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公开(公告)号：US5643464A
公开(公告)日：1997-07-01
申请号：US497573
申请日：1995-06-30
申请人： Woonza M. Rhee , Richard A. Berg , Joel S. Rosenblatt , Jacqueline A. Schroeder , Larry J. Braga , Thomas L. Smestad , Abigail Freeman
发明人： Woonza M. Rhee , Richard A. Berg , Joel S. Rosenblatt , Jacqueline A. Schroeder , Larry J. Braga , Thomas L. Smestad , Abigail Freeman
IPC分类号： A61F2/00 , A61F2/06 , A61K38/00 , A61K47/48 , A61L15/22 , A61L24/08 , A61L24/10 , A61L26/00 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L29/04 , A61L29/06 , A61L29/16 , A61L31/04 , A61L31/10 , A61L31/12 , C07K14/495 , C07K14/78 , C08B37/08 , C08H1/06 , C08L89/06 , C09J189/06 , G02B1/04 , B01J19/08 , A01N1/02
CPC分类号： C08H1/06 , A61K47/48215 , A61K47/4823 , A61L24/08 , A61L26/0033 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/34 , A61L27/44 , A61L31/042 , A61L31/044 , A61L31/125 , C07K14/495 , C07K14/78 , C08B37/0069 , C08B37/0072 , C08L89/06 , C09J189/06 , G02B1/043 , A61F2/07 , A61F2310/00365 , A61K38/00
摘要： The present invention discloses a novel method for preparing crosslinked biomaterial compositions for use in the augmentation of soft or hard tissue. In general, the method comprises mixing a biocompatible polymer, which is preferably collagen, with a sterile, dry crosslinking agent, which is preferably a synthetic hydrophilic polymer such as a functionally activated polyethylene glycol. Also provided are preferred processes for preparing sterile, dry crosslinking agents contained within syringes for use in the method of the invention. Methods for sterilization of the crosslinking agent include, but are not limited to, sterile filtration, aseptic processing, and e-beam or gamma irradiation. Methods for providing augmentation of soft or hard tissue using crosslinked biomaterial compositions prepared according to the method of the invention are also disclosed.
摘要翻译： 本发明公开了一种制备用于增加软组织或硬组织的交联生物材料组合物的新方法。 一般来说，该方法包括将优选胶原的生物相容性聚合物与无菌的干燥交联剂混合，所述交联剂优选为合成的亲水性聚合物，例如功能活化的聚乙二醇。 还提供了用于制备用于本发明方法的针筒内含有的无菌干燥交联剂的优选方法。 交联剂的灭菌方法包括但不限于无菌过滤，无菌处理和电子束或γ照射。 还公开了使用根据本发明的方法制备的交联生物材料组合物提供软组织或硬组织的方法。
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2.发明授权Method of preparing crosslinked biomaterial compositions for use in tissue augmentation 失效制备用于组织增生的交联生物材料组合物的方法
公开(公告)号：US5550187A
公开(公告)日：1996-08-27
申请号：US287549
申请日：1994-08-08
申请人： Woonza M. Rhee , Richard A. Berg , Joel S. Rosenblatt , Jacqueline A. Tefft , Larry J. Braga , Thomas L. Smestad
发明人： Woonza M. Rhee , Richard A. Berg , Joel S. Rosenblatt , Jacqueline A. Tefft , Larry J. Braga , Thomas L. Smestad
IPC分类号： A61F2/00 , A61F2/06 , A61K47/48 , A61L15/22 , A61L24/08 , A61L24/10 , A61L26/00 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L31/04 , A61L31/10 , A61L31/12 , C08H1/06 , C08L89/06 , C09J189/06 , G02B1/04 , C08G63/49 , C08G63/91
CPC分类号： A61L31/125 , A61K47/48215 , A61L15/225 , A61L24/08 , A61L24/102 , A61L26/0033 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L31/041 , A61L31/042 , A61L31/044 , A61L31/10 , C08H1/06 , C08L89/06 , C09J189/06 , G02B1/043 , A61F2/07 , A61F2310/00365 , A61L2430/16
摘要： The present invention discloses a novel method for preparing crosslinked biomaterial compositions for use in the augmentation of soft or hard tissue. In general, the method comprises mixing a biocompatible polymer, which is preferably collagen, with a sterile, dry crosslinking agent, which is preferably a synthetic hydrophilic polymer such as a functionally activated polyethylene glycol. Also provided are preferred processes for preparing sterile, dry crosslinking agents contained within syringes for use in the method of the invention. Methods for sterilization of the crosslinking agent include, but are not limited to, sterile filtration, aseptic processing, and e-beam or gamma irradiation. Methods for providing augmentation of soft or hard tissue using crosslinked biomaterial compositions prepared according to the method of the invention are also disclosed.
摘要翻译： 本发明公开了一种制备用于增加软组织或硬组织的交联生物材料组合物的新方法。 一般来说，该方法包括将优选胶原的生物相容性聚合物与无菌的干燥交联剂混合，所述交联剂优选为合成的亲水性聚合物，例如功能活化的聚乙二醇。 还提供了用于制备用于本发明方法的针筒内含有的无菌干燥交联剂的优选方法。 交联剂的灭菌方法包括但不限于无菌过滤，无菌处理和电子束或γ照射。 还公开了使用根据本发明的方法制备的交联的生物材料组合物提供软组织或硬组织的方法。
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3.发明授权Method of preparing crosslinked biomaterial compositions for use in tissue augmentation 失效制备用于组织增生的交联生物材料组合物的方法
公开(公告)号：US5527856A
公开(公告)日：1996-06-18
申请号：US440274
申请日：1995-05-12
申请人： Woonza M. Rhee , Richard A. Berg , Joel S. Rosenblatt , Jacqueline A. Tefft , Larry J. Braga , Thomas L. Smestad
发明人： Woonza M. Rhee , Richard A. Berg , Joel S. Rosenblatt , Jacqueline A. Tefft , Larry J. Braga , Thomas L. Smestad
IPC分类号： A61F2/00 , A61F2/06 , A61K38/00 , A61K47/48 , A61L15/22 , A61L24/08 , A61L24/10 , A61L26/00 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L29/04 , A61L29/06 , A61L29/16 , A61L31/04 , A61L31/10 , A61L31/12 , C07K14/495 , C07K14/78 , C08B37/08 , C08H1/06 , C08L89/06 , C09J189/06 , G02B1/04 , C08G63/48 , C08G63/91
CPC分类号： A61K47/4823 , A61K47/48215 , C07K14/495 , C07K14/78 , C08B37/0069 , C08B37/0072 , C08H1/06 , C08L89/06 , C09J189/06 , G02B1/043 , A61F2/07 , A61F2310/00365 , A61K38/00
摘要： The present invention discloses a novel method for preparing crosslinked biomaterial compositions for use in the augmentation of soft or hard tissue. In general, the method comprises mixing a biocompatible polymer, which is preferably collagen, with a sterile, dry crosslinking agent, which is preferably a synthetic hydrophilic polymer such as a functionally activated polyethylene glycol. Also provided are preferred processes for preparing sterile, dry crosslinking agents contained within syringes for use in the method of the invention. Methods for sterilization of the crosslinking agent include, but are not limited to, sterile filtration, aseptic processing, and e-beam or gamma irradiation. Methods for providing augmentation of soft or hard tissue using crosslinked biomaterial compositions prepared according to the method of the invention am also disclosed.
摘要翻译： 本发明公开了一种制备用于增加软组织或硬组织的交联生物材料组合物的新方法。 一般来说，该方法包括将优选胶原的生物相容性聚合物与无菌的干燥交联剂混合，所述交联剂优选为合成的亲水性聚合物，例如功能活化的聚乙二醇。 还提供了用于制备用于本发明方法的针筒内含有的无菌干燥交联剂的优选方法。 交联剂的灭菌方法包括但不限于无菌过滤，无菌处理和电子束或γ照射。 还公开了使用根据本发明的方法制备的交联的生物材料组合物提供软组织或硬组织的方法。
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公开(公告)号：US5383930A
公开(公告)日：1995-01-24
申请号：US927146
申请日：1992-11-02
申请人： Ann Brannan , Roseann Burhenne , Frank A. Delustro , Thomas L. Smestad , Louis Fries , Rees M. Orland
发明人： Ann Brannan , Roseann Burhenne , Frank A. Delustro , Thomas L. Smestad , Louis Fries , Rees M. Orland
IPC分类号： A61F2/10 , A61F2/00 , A61K8/02 , A61K8/04 , A61K8/65 , A61L27/24 , A61L31/04 , A61M5/32 , A61M5/42 , A61Q19/00 , A61F2/02
CPC分类号： A61Q19/08 , A61F2/0059 , A61K8/02 , A61K8/027 , A61K8/04 , A61K8/65 , A61L27/24 , A61L31/044 , A61F2310/00365 , A61K2800/87 , A61K2800/91 , A61M5/32 , A61M5/422
摘要： A device for correcting fine superficial facial lines which comprises a syringe fitted with a 31-33 gauge needle and an aqueous suspension of noncrosslinked fibrillar atelopeptide collagen contained within the syringe barrel, the concentration of collagen in the suspension being in the range of 10 to 50 mg/ml and the suspension exhibiting an extrusion plot in which there is a smooth substantially linear increase in force up to a substantially constant force in the range of 5 to 30 newtons.
摘要翻译： 用于矫正精细表面面部线的装置，其包括装有31-33号针头的注射器和包含在注射器筒内的非交联纤维状三肽胶原的水性悬浮液，悬浮液中胶原浓度在10至50范围内 mg / ml，并且悬浮液呈现挤出图，其中在5至30牛顿范围内基本上恒定的力具有平滑的基本线性增加的力。
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公开(公告)号：US5123925A
公开(公告)日：1992-06-23
申请号：US647758
申请日：1991-01-29
CPC分类号： A61L2/0035 , A61L27/46 , Y10S128/08 , Y10S623/923
摘要： The present invention is a method for treating bony defects. The method involves contacting the bony defect with a formable composition and allowing the formable composition to solidify. The formable composition is comprised of 2-40% of reconstituted fibrillar atelopeptide collagen and 60-98% calcium phosphate mineral by weight exclusive of moisture. After the formable composition is placed in intimate contact with the bony defect, it is allowed to solidify until it acquires an additional characteristic selected from the group consisting of a compressive modulus of at 10 N/cm.sup.2 or a tensile strength of at least 1 N/cm.sup.2. The method can be used to repair a variety of bony defects such as bone non-union, fresh fractures, periodontal bony pockets, tooth extraction sockets and jaw cysts. Further, the composition can be used to augment an alveolar ridge.
摘要翻译： 本发明是一种治疗骨缺损的方法。 该方法包括使骨缺损与可成形组合物接触并允许可成型组合物固化。 可成型组合物由2-40％的重构纤维状三肽胶原蛋白和60-98％的磷酸钙矿物质组成，不包括水分。 将可成形组合物与骨缺损紧密接触后，使其固化，直到获得额外的特征，其选自压缩模量为10N / cm 2或拉伸强度为至少1N / cm2。 该方法可用于修复各种骨缺损，如骨不愈合，新鲜骨折，牙周骨袋，拔牙套和颌囊肿。 此外，该组合物可用于增加牙槽嵴。
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公开(公告)号：US5246457A
公开(公告)日：1993-09-21
申请号：US629074
申请日：1990-12-17
CPC分类号： A61L27/46 , A61F2002/2835 , A61L2430/02 , Y10S128/08 , Y10S623/923
摘要： A composition for use in bone repair, in particular, in only procedures, which comprises calcium phosphate mineral particles in admixture with atelopeptide reconstituted fibrillar collagen preparations is disclosed. This composition is non-immunogenic and encourages the fusion of host bone with new bone growth through the implant. Additional processes for curing the implant to improve its compressive strength include heat curing, maturation, and cross-linking.
摘要翻译： 公开了一种用于骨修复的组合物，特别是在仅包含磷酸钙矿物颗粒与阿替肽重构纤维状胶原蛋白制剂混合的方法中。 该组合物是非免疫原性的，并且通过植入物促进宿主骨与新骨生长的融合。 用于固化植入物以提高其抗压强度的其它方法包括热固化，成熟和交联。
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7.发明授权Method of making molds with xenogeneic collagen/mineral preparations for bone repair 失效用于骨修复的异种胶原蛋白/矿物质制剂的制备方法
公开(公告)号：US4992226A
公开(公告)日：1991-02-12
申请号：US245449
申请日：1988-09-16
CPC分类号： A61L27/46 , A61F2002/2835 , A61L2430/02 , Y10S623/901 , Y10S623/923
摘要： A process for coating the pores of a mineral matrix with collagen by pumping collagen through the molded matrix is disclosed. The resulting coated matrix can be used as a prosthesis in bone repair.
摘要翻译： 公开了一种通过将胶原蛋白泵送通过模塑基质来涂覆矿物基质的孔的方法。 所得涂层基质可用作骨修复中的假体。
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公开(公告)号：US4865602A
公开(公告)日：1989-09-12
申请号：US928306
申请日：1986-11-06
CPC分类号： A61L2/0035 , A61L27/46 , Y10S128/08 , Y10S623/923
摘要： A process for sterilization of collagen/mineral compositions using .gamma. radiation is conducted under conditions which produce a product of desired handling and biocompatibility properties.
摘要翻译： 使用γ辐射灭菌胶原蛋白/矿物质组合物的方法是在产生所需操作和生物相容性的产物的条件下进行的。
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公开(公告)号：US4582640A
公开(公告)日：1986-04-15
申请号：US663478
申请日：1984-10-22
CPC分类号： A61L27/24 , C07K14/78 , Y10S128/08 , Y10S514/801
摘要： Cross-linked atelopeptide collagen that is substantially free of residual cross-linking agent is prepared by: reconstituting atelopeptide collagen from solution by neutralizing the solution at a reduced temperature and a hypotonic ionic strength; cross-linking the reconstituted fibers in an aqueous medium at a concentration of 0.1 to 10 mg/ml with glutaraldehyde under conditions that produce cross-linked collagen that when in suspension in physiological saline at a concentration of 35 mg/ml exhibits a shear viscosity whose log varies linearly with the log of the shear rate and is approximated by the formulalog .eta..ltoreq.-0.96 log .gamma.+2.3where .gamma. is the shear rate in sec.sup.-1, log .gamma. is in the range of -6 to +2 and .eta. is the viscosity of the suspension in Pascal-sec; optionally quenching the cross-linking reaction with an amino acid; and separating the cross-linked atelopeptide collagen from the reaction mixture. This collagen is dispersed in an isotonic aqueous medium for use in soft tissue dermal augmentation and is injectable and forms implants that have excellent persistence.
摘要翻译： 通过以下方法制备基本上不含残留交联剂的交联的atelopeptide胶原蛋白：通过在降低的温度和低渗离子强度下中和溶液来重构来自溶液的阿曲肽胶原; 在产生交联胶原的条件下，用浓度为0.1至10mg / ml的水性介质在水性介质中交联重构纤维，当在浓度为35mg / ml的生理盐水中悬浮时，表现出剪切粘度， 对数随着剪切速率的对数线性变化，并且通过公式log eta = 0.96logγ+ 2.3近似，其中γ是sec-1中的剪切速率，logγ在-6至+2的范围内 eta是悬浮液的粘度（Pascal-sec）; 任选地用氨基酸淬灭交联反应; 并从反应混合物中分离交联的阿肽肽胶原。 该胶原分散在等渗水性介质中，用于软组织皮肤增生，并且是可注射的并且形成具有优异持久性的植入物。
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公开(公告)号：US5425770A
公开(公告)日：1995-06-20
申请号：US99610
申请日：1993-07-30
CPC分类号： A61L27/46 , A61F2002/2835 , A61L2430/02 , Y10S128/08 , Y10S623/923
摘要： Processes for the preparation of compositions used in conductive bone repair are disclosed. The compositions contain a mixture consisting essentially of either a calcium phosphate particulate mineral component or particulate hydroxyapatite in admixture with atelopeptide reconstituted fibrillar collagen. The method is comprised of mixing a dispersion of the collagen and mineral, the latter which is present in dry particulate form, followed by molding and drying the composition in a mold to obtain a dried composition.
摘要翻译： 公开了用于制备用于导电骨修复的组合物的方法。 组合物含有基本上由磷酸钙颗粒状矿物组分或颗粒状羟基磷灰石组成的混合物，与磷酸腺苷重构的纤维状胶原混合。 该方法包括混合胶原蛋白和矿物质的分散体，后者以干燥颗粒形式存在，然后在模具中成型和干燥组合物以获得干燥的组合物。
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