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    Oligonucleotide probes bearing quenchable fluorescent labels, and methods of use thereof
    1.
    发明授权
    Oligonucleotide probes bearing quenchable fluorescent labels, and methods of use thereof 失效
    带有可淬灭荧光标记的寡核苷酸探针及其使用方法

    公开(公告)号：US06465175B2

    公开(公告)日：2002-10-15

    申请号：US09146157

    申请日：1998-09-03

    申请人： Thomas Horn ,  Hartmut R. Schroeder ,  Brian D. Warner ,  Ellen Fiss ,  Todd Sells ,  Say-Jong Law

    发明人： Thomas Horn ,  Hartmut R. Schroeder ,  Brian D. Warner ,  Ellen Fiss ,  Todd Sells ,  Say-Jong Law

    IPC分类号： C12Q168

    CPC分类号： C07H21/00 ,  C12Q1/6816 ,  C12Q1/6818

    摘要： Methods are provided for reducing background signals encountered in nucleic acid hybridization assays and other assays that involve hybridization of a labeled oligomer to its complement. The method is premised on the significant reduction of signal generation that occurs when a quenchable dye-labeled oligomer forms a hybrid complex. In addition, a method is provided for enhancing the detectable signal emitted from an amplification multimer hybridized to an oligomer probe to which a quenchable dye has been conjugated through a linker such that the emission from the dye is not quenched upon hybrid complex formation. Novel oligonucleotide probes are also provided that comprise an oligomer to which has been directly or indirectly through a linker a quenchable dye.

    摘要翻译： 提供了用于减少在核酸杂交测定中遇到的背景信号的方法和涉及标记的寡聚物与其互补体杂交的其它测定。 该方法的前提是当可淬灭的染料标记的寡聚物形成杂交复合物时发生的信号产生的显着减少。 此外，提供了一种用于增强从与已经通过接头共轭可淬灭染料的寡聚体探针杂交的扩增多聚体发射的可检测信号的方法，使得来自染料的发射在杂交复合物形成时不被淬灭。 还提供了新的寡核苷酸探针，其包含已经通过接头直接或间接通过可淬灭染料的低聚物。

    EXPLOSION-PROTECTED FUEL CELL
    5.
    发明申请
    EXPLOSION-PROTECTED FUEL CELL 审中-公开
    爆炸保护燃料电池

    公开(公告)号：US20130209910A1

    公开(公告)日：2013-08-15

    申请号：US13697571

    申请日：2011-05-12

    申请人： Thomas Horn ,  Ulrich Johannsmeyer ,  Anton Schimmele

    发明人： Thomas Horn ,  Ulrich Johannsmeyer ,  Anton Schimmele

    IPC分类号： H01M8/04

    CPC分类号： H01M8/04029 ,  H01M8/04052 ,  H01M8/04343 ,  H01M8/0435 ,  H01M8/04358 ,  H01M8/04679 ,  H01M8/2475

    摘要： A fuel cell arrangement operable in environments that are prone to explosions including a fuel cell stack 14 that is housed in a containment vessel 15 filled with a heat equalizing fluid 26 and provided with a cooling system. The heat equalizing fluid 26 flows around all sides of the fuel cell stack 14 and prevents a direct concentrated heat transfer from the surface of the fuel cell stack 14 to the containment housing 15. The heat equalizing fluid 26 buffers and distributes local heat peaks originating from the fuel cell stack 14 and thus eliminates ignition sources.

    摘要翻译： 燃料电池装置可在容易发生爆炸的环境中操作，所述环境包括燃料电池堆14，所述燃料电池堆14容纳在填充有均热流体26并设置有冷却系统的容纳容器15中。 均热流体26流过燃料电池堆14的所有侧面，并且防止从燃料电池堆14的表面到容纳壳体15的直接集中的热传递。热均衡流体26缓冲并分配源自 燃料电池堆14，从而消除点火源。

    Radio frequency localization
    6.
    发明申请
    Radio frequency localization 失效
    射频定位

    公开(公告)号：US20080143510A1

    公开(公告)日：2008-06-19

    申请号：US11638865

    申请日：2006-12-14

    申请人： Thomas Horn

    发明人： Thomas Horn

    IPC分类号： G08B23/00 ,  G08B21/00 ,  H04B1/38

    CPC分类号： H04B5/0087 ,  H04B17/27

    摘要： One aspect of the invention relates to a system for and a method of monitoring a plurality of transceivers located in an area, e.g. a patch panel, to be monitored.In accordance with an aspect of the invention, there is provided a method for monitoring a plurality of transceivers located in an area to be monitored. The method includes enabling one transceiver of the plurality of transceivers. The method also includes disabling all other transceivers of the plurality of transceivers. A transmit coil emits a high frequency electromagnetic field, the one transceiver transmitting a signal in response to the field of the transmit coil. At least one of a plurality of reader coils receives the signal transmitted by the one transceiver, the plurality of reader coils being suitably arranged in the vicinity of the area to be monitored. An evaluator determines a position of the one transceiver from the signal received from the one transceiver by the at least one of the plurality of reader coils.

    摘要翻译： 本发明的一个方面涉及一种监视位于一个区域中的多个收发器的系统和方法，例如， 一个接线板，待监控。 根据本发明的一个方面，提供了一种用于监视位于待监视区域中的多个收发器的方法。 该方法包括启用多个收发器中的一个收发器。 该方法还包括禁用多个收发器的所有其他收发器。 发射线圈发射高频电磁场，一个收发器响应于发射线圈的场发送信号。 多个读取器线圈中的至少一个接收由一个收发器发送的信号，多个读取器线圈适当地布置在待监视的区域附近。 评估器根据由多个读取器线圈中的至少一个从一个收发器接收的信号来确定一个收发器的位置。

    Immunotherapy of epithelial tumors using intralesional injection of antigens that induce a delayed type hypersensitivity reaction
    7.
    发明申请
    Immunotherapy of epithelial tumors using intralesional injection of antigens that induce a delayed type hypersensitivity reaction 审中-公开
    免疫治疗上皮性肿瘤使用病灶内注射诱导迟发型超敏反应的抗原

    公开(公告)号：US20050175634A1

    公开(公告)日：2005-08-11

    申请号：US11061996

    申请日：2005-02-21

    申请人： Thomas Horn ,  Sandra Johnson

    发明人： Thomas Horn ,  Sandra Johnson

    IPC分类号： A61K39/00 ,  A61K39/165 ,  A61K39/12

    CPC分类号： A61K39/165 ,  A61K39/0002 ,  A61K39/12 ,  A61K2039/58 ,  A61K2039/585

    摘要： The pharmaceutical composition is useful for treating epithelial tumors in a subject and contains at least two antigens and a pharmaceutically acceptable carrier, where each of the antigens induces or is capable of inducing a cutaneous delayed type hypersensitivity (DTH) response in the subject. This composition is particularly useful in treating epithelial tumors, such as warts or verrucae, that are induced by or related to papillomavirus. Antigens useful in the present pharmaceutical composition are anergy panel antigens, such as killed mumps virus, candida extract, trichophyton extract or comparable antigenic extracts. An additional pharmaceutical composition, also useful for treating epithelial tumors, contains at least one antigen that induces or is capable of inducing a cutaneous DTH response in a subject, at least one cytokine or colony stimulating factor and a pharmaceutically acceptable carrier. Kits containing these pharmaceutical compositions are useful for this immunotherapy.

    摘要翻译： 药物组合物可用于治疗受试者中的上皮肿瘤，并且含有至少两种抗原和药学上可接受的载体，其中每种抗原诱导或能够诱导受试者的皮肤迟发型超敏反应（DTH）反应。 该组合物特别可用于治疗由乳头瘤病毒引起或与乳头瘤病毒有关的上皮肿瘤，例如疣或疣。 本发明药物组合物中有用的抗原是抗病毒抗原，例如杀死的腮腺炎病毒，念珠菌提取物，毛发提取物或类似抗原提取物。 也可用于治疗上皮肿瘤的另外的药物组合物含有至少一种诱导或能诱导受试者皮肤DTH反应的抗原，至少一种细胞因子或集落刺激因子和药学上可接受的载体。 含有这些药物组合物的试剂盒可用于该免疫疗法。

    Pulse width modulated solenoid
    8.
    发明申请
    Pulse width modulated solenoid 有权
    脉宽调制电磁铁

    公开(公告)号：US20050121089A1

    公开(公告)日：2005-06-09

    申请号：US10989616

    申请日：2004-11-16

    申请人： Kenneth Morgan ,  Thomas Hemak ,  Aaron Wolfson ,  Thomas Horn ,  Gregory Lewis ,  Howard Saxon

    发明人： Kenneth Morgan ,  Thomas Hemak ,  Aaron Wolfson ,  Thomas Horn ,  Gregory Lewis ,  Howard Saxon

    IPC分类号： F15B13/044 ,  F16H61/00 ,  F16K27/00 ,  F16K31/06 ,  H01F7/16

    CPC分类号： F16K31/0693 ,  F15B13/044 ,  F16K27/003 ,  Y10T137/86622 ,  Y10T137/87217 ,  Y10T137/87233

    摘要： A pulse width modulated solenoid system having low noise characteristics is described. Noise reduction is primarily achieved by separating the solenoid device from the insulator and the manifold housing through the use of rubber isolators and multiple sets of o-rings, thus preventing metal to metal contact. Additional noise reduction is achieved by encapsulating all of the solenoids, using the insulator, the cover plate, the housing, and the screen carrier. Noise levels are also further reduced by minimizing the impact force of the armature against the sleeve by allowing fluid to vent into the upper area of the sleeve, thus causing a dampening effect.

    摘要翻译： 描述了具有低噪声特性的脉宽调制电磁阀系统。 降噪主要是通过使用橡胶隔离器和多组O形环将螺线管装置从绝缘体和歧管壳体分离出来的，从而防止金属与金属的接触。 通过使用绝缘体，盖板，壳体和屏幕载体封装所有螺线管来实现额外的降噪。 通过允许流体排放到套筒的上部区域中，通过使衔铁抵抗套筒的冲击力最小化，从而进一步降低噪音水平，从而产生阻尼作用。