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17 条记录 (耗时 0.024 秒)

    Composition Comprising Separated or Proliferated Cells from Umbilical Cord Blood for Treating Developmental and/or Chronic Lung Disease
    1.
    发明申请
    Composition Comprising Separated or Proliferated Cells from Umbilical Cord Blood for Treating Developmental and/or Chronic Lung Disease 审中-公开
    包含分离或增殖的细胞从脐带血用于治疗发展和/或慢性肺病的组合

    公开(公告)号：US20070178073A1

    公开(公告)日：2007-08-02

    申请号：US11425949

    申请日：2006-06-22

    申请人： Yun Sil Chang ,  Won Soon Park ,  Yoon-Sun Yang

    发明人： Yun Sil Chang ,  Won Soon Park ,  Yoon-Sun Yang

    IPC分类号： A61K35/14

    CPC分类号： A61K35/28 ,  A61K35/16 ,  A61K35/51 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention relates to a composition comprising separated or proliferated cells from umbilical cord blood for treating developmental and/or chronic lung disease, more precisely a composition containing separated or proliferated cells from umbilical cord blood for intratracheal administration for treating developmental and/or chronic lung disease. The cells of the composition of the present invention have excellent activities of proliferation and differentiation, so that the extraction, separation and selection of a tissue donor are all very easy. Besides, the composition of the invention can be very effectively used for the treatment of developmental and/or chronic diseases by intratracheal administration.

    摘要翻译： 本发明涉及包含用于治疗发育和/或慢性肺部疾病的分离或增殖的来自脐带血的细胞的组合物，更确切地说，包含用于气管内施用的用于治疗发育和/或慢性肺的脐带血分离或增殖的细胞的组合物 疾病。 本发明的组合物的细胞具有优异的增殖和分化活性，使得组织供体的提取，分离和选择都非常容易。 此外，本发明的组合物可以非常有效地用于通过气管内给药治疗发育和/或慢性疾病。

    Isolation and Culture-Expansion Methods of Mesenchymal Stem/Progenitor Cells From Umbilical Cord Blood, And Differentiation Method of Umbilical Cord Blood-Derived Meschymal Stem/Progenitor Cells Into Various Mesenchymal Tissues
    4.
    发明申请
    Isolation and Culture-Expansion Methods of Mesenchymal Stem/Progenitor Cells From Umbilical Cord Blood, And Differentiation Method of Umbilical Cord Blood-Derived Meschymal Stem/Progenitor Cells Into Various Mesenchymal Tissues 审中-公开
    脐带血间充质干/祖细胞的分离培养扩增方法及脐带血衍生的间充质干/祖细胞分化成各种间质组织

    公开(公告)号：US20100184218A1

    公开(公告)日：2010-07-22

    申请号：US12579140

    申请日：2009-10-14

    申请人： Chul-Won HA ,  Yoon-Sun Yang ,  Sung-Eun Yang

    发明人： Chul-Won HA ,  Yoon-Sun Yang ,  Sung-Eun Yang

    IPC分类号： C12N5/00 ,  C12N5/02

    CPC分类号： C12N5/0665 ,  C12N2500/24 ,  C12N2500/32 ,  C12N2500/42 ,  C12N2501/15

    摘要： There is provided a method for the isolation and cultivation of mesenchymal stem/progenitor cells from umbilical cord blood, and also to a method for the differentiation of the umbilical cord blood-derived mesenchymal stem/progenitor cells into various mesenchymal tissues. The method include overlaying umbilical cord blood onto Ficoll-Hypaque solution; centrifuging the umbilical cord blood on the Ficoll-Hypaque solution to obtain a mononuclear cell layer; reacting cells obtained by monolayer culture of the mononuclear cells with antibodies to mesenchymal stem/progenitor cell-specific antigens for a predetermined period of incubation time; isolating only cells bound to their corresponding antibodies using a cell sorter; and cultivating the isolated cells, thereby obtaining mesenchymal stem/progenitor cells with high purity and excellent viability.

    摘要翻译： 提供了从脐带血分离和培养间充质干/祖细胞的方法，以及将脐带血来源的间充质干/祖细胞分化成各种间充质组织的方法。 该方法包括将脐带血覆盖在Ficoll-Hypaque溶液上; 在Ficoll-Hypaque溶液上离心脐带血，获得单核细胞层; 将单核细胞的单层培养获得的细胞与间充质干/祖细胞特异性抗原的抗体反应预定的孵育时间; 使用细胞分选器分离仅与其相应抗体结合的细胞; 并培养分离的细胞，从而获得高纯度和优良活力的间充质干细胞/祖细胞。

    SISP-1, a novel p53 target gene and use thereof
    5.
    发明授权
    SISP-1, a novel p53 target gene and use thereof 有权
    SISP-1，一种新型的p53靶基因及其用途

    公开(公告)号：US07655778B2

    公开(公告)日：2010-02-02

    申请号：US11679803

    申请日：2007-02-27

    申请人： Yoon-Sun Yang

    发明人： Yoon-Sun Yang

    IPC分类号： C07H21/02 ,  C12N15/00 ,  C12N5/00

    CPC分类号： C07K14/4747 ,  A61K38/00 ,  C07K14/47

    摘要： The present invention relates to a novel p53 target gene SISP-1 (Stress induced Secreted Protein 1) and a SISP-1 protein encoded by the gene. The SISP-1 protein of the present invention induces apoptosis by interaction with p53. The present invention provides the use of the gene/protein associated with treating abnormal apoptosis such as tumor.

    摘要翻译： 本发明涉及新型p53靶基因SISP-1（应激诱导分泌蛋白1）和由该基因编码的SISP-1蛋白。 本发明的SISP-1蛋白通过与p53的相互作用诱导凋亡。 本发明提供与治疗异常细胞凋亡相关的基因/蛋白质如肿瘤的用途。

    Use of ICAM-1 for prevention or treatment of neurological diseases
    6.
    发明授权
    Use of ICAM-1 for prevention or treatment of neurological diseases 有权
    使用ICAM-1预防或治疗神经系统疾病

    公开(公告)号：US08614191B2

    公开(公告)日：2013-12-24

    申请号：US13365022

    申请日：2012-02-02

    申请人： Yoon-Sun Yang ,  Won Il Oh ,  Jong Wook Chang ,  Ji Hyun Kim

    发明人： Yoon-Sun Yang ,  Won Il Oh ,  Jong Wook Chang ,  Ji Hyun Kim

    IPC分类号： A61K38/00

    CPC分类号： A61K38/1774

    摘要： The present invention relates to a pharmaceutical composition for the prevention or treatment of neurological disorders, comprising an ICAM-1 (intercellular adhesion molecule-1) protein, or a fragment or a variant thereof as an active ingredient, which can increase the expression of neprilysin to remove amyloid-beta (Aβ), a cause of dementia, and is thus useful in preventing or treating a neurological disease including Alzheimer's disease.

    摘要翻译： 本发明涉及一种用于预防或治疗神经系统疾病的药物组合物，其包含作为活性成分的ICAM-1（细胞间粘附分子-1）蛋白或其片段或变体，其可以增加内皮素的表达 去除淀粉样蛋白-β（Abeta），这是痴呆的一个原因，因此可用于预防或治疗包括阿尔茨海默病在内的神经疾病。

    UCB-MSCs comprising a tumor suppressor gene reduce the size of an IL-8 or GRO-αexpressing tumor
    8.
    发明授权
    UCB-MSCs comprising a tumor suppressor gene reduce the size of an IL-8 or GRO-αexpressing tumor 有权
    包含肿瘤抑制基因的UCB-MSC减少IL-8或GRO-α表达肿瘤的大小

    公开(公告)号：US08506948B2

    公开(公告)日：2013-08-13

    申请号：US12633622

    申请日：2009-12-08

    申请人： Jong Wook Chang ,  Dal Soo Kim ,  Yoon-Sun Yang ,  Won Il Oh

    发明人： Jong Wook Chang ,  Dal Soo Kim ,  Yoon-Sun Yang ,  Won Il Oh

    IPC分类号： C12N15/00 ,  A01N63/00 ,  A61K48/00

    CPC分类号： A61K49/08 ,  A61K35/44 ,  A61K48/00 ,  A61K49/0002 ,  A61K49/0017

    摘要： Provided is a gene therapy composition for transferring one of a therapeutic gene, a maker gene, or a mixture thereof to a cell that expresses interleukin-8 (IL-8) or GRO-α and induces tropism of mesenchymal stem cells isolated from umbilical cord blood and/or the mesenchymal stem cells expanded from said mesenchymal stem cells (UCB-MSCs), wherein the cell-treating composition includes UCB-MSCs. Provided is a composition for treating disease related to a cell expressing IL-8 or GRO-α, that is, a brain tumor in gene therapy, by using UCB-MSCs. Provided is a composition or kit for diagnosing brain tumors, preventing brain tumors, treating brain tumors, or monitoring brain tumor treatment progression by using UCB-MSCs.

    摘要翻译： 提供了将治疗基因，制造者基因或其混合物中的一种转移至表达白细胞介素-8（IL-8）或GRO-α的细胞并诱导从脐带分离的间充质干细胞向性的基因治疗组合物 血液和/或从所述间充质干细胞（UCB-MSC）扩增的间充质干细胞，其中细胞处理组合物包括UCB-MSC。 提供了通过使用UCB-MSC来治疗与表达IL-8或GRO-α的细胞，即基因治疗中的脑肿瘤有关的疾病的组合物。 提供了用于诊断脑肿瘤，预防脑肿瘤，治疗脑肿瘤或通过使用UCB-MSC监测脑肿瘤治疗进展的组合物或试剂盒。

    Composition For Treatment of Articular Cartilage Damage
    10.
    发明申请
    Composition For Treatment of Articular Cartilage Damage 审中-公开
    用于治疗关节软骨损伤的组合物

    公开(公告)号：US20090060885A1

    公开(公告)日：2009-03-05

    申请号：US12237182

    申请日：2008-09-24

    申请人： Chul-Won Ha ,  Yoon-Sun Yang ,  Sung-Eun Yang

    发明人： Chul-Won Ha ,  Yoon-Sun Yang ,  Sung-Eun Yang

    IPC分类号： A61K35/12 ,  A61P19/04

    CPC分类号： A61K35/28 ,  A61K35/51 ,  Y02A50/411

    摘要： Disclosed is a composition for the treatment of cartilage or bone damage or loss or defect. The composition comprises mesenchymal stem cells separated from umbilical cord blood and/or mesenchymal stem cells proliferated and/or differentiated. The composition also comprise chondrocytes and/or chondroblasts, or osteocytes and/or osteoblasts, differentiated from the mesenchymal stem cells separated from the umbilical cord blood.

    摘要翻译： 公开了用于治疗软骨或骨损伤或损失或缺陷的组合物。 该组合物包含从脐带血和/或间充质干细胞分离的间充质干细胞增殖和/或分化。 组合物还包括与从脐带血分离的间充质干细胞分化的软骨细胞和/或软骨细胞，或骨细胞和/或成骨细胞。