    MEASURING CHIP
    4.
    发明申请
    MEASURING CHIP 有权
    测量芯片

    公开(公告)号：US20100266452A1

    公开(公告)日：2010-10-21

    申请号：US12741435

    申请日：2008-11-21

    申请人： Shuhei Tanaka ,  Tomohiro Yamamoto ,  Nobuhiko Ozaki ,  Shinki Kojima

    发明人： Shuhei Tanaka ,  Tomohiro Yamamoto ,  Nobuhiko Ozaki ,  Shinki Kojima

    IPC分类号： G01N33/544

    CPC分类号： G01N33/54366 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2300/0645 ,  B01L2300/0877 ,  B01L2300/0887 ,  B01L2400/0415 ,  Y10T436/11

    摘要： Provided is a measuring chip, which can spot a specimen liquid of a minute quantity for an immune agglutination easily and precisely to the measuring chip and which can prevent the flow of the specimen liquid and the contamination of the specimen. The measuring chip comprises at least two substrates, a spacer arranged between the substrates, at least one passage made of the substrates and the spacer into a hollow shape and having two open ends, counter electrodes for applying an electric field, and a specimen-spotted portion to be spotted with the specimen. The specimen-spotted portion has a structure made of a square, circular, elliptical or sector shape by that spacer. Moreover, the specimen-spotted portion has two open ends, one of which is connected to one open end of that passage.

    摘要翻译： 提供了一种测量芯片，其可以容易且准确地将测量芯片上的微量的微量样品液体点样，并且可以防止样品液体的流动和样品的污染。 测量芯片包括至少两个基板，布置在基板之间的间隔件，由基板和间隔件形成中空形状的至少一个通道，并具有两个开口端，用于施加电场的对电极和被检测点 用样品点样的部分。 样品点状部分具有由该间隔物形成的正方形，圆形，椭圆形或扇形的结构。 此外，样本点状部分具有两个开口端，其中一个连接到该通道的一个开口端。

    Substrate having channel portion including chambers, and method of transferring liquid by using the substrate
    5.
    发明授权
    Substrate having channel portion including chambers, and method of transferring liquid by using the substrate 有权
    具有包括腔室的通道部分的基板，以及通过使用基板传送液体的方法

    公开(公告)号：US08168444B2

    公开(公告)日：2012-05-01

    申请号：US12595077

    申请日：2008-04-04

    申请人： Nobuhiko Ozaki ,  Tomohiro Yamamoto

    发明人： Nobuhiko Ozaki ,  Tomohiro Yamamoto

    IPC分类号： B01L3/00

    CPC分类号： G01N35/10 ,  G01N2035/0449 ,  G01N2035/1034 ,  Y10T436/25 ,  Y10T436/2575

    摘要： A substrate having a channel portion in which a liquid transfers, wherein, even if the channel portion has no micro-channel interconnecting chambers, a liquid can transfer stepwise from one region to the next region according to the speed of rotation of the substrate. The substrate can be rotated about a rotation axis as the center, and has the channel portion including the chambers formed therein. The inner wall of each chamber has a first area including an area intersecting with a centrifugal direction from the center; and also has a second area placed at a position farther from the center than the first area, and including a surface intersecting with the centrifugal direction from the center. Further, the first area has a region for holding a droplet of a liquid provided; and also has a region where a contact with the droplet expands when the substrate is rotated, and that communicate with the second area.

    摘要翻译： 具有液体转移的通道部分的基板，其中即使通道部分没有微通道互连室，液体也可以根据基板的旋转速度从一个区域逐步转移到下一个区域。 基板可以围绕作为中心的旋转轴线旋转，并且具有包括形成在其中的室的通道部分。 每个室的内壁具有第一区域，其包括从中心与离心方向相交的区域; 并且还具有放置在比第一区域更远离中心的位置的第二区域，并且包括从中心与离心方向相交的表面。 此外，第一区域具有用于保持设置的液体的液滴的区域; 并且还具有当基板旋转时与液滴的接触膨胀并且与第二区域连通的区域。

    Seal structure
    7.
    发明申请
    Seal structure 审中-公开
    密封结构

    公开(公告)号：US20090200756A1

    公开(公告)日：2009-08-13

    申请号：US12319461

    申请日：2009-01-06

    申请人： Tomohiro Yamamoto

    发明人： Tomohiro Yamamoto

    IPC分类号： F16J15/06

    CPC分类号： B60H1/00571 ,  B60H2001/00635

    摘要： A seal structure is disclosed, wherein a casing 10 has an annular protrusion 11 making up a hole-formed portion of a through hole 12. The portion of a joint member 30 around a joint body 31 is wound with a band-shaped seal member 60. A first peripheral end portion 60a and a second peripheral end portion 60b of the seal member 60 are formed progressively upward in the direction from the engine compartment to the passenger compartment. In the process of inserting the joint body 31 and the seal member 60 into the through hole 12 of the casing 10, the first peripheral end portion 60a and the second peripheral end portion 60b of the seal member 60 are butted against each other in the peripheral direction. As a result, a gap is difficult to form between the first peripheral end portion 60a and the second peripheral end portion 60b.

    摘要翻译： 公开了一种密封结构，其中壳体10具有构成通孔12的孔形部分的环形突起11.接头构件30围绕接头本体31的部分缠绕有带状密封构件60 密封构件60的第一周缘部60a和第二周缘部60b沿着从发动机室到乘客室的方向逐渐向上形成。 在将接头体31和密封构件60插入壳体10的通孔12的过程中，密封构件60的第一周缘部60a和第二周边端部60b在周边 方向。 结果，在第一周边端部60a和第二周边端部60b之间难以形成间隙。

    Biosensor
    9.
    发明授权
    Biosensor 失效
    生物传感器

    公开(公告)号：US06966977B2

    公开(公告)日：2005-11-22

    申请号：US10350139

    申请日：2003-01-24

    申请人： Miwa Hasegawa ,  Tomohiro Yamamoto ,  Motokazu Watanabe ,  Shin Ikeda ,  Shiro Nankai

    发明人： Miwa Hasegawa ,  Tomohiro Yamamoto ,  Motokazu Watanabe ,  Shin Ikeda ,  Shiro Nankai

    IPC分类号： C12Q1/00 ,  G01N33/487 ,  G01N33/49 ,  G01N33/543 ,  G01N27/327

    CPC分类号： C12Q1/004 ,  G01N27/3272

    摘要： A sensor including an insulating base plate; an electrode system, provided on the base plate, having a measuring electrode and a counter electrode; a reaction layer including at least an oxidoreductase and an electron mediator; a sample solution supply pathway including the electrode system and the reaction layer; and a sample supply unit, wherein the sensor is so structured that, between the sample supply unit and the sample solution supply pathway, there is provided a filter having a function to filter out hemocytes and having a cross-sectional area larger than an opening of the sample solution supply pathway, and that plasma of a blood with hemocytes thereof having been filtered out is sucked into the inside of the sample solution supply pathway owing to capillary phenomena.

    摘要翻译： 一种传感器，包括绝缘基板; 设置在基板上的具有测量电极和对电极的电极系统; 至少包含氧化还原酶和电子介体的反应层; 包括电极系统和反应层的样品溶液供给路径; 以及样本供应单元，其中所述传感器的结构使得在所述样品供应单元和所述样品溶液供应通道之间提供过滤器，所述过滤器具有过滤出血细胞并且具有大于所述样品供应单元的开口的横截面积 样品溶液供给路径，由于毛细血管现象，血液中已经滤出血细胞的血浆被吸入到样品溶液供给路径的内部。

    Biosensor
    10.
    发明授权
    Biosensor 有权
    生物传感器

    公开(公告)号：US06719887B2

    公开(公告)日：2004-04-13

    申请号：US10221990

    申请日：2002-09-17

    申请人： Miwa Hasegawa ,  Motokazu Watanabe ,  Tomohiro Yamamoto ,  Shin Ikeda ,  Shiro Nankai

    发明人： Miwa Hasegawa ,  Motokazu Watanabe ,  Tomohiro Yamamoto ,  Shin Ikeda ,  Shiro Nankai

    IPC分类号： G01N27327

    CPC分类号： G01N33/92 ,  C12Q1/005 ,  G01N33/5438

    摘要： A biosensor includes: an insulating base plate; an electrode system which is provided on the base plate and has a measurement electrode and a counter electrode; a reaction layer including at least oxidoreductase and an electron mediator; a sample solution supply pathway which includes the electrode system and the reaction layer and has an air aperture on the termination side thereof; a sample supply portion; and a filter which is disposed between the sample solution supply pathway and the sample supply portion and filters hemocytes, where plasma with the hemocytes therein filtered with the filter is sucked into the sample solution supply pathway due to capillarity, the central part of a secondary side portion of the filter is protruded into the sample solution supply pathway more than both the right and left ends thereof.

    摘要翻译： 生物传感器包括：绝缘基板; 电极系统，设置在基板上，具有测量电极和对电极; 至少包含氧化还原酶和电子介体的反应层; 样品溶液供给路径，其包括电极系统和反应层，并且在其终端侧具有空气孔; 样品供应部分; 以及过滤器，其设置在样品溶液供给路径和样品供给部之间，并且过滤血细胞，其中由过滤器过滤的血细胞的血浆由于毛细作用而被吸入样品溶液供给通道，次级侧的中心部分 过滤器的一部分比其右端和左端都突出到样品溶液供给路径中。