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    PIEZOELECTRIC DISPENSER WITH A LONGITUDINAL TRANSDUCER AND REPLACEABLE CAPILLARY TUBE
    2.
    发明申请
    PIEZOELECTRIC DISPENSER WITH A LONGITUDINAL TRANSDUCER AND REPLACEABLE CAPILLARY TUBE 有权

    公开(公告)号：US20220305515A1

    公开(公告)日：2022-09-29

    申请号：US17451310

    申请日：2021-10-18

    申请人： BioDot, Inc.

    发明人： Yehuda Ivri ,  Thomas C. Tisone ,  Eric P. Kuo ,  Shane Gunsalus

    IPC分类号： B05B17/06 ,  B01L3/02 ,  B01J19/00

    摘要： A dispenser and methods for transferring liquids are disclosed. The dispenser may include a capillary tube with tip having an aperture, a piezoelectric actuator coupled to the capillary tube at a location. Actuation of the piezoelectric actuator causes a pressure wave to propagate along the capillary tube toward the tip such that radial motion at the location is transmitted as distally extending axial motion of the tip, thereby causing a droplet of a predetermined volume to be ejected from the aperture. In some embodiments, the capillary tube has a modulus of elasticity in a range which dampens acoustical noise from the actuation and provides single drop stability over a range of drop sizes.

    Controlled printing of a cell sample for karyotyping
    3.
    发明授权
    Controlled printing of a cell sample for karyotyping 有权

    公开(公告)号：US11181448B2

    公开(公告)日：2021-11-23

    申请号：US14440843

    申请日：2013-11-04

    申请人： Biodot, Inc.

    发明人： Brian L. Kirk ,  Anthony V. Lemmo ,  Thomas C. Tisone

    IPC分类号： G01N1/28 ,  G01N1/31 ,  G01N35/10

    摘要： Methods and techniques for controlled printing of a cell sample for karyotyping are provided. The methods can involve matrix printing using on-the-fly printing or dispensing to accurately spread cells within at least one cell sample on a surface in preparation for karyotyping, and further analysis. Advantageously, the methods result in a uniform distribution of chromosomes of the cell suspension or sample on the surface of a substrate which can be substantially discretely identified, and also provide for efficiency in a subsequent staining process and any further analysis of the stained chromosomes using a microscope or other imaging device.

    PIEZOELECTRIC DISPENSER WITH A LONGITUDINAL TRANSDUCER AND REPLACEABLE CAPILLARY TUBE
    4.
    发明申请
    PIEZOELECTRIC DISPENSER WITH A LONGITUDINAL TRANSDUCER AND REPLACEABLE CAPILLARY TUBE 审中-公开
    具有纵向传感器和可更换毛细管的压电分配器

    公开(公告)号：US20130206857A1

    公开(公告)日：2013-08-15

    申请号：US13841978

    申请日：2013-03-15

    申请人： Biodot, Inc.

    发明人： Yehuda Ivri

    IPC分类号： B05B17/06

    CPC分类号： B05B17/0653 ,  B05B17/0607 ,  B05B17/063 ,  B05B17/0669 ,  B05B17/0676 ,  F04B43/046 ,  F04F7/00

    摘要： Systems, devices and methods are provided, for acquiring and dispensing predetermined volumes of liquids and, in particular, to a unique piezoelectric dispenser for acquiring and dispensing of small volumes of fluid in an automatic or manual production of DNA arrays and assays, wherein droplets are dispensed in a single drop format with volumes that may range from about a few picoliters to several nanoliters. The dispenser can advantageously utilize a disposable capillary tube assembly while desirably retaining the piezoelectric actuator for subsequent further uses, thereby mitigating the possibility of cross contamination of fluids and providing an economical and cost effective approach with reuse of the piezoelectric actuator for further operation such as with a variety of liquids to be dispensed and transferred. A unique longitudinal transducer can transmit radial tube displacement into controlled axial motion of the tube.

    摘要翻译： 提供了用于获取和分配预定体积的液体的系统，装置和方法，特别是用于在自动或手动生产DNA阵列和测定中获取和分配小体积流体的独特的压电分配器，其中液滴是 以一滴式格式分配，体积可以在约几微摩尔至几纳升。 分配器可以有利地使用一次性毛细管组件，同时期望地保持压电致动器用于随后的进一步使用，从而减轻流体的交叉污染的可能性，并提供经济和成本有效的方法，重复使用压电致动器用于进一步操作， 各种待分配和转移的液体。 独特的纵向传感器可将径向管位移传递到管的受控轴向运动。

    PIEZOELECTRIC DISPENSER WITH A LONGITUDINAL TRANSDUCER AND REPLACEABLE CAPILLARY TUBE
    6.
    发明申请
    PIEZOELECTRIC DISPENSER WITH A LONGITUDINAL TRANSDUCER AND REPLACEABLE CAPILLARY TUBE 有权
    具有纵向传感器和可更换毛细管的压电分配器

    公开(公告)号：US20120304929A1

    公开(公告)日：2012-12-06

    申请号：US13355150

    申请日：2012-01-20

    申请人： Yehuda Ivri

    发明人： Yehuda Ivri

    IPC分类号： F04B43/09 ,  B05C5/00 ,  B05C11/00 ,  B65D83/00

    CPC分类号： F04B43/046 ,  B01J2219/00378 ,  B05B15/62 ,  B05B17/0607 ,  B05B17/0623 ,  F04F7/00

    摘要： Systems, devices and methods are provided, for acquiring and dispensing predetermined volumes of liquids and, in particular, to a unique piezoelectric dispenser for acquiring and dispensing of small volumes of fluid in an automatic or manual production of DNA arrays and assays, wherein droplets are dispensed in a single drop format with volumes that may range from about a few picoliters to several nanoliters. The dispenser can advantageously utilize a disposable capillary tube assembly while desirably retaining the piezoelectric actuator for subsequent further uses, thereby mitigating the possibility of cross contamination of fluids and providing an economical and cost effective approach with reuse of the piezoelectric actuator for further operation such as with a variety of liquids to be dispensed and transferred. A unique longitudinal transducer can transmit radial tube displacement into controlled axial motion of the tube.

    摘要翻译： 提供了用于获取和分配预定体积的液体的系统，装置和方法，特别是用于在自动或手动生产DNA阵列和测定中获取和分配小体积流体的独特的压电分配器，其中液滴是 以一滴式格式分配，体积可以在约几微摩尔至几纳升。 分配器可以有利地使用一次性毛细管组件，同时期望地保持压电致动器用于随后的进一步使用，从而减轻流体的交叉污染的可能性，并提供经济和成本有效的方法，重复使用压电致动器用于进一步操作， 各种待分配和转移的液体。 独特的纵向传感器可将径向管位移传递到管的受控轴向运动。