公开(公告)号：US08382812B2

公开(公告)日：2013-02-26

申请号：US12473745

申请日：2009-05-28

申请人： Uk Kang ,  Garri. V Papayan

发明人： Uk Kang ,  Garri. V Papayan

IPC分类号： A61N5/06

CPC分类号： G01N21/6486 ,  A61B5/0059 ,  A61N5/0601 ,  A61N5/062 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0248 ,  G01J3/10 ,  G01J3/12 ,  G01J3/36 ,  G01J3/4406 ,  G01N21/255 ,  G01N21/29 ,  G01N21/31 ,  G01N21/4738 ,  G01N21/6456 ,  G01N2201/0618

摘要： The present invention provides an apparatus for photodynamic therapy and fluorescence detection, in which a combined light source is provided to illuminate an object body and a multispectral fluorescence-reflectance image is provided to reproduce various and complex spectral images for an object tissue, thus performing effective photodynamic therapy for various diseases both outside and inside of the body.For this purpose, the present invention provides an apparatus for photodynamic therapy and photodetection, which provides illumination with light of various wavelengths and multispectral images, the apparatus including: an optical imaging system producing an image of an object tissue and transmitting the image to a naked eye or an imaging device; a combined light source including a plurality of coherent and non-coherent light sources and a light guide guiding incident light emitted from the light sources; a multispectral imaging system including at least one image sensor; and a computer system outputting an image of the object tissue to the outside. Thus, the apparatus for photodynamic therapy and photodetection of the present invention can effectively perform the photodynamic therapy and photodetection by means of the combined light source capable of irradiating light having various spectral components to an object tissue and the multispectral imaging system capable of obtaining images from several spectral portions for these various spectral ranges at the same time, thus improving the accuracy of diagnosis and efficiency of the photodynamic therapy.

摘要翻译： 本发明提供了一种用于光动力学治疗和荧光检测的装置，其中提供组合光源以照射物体，并且提供多光谱荧光反射图像以再现对象组织的各种和复杂的光谱图像，从而执行有效 身体各种疾病的光动力治疗。 为此，本发明提供了一种用于光动力学治疗和光电检测的装置，其提供具有各种波长和多光谱图像的光的照明，所述装置包括：光学成像系统，其产生对象组织的图像并将图像发送到裸体 眼睛或成像装置; 包括多个相干和非相干光源的组合光源和引导从光源发射的入射光的光导; 包括至少一个图像传感器的多光谱成像系统; 以及将对象组织的图像输出到外部的计算机系统。 因此，本发明的光动力学治疗和光电检测装置可以通过能够将具有各种光谱成分的光照射到对象组织上的组合光源和能够获得图像的多光谱成像系统而有效地进行光动力学治疗和光电检测 同时对于这些不同光谱范围的几个光谱部分，从而提高光动力疗法的诊断准确性和效率。

公开(公告)号：US08017079B2

公开(公告)日：2011-09-13

申请号：US11810915

申请日：2007-06-07

申请人： Uk Kang ,  Soo Jin Bae ,  Geri V Papayan

发明人： Uk Kang ,  Soo Jin Bae ,  Geri V Papayan

IPC分类号： G01N21/00

CPC分类号： G01N21/6452 ,  G01N21/648 ,  G01N2201/063

摘要： Disclosed herein is an apparatus for and method of measuring bio-chips, which can implement an illumination method of a novel type that illuminates a bio sample (which may be also referred to as a “bio specimen”) through a side face of a substrate using a diffusion plate to form an evanescent field by the illumination light over the entire surface of a substrate so as to uniformly secure brightness of the illuminated light over a wide area of a substrate, thereby more efficiently measuring fluorescence information of a bio-chip over a wide field of view.

摘要翻译： 本文公开了一种测量生物芯片的装置和方法，其可以实现通过衬底的侧面照射生物样品（其也可以称为“生物样本”）的新型照明方法 使用扩散板通过在基板的整个表面上的照明光形成消逝场，从而均匀地将照明光的亮度保持在基板的宽阔区域上，从而更有效地测量生物芯片的荧光信息 广泛的视野。

公开(公告)号：US20100121418A1

公开(公告)日：2010-05-13

申请号：US12474522

申请日：2009-05-29

申请人： Dae Sic LEE ,  Guang Hoon Kim ,  Uk Kang ,  R. Andreev

发明人： Dae Sic LEE ,  Guang Hoon Kim ,  Uk Kang ,  R. Andreev

IPC分类号： A61N5/067 ,  A61F7/00

CPC分类号： A61B18/203 ,  A61B2018/00029 ,  A61B2018/00452 ,  A61N5/0616

摘要： The present invention provides a skin cooling system which can improve skin cooling efficiency and significantly reduce thermal damage and pain caused by heat generated during treatment, using a handpiece for injecting cold air, water, or a mixture of cold air and water.For this purpose, the present invention provides a skin cooling system including: a handpiece for focusing therapeutic light energy onto the surface of the skin for treatment and injecting cold air, water, or a mixture of cold air and water to the skin during treatment; a cold air supply means connected to the handpiece to supply cold air; and a cold water supply means connected to the handpiece to supply cooling water.

摘要翻译： 本发明提供了一种皮肤冷却系统，其可以使用用于注射冷空气，水或冷空气和水的混合物的手持件来改善皮肤冷却效率并显着减少由治疗期间产生的热引起的热损伤和疼痛。 为此目的，本发明提供了一种皮肤冷却系统，包括：用于将治疗光能聚焦到皮肤表面上的手持件，用于在治疗期间将冷空气，水或冷空气和水的混合物注入皮肤; 连接到所述手持件以供应冷空气的冷气供应装置; 以及连接到所述手持件以供应冷却水的冷水供应装置。

公开(公告)号：US20080269576A1

公开(公告)日：2008-10-30

申请号：US12096029

申请日：2006-12-05

申请人： Uk Kang ,  Garri Papayan ,  Soo Jin Bae ,  Geun Hie Rim

发明人： Uk Kang ,  Garri Papayan ,  Soo Jin Bae ,  Geun Hie Rim

IPC分类号： A61B5/00 ,  A61B18/18

CPC分类号： A61B5/444 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/441 ,  A61N5/062 ,  A61N2005/0654

摘要： Disclosed herein is a light source device for fluorescence diagnosis and photodynamic therapy comprising: a plurality of light source means having a wavelength range different from each other and providing selected light; a light path coupling means coupling light emitted from the light source means to the incident direction of a light guide; a filtering means selectively transmitting the emitted light based on the wavelength; and a switching device that is directed to an opening/closing means, established at a long distance to be controlled by a remote control device and selecting the kinds of light sources of the light source means to change the modes of the light. Accordingly, the device simplifies the configuration by excluding elements causing errors in the process of fluorescence diagnosis in the diagnostic region. Moreover, the light source device for fluorescence diagnosis and photodynamic therapy couples the light emitted from a combined light source to provide a sufficient light strength in the visible light region, thus improving the illumination quality to increase the accuracy of the diagnosis and further improving the therapeutic efficiency.

摘要翻译： 本文公开了一种用于荧光诊断和光动力疗法的光源装置，包括：多个光源装置，其具有彼此不同的波长范围并提供所选择的光; 将从所述光源装置发射的光耦合到光导的入射方向的光路耦合装置; 滤波装置根据波长有选择地发射发射的光; 以及开关装置，其被引导到打开/关闭装置，其建立在远距离处，由遥控装置控制，并且选择光源装置的光源的种类以改变光的模式。 因此，该装置通过排除在诊断区域中引起荧光诊断过程中的错误的元件来简化配置。 此外，用于荧光诊断和光动力学治疗的光源装置将从组合光源发射的光耦合以在可见光区域提供足够的光强度，从而提高照明质量，从而提高诊断的准确性并进一步改善治疗 效率。

公开(公告)号：US20150201840A1

公开(公告)日：2015-07-23

申请号：US14676802

申请日：2015-04-01

申请人： Uk Kang ,  Garry V. Papayan

发明人： Uk Kang ,  Garry V. Papayan

IPC分类号： A61B5/00

CPC分类号： A61B5/0071 ,  A61B5/441

摘要： Provided is a reflection detection type measurement apparatus for skin fluorescence. The apparatus includes: a first light source irradiating excitation light on a measurement target; a second light source irradiating light of a wavelength different from that of light from the first light source on the measurement target; a first optical detector detecting a reflected light generated from the measurement target due to the excitation light of the first light source; and a second optical detector detecting a skin fluorescence generated from the measurement target due to the excitation light of the first light source, and detecting a reflected light generated from the measurement target due to the excitation light of the second light source. The first optical detector is disposed in an area other than a total reflection area to which the excitation light of the first light source is reflected after irradiating to the measurement target.

摘要翻译： 提供了一种用于皮肤荧光的反射检测型测量装置。 该装置包括：在测量对象物上照射激发光的第一光源; 第二光源，将与来自第一光源的光不同的波长的光照射在测量对象上; 第一光学检测器，由于所述第一光源的激发光检测从所述测量对象产生的反射光; 以及第二光学检测器，其检测由于所述第一光源的激发光而从所述测量对象产生的皮肤荧光，并且检测由于所述第二光源的激发光而由所述测量对象产生的反射光。 第一光检测器设置在除了在照射到测量对象之后第一光源的激发光被反射的全反射区域以外的区域中。

公开(公告)号：US08647372B2

公开(公告)日：2014-02-11

申请号：US12168351

申请日：2008-07-07

申请人： Uk Kang ,  Soo Jin Bae ,  Seung Yup Lee ,  Guang Hoon Kim ,  Geun Hee Rim ,  Geri. V Papyan ,  Dmitry Makarov

发明人： Uk Kang ,  Soo Jin Bae ,  Seung Yup Lee ,  Guang Hoon Kim ,  Geun Hee Rim ,  Geri. V Papyan ,  Dmitry Makarov

IPC分类号： A61N5/06

CPC分类号： A61N5/0616 ,  A61B2018/207 ,  A61N2005/063 ,  A61N2005/0659 ,  A61N2005/0661

摘要： The present invention provides a composite light source apparatus for phototherapy of skin disease, in which a light beam having the wavelength and optical power suitable for light-beam treatment is provided to a region to be treated (also called a ‘to-be-treated region’) through a light guide by using a composite light source so as to improve efficiency of phototherapy of skin diseases of the body including acne, malignant tumors and the like. According to the composite light source apparatus, uniform optical power can be provided through a combination of a plurality of light sources, the optical power can be provided through selection of light of a wavelength range that a user wants, and light from the light sources can be utilized to the maximum with increased light intensity.

摘要翻译： 本发明提供了一种用于皮肤病光疗的复合光源装置，其中具有适用于光束处理的波长和光焦度的光束被提供给待治疗的区域（也称为待治疗的区域 区域'）通过使用复合光源通过光导，以提高身体皮肤疾病（包括痤疮，恶性肿瘤等）的光疗效率。 根据复合光源装置，可以通过多个光源的组合来提供均匀的光功率，可以通过选择用户想要的波长范围的光来提供光功率，并且来自光源的光可以 最大限度地利用增加的光强度。

公开(公告)号：US08496695B2

公开(公告)日：2013-07-30

申请号：US11811912

申请日：2007-06-11

申请人： Uk Kang ,  Soo Jin Bae ,  Geun Hie Rim ,  Guang Hoon Kim ,  Geri V. Papayan

发明人： Uk Kang ,  Soo Jin Bae ,  Geun Hie Rim ,  Guang Hoon Kim ,  Geri V. Papayan

IPC分类号： A61N5/06

CPC分类号： A61N5/062 ,  A61B5/0071 ,  A61B5/441 ,  A61B2017/00057 ,  A61B2017/00747 ,  A61B2090/373 ,  A61N5/0616 ,  G01N21/6456 ,  G01N21/6486

摘要： A system is provided for photodynamic diagnosis and therapy of skin diseases. In particular, a camera head is provided to irradiate a white light, a fluorescent excitation light and a therapeutic light for the photodynamic therapy from the inside of a case onto the skin region being in contact with a view hole. Additionally, a digital color TV camera collects the light from the skin region and outputs a generated image signal. In particular, an image processing and analysis system receives the image signals from the camera head to process, analyze and store the same, displays a color image by the white light, a fluorescent image by the excitation light and the therapeutic light for the photodynamic therapy, obtained by the digital color TV camera, and a synthesized image thereof, and controls the general operations of the camera and the light source system.

摘要翻译： 提供一种用于光动力诊断和治疗皮肤疾病的系统。 特别地，提供一种照相机头，用于将来自外壳内部的光动力学治疗的白光，荧光激发光和治疗光照射到与观察孔接触的皮肤区域上。 此外，数字彩色电视摄像机收集来自皮肤区域的光并输出生成的图像信号。 特别地，图像处理和分析系统接收来自相机头的图像信号以进行处理，分析和存储，通过白光显示彩色图像，通过激发光显示荧光图像和用于光动力学治疗的治疗光 ，由数字彩色电视摄像机获得，并且其合成图像，并且控制照相机和光源系统的一般操作。

公开(公告)号：US20090093866A1

公开(公告)日：2009-04-09

申请号：US12168351

申请日：2008-07-07

申请人： Uk Kang ,  Soo Jin Bae ,  Seung Yup Lee ,  Guang Hoon Kim ,  Geun Hee Rim ,  Geri V. Papayan ,  Dmitry Makarov

发明人： Uk Kang ,  Soo Jin Bae ,  Seung Yup Lee ,  Guang Hoon Kim ,  Geun Hee Rim ,  Geri V. Papayan ,  Dmitry Makarov

IPC分类号： A61N5/06

CPC分类号： A61N5/0616 ,  A61B2018/207 ,  A61N2005/063 ,  A61N2005/0659 ,  A61N2005/0661

摘要： The present invention provides a composite light source apparatus for phototherapy of skin disease, in which a light beam having the wavelength and optical power suitable for light-beam treatment is provided to a region to be treated (also called a ‘to-be-treated region’) through a light guide by using a composite light source so as to improve efficiency of phototherapy of skin diseases of the body including acne, malignant tumors and the like. According to the composite light source apparatus, uniform optical power can be provided through a combination of a plurality of light sources, the optical power can be provided through selection of light of a wavelength range that a user wants, and light from the light sources can be utilized to the maximum with increased light intensity.

摘要翻译： 本发明提供了一种用于皮肤病光疗的复合光源装置，其中具有适用于光束处理的波长和光焦度的光束被提供给待治疗的区域（也称为待治疗的区域 区域'）通过使用复合光源通过光导，以提高身体皮肤疾病（包括痤疮，恶性肿瘤等）的光疗效率。 根据复合光源装置，可以通过多个光源的组合来提供均匀的光功率，可以通过选择用户想要的波长范围的光来提供光功率，并且来自光源的光可以 最大限度地利用增加的光强度。

公开(公告)号：US20080180950A1

公开(公告)日：2008-07-31

申请号：US11811677

申请日：2007-06-11

申请人： Uk Kang ,  Soo Jin Bae ,  Geun Hie Rim ,  Guang Hoon Kim ,  Geri V. Papayan

发明人： Uk Kang ,  Soo Jin Bae ,  Geun Hie Rim ,  Guang Hoon Kim ,  Geri V. Papayan

IPC分类号： F21S13/14

CPC分类号： G01N21/6486 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/441

摘要： The present invention provides an apparatus for white light observation and fluorescence diagnosis of skin diseases. More particularly, the present invention provides an apparatus for photodynamic diagnosis in which a plurality of excitation light emitting diodes (LEDs) is provided in an image pick-up head, the excitation LEDs being arranged to illuminate the entire examination region in the form of a mosaic by setting respective illumination light axes of the excitation LEDs to illuminate preassigned individual areas of the examination region, thus uniformly illuminating the examination region in a wide field of view with excitation light. In the apparatus for photodynamic diagnosis, the respective excitation LEDs are provided at the same or different angles based on the light axis of the object lens, and thereby it is possible that the beams of the light sources composed of the LEDs illuminate the field of view of the examination region uniformly, thus improving the uniformity of illumination. Moreover, the present invention provides an apparatus for photodynamic diagnosis in which warm white LEDs and cold white LEDs as white light sources are appropriately arranged so as to deliver natural colors and thereby to reproduce natural color images.

摘要翻译： 本发明提供了一种用于白光观察和皮肤疾病的荧光诊断的装置。 更具体地说，本发明提供了一种用于光动力学诊断的装置，其中多个激发发光二极管（LED）被提供在图像拾取头中，激发LED被布置成以整体形式照射整个检查区域 通过设置激发LED的各个照明光轴来照亮检查区域的预分配的各个区域，从而在激发光的宽视场内均匀地照射检查区域。 在光动力诊断装置中，基于物镜的光轴以相同或不同的角度设置各激发LED，由此，由LED组成的光源的光束可以照射视场 的检查区域均匀，从而提高了照明的均匀性。 此外，本发明提供了一种用于光动力诊断的装置，其中温白色LED和作为白光源的冷白光LED被适当地布置以便传送自然色，从而再现自然色图像。

公开(公告)号：US20080147053A1

公开(公告)日：2008-06-19

申请号：US11811912

申请日：2007-06-11

申请人： Uk Kang ,  Soo Jin Bae ,  Geun Hie Rim ,  Guang Hoon Kim ,  Geri V. Papayan

发明人： Uk Kang ,  Soo Jin Bae ,  Geun Hie Rim ,  Guang Hoon Kim ,  Geri V. Papayan

IPC分类号： A61B18/18

CPC分类号： A61N5/062 ,  A61B5/0071 ,  A61B5/441 ,  A61B2017/00057 ,  A61B2017/00747 ,  A61B2090/373 ,  A61N5/0616 ,  G01N21/6456 ,  G01N21/6486

摘要： The present invention provides an apparatus and method for photodynamic diagnosis and therapy of skin diseases and a light source system thereof that can improve the efficiency of skin diagnosis by accurately analyzing skin conditions using fluorescence and white light simultaneously and further carry out fluorescent diagnosis and photodynamic therapy in the same skin region simultaneously. The apparatus for photodynamic diagnosis and therapy of skin diseases of the present invention includes: a camera head including a case having a view hole, provided in front thereof, to be in contact with a skin region, a white light source provided so as to irradiate a white light from the inside of the case through the view hole onto the skin region, a digital color TV camera provided in the rear of the case, the camera head being provided to irradiate the white light, a fluorescence excitation light and a therapeutic light for the photodynamic therapy from the inside of the case onto the skin region being in contact with the view hole, and the digital color TV camera collecting the light from the skin region and outputting a generated image signal; a light source system, connected to the case of the camera head through a light guide capable of light transmission, for providing the fluorescence excitation light, the therapeutic light for the photodynamic therapy and the white light to be irradiated onto the skin region to the camera head; and an image processing and analysis system for receiving the image signal from the camera head to process, analyze and store to same, for displaying a color image by the white light, a fluorescence image by the excitation light and the therapeutic light for the photodynamic therapy, obtained by the digital color TV camera, and a synthesized image thereof, and for controlling the general operations of the camera head and the light source system.