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公开(公告)号：US07932098B2
公开(公告)日：2011-04-26
申请号：US10286314
申请日：2002-10-31
CPC分类号： B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L2200/10 , B01L2200/12 , B01L2200/14 , B01L2300/02 , B01L2300/0645 , B01L2300/0887 , B01L2300/1827 , B01L2400/0415 , G01N1/28 , Y10T436/25 , Y10T436/25125 , Y10T436/2525 , Y10T436/25375 , Y10T436/255 , Y10T436/25625 , Y10T436/2575 , Y10T436/25875
摘要： Systems, including apparatus and methods, for microfluidic processing and/or analysis of samples. The systems include a microfluidic device having a substrate and a thin-film layer formed on the substrate. The thin-film layer may be included in electronics formed on the substrate. The electronics may provide electronic devices configured to sense or modify a property of the sample. The thin-film layer defines an opening for routing movement of fluid and/or sample within the device.
摘要翻译： 用于微流体处理和/或样品分析的系统，包括装置和方法。 该系统包括具有衬底和形成在衬底上的薄膜层的微流体器件。 薄膜层可以包含在基板上形成的电子元件中。 电子设备可以提供被配置为感测或修改样品的性质的电子设备。 薄膜层限定用于在装置内引导流体和/或样品的运动的开口。
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公开(公告)号：US07741123B2
公开(公告)日：2010-06-22
申请号：US12069628
申请日：2008-02-11
申请人： Grant Pease , Adam L Ghozeil , John Stephen Dunfield , Winthrop D. Childers , David Tyvoll , Douglas A. Sexton , Paul Crivelli
发明人： Grant Pease , Adam L Ghozeil , John Stephen Dunfield , Winthrop D. Childers , David Tyvoll , Douglas A. Sexton , Paul Crivelli
CPC分类号： B01L7/525 , B01L3/5027 , B01L3/502715 , B01L2200/10 , B01L2200/147 , B01L2300/024 , B01L2300/0816 , B01L2300/0874 , B01L2300/1827 , B01L2300/1883 , B01L2400/0415 , Y10T436/11 , Y10T436/2575
摘要： A microfluidic device for analysis of a sample. The microfluidic device includes a substrate portion that at least partially defines a chamber for receiving the sample. The substrate portion includes a substrate having a surface. The substrate portion also includes a plurality of thin-film layers formed on the substrate adjacent the surface. The thin-film layers form a plurality of electronic devices. Each of at least two of the electronic devices is formed by a different set of the thin-film layers.
摘要翻译： 用于分析样品的微流体装置。 微流体装置包括至少部分地限定用于接收样品的室的基底部分。 基板部分包括具有表面的基板。 衬底部分还包括在邻近表面的衬底上形成的多个薄膜层。 薄膜层形成多个电子装置。 至少两个电子设备中的每一个由不同的薄膜层组形成。
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公开(公告)号：US20080164155A1
公开(公告)日：2008-07-10
申请号：US12069628
申请日：2008-02-11
申请人： Grant Pease , Adam L. Ghozeil , John Stephen Dunfield , Winthrop D. Childers , David Tyvoll , Douglas A. Sexton , Paul Crivelli
发明人： Grant Pease , Adam L. Ghozeil , John Stephen Dunfield , Winthrop D. Childers , David Tyvoll , Douglas A. Sexton , Paul Crivelli
IPC分类号： G01N27/26
CPC分类号： B01L7/525 , B01L3/5027 , B01L3/502715 , B01L2200/10 , B01L2200/147 , B01L2300/024 , B01L2300/0816 , B01L2300/0874 , B01L2300/1827 , B01L2300/1883 , B01L2400/0415 , Y10T436/11 , Y10T436/2575
摘要： A microfluidic device for analysis of a sample. The microfluidic device includes a substrate portion that at least partially defines a chamber for receiving the sample. The substrate portion includes a substrate having a surface. The substrate portion also includes a plurality of thin-film layers formed on the substrate adjacent the surface. The thin-film layers form a plurality of electronic devices. Each of at least two of the electronic devices is formed by a different set of the thin-film layers.
摘要翻译： 用于分析样品的微流体装置。 微流体装置包括至少部分地限定用于接收样品的室的基底部分。 基板部分包括具有表面的基板。 衬底部分还包括在邻近表面的衬底上形成的多个薄膜层。 薄膜层形成多个电子装置。 至少两个电子设备中的每一个由不同的薄膜层组形成。
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公开(公告)号：US07338637B2
公开(公告)日：2008-03-04
申请号：US10355397
申请日：2003-01-31
申请人： Grant Pease , Adam L Ghozeil , John Stephen Dunfield , Winthrop D. Childers , David Tyvoll , Douglas A. Sexton , Paul Crivelli
发明人： Grant Pease , Adam L Ghozeil , John Stephen Dunfield , Winthrop D. Childers , David Tyvoll , Douglas A. Sexton , Paul Crivelli
CPC分类号： B01L7/525 , B01L3/5027 , B01L3/502715 , B01L2200/10 , B01L2200/147 , B01L2300/024 , B01L2300/0816 , B01L2300/0874 , B01L2300/1827 , B01L2300/1883 , B01L2400/0415 , Y10T436/11 , Y10T436/2575
摘要： A microfluidic device for analysis of a sample. The microfluidic device includes a substrate portion that at least partially defines a chamber for receiving the sample. The substrate portion includes a substrate having a surface. The substrate portion also includes a plurality of thin-film layers formed on the substrate adjacent the surface. The thin-film layers form a plurality of electronic devices. Each of at least two of the electronic devices is formed by a different set of the thin-film layers. The at least two electronic devices may include 1) a temperature control device for controlling the temperature of fluid in the chamber, and 2) an other electronic device configured to sense or modify a property of fluid in the chamber.
摘要翻译： 用于分析样品的微流体装置。 微流体装置包括至少部分地限定用于接收样品的室的基底部分。 基板部分包括具有表面的基板。 衬底部分还包括在邻近表面的衬底上形成的多个薄膜层。 薄膜层形成多个电子装置。 至少两个电子设备中的每一个由不同的薄膜层组形成。 所述至少两个电子设备可以包括：1）用于控制所述腔室中的流体的温度的温度控制装置，以及2）构造成感测或改变所述腔室中的流体性质的另一电子装置。
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公开(公告)号：US08056556B2
公开(公告)日：2011-11-15
申请号：US10823475
申请日：2004-04-12
IPC分类号： A61M11/00 , A61M15/00 , A61M16/00 , F16K31/02 , B05B1/08 , B05B17/04 , G01D15/16 , G01D15/02
CPC分类号： A61M15/025 , A61M11/001 , A61M15/0003 , A61M15/0065 , A61M2205/70
摘要： A medication dispenser includes a thermal drop generator ejector head. Medication is maintained in a pressurized container connected to a valve under the control of control electronics and to a compliant chamber. Fluid flows from the container to the chamber and to the ejector head. In a first mode the dispenser is operable to dispense aerosolized medication. In a second mode the ejector head is purged with fluid from the container to maintain the ejector head.
摘要翻译： 药物分配器包括热滴发生器喷射头。 在控制电子装置的控制下，将药物保持在连接到阀的加压容器中并且与顺应室相连。 流体从容器流到腔室和喷射头。 在第一模式中，分配器可操作以分配雾化药物。 在第二模式中，喷射头用来自容器的流体吹扫以保持喷射头。
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公开(公告)号：US07389879B2
公开(公告)日：2008-06-24
申请号：US10763112
申请日：2004-01-21
IPC分类号： B07C5/02
CPC分类号： G01N15/1459 , G01N15/1056 , G01N2015/1081 , G01N2015/149 , Y10S209/906
摘要： A device for sorting particles. The device may include a channel structure that defines a channel having an inlet and first and second outlets. The device also may include first and second transport mechanisms. The first transport mechanism may be configured to create a particle stream of first particles and one or more second particles. Each particle may move along the channel from the inlet toward the first outlet and may be disposed in a fluid supported by the channel structure. The second transport mechanism may be configured to be pulse-activated to selectively move at least one of the second particles from the particle stream and toward the second outlet.
摘要翻译： 用于分选颗粒的装置。 该装置可以包括限定具有入口和第一和第二出口的通道的通道结构。 该装置还可以包括第一和第二传送机构。 第一输送机构可以被配置成产生第一颗粒和一个或多个第二颗粒的颗粒物流。 每个颗粒可以沿着通道从入口移动到第一出口，并且可以设置在由通道结构支撑的流体中。 第二传送机构可以被配置为被脉冲激活以选择性地将颗粒流中的至少一个第二颗粒移动到第二出口。
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公开(公告)号：US07497334B2
公开(公告)日：2009-03-03
申请号：US11999943
申请日：2007-12-07
IPC分类号： B07C5/02
CPC分类号： G01N15/1459 , G01N15/1056 , G01N2015/1081 , G01N2015/149 , Y10S209/906
摘要： A device for sorting particles. The device may include a channel structure that defines a channel having an inlet and first and second outlets. The device also may include first and second transport mechanisms. The first transport mechanism may be configured to create a particle stream of first particles and one or more second particles. Each particle may move along the channel from the inlet toward the first outlet and may be disposed in a fluid supported by the channel structure. The second transport mechanism may be configured to be pulse-activated to selectively move at least one of the second particles from the particle stream and toward the second outlet.
摘要翻译： 用于分选颗粒的装置。 该装置可以包括限定具有入口和第一和第二出口的通道的通道结构。 该装置还可以包括第一和第二传送机构。 第一输送机构可以被配置成产生第一颗粒和一个或多个第二颗粒的颗粒物流。 每个颗粒可以沿着通道从入口移动到第一出口，并且可以设置在由通道结构支撑的流体中。 第二传送机构可以被配置为被脉冲激活以选择性地将颗粒流中的至少一个第二颗粒移动到第二出口。
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公开(公告)号：US07776559B2
公开(公告)日：2010-08-17
申请号：US10762784
申请日：2004-01-22
申请人： Winthrop D. Childers , David Tyvoll
发明人： Winthrop D. Childers , David Tyvoll
IPC分类号： G01N33/567
CPC分类号： A61B5/14532 , A61B5/1486 , A61B2562/085 , G01N33/48771
摘要： A disposable blood test device comprises a substrate configured for carrying a chemical reagent and circuitry formed on the substrate. The circuitry comprises a sensor portion associated with the chemical reagent to enable measurement of at least one of a presence and a concentration of a blood analyte, and an information storage portion configured to store information indicative of a property of the chemical reagent.
摘要翻译： 一次性血液检查装置包括被配置为承载形成在基底上的化学试剂和电路的基底。 电路包括与化学试剂相关联的传感器部分，以能够测量血液分析物的存在和浓度中的至少一种，以及配置为存储指示化学试剂的性质的信息的信息存储部分。
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公开(公告)号：US07275534B2
公开(公告)日：2007-10-02
申请号：US10356077
申请日：2003-01-31
CPC分类号： A61M15/025 , B05B15/52
摘要： A medicament ejector is provided which includes an ejection mechanism and a service mechanism. The ejection mechanism includes at least one ejection port configured to eject a medicament-containing fluid. The service mechanism is selectively deployable to service the at least one ejection port.
摘要翻译： 提供了一种药物喷射器，其包括弹出机构和服务机构。 排出机构包括构造成喷射含药液体的至少一个喷射口。 所述维护机构可选择地可部署以服务于所述至少一个排出口。
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公开(公告)号：US07217542B2
公开(公告)日：2007-05-15
申请号：US10286104
申请日：2002-10-31
申请人： David Tyvoll , Winthrop D. Childers
发明人： David Tyvoll , Winthrop D. Childers
CPC分类号： B01L3/50273 , B01L3/502715 , B01L7/52 , B01L2200/027 , B01L2200/0647 , B01L2200/10 , B01L2300/023 , B01L2300/024 , B01L2300/0663 , B01L2300/0809 , B01L2300/087 , B01L2300/0874 , B01L2300/1827 , B01L2400/0415 , B01L2400/0487 , B01L2400/0633
摘要： A system, including methods and apparatus, for microfluidic analysis of a nucleic acid target in a nucleic acid mixture. The system includes a method to preselect the target from the mixture before amplification. Preselection enriches the mixture for the target by retaining the target on a target-selective receptor and then removing unretained non-target nucleic acids. The preselected target then may be amplified from the enriched mixture and assayed. Devices configured to carry out the method are also disclosed.
摘要翻译： 一种用于核酸混合物中核酸靶的微流体分析的系统，包括方法和装置。 该系统包括在扩增前从混合物中预选靶的方法。 预选通过将靶标保留在靶选择性受体上，然后除去未保留的非靶核酸，从而丰富目的物的混合物。 然后可以从富集的混合物中扩增预选靶，并进行测定。 还公开了被配置为执行该方法的设备。
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