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    Methylxanthines in the diagnosis and treatment of autistic disorder
    5.
    发明授权
    Methylxanthines in the diagnosis and treatment of autistic disorder 失效
    甲基黄嘌呤在诊断和治疗自闭症中的作用

    公开(公告)号：US06365593B2

    公开(公告)日：2002-04-02

    申请号：US09834169

    申请日：2001-04-12

    申请人： James R. Rusche ,  Jundong Zhang

    发明人： James R. Rusche ,  Jundong Zhang

    IPC分类号： A61K3152

    CPC分类号： G01N33/6896 ,  A61K31/522 ,  G01N33/52 ,  Y10T436/145555

    摘要： The invention is based on the discovery that the levels of one or more methylxanthines in urine samples are significantly decreased in children diagnosed with symptoms of autistic disorder, compared to the levels in normal children, and that levels of xanthines in urine are increased in autistic children. Consequently, the presence in the urine of levels of methylxanthines below a certain range and the level of xanthine above a certain range, are diagnostic of autistic disorder. In another aspect, one or more of these methylxanthines can be used to treat individuals exhibiting symptoms of autistic disorder.

    摘要翻译： 本发明基于以下发现：与正常儿童中的水平相比，诊断为自闭症症状的儿童尿样中一种或多种甲基黄嘌呤的水平显着降低，并且在自闭症儿童中尿中黄嘌呤水平升高 。 因此，低于一定范围的甲基黄嘌呤水平的尿液含量高于一定范围内的黄嘌呤水平是自闭症的诊断。 另一方面，这些甲基黄嘌呤中的一种或多种可用于治疗表现自闭症症状的个体。

    METHODS OF IDENTIFYING HISTONE DEACETYLASE INHIBITORS USEFUL FOR NEUROLOGICAL DISORDERS
    6.
    发明申请
    METHODS OF IDENTIFYING HISTONE DEACETYLASE INHIBITORS USEFUL FOR NEUROLOGICAL DISORDERS 审中-公开
    鉴定用于神经病的HISTONE脱乙酰壳菌酶抑制剂的方法

    公开(公告)号：US20100285476A1

    公开(公告)日：2010-11-11

    申请号：US12739466

    申请日：2008-10-24

    申请人： James R. Rusche ,  Andrew Cooper

    发明人： James R. Rusche ,  Andrew Cooper

    IPC分类号： C12Q1/68 ,  C12Q1/34

    CPC分类号： G01N33/6896 ,  G01N2333/98 ,  G01N2500/04 ,  G01N2800/2835 ,  G01N2800/2878 ,  G01N2800/2892

    摘要： A method of identifying a candidate compound for treatment of a neurological condition includes obtaining a test compound; assaying a first activity of the test compound to inhibit histone deacetylase activity of a histone deacetylase 3 (HDAC3); assaying a second activity of the test compound to inhibit histone deacetylase activity of a histone deacetylase other than a HDAC3; and identifying the test compound as a candidate compound for treatment of a neurological condition if the first activity of the test compound is greater than the second activity of the test compound.

    摘要翻译： 鉴定用于治疗神经病症的候选化合物的方法包括获得测试化合物; 测定测试化合物的第一活性以抑制组蛋白脱乙酰酶3（HDAC3）的组蛋白脱乙酰酶活性; 测定测试化合物的第二活性以抑制除HDAC3之外的组蛋白脱乙酰酶的组蛋白脱乙酰酶活性; 并且如果所述测试化合物的第一活性大于所述测试化合物的第二活性，则将所述测试化合物鉴定为用于治疗神经病症的候选化合物。

    Thioredoxin shufflease and use thereof
    8.
    发明授权
    Thioredoxin shufflease and use thereof 失效
    硫氧还蛋白洗发液及其用途

    公开(公告)号：US4904602A

    公开(公告)日：1990-02-27

    申请号：US894421

    申请日：1986-08-08

    申请人： Vincent P. Pigiet ,  James R. Rusche ,  Barbara J. Schuster

    发明人： Vincent P. Pigiet ,  James R. Rusche ,  Barbara J. Schuster

    IPC分类号： C07K1/113 ,  C07K14/00 ,  C12N9/00 ,  C12N9/22 ,  C12N15/52

    CPC分类号： C07K1/1133 ,  C07K14/00 ,  C12N15/52 ,  C12N9/00 ,  C12N9/22

    摘要： The subject invention concerns a novel enzyme named thioredoxin shufflease, means for preparing the same, and procedures for using thioredoxin shufflease to fold proteins containing disulfide crosslinks. Thioredoxin shufflease is a generic term to define enzymes which have the following characteristics: (a) contain a single reactive thiol group; (b) catalyze the exchange of disulfides in a protein undergoing the refolding process; and (c) are not consumed in the oxidation/refolding process. Specifically exemplified is a thioredoxin shufflease produced from an E. coli thioredoxin gene.

    摘要翻译： 本发明涉及一种名为硫氧还蛋白shufflease的新型酶，其制备方法，以及使用硫氧还蛋白shufflease折叠含有二硫键交联蛋白的方法。 硫氧还蛋白shufflease是定义具有以下特征的酶的通用术语：（a）含有单个反应性硫醇基团; （b）催化经历重折叠过程的蛋白质中二硫化物的交换; 和（c）在氧化/再折叠过程中不被消耗。 具体示例是由大肠杆菌硫氧还蛋白基因产生的硫氧还蛋白洗发酵母。