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公开(公告)号：US20070231883A1
公开(公告)日：2007-10-04
申请号：US11726973
申请日：2007-03-22
CPC分类号： G01N21/6428 , G01N21/645 , G01N2021/6465
摘要： Fluorescence reader (10) for an optical assay arrangement comprising a polymeric sample substrate (1) having a reaction site-surface and a substrate surface (3), the fluorescence reader comprising a light source (5) arranged to illuminate the reaction site-surface through the substrate surface, and a detector device (6) arranged to detect fluorescent light emitted from said reaction site-surface and transmitted through the substrate surface, the substrate surface provided with total-internal-reflection suppressing means (15).
摘要翻译： 用于光学测定装置的荧光读取器（10），包括具有反应位点表面和基底表面（3）的聚合物样品基底（1），所述荧光读取器包括光源（5），其被布置成照亮反应位点表面 以及检测器装置（6），其被配置为检测从所述反应位置表面发射并透过所述基板表面的荧光，所述基板表面设置有全内反射抑制装置（15）。
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公开(公告)号：US08691153B2
公开(公告)日：2014-04-08
申请号：US11726973
申请日：2007-03-22
CPC分类号： G01N21/6428 , G01N21/645 , G01N2021/6465
摘要： A fluorescence reader for an optical assay arrangement includes a polymeric sample substrate having a reaction site-surface and a substrate surface. A light source is arranged to illuminate the reaction site-surface through the substrate surface, and a detector device is arranged to detect fluorescent light emitted from the reaction site-surface and transmitted through the substrate surface, the substrate surface provided, for example, as a light-collecting body to allow fluorescent light rays exceeding a critical emission angle for total internal reflection to escape the substrate and enter the body.
摘要翻译： 用于光学测定装置的荧光读取器包括具有反应位点表面和基底表面的聚合物样品基底。 光源被布置成通过基板表面照亮反应位点表面，并且检测器装置被布置成检测从反应位点表面发射并透射通过基板表面的荧光，基板表面提供例如 集光体，其允许超过全内反射的临界发射角的荧光线离开基板并进入体内。
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公开(公告)号：US07564045B2
公开(公告)日：2009-07-21
申请号：US11454993
申请日：2006-06-15
IPC分类号： G01N21/64
CPC分类号： G01N21/648 , B01L3/502746 , B01L2300/0654 , B01L2300/0822 , B01L2400/0406 , B01L2400/086 , G01N21/6428 , G01N21/6452 , G01N21/7703 , G02B6/2852
摘要： An optical reader for an optical assay arrangement including a polymeric sample substrate having a reaction-site surface provided with protruding microstructures and at least one reaction-site area; a light source for illuminating the reaction-site area; and a detector device for detecting light emitted from the reaction-site area. The light source is arranged to inject exciting light rays into the polymeric sample substrate with a controlled angle of incidence such that the protruding microstructures guide the exciting light rays in the direction of the reaction-site area, and the detector device detects light emitted from the at least one reaction-site area.
摘要翻译： 一种用于光学测定装置的光学读取器，其包括聚合物样品基底，其具有设置有突出微结构的反应位点表面和至少一个反应位点区域; 用于照亮反应部位区域的光源; 以及用于检测从反应部位区域发射的光的检测器装置。 光源设置成以可控的入射角将激发的光线注入到聚合物样品基底中，使得突出的微结构在反应位置区域的方向上引导激发光线，并且检测器装置检测从 至少一个反应部位。
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公开(公告)号：US08025854B2
公开(公告)日：2011-09-27
申请号：US10492453
申请日：2003-06-04
申请人： Ove Ohman , Ib Mendel-Hartvig
发明人： Ove Ohman , Ib Mendel-Hartvig
IPC分类号： B01L3/00
CPC分类号： B01L3/50273 , B01L3/502746 , B01L3/502761 , B01L2200/0668 , B01L2300/18 , B01L2400/0406 , B01L2400/086 , G01N30/6065 , G01N30/6095 , G01N2030/525 , Y10T436/25
摘要： The invention relates to a micro fluidic system comprising a substrate, and, provided on said substrate, at least one flow path interconnecting with functional means in which liquid samples can be treated by desired procedures. The flow paths are laid out to form a pattern for the transport of liquid samples to and from said functional means. These flow paths comprise a plurality of micro posts protruding upwards from said substrate, the spacing between the micro posts being small enough to induce a capillary action in a liquid sample applied anywhere within any of said flow paths, so as to force said liquid to move from where said liquid sample was applied.
摘要翻译： 本发明涉及一种微流体系统，其包括衬底，并且在所述衬底上提供与功能装置相互连接的至少一个流路，其中可以通过期望的程序处理液体样品。 布置流动路径以形成用于将液体样品运送到所述功能装置和从所述功能装置输送液体样品的图案。 这些流动路径包括从所述基底向上突出的多个微柱，微柱之间的间隔足够小，以在任何一个所述流动路径内的任何地方施加液体样品中的毛细管作用，以迫使所述液体移动 从其中应用所述液体样品。
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公开(公告)号：US20050042766A1
公开(公告)日：2005-02-24
申请号：US10492453
申请日：2003-06-04
申请人： Ove Ohman , Ib Mendel-Hartvig
发明人： Ove Ohman , Ib Mendel-Hartvig
IPC分类号： G01N35/08 , B01J4/00 , B01J19/00 , B01L3/00 , B81B1/00 , C12M1/00 , G01N30/52 , G01N30/60 , G01N37/00
CPC分类号： B01L3/50273 , B01L3/502746 , B01L3/502761 , B01L2200/0668 , B01L2300/18 , B01L2400/0406 , B01L2400/086 , G01N30/6065 , G01N30/6095 , G01N2030/525 , Y10T436/25
摘要： The invention relates to a micro fluidic system comprising a substrate, and, provided on said substrate, at least one flow path interconnecting with functional means in which liquid samples can be treated by desired procedures. The flow paths are laid out to form a pattern for the transport of liquid samples to and from said functional means. These flow paths comprise a plurality of micro posts protruding upwards from said substrate, the spacing between the micro posts being small enough to induce a capillary action in a liquid sample applied anywhere within any of said flow paths, so as to force said liquid to move from where said liquid sample was applied.
摘要翻译： 本发明涉及一种微流体系统，其包括衬底，并且在所述衬底上提供与功能装置相互连接的至少一个流路，其中液体样品可以通过期望的程序进行处理。 布置流动路径以形成用于将液体样品运送到所述功能装置和从所述功能装置输送液体样品的图案。 这些流动路径包括从所述基底向上突出的多个微柱，微柱之间的间隔足够小，以在任何一个所述流动路径内的任何地方施加液体样品中的毛细管作用，以迫使所述液体移动 从其中应用所述液体样品。
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公开(公告)号：US20100248394A1
公开(公告)日：2010-09-30
申请号：US12796351
申请日：2010-06-08
申请人： Per Ove Ohman , Ib Mendel-Hartvig
发明人： Per Ove Ohman , Ib Mendel-Hartvig
IPC分类号： G01N33/543
CPC分类号： B01L3/502746 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/0415 , B01L2400/0433 , B01L2400/0442 , B01L2400/086 , Y10T436/2575
摘要： A device for handling liquid samples, comprising a flow path with at least one zone for receiving the sample, and a transport or incubation zone, said zones connected by or comprising an area having projections substantially vertical to its surface, said device provided with a sink with a capacity of receiving said liquid sample, said sink comprising an area having projections substantially vertical to its surface, and said sink being adapted to respond to an external influence regulating its capacity to receive said liquid sample.
摘要翻译： 一种用于处理液体样品的装置，包括具有用于接收样品的至少一个区域的流动路径，以及运输或孵化区域，所述区域由具有基本上垂直于其表面的突起的区域连接或包括具有突出部的区域，所述装置设置有水槽 具有接收所述液体样品的能力，所述水槽包括具有基本上垂直于其表面的突起的区域，并且所述水槽适于响应于调节其接收所述液体样品的能力的外部影响。
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公开(公告)号：US08753585B2
公开(公告)日：2014-06-17
申请号：US12796351
申请日：2010-06-08
申请人： Per Ove Ohman , Ib Mendel-Hartvig
发明人： Per Ove Ohman , Ib Mendel-Hartvig
IPC分类号： B01L3/00
CPC分类号： B01L3/502746 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/0415 , B01L2400/0433 , B01L2400/0442 , B01L2400/086 , Y10T436/2575
摘要： A device for handling liquid samples, comprising a flow path with at least one zone for receiving the sample, and a transport or incubation zone, said zones connected by or comprising an area having projections substantially vertical to its surface, said device provided with a sink with a capacity of receiving said liquid sample, said sink comprising an area having projections substantially vertical to its surface, and said sink being adapted to respond to an external influence regulating its capacity to receive said liquid sample.
摘要翻译： 一种用于处理液体样品的装置，包括具有用于接收样品的至少一个区域的流动路径，以及运输或孵化区域，所述区域由具有基本上垂直于其表面的突起的区域连接或包括具有突出部的区域，所述装置设置有水槽 具有接收所述液体样品的能力，所述水槽包括具有基本上垂直于其表面的突起的区域，并且所述水槽适于响应于调节其接收所述液体样品的能力的外部影响。
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公开(公告)号：US20060289787A1
公开(公告)日：2006-12-28
申请号：US11454993
申请日：2006-06-15
申请人： Per Ohman , Tomas Lindstrom , Ib Mendel-Hartvig
发明人： Per Ohman , Tomas Lindstrom , Ib Mendel-Hartvig
IPC分类号： G01N21/64
CPC分类号： G01N21/648 , B01L3/502746 , B01L2300/0654 , B01L2300/0822 , B01L2400/0406 , B01L2400/086 , G01N21/6428 , G01N21/6452 , G01N21/7703 , G02B6/2852
摘要： Optical reader (33, 43, 53, 63, 73, 83) for an optical assay arrangement comprising a polymeric sample substrate (1) having a reaction site-area (5) provided with protruding microstructures (2), the optical reader comprising a light source (6, 11) for illuminating the reaction site-area (5), and a detector device (7, 12) for detecting light emitted from said reaction site-area.
摘要翻译： 一种用于光学测定装置的光学读取器（33,43,53,63,73,83），其包括具有设置有突出微结构（2）的反应位置区域（5）的聚合物样品基底（1），所述光学读取器包括 用于照射反应位置区域（5）的光源（6,11）和用于检测从所述反应位置区域发射的光的检测器装置（7,12）。
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9.发明授权公开(公告)号：US09347931B2
公开(公告)日：2016-05-24
申请号：US13265813
申请日：2010-04-23
申请人： Anthony Joseph Killard , Magdalena Maria Dudek , Brian MacCraith , Ib Mendel-Hartvig , Ove Öhman
发明人： Anthony Joseph Killard , Magdalena Maria Dudek , Brian MacCraith , Ib Mendel-Hartvig , Ove Öhman
IPC分类号： G01N33/00 , G01N33/49 , G01N33/543 , G01N33/545 , G01N33/558 , G01N33/86 , B01L3/00
CPC分类号： G01N33/4905 , B01L3/502707 , B01L3/502753 , B01L2300/161 , B01L2400/0406 , B01L2400/086 , G01N33/54353 , G01N33/545 , G01N33/558 , G01N33/86
摘要： The present invention is directed to a lateral flow assay device for the monitoring and measuring of coagulation and method thereof. Ideally, the invention is directed to a lateral capillary flow device for the monitoring and/or measurement of coagulation in a liquid sample wherein the device comprises a non-porous substrate with a zone for receiving a sample and a defined flow path zone wherein a clotting agent is deposited on at least part of the defined flow path zone to accelerate the coagulation of the liquid sample, enable the formation of an evenly distributed clot along the defined flow path zone and to result in the change in flow rate or cessation of flow of the liquid sample along the defined flow path zone.
摘要翻译： 本发明涉及一种用于监测和测量凝血的侧流测定装置及其方法。 理想地，本发明涉及用于监测和/或测量液体样品中的凝结的侧向毛细管流动装置，其中该装置包括具有用于接收样品的区域和限定的流动路径区域的无孔基材，其中凝固 试剂沉积在限定的流动路径区的至少部分上以加速液体样品的凝结，使得能够沿着限定的流动路径区形成均匀分布的凝块，并导致流速的变化或流动停止 液体样品沿着限定的流路区域。
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10.发明申请公开(公告)号：US20120107851A1
公开(公告)日：2012-05-03
申请号：US13265813
申请日：2010-04-23
申请人： Anthony Joseph Killard , Magdalena Maria Dudek , Brian MacCraith , Ib Mendel-Hartvig , Ove Öhman
发明人： Anthony Joseph Killard , Magdalena Maria Dudek , Brian MacCraith , Ib Mendel-Hartvig , Ove Öhman
CPC分类号： G01N33/4905 , B01L3/502707 , B01L3/502753 , B01L2300/161 , B01L2400/0406 , B01L2400/086 , G01N33/54353 , G01N33/545 , G01N33/558 , G01N33/86
摘要： The present invention is directed to a lateral flow assay device for the monitoring and measuring of coagulation and method thereof. Ideally, the invention is directed to a lateral capillary flow device for the monitoring and/or measurement of coagulation in a liquid sample wherein the device comprises a non-porous substrate with a zone for receiving a sample and a defined flow path zone wherein a clotting agent is deposited on at least part of the defined flow path zone to accelerate the coagulation of the liquid sample, enable the formation of an evenly distributed clot along the defined flow path zone and to result in the change in flow rate or cessation of flow of the liquid sample along the defined flow path zone.
摘要翻译： 本发明涉及一种用于监测和测量凝血的侧流测定装置及其方法。 理想地，本发明涉及用于监测和/或测量液体样品中的凝结的侧向毛细管流动装置，其中该装置包括具有用于接收样品的区域和限定的流动路径区域的无孔基材，其中凝固 试剂沉积在限定的流动路径区的至少部分上以加速液体样品的凝结，使得能够沿着限定的流动路径区形成均匀分布的凝块，并导致流速的变化或流动停止 液体样品沿着限定的流路区域。
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