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41 条记录 (耗时 0.063 秒)

    Novel prostaglandin derivatives
    4.
    发明授权
    Novel prostaglandin derivatives 失效
    新型前列腺素衍生物

    公开(公告)号：US4182773A

    公开(公告)日：1980-01-08

    申请号：US816207

    申请日：1977-07-15

    申请人： Wilhelm Bartmann ,  Ulrich Lerch ,  Hermann Teufel ,  Bernward Scholkens ,  Gerhard Beck

    发明人： Wilhelm Bartmann ,  Ulrich Lerch ,  Hermann Teufel ,  Bernward Scholkens ,  Gerhard Beck

    IPC分类号： C07D339/08 ,  A61K31/19 ,  A61K31/215 ,  A61P43/00 ,  C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07D317/72 ,  C07D339/06 ,  C07C177/00

    CPC分类号： C07D317/72 ,  C07C405/00 ,  C07D339/06

    摘要： What is disclosed are prostaglandin-analogous cyclopentane derivatives of the formula I ##STR1## wherein R.sup.1 is hydrogen or a linear or branched, saturated or unsaturated aliphatic or cycloaliphatic radical having from 1 to 8 carbon atoms, or an araliphatic radical having from 7 to 9 carbon atoms, or a physiologically tolerable metal, NH.sub.4 or substituted ammonium ion derived from a primary, secondary or tertiary amine;R.sup.2 is a linear or branched, saturated or unsaturated aliphatic hydrocarbon radical having from 1 to 8 carbon atoms;R.sup.3 is hydrogen or a R.sup.4 CO group wherein R.sup.4 is a hydrogen atom or a linear or branched alkyl group having up to 10 carbon atoms;A is a saturated, linear or branched alkylene group having from 2 to 5 carbon atoms, and a process for the manufacture thereof.

    摘要翻译： 公开的是具有式I的前列腺素类似环戊烷衍生物，其中R 1是氢或具有1至8个碳原子的直链或支链，饱和或不饱和的脂族或脂环族基团，或具有7至9个 碳原子或生理上可耐受的金属，NH 4或衍生自伯，仲或叔胺的取代的铵离子; R2是具有1至8个碳原子的直链或支链饱和或不饱和的脂族烃基; R3是氢或R4CO基，其中R4是氢原子或具有至多10个碳原子的直链或支链烷基; A是具有2至5个碳原子的饱和直链或支链亚烷基及其制备方法。

    Pharmacologically active O-acyl-2,3-diaryl-3-halogeno-acryl-aldoximes
    5.
    发明授权
    Pharmacologically active O-acyl-2,3-diaryl-3-halogeno-acryl-aldoximes 失效
    药理活性的O-酰基-2,3-二芳基-3-卤代丙烯酰基肟

    公开(公告)号：US4056629A

    公开(公告)日：1977-11-01

    申请号：US716277

    申请日：1976-08-20

    申请人： Wilhelm Bartmann ,  Gerhard Beck ,  Ernold Granzer ,  Josef Musil ,  Hermann Teufel

    发明人： Wilhelm Bartmann ,  Gerhard Beck ,  Ernold Granzer ,  Josef Musil ,  Hermann Teufel

    IPC分类号： A61K20060101 ,  A61K31/15 ,  A61K31/215 ,  A61K31/27 ,  C07C20060101

    CPC分类号： C07D417/04

    摘要： A medicament consisting of or containing an O-acyl-2,3-diaryl-3-halogeno-acrylaldoxime of the formula I ##STR1## in which X represents a chlorine or bromine atom, R stands for an alkyl, alkenyl, alkoxy, alkenoxy or alkylamino group having from 1 to 12 carbon atoms each, or for an aryl, aryloxy, arylalkyl, arylalkoxy, arylamino or arylalkylamino group substituted optionally by 1 or 2 alkyl groups each having from 1 to 6 carbon atoms, and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are identical or different, each representing a hydrogen atom, a halogen atom or an alkyl or alkoxy group having each from 1 to 6 carbon atoms, a process for preparing them and a method for the treatment of disorders of the purine metabolism.

    摘要翻译： 由式I（I）的O-酰基-2,3-二芳基-3-卤代 - 丙烯醛肟组成或含有其中X表示氯或溴原子的药​​物，R代表烷基，烯基， 或具有1至12个碳原子的芳基，芳氧基，芳基烷基，芳基烷氧基，芳基氨基或芳基烷基氨基，任选地被1或2个具有1至6个碳原子的烷基取代的烷氧基，链烯氧基或烷基氨基， R2，R3和R4相同或不同，各自表示氢原子，卤素原子或具有1至6个碳原子的烷基或烷氧基，其制备方法和治疗嘌呤病症的方法 代谢。