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17 条记录 (耗时 0.055 秒)

    Proteases, nucleic acids encoding them and methods for making and using them
    2.
    发明申请
    Proteases, nucleic acids encoding them and methods for making and using them 有权
    蛋白酶，编码它们的核酸和制备和使用它们的方法

    公开(公告)号：US20060259995A1

    公开(公告)日：2006-11-16

    申请号：US10530643

    申请日：2003-10-10

    申请人： Michelle Cayouette ,  Connie Hansen ,  Amy McClure ,  May Sun ,  Svetlana Gramatikova ,  Mark Dycaico ,  Nelson Barton ,  Justin Stege ,  Nahla Aboushadi

    发明人： Michelle Cayouette ,  Connie Hansen ,  Amy McClure ,  May Sun ,  Svetlana Gramatikova ,  Mark Dycaico ,  Nelson Barton ,  Justin Stege ,  Nahla Aboushadi

    IPC分类号： A01K67/027 ,  C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C12N9/64 ,  A01H1/00

    CPC分类号： C12N9/52 ,  A01K2217/05

    摘要： The invention is directed to polypeptides having protease activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used in a variety of diagnostic, therapeutic, and industrial contexts. The polypeptides of the invention can be used as, e.g., an additive for a detergent, for processing foods and for chemical synthesis utilizing a reverse reaction. Additionally, the polypeptides of the invention can be used in food processing, brewing, bath additives, alcohol production, peptide synthesis, enantioselectivity, hide preparation in the leather industry, waste management and animal degradation, silver recovery in the photographic industry, medical treatment, silk degumming, biofilm degradation, biomass conversion to ethanol diodefense, antimicrobial agents and disinfectants, personal care and cosmetics, biotech reagents, in increasing starch yield from corn wet milling and pharmaceuticals such as digestive aids and anti-inflammatory (anti-phlogistic) agents.

    摘要翻译： 本发明涉及具有蛋白酶活性的多肽，编码多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。 本发明的多肽可用于多种诊断，治疗和工业背景。 本发明的多肽可用作例如用于洗涤剂的添加剂，用于加工食品和利用反向反应进行化学合成。 此外，本发明的多肽可用于食品加工，酿造，浴添加剂，醇生产，肽合成，对映选择性，皮革工业中的皮革制备，废物管理和动物降解，摄影工业中的银回收，医疗， 丝绸脱胶，生物膜降解，生物质转化为乙醇二聚体，抗微生物剂和消毒剂，个人护理和化妆品，生物技术试剂，用于增加玉米湿法研磨的淀粉产量，以及药物如消化助剂和抗炎（抗炎）剂。

    Methods for enzymatic decolorization of chlorophyll
    3.
    发明授权
    Methods for enzymatic decolorization of chlorophyll 有权
    叶绿素酶脱色方法

    公开(公告)号：US09017990B2

    公开(公告)日：2015-04-28

    申请号：US13103276

    申请日：2011-05-09

    申请人： David Lam ,  David Weiner ,  Timothy Hitchman ,  Nelson Barton ,  Mark Burk

    发明人： David Lam ,  David Weiner ,  Timothy Hitchman ,  Nelson Barton ,  Mark Burk

    IPC分类号： C12P7/64 ,  C12S3/00 ,  C12S3/18 ,  C12N9/18

    CPC分类号： C11B3/003 ,  C12N9/18

    摘要： The invention provides the invention provides compositions and methods for the enzymatic treatment (“bleaching” or “de-colorizing”) of chlorophyll-comprising compositions, e.g., algae preparations, chlorophyll-containing or chlorophyll-contaminated feeds, foods or oils, for example, vegetable oils, including oils processed from oilseeds, such as canola (rapeseed) oil or soybean oil, or oil fruits, such as palm oil. In one aspect, the invention provides methods using a chlorophyllase enzyme for the enzymatic hydrolysis of chlorophyll in an algae, an animal (e.g., a fish) or plant preparation, a food or an oil. In one aspect, the chlorophyllase is immobilized onto a silica. The invention also provides compositions of manufacture and detergents.

    摘要翻译： 本发明提供了本发明提供了含叶绿素组合物的酶处理（“漂白”或“脱色”）的组合物和方法，例如藻类制剂，含叶绿素或叶绿素污染的饲料，食品或油，例如 植物油，包括从油籽加工的油，例如油菜籽油菜籽油或大豆油，或油果如棕榈油。 一方面，本发明提供了使用叶绿素酶在藻类，动物（例如鱼）或植物制剂，食品或油中进行叶绿素的酶水解的方法。 一方面，将叶绿素酶固定在二氧化硅上。 本发明还提供了制造和洗涤剂的组合物。

    Amidases, nucleic acids encoding them and methods for making and using them
    7.
    发明申请
    Amidases, nucleic acids encoding them and methods for making and using them 审中-公开
    酰胺酶，编码它们的核酸和制备和使用它们的方法

    公开(公告)号：US20060259993A1

    公开(公告)日：2006-11-16

    申请号：US10502832

    申请日：2003-01-28

    申请人： Nelson Barton ,  David Weiner ,  William Greenberg ,  Samantha Luu ,  Kristine Chang ,  Elizabeth Waters

    发明人： Nelson Barton ,  David Weiner ,  William Greenberg ,  Samantha Luu ,  Kristine Chang ,  Elizabeth Waters

    IPC分类号： A01K67/027 ,  A01H5/00 ,  C12N1/21 ,  C12Q1/68 ,  C07H21/04 ,  C07D501/00 ,  C12N9/80 ,  C07D501/14 ,  C12N15/74 ,  C12N15/82 ,  C12P35/02

    CPC分类号： C07D501/00 ,  A01K2217/05 ,  A61K38/00 ,  C12N9/78 ,  C12P35/00 ,  C12P35/02 ,  C12P41/007 ,  C12Q1/34

    摘要： This invention provides amidases, polynucleotides encoding the amidases, methods of making and using these polynucleotides and polypeptides. In one aspect, the invention provides enzymes having secondary amidase activity, e.g., having activity in the hydrolysis of amides, including enzymes having peptidase, protease and/or hydantoinase activity. In alternative aspects, the enzymes of the invention can be used to used to increase flavor in food (e.g., enzyme ripened cheese), promote bacterial and fungal killing, modify and de-protect fine chemical intermediates, synthesize peptide bonds, carry out chiral resolutions, hydrolyze Cephalosporin C. The enzymes of the invention can be used to generate 7-aminocephalosporanic acid (7-ACA) and semi-synthetic cephalosporin antibiotics, including caphalothin, cephaloridine and cefuroxime. The enzymes of the invention can be used as antimicrobial agents, e.g., as cell wall hydrolytic agents. The invention also provides a fluorescent amidase substrate comprising 7-(ε-D-2-aminoadipoyladipoylamido)-4-methylcoumarin.

    摘要翻译： 本发明提供酰胺酶，编码酰胺酶的多核苷酸，制备和使用这些多核苷酸和多肽的方法。 一方面，本发明提供了具有仲酰胺酶活性的酶，例如在酰胺水解中具有活性，包括具有肽酶，蛋白酶和/或乙内酰脲酶活性的酶。 在替代方面，本发明的酶可用于增加食物中的风味（例如酶熟干酪），促进细菌和真菌杀死，改善和去保护精细化学中间体，合成肽键，进行手性拆分 ，水解头孢菌素C.本发明的酶可用于产生7-氨基头孢烷酸（7-ACA）和半合成头孢菌素抗生素，包括沙司他啶，头孢菌啶和头孢呋辛。 本发明的酶可以用作抗微生物剂，例如细胞壁水解剂。 本发明还提供了包含7-（ε-D-2-氨基己二酰己二酰氨基）-4-甲基香豆素的荧光酰胺酶底物。

    Polymeric cannulae proteins, nucleic acids encoding them and methods for making and using them
    8.
    发明申请
    Polymeric cannulae proteins, nucleic acids encoding them and methods for making and using them 审中-公开
    聚合插管蛋白，编码它们的核酸以及制备和使用它们的方法

    公开(公告)号：US20050208121A1

    公开(公告)日：2005-09-22

    申请号：US11046203

    申请日：2005-01-28

    申请人： Nelson Barton ,  Eileen O'Donoghue ,  Gerhard Frey ,  Jay Short ,  W. Lafferty ,  Kevin Chow

    发明人： Nelson Barton ,  Eileen O'Donoghue ,  Gerhard Frey ,  Jay Short ,  W. Lafferty ,  Kevin Chow

    IPC分类号： A01K67/00 ,  A61K33/44 ,  A61K38/17 ,  C07B57/00 ,  C07H21/04 ,  C07K14/195 ,  C07K14/705 ,  C12P21/04 ,  G01N33/573 ,  G01N33/68

    CPC分类号： B82Y5/00 ,  A01K2217/05 ,  A61K9/127 ,  A61K9/1274 ,  B82Y30/00 ,  C07K14/195 ,  C07K2319/00 ,  G01N33/573 ,  G01N33/68 ,  G01N2333/195

    摘要： The invention provides chimeric cannulae polypeptides and methods for making and using them. In one aspect, the invention provides compositions and methods for the identification, separation or synthesis of proteins or ligands. In one aspect, the invention provides compositions and methods for making and using nanotubules. In one aspect, the invention provides compositions and methods for the selection and purification of chiral compositions from racemic mixtures. The invention provides compositions comprising polymers prepared by self-assembly of a plurality of monomeric polypeptide units, including nanorobots, biochips, drug delivery systems. In one aspect, the polymer can form a nanotube, and the polymer (nanotubule) can encapsulate a drug molecule—a drug delivery systems of the invention. A drug delivery system of the invention may be delivered to a particular location of human body to effectively cure a disease or treat a symptom. In one aspect, a targeting vector can be attached to a monomeric polypeptide unit or a polymer to facilitate the targeting of the drug delivery system of the invention.

    摘要翻译： 本发明提供了嵌合插管多肽及其制备和使用方法。 一方面，本发明提供用于鉴定，分离或合成蛋白质或配体的组合物和方法。 一方面，本发明提供了制备和使用纳米管的组合物和方法。 一方面，本发明提供了用于从外消旋混合物中选择和纯化手性组合物的组合物和方法。 本发明提供了包含通过自组装多个单体多肽单元制备的聚合物的组合物，包括纳米机器人，生物芯片，药物递送系统。 在一个方面，聚合物可以形成纳米管，并且聚合物（纳米管）可以包封药物分子 - 本发明的药物递送系统。 本发明的药物递送系统可以被递送到人体的特定位置以有效地治愈疾病或治疗症状。 在一个方面，靶向载体可以连接到单体多肽单元或聚合物以促进本发明的药物递送系统的靶向。