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公开(公告)号：US5225750A
公开(公告)日：1993-07-06
申请号：US588261
申请日：1990-09-26
申请人： Toshiro Higuchi , Ken-ichi Kudoh , Atsushi Mimatsu , Hisao Ueno
发明人： Toshiro Higuchi , Ken-ichi Kudoh , Atsushi Mimatsu , Hisao Ueno
摘要： A microinjection apparatus according to the invention includes a microsyringe having a plunger, a rotative moving member which rotates together with a shaft, and a micromovement device mounted on the rotative moving member and having a piezoelectric/electro-strictive element equipped with an inertial member. Applying an electric signal to the micromovement device produces a driving force which causes the rotative moving member to rotate by a minute amount. As a result, the plunger is moved a minute amount in the axial direction to move a liquid within the microsyringe. Also provided is a microinjection apparatus which includes a microsyringe having an internal rotary plate serving as a plunger and attached to a center shaft, a rotative moving member which rotates together with the center shaft, and a micromovement device mounted on the rotative moving member and having a piezoelectric/electro-strictive element equipped with an inertial member. Applying an electric signal to the micromovement device produces a driving force which causes the rotative moving member to rotate by a minute amount. As a result, the rotary plate serving as the plunger is rotated a minute amount to move a liquid within the microsyringe. Further, the microinjection apparatus is so adapted that a micromovement device having a piezoelectric/electrostrictive element equipped with an inertial member is driven to drive a rectilinear moving member directly in a linear direction, thereby operating a plunger.
摘要翻译： 根据本发明的显微注射装置包括具有柱塞的微注射器，与轴一起旋转的旋转移动构件，以及安装在旋转运动构件上并具有配备有惯性构件的压电/电致密元件的微运动装置。 将电信号施加到微动装置产生驱动力，其使旋转移动构件旋转微量。 结果，柱塞沿轴向移动微小量以移动微量注射器内的液体。 还提供一种显微注射装置，其包括具有用作柱塞的内部旋转板并附接到中心轴的微型注射器，与中心轴一起旋转的旋转移动构件和安装在旋转运动构件上的微动装置， 配备有惯性构件的压电/电致密元件。 将电信号施加到微动装置产生驱动力，其使旋转移动构件旋转微量。 结果，用作柱塞的旋转板旋转微量以移动微量注射器内的液体。 此外，显微注射装置适于使具有配备有惯性构件的压电/电致伸缩元件的微动装置被驱动以直线驱动直线移动构件，从而操作柱塞。
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公开(公告)号：US5229679A
公开(公告)日：1993-07-20
申请号：US697499
申请日：1991-05-03
申请人： Toshiro Higuchi , Ken-ichi Kudoh , Atsushi Mimatsu
发明人： Toshiro Higuchi , Ken-ichi Kudoh , Atsushi Mimatsu
摘要： A microdrive apparatus of a micromanipulator according to the present invention is such that a piezoelectric/electrostrictive element having an inertial member mounted at its tip is attached to a moving member supported on a frictional surface of a support member, and a miniature instrument for manipulation is attached to the moving member. By applying an electric field to the piezoelectric/electrostrictive element, the miniature instrument for manipulation is controlled for fine movement by utilizing this kinetic energy, the inertial effect of the inertial member, and the reaction force acting upon the moving member. In addition, the miniature instrument for manipulation can be controlled to assume a predetermined position and predetermined attitude by a micropositioning device having an articulated portion in which an inertial member is attached to an arm via a piezoelectric/electrostrictive element.
摘要翻译： 根据本发明的显微操纵器的微驱动装置是这样一种将其顶端安装有惯性构件的压电/电致伸缩元件安装在支撑在支撑构件的摩擦表面上的移动构件上，并且用于操纵的微型仪器是 连接到移动构件。 通过对压电/电致伸缩元件施加电场，通过利用该动能，惯性构件的惯性效应和作用在移动构件上的反作用力来控制用于操纵的微型仪器的精细运动。 此外，用于操纵的微型仪器可以通过具有铰接部分的微型定位装置来控制以呈现预定位置和预定姿态，其中惯性构件经由压电/电致伸缩元件附接到臂。
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公开(公告)号：US09664243B2
公开(公告)日：2017-05-30
申请号：US14630927
申请日：2015-02-25
IPC分类号： B60L7/00 , F16D63/00 , H02K1/34 , H02K7/14 , H02N2/04 , B25J15/02 , H01F7/08 , H01F7/16 , H01L41/12 , H02N2/02 , B06B1/04
CPC分类号： F16D63/002 , B06B1/04 , B25J15/0246 , H01F7/081 , H01F7/1638 , H01L41/12 , H02K1/34 , H02K7/14 , H02N2/023 , H02N2/043
摘要： A gripper mechanism and a movement mechanism which utilize an electromagnetic actuator which can secure a sufficient thrust force at least at a certain level over a wide range of displacement. The movement mechanism includes a pair of electromagnetic actuators disposed inside a pair of rails and an intermediate actuator provided between the electromagnetic actuators. The electromagnetic actuators function as a gripper mechanism to be gripped by the rails. The electromagnetic actuators each include a displacement amplification mechanism including a magnetic body, and coils provided in the displacement amplification mechanism. A magnetic flux is generated in the magnetic body by passing an electric current through the coils so as to displace the displacement amplification points of the displacement amplification mechanism.
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公开(公告)号：US08883864B2
公开(公告)日：2014-11-11
申请号：US12826845
申请日：2010-06-30
CPC分类号： B01F13/0062 , B01F3/0807 , B01F3/0811 , B01F5/045 , B01F5/0471 , B01F13/0076 , B01F15/0201 , B01F15/0255 , B01F2003/0834 , B01F2003/0838 , B01F2215/0431 , B01J13/04 , B01J19/0093 , B01J2219/00783 , B01J2219/00853 , B01L3/5027 , Y10S366/04 , Y10S516/924 , Y10S516/927 , Y10T137/0329 , Y10T428/2984
摘要： A process and apparatus for rapidly producing an emulsion and microcapsules in a simple manner is provided wherein a dispersion phase is ejected from a dispersion phase-feeding port toward a continuous phase flowing in a microchannel in such a manner that flows of the dispersion phase and the continuous phase cross each other, thereby obtaining microdroplets, formed by the shear force of the continuous phase, having a size smaller than the width of the channel for feeding the dispersion phase.
摘要翻译： 提供一种用于以简单的方式快速生产乳液和微胶囊的方法和装置，其中将分散相从分散相进料口朝向在微通道中流动的连续相喷射，使得分散相和 连续相交叉，从而获得由连续相的剪切力形成的微滴，其尺寸小于用于进料分散相的通道的宽度。
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公开(公告)号：US07378473B2
公开(公告)日：2008-05-27
申请号：US10537602
申请日：2003-12-05
CPC分类号： C08F2/44 , Y10T137/0329
摘要： Monodisperse colored spherical particles each having two separated color regions of two hues, that is, two-colored spherical particles, useful, for example, for displays of characters, graphics, images and the like, the two hues being for reverse display in terms of electricity and magnetism from the viewpoint of good suitability for display are provided. In the production process and the apparatus for producing the colored spherical polymer particles, microchannels are utilized including a first microchannel through which a colored continuous phase comprising a color dye/pigment dispersed in a fluid dispersing medium containing a polymerizable resin component and having colored phases of different hues is transferred, and a second microchannel through which a spheroidizing disperse phase flows. The process and apparatus spheroidizes the discharged colored continuous phase having two hues and cures the polymerizable resin component in the colored continuous phase, whereby colored spherical polymer particles are formed.
摘要翻译： 每个具有两个分离的两个色调的颜色区域的单分散着色球形颗粒，即双色球形颗粒，例如可用于显示字符，图形，图像等，这两个色调用于反向显示 提供了从显示适用性的观点出发的电力和磁性。 在制造方法和着色球形聚合物颗粒的制造装置中，使用微通道，其包括第一微通道，通过该第一微通道，包含分散在含有可聚合树脂组分的流体分散介质中并具有着色相的着色染料/颜料的着色连续相 不同的色调被转移，并且第二微通道通过球状分散相流过。 该方法和装置对具有两个色调的排出的有色连续相进行球化并固化着色连续相中的可聚合树脂组分，从而形成着色的球形聚合物颗粒。
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6.发明授权公开(公告)号：US07280680B2
公开(公告)日：2007-10-09
申请号：US10377671
申请日：2003-03-04
申请人： Hideo Yokota , Sakiko Nakamura , Atsushi Yoshiki , Akitake Makinouchi , Ryutaro Himeno , Toshiro Higuchi
发明人： Hideo Yokota , Sakiko Nakamura , Atsushi Yoshiki , Akitake Makinouchi , Ryutaro Himeno , Toshiro Higuchi
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06T7/70 , G06T2207/30004
摘要： In order to make observation of localizations of in vivo expressed genes possible in an entire individual living organism such as animals, and plants, a living genetic recombinant specimen containing a marker that can be detected at the time when specific genes are expressed is sequentially severed, sectional images each of which corresponds to an image of sections severed are photographed in every scissions of the living specimen, and three-dimensional observation of the living specimen is implemented on the basis of the images photographed in every scissions described above, whereby three-dimensional localizations of expressed genes are observed in the living specimen.
摘要翻译： 为了观察在动物和植物等整个个体活体中可能存在的体内表达基因的定位，依次切断含有表达特定基因时可检测的标志物的活的遗传重组标本， 在活体样本的每个划痕中拍摄各自对应于切片的图像的截面图像，并且基于在上述每个扫描中拍摄的图像来实施活体样本的三维观察，由此三维 在活体标本中观察到表达基因的定位。
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7.发明申请公开(公告)号：US20060172336A1
公开(公告)日：2006-08-03
申请号：US11392505
申请日：2006-03-30
CPC分类号： B01L3/50273 , B01J2219/00274 , B01L3/502792 , B01L7/525 , B01L2200/0647 , B01L2300/0645 , B01L2300/089 , B01L2300/1827 , B01L2400/0415 , C12Q1/6813 , C12Q1/686 , G01N2035/00366 , G01N2035/00376 , C12Q2565/607 , C12Q2563/173 , C12Q2531/113 , C12Q2523/307
摘要： To provide a PCR method utilizing electrostatic transportation which allows separate control of individual DNA-containing droplets by accurately transporting the droplets, suitably controlling the temperature thereof and allowing a primer to react therewith; a hybridization method utilizing electrostatic transportation which allows rapid and easy detection of hybridization; and devices therefor. A biological sample (droplets containing DNA and primer) (9) is prepared in a chemically inert liquid layer (8), is electrostatically transported by the action of an electrostatic transportation plate (1) with electrostatic transportation electrodes (2) and is heated at a predetermined position of the electrostatic transportation plate (1), thus carrying out PCR.
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公开(公告)号：US20060079584A1
公开(公告)日：2006-04-13
申请号：US11287252
申请日：2005-11-28
CPC分类号： B01F13/0062 , B01F3/0807 , B01F3/0811 , B01F5/045 , B01F5/0471 , B01F13/0076 , B01F15/0201 , B01F15/0255 , B01F2003/0834 , B01F2003/0838 , B01F2215/0431 , B01J13/04 , B01J19/0093 , B01J2219/00783 , B01J2219/00853 , B01L3/5027 , Y10S366/04 , Y10S516/924 , Y10S516/927 , Y10T137/0329 , Y10T428/2984
摘要： A process and apparatus for rapidly producing an emulsion and microcapsules in a simple manner is provided wherein a dispersion phase is ejected from a dispersion phase-feeding port toward a continuous phase flowing in a microchannel in such a manner that flows of the dispersion phase and the continuous phase cross each other, thereby obtaining microdroplets, formed by the shear force of the continuous phase, having a size smaller than the width of the channel for feeding the dispersion phase.
摘要翻译： 提供一种用于以简单的方式快速生产乳液和微胶囊的方法和装置，其中将分散相从分散相进料口朝向在微通道中流动的连续相喷射，使得分散相和 连续相交叉，从而获得由连续相的剪切力形成的微滴，其尺寸小于用于进料分散相的通道的宽度。
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公开(公告)号：US20060077755A1
公开(公告)日：2006-04-13
申请号：US11287253
申请日：2005-11-28
CPC分类号： B01F13/0062 , B01F3/0807 , B01F3/0811 , B01F5/045 , B01F5/0471 , B01F13/0076 , B01F15/0201 , B01F15/0255 , B01F2003/0834 , B01F2003/0838 , B01F2215/0431 , B01J13/04 , B01J19/0093 , B01J2219/00783 , B01J2219/00853 , B01L3/5027 , Y10S366/04 , Y10S516/924 , Y10S516/927 , Y10T137/0329 , Y10T428/2984
摘要： The present invention provides a process and apparatus for rapidly producing an emulsion and microcapsules in a simple manner. A dispersion phase is ejected from a dispersion phase-feeding port toward a continuous phase flowing in a microchannel in such a manner that flows of the dispersion phase and the continuous phase cross each other, thereby obtaining microdroplets, formed by the shear force of the continuous phase, having a size smaller than the width of the channel for feeding the dispersion phase.
摘要翻译： 本发明提供了一种以简单的方式快速生产乳液和微胶囊的方法和装置。 将分散相从分散相进料口朝着在微通道中流动的连续相流出，使得分散相和连续相的流动相互交叉，由此获得由连续的剪切力形成的微滴 相位，其尺寸小于用于馈送分散相的通道的宽度。
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10.发明授权Actuator using electromechanical transducer and drive pulse generator suitable thereof 有权使用机电换能器和驱动脉冲发生器的执行器适合公开(公告)号：US06218764B1
公开(公告)日：2001-04-17
申请号：US09150464
申请日：1998-09-09
IPC分类号： H02N200
摘要： An actuator using an electromechanical transducer capable of driving efficiently and at high speed and a drive pulse generating apparatus, in which the frequency f of a drive pulse is set in a range satisfying equation (1) and the wavelength T is set in a range satisfying equations (2), (3) and (4); (1/3)fr
摘要翻译： 使用能够高效且高速驱动的机电换能器的致动器以及将驱动脉冲的频率f设定在满足式（1）和波长T的范围内的驱动脉冲发生装置，其设定在满足 等式（2），（3）和（4）;其中fr：包括机电换能器的振荡构件的共振频率，T1：驱动脉冲宽度，T2：驱动脉冲电压的逐渐变化部分的宽度，T3：宽度 可以满足驱动脉冲电压的快速变化部分，并且可以满足0.1 <（T3 / T2）<0.3。
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