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    Benzene compound and pharmaceutical use thereof
    1.
    发明授权
    Benzene compound and pharmaceutical use thereof 有权
    苯化合物及其药物用途

    公开(公告)号：US06372800B1

    公开(公告)日：2002-04-16

    申请号：US09691099

    申请日：2000-10-19

    申请人： Tetsuro Fujita ,  Kunitomo Adachi ,  Toshiyuki Kohara ,  Masatoshi Kiuchi ,  Kenji Chiba ,  Koji Teshima ,  Tadashi Mishina

    发明人： Tetsuro Fujita ,  Kunitomo Adachi ,  Toshiyuki Kohara ,  Masatoshi Kiuchi ,  Kenji Chiba ,  Koji Teshima ,  Tadashi Mishina

    IPC分类号： A61K3135

    CPC分类号： C07C215/56 ,  C07C215/28 ,  C07C215/30 ,  C07C217/64 ,  C07C217/72 ,  C07C219/22 ,  C07C225/16 ,  C07C233/18 ,  C07C233/31 ,  C07C233/36 ,  C07C233/73 ,  C07C271/16 ,  C07C271/18 ,  C07C2601/02

    摘要： A benzene compound of the formula wherein each symbol is as defined in the specification; an optically active isomer or salt thereof, a medicinal composition containing the same, and an immunosuppressant containing the same as the active ingredient. The compound, optically active isomer or salt has an excellent immunosuppressive effect and is useful as an inhibitor for the rejection reaction occurring in organ or bone marrow transplantation, and as a preventive or remedy for articular rheumatism, atopic eczema (dermatitis), Behcet's disease, uveal disease, systemic lupus erythematosus, Sjögren's syndrome, multiple sclerosis, myasthenia gravis, type I diabetes, endocrine ophthalmopathy, primary biliary, cirrhosis, Crohn's disease, glomerulonephritis, sarcoidosis, psoriasis, pemphigus, aplastic anemia, idiopathic thrombocytopenic purpura, allergy, polyarteritis nodosa, progressive systemic sclerosis, mixed connective-tissue disease, aortitis syndrome, polymyositis, dermatomyositis, Wegener's granuloma, ulcerative colitis, active chronic hepatitis, autoimmune hemolytic anemia, Evans' syndrome, bronchial asthma and pollinosis. It is useful also as an antifingal agent and hair growth stimulant.

    摘要翻译： 每个符号的苯甲醛的苯化合物如说明书中所定义; 其光学活性异构体或其盐，含有它们的药用组合物和含有该活性成分的免疫抑制剂。该化合物，旋光异构体或盐具有优异的免疫抑制作用，可用作抑制反应发生的抑制剂 在器官或骨髓移植中，作为关节风湿病，特应性湿疹（皮炎），贝切特氏病，葡萄膜疾病，系统性红斑狼疮，Sjögren综合征，多发性硬化症，重症肌无力，I型糖尿病，内分泌眼病，原发性 胆汁，肝硬化，克罗恩病，肾小球肾炎，结节病，牛皮癣，天疱疮，再生障碍性贫血，特发性血小板减少性紫癜，变态反应，结节性多动脉炎，进行性系统性硬化症，混合性结缔组织病，主动脉炎综合征，多发性肌炎，皮肌炎，韦格纳肉芽肿，溃疡性结肠炎， 活动性慢性肝炎，自身免疫性溶血性贫血， 伊文思综合征，支气管哮喘和花粉症。 它也可用作抗衰老剂和毛发生长兴奋剂。

    Benzene compound and pharmaceutical use thereof
    2.
    发明授权
    Benzene compound and pharmaceutical use thereof 有权
    苯化合物及其药物用途

    公开(公告)号：US06187821B1

    公开(公告)日：2001-02-13

    申请号：US09309818

    申请日：1999-05-12

    申请人： Tetsuro Fujita ,  Kunitomo Adachi ,  Toshiyuki Kohara ,  Masatoshi Kiuchi ,  Kenji Chiba ,  Koji Teshima ,  Tadashi Mishina

    发明人： Tetsuro Fujita ,  Kunitomo Adachi ,  Toshiyuki Kohara ,  Masatoshi Kiuchi ,  Kenji Chiba ,  Koji Teshima ,  Tadashi Mishina

    IPC分类号： A61K31135

    CPC分类号： C07C215/56 ,  C07C215/28 ,  C07C215/30 ,  C07C217/64 ,  C07C217/72 ,  C07C219/22 ,  C07C225/16 ,  C07C233/18 ,  C07C233/31 ,  C07C233/36 ,  C07C233/73 ,  C07C271/16 ,  C07C271/18 ,  C07C2601/02

    摘要： A benzene compound of the formula: wherein each symbol is as defined in the specification; an optically active isomer or salt thereof, a medicinal composition containing the same, and an immunosuppressant containing the same as the active ingredient. The compound, optically active isomer or salt has an excellent immunosuppressive effect and is useful as an inhibitor for the rejection reaction occurring in organ or bone marrow transplantation, and as a preventive or remedy for articular rheumatism, atopic eczema (dermatitis), Behcet's disease, uveal disease, systemic lupus erythematosus, Sjögren's syndrome, multiple sclerosis, myasthenia gravis, type I diabetes, endocrine ophthalmopathy, primary biliary, cirrhosis, Crohn's disease, glomerulonephritis, sarcoidosis, psoriasis, pemphigus, aplastic anemia, idiopathic thrombocytopenic purpura, allergy, polyarteritis nodosa, progressive systemic sclerosis, mixed connective-tissue disease, aortitis syndrome, polymyositis, dermatomyositis, Wegener's granuloma, ulcerative colitis, active chronic hepatitis, autoimmune hemolytic anemia, Evans' syndrome, bronchial asthma and pollinosis. It is useful also as an antifungal agent and hair growth stimulant.

    摘要翻译： 一种下式的苯化合物：其中每个符号如说明书中所定义;光学活性异构体或其盐，含有该化合物的药用组合物和含有该有效成分的免疫抑制剂。化合物，旋光异构体或 盐具有优异的免疫抑制作用，可用作器官或骨髓移植中发生的排斥反应的抑制剂，并且作为关节风湿病，特应性湿疹（皮炎），贝切特氏病，葡萄膜疾病，系统性红斑狼疮， Sjögren综合征，多发性硬化症，重症肌无力，I型糖尿病，内分泌眼病，原发性胆汁性肝硬化，克罗恩病，肾小球性肾炎，结节病，牛皮癣，天疱疮，再生障碍性贫血，特发性血小板减少性紫癜，变态反应，结节性多动脉炎，进行性系统性硬化症 组织病，主动脉炎综合征，多发性肌炎，皮肌炎，威基 r肉芽肿，溃疡性结肠炎，活动性慢性肝炎，自身免疫性溶血性贫血，伊文思综合征，支气管哮喘和花粉症。 它也可用作抗真菌剂和毛发生长兴奋剂。

    Benzene compound and pharmaceutical use thereof
    3.
    发明授权
    Benzene compound and pharmaceutical use thereof 失效
    苯化合物及其药物用途

    公开(公告)号：US5948820A

    公开(公告)日：1999-09-07

    申请号：US801390

    申请日：1997-02-20

    申请人： Tetsuro Fujita ,  Kunitomo Adachi ,  Toshiyuki Kohara ,  Masatoshi Kiuchi ,  Kenji Chiba ,  Koji Teshima ,  Tadashi Mishina

    发明人： Tetsuro Fujita ,  Kunitomo Adachi ,  Toshiyuki Kohara ,  Masatoshi Kiuchi ,  Kenji Chiba ,  Koji Teshima ,  Tadashi Mishina

    IPC分类号： C07C215/28 ,  C07C215/30 ,  C07C215/56 ,  C07C217/64 ,  C07C217/72 ,  C07C219/22 ,  C07C225/16 ,  C07C233/18 ,  C07C233/31 ,  C07C233/36 ,  C07C233/73 ,  C07C271/16 ,  C07C271/18 ,  A61K31/135

    CPC分类号： C07C215/56 ,  C07C215/28 ,  C07C215/30 ,  C07C217/64 ,  C07C217/72 ,  C07C219/22 ,  C07C225/16 ,  C07C233/18 ,  C07C233/31 ,  C07C233/36 ,  C07C233/73 ,  C07C271/16 ,  C07C271/18 ,  C07C2101/02

    摘要： A benzene compound of the formula ##STR1## wherein each symbol is as defined in the specification; an optically active isomer or salt thereof, a medicinal composition containing the same, and an immunosuppressant containing the same as the active ingredient.The compound, optically active isomer or salt has an excellent immunosuppressive effect and is useful as an inhibitor for the rejection reaction occurring in organ or bone marrow transplantation, and as a preventive or remedy for articular rheumatism, atopic eczema (dermatitis), Beh.cedilla.et's disease, uveal disease, systemic lupus erythematosus, Sjogren's syndrome, multiple sclerosis, myasthenia gravis, type I diabetes, endocrine ophthalmopathy, primary biliary, cirrhosis, Crohn's disease, glomerulonephritis, sarcoidosis, psoriasis, pemphigus, aplastic anemia, idiopathic thrombocytopenic purpura, allergy, polyarteritis nodosa, progressive systemic sclerosis, mixed connective-tissue disease, aortitis syndrome, polymyositis, dermatomyositis, Wegener's granuloma, ulcerative colitis, active chronic hepatitis, autoimmune hemolytic anemia, Evans' syndrome, bronchial asthma and pollinosis. It is useful also as an antifungal agent and hair growth stimulant.

    摘要翻译： 下式的苯化合物其中每个符号如说明书中所定义; 其光学活性异构体或其盐，含有它们的药用组合物和含有该活性成分的免疫抑制剂。 化合物，光学活性异构体或盐具有优异的免疫抑制作用，可用作器官或骨髓移植中发生的排斥反应的抑制剂，并且作为关节风湿病，特应性湿疹（皮炎）Beh + 525 多发性硬化症，重症肌无力，I型糖尿病，内分泌眼病，原发性胆汁性肝硬化，克罗恩病，肾小球性肾炎，结节病，牛皮癣，天疱疮，多发性硬化症， 再生障碍性贫血，特发性血小板减少性紫癜，过敏，结节性多动脉炎，进行性系统性硬化症，混合性结缔组织病，主动脉炎综合征，多发性肌炎，皮肌炎，韦格纳肉芽肿，溃疡性结肠炎，活动性慢性肝炎，自身免疫性溶血性贫血，伊文思综合征，支气管哮喘和 花粉症 它也可用作抗真菌剂和毛发生长兴奋剂。