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    Targeted gene delivery system
    2.
    发明授权
    Targeted gene delivery system 有权
    靶向基因传递系统

    公开(公告)号：US06410517B1

    公开(公告)日：2002-06-25

    申请号：US09315033

    申请日：1999-05-20

    申请人： Vu L. Truong ,  Thomas August ,  Kam W. Leong

    发明人： Vu L. Truong ,  Thomas August ,  Kam W. Leong

    IPC分类号： A61K4800

    CPC分类号： B82Y5/00 ,  A61K9/167 ,  A61K47/6927 ,  A61K48/00 ,  C12N15/87 ,  C12N15/88 ,  Y10S977/906 ,  Y10S977/907 ,  Y10S977/916 ,  Y10S977/92

    摘要： A target-specific gene delivery system is made of enzymatically degradable gelatin and nucleic acids (DNA or RNA) microparticles with a linking moiety or a targeting ligand attached to the surface. The delivery system can be made by a simple method. Targeting ligands can be attached to the microparticle directly or via a linking moiety. The linkage design allows the attachment of any molecule onto the microparticle surface including antibodies, cell adhesion molecules, hormones and other cell-specific ligands.

    摘要翻译： 目标特异性基因递送系统由可酶降解的明胶和具有连接部分的连接部分或连接于表面的靶向配体的核酸（DNA或RNA）微粒制成。 输送系统可以通过简单的方法进行。 靶向配体可以直接或通过连接部分连接到微粒上。 连接设计允许将任何分子附着在微粒表面上，包括抗体，细胞粘附分子，激素和其他细胞特异性配体。

    Methods and products for delivering biological molecules to cells using multicomponent nanostructures
    6.
    发明授权
    Methods and products for delivering biological molecules to cells using multicomponent nanostructures 失效
    使用多组分纳米结构将生物分子递送到细胞的方法和产品

    公开(公告)号：US07344887B2

    公开(公告)日：2008-03-18

    申请号：US10875543

    申请日：2004-06-24

    申请人： Aliasger Karimjee Salem ,  Kam W. Leong ,  Peter Charles Searson

    发明人： Aliasger Karimjee Salem ,  Kam W. Leong ,  Peter Charles Searson

    IPC分类号： C12N15/64

    CPC分类号： A61K9/5115 ,  A61K47/02 ,  A61K47/6923 ,  A61K47/6929 ,  B82Y30/00 ,  C12N15/87

    摘要： This invention is predicated on the present applicants' discovery that nanostructures comprising discrete regions of different composition can be used to deliver to a biological cell a desired combination of molecules in close proximity. Different molecules can be selectively bonded to discrete regions of different composition in sufficiently close physical relationship to enhance delivery or effectiveness within the cell. The preferred nanostructures are multicomponent nanorods. Important applications include delivery of missing DNA sequences for gene therapy and delivery of antigens or DNA encoding antigens for vaccination.

    摘要翻译： 本发明基于本申请人的发现，包括不同组成的离散区域的纳米结构可以用于向生物细胞递送非常接近的期望的分子组合。 不同分子可以以足够接近的物理关系选择性地键合到不同组成的离散区域，以增强细胞内的递送或有效性。 优选的纳米结构是多组分纳米棒。 重要的应用包括递送缺失的DNA序列用于基因治疗和递送抗原或DNA编码抗原用于疫苗接种。

    Controlled delivery of therapeutic agents by insertable medical devices
    8.
    发明授权
    Controlled delivery of therapeutic agents by insertable medical devices 失效
    通过可插入的医疗设备控制治疗剂的输送

    公开(公告)号：US06899731B2

    公开(公告)日：2005-05-31

    申请号：US09750779

    申请日：2001-01-02

    申请人： Weiping Li ,  Hai-Quan Mao ,  Kam W. Leong

    发明人： Weiping Li ,  Hai-Quan Mao ,  Kam W. Leong

    IPC分类号： A61L29/16 ,  A61L31/16 ,  A61F2/06 ,  A61K48/00

    CPC分类号： A61L31/16 ,  A61L29/16 ,  A61L2300/258 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/608 ,  A61L2300/802

    摘要： A medical device and method for transportation and release of a therapeutic agent into a mammalian body are disclosed. The medical device is coated with alternating layers of a negatively charged therapeutic agent and a cationic polyelectrolyte, following a controlled adsorption technique. The method is simple, with minimal perturbation to the therapeutic agent and uses clinically acceptable biopolymers such as human serum albumin. The amount of the therapeutic agent that can be delivered by this technique is optimized by the number of the layers of the therapeutic agent adsorbed on the surface of medical device. There is a washing step between alternate layers of the therapeutic agent and cationic polyelectrolyte carrier, so that the amount of the therapeutic agent on the insertable medical device represents the portion that is stably entrapped and adsorbed on to the medical device. The insertable medical device and method according to this invention are capable of reproducibly delivering therapeutic agent to a site in a mammalian body, and allow for a highly reproducible and controllable release kinetics of the therapeutic agent.

    摘要翻译： 公开了用于将哺乳动物体内的治疗剂输送和释放的医疗装置和方法。 在受控吸附技术之后，医疗装置涂覆有带负电的治疗剂和阳离子聚电解质的交替层。 该方法简单，对治疗剂的扰动最小，并且使用临床可接受的生物聚合物例如人血清白蛋白。 通过该技术可以递送的治疗剂的量通过吸收在医疗装置表面上的治疗剂的层数来优化。 在治疗剂和阳离子聚电解质载体的交替层之间存在洗涤步骤，使得可插入医疗装置上的治疗剂的量表示稳定地截留并吸附到医疗装置上的部分。 根据本发明的可插入医疗装置和方法能够将治疗剂可再现地递送到哺乳动物体内的部位，并且允许治疗剂的高度可重现和可控的释放动力学。

    Therapeutic nanospheres
    10.
    发明授权
    Therapeutic nanospheres 失效
    治疗纳米球

    公开(公告)号：US06207195B1

    公开(公告)日：2001-03-27

    申请号：US09095882

    申请日：1998-06-11

    申请人： Scott Walsh ,  Ronald Rubenstein ,  Pam Zeitlin ,  Kam W. Leong

    发明人： Scott Walsh ,  Ronald Rubenstein ,  Pam Zeitlin ,  Kam W. Leong

    IPC分类号： C12N1500

    CPC分类号： A61K9/5169 ,  A61K31/192 ,  A61K45/06 ,  A61K47/62 ,  A61K47/6435 ,  A61K47/6929 ,  A61K48/00 ,  B82Y5/00 ,  Y10S977/884 ,  Y10S977/906 ,  Y10S977/915 ,  Y10S977/92 ,  Y10S977/923

    摘要： 4-Phenylbutyrate exerts many beneficial biological effects. It appears to induce the transcription of certain promoters, as well as having a remedial effect on proteins which are aberrantly localized within the cell. In addition, it appears to cause cells to developmentally differentiate. The present invention provides nanosphere formulations of 4-phenylbutyrate and other drugs which remediate defective protein localization intracellularly. These formulations permit lower concentrations of drugs to be administered, providing both cost and safety benefits.

    摘要翻译： 4-苯基丁酸酯具有许多有益的生物学效应。 似乎诱导某些启动子的转录，以及对细胞内异常定位的蛋白质具有补救作用。 此外，它似乎导致细胞发育分化。 本发明提供4-苯基丁酸酯和其它药物的纳米球配方，其可以修复细胞内的缺陷蛋白质定位。 这些制剂允许施用较低浓度的药物，既提供成本和安全性益处。