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公开(公告)号：US20070003566A1
公开(公告)日：2007-01-04
申请号：US11030635
申请日：2005-01-06
申请人： Rino Rappuoli , Guido Grandi
发明人： Rino Rappuoli , Guido Grandi
IPC分类号： A61K39/12 , A61K39/02 , A61K39/005 , C07K14/74 , C07K14/44 , C07K14/195 , C07K14/005
CPC分类号： C07K14/005 , A01K2217/05 , A61K38/00 , A61K39/00 , C07K14/22 , C07K14/235 , C07K14/33 , C07K14/34 , C07K14/445 , C07K2319/00 , C12N2730/10122 , C12N2760/16222 , Y02A50/412 , Y10S424/831 , Y10S424/832 , Y10S530/806 , Y10S530/807 , Y10S530/822 , Y10S530/825 , Y10S530/826
摘要： The invention relates to polyepitope carrier proteins that comprise at least five CD4+T cell epitopes, for conjugation to capsular polysaccharides. The carrier proteins are use useful as components of vaccines that can elicit a T-cell dependent immune response. These vaccines are particularly useful to confer protection against infection from encapsulated bacteria in infants between the ages of 3 months and about 2 years.
摘要翻译： 本发明涉及包含至少五个CD4 + T细胞表位的多表位载体蛋白，用于与荚膜多糖缀合。 载体蛋白可用作可引发T细胞依赖性免疫应答的疫苗的组分。 这些疫苗特别适用于在3个月至2年之间的婴儿中赋予防止包囊细菌感染的保护作用。
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公开(公告)号：US20050281793A1
公开(公告)日：2005-12-22
申请号：US11185273
申请日：2005-07-19
申请人： Sergio Abrignani
发明人： Sergio Abrignani
IPC分类号： A61K35/12 , A61K35/14 , A61K38/00 , A61K38/20 , A61P31/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P37/04 , A61P43/00 , C07K14/52 , C12N5/0783 , A61K45/00 , A61K38/19
CPC分类号： C12N5/0636 , A61K38/2013 , A61K2035/124 , C07K14/52 , C12N2501/23 , C12N2501/25 , A61K2300/00
摘要： A method for antigen independent activation of T cells comprising contacting T cells with a combination of cytokines such as two or more of interleukin-2, interleukin-6 and tumor necrosis factor α.
摘要翻译： 一种用于T细胞的抗原独立活化的方法，包括使T细胞与细胞因子例如白细胞介素-2，白细胞介素-6和肿瘤坏死因子α两种或更多种的组合接触。
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公开(公告)号：US20040126391A1
公开(公告)日：2004-07-01
申请号：US10695499
申请日：2003-10-28
申请人： Chiron S.P.A.
IPC分类号： C12Q001/68 , C07H021/04 , A61K039/02 , C12N001/21 , C07K014/22
摘要： The invention provides proteins from Neissena meningitidis (strains A & B), including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics.
摘要翻译： 本发明提供来自脑膜炎奈瑟氏球菌（A＆B）菌株的蛋白质，包括氨基酸序列，相应的核苷酸序列，表达数据和血清学数据。 蛋白质是疫苗，免疫原性组合物和/或诊断的有用的抗原。
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公开(公告)号：US20040048353A1
公开(公告)日：2004-03-11
申请号：US09921157
申请日：2001-08-02
申请人： Chiron, S.p.A.
IPC分类号： A61K039/02 , C07H021/04 , C12P021/02 , C12N001/21 , C07K014/195
CPC分类号： C07K14/195 , A61K38/00 , A61K39/00 , C07K14/205 , C07K2319/00 , C07K2319/35 , C07K2319/40 , C12Q1/689
摘要： This invention provides polypeptides of Helicobacter pylori cytotoxin protein. The invention also provides prophylactic and therapeutic vaccines comprising the polypeptides of Helicobacter pylori cytotoxin protein, and methods for their preparation.
摘要翻译： 本发明提供了幽门螺杆菌细胞毒素蛋白质的多肽。 本发明还提供包含幽门螺杆菌细胞毒素蛋白多肽的预防和治疗疫苗及其制备方法。
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公开(公告)号：US6110705A
公开(公告)日：2000-08-29
申请号：US444189
申请日：1995-05-18
IPC分类号： A61K38/00 , A61K39/00 , C07K14/295 , C07K16/12 , C12N15/30 , C12N15/74 , C12P21/06 , C12P21/04
CPC分类号： C07K14/295 , C07K16/125 , C12N15/74 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/75
摘要： A plasmid isolated from Chlamydia trachomatis is described, which comprises 8 genes encoding proteins useful in the formation of vaccines or diagnostic test for determining the bacterium or specific antibodies generated during C. trachomatis infections. In particular, the recombinant fusion protein MS2-pgp3D is described, which comprises polypeptide sequences encoded by pCT and is immunogenic in the course of infections in man. A method for preparing the recombinant fusion protein MS2-pgp3D in E. coli is also described.
摘要翻译： 描述了从沙眼衣原体分离的质粒，其包含编码用于疫苗形成的蛋白质的8种基因或用于确定在沙眼衣原体感染期间产生的细菌或特异性抗体的诊断试验。 特别地，描述了重组融合蛋白MS2-pgp3D，其包含由pCT编码的多肽序列，并且在人的感染过程中是免疫原性的。 还描述了在大肠杆菌中制备重组融合蛋白MS2-pgp3D的方法。
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6.发明授权Immunologically active polypeptides with altered toxicity useful for the preparation of an antipertussis vaccine 失效具有改变的毒性的免疫活性多肽可用于制备抗百日咳疫苗
公开(公告)号：US5925546A
公开(公告)日：1999-07-20
申请号：US478714
申请日：1995-06-07
IPC分类号： A61K39/00 , C07K14/235 , C12P21/02 , C12N15/00
CPC分类号： C07K14/235 , A61K39/00 , Y10S424/832
摘要： Immunological active polypeptides with no or reduced toxicity useful for the preparation of an antipertussis vaccine. Method for the preparation of said polypeptides which comprises, cultivating a microorganism transformed with a hybrid plasmid including the gene/s which codes for at least one of said polypeptides in a suitable medium and recovering the desired polypeptide from the cells or from the culture medium.
摘要翻译： 无毒性或降低毒性的免疫活性多肽可用于制备抗百日咳疫苗。 用于制备所述多肽的方法，其包括用合适培养基培养用包含编码所述多肽的至少一种的基因的杂交质粒转化的微生物，并从所述细胞或培养基中回收所需的多肽。
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公开(公告)号：US5889172A
公开(公告)日：1999-03-30
申请号：US479626
申请日：1995-06-07
IPC分类号： A61K39/00 , C07K14/235 , C12N15/31
CPC分类号： C07K14/235 , A61K39/00 , Y10S424/832
摘要： Immunologically active polypeptides with no or reduced toxicity useful for the preparation of an antipertussis vaccine. Method for the preparation of said polypeptides which comprises, cultivating a microorganism transformed with a hybrid plasmid including the gene/s which codes for at least one of said polypeptides in a suitable medium and recovering the desired polypeptide from the cells or from the culture medium.
摘要翻译： 无毒性或降低毒性的免疫活性多肽可用于制备抗百日咳疫苗。 用于制备所述多肽的方法，其包括用合适培养基培养用包含编码所述多肽的至少一种的基因的杂交质粒转化的微生物，并从所述细胞或培养基中回收所需的多肽。
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公开(公告)号：US20070231342A1
公开(公告)日：2007-10-04
申请号：US10982703
申请日：2004-11-05
IPC分类号： A61K39/095 , C07K14/22 , C12Q1/18
CPC分类号： A61K39/095 , A61K38/164 , A61K39/00 , A61K39/02 , A61K39/39 , A61K2039/53 , A61K2039/55505 , A61K2039/70 , C07K14/22
摘要： Compositions comprising a first biological molecule from a Neisseria bacterium and a second biological molecule from a Neisseria bacterium. The term “biological molecule” includes proteins and nucleic acids. Preferred Neisseria species are N. meningitidis and N. gonorrhoeae
摘要翻译： 组合物包含来自奈瑟氏球菌细菌的第一生物分子和来自奈顿球菌细菌的第二生物分子。 术语“生物分子”包括蛋白质和核酸。 优选的奈瑟氏菌属是脑膜炎奈瑟氏球菌和淋病奈瑟氏球菌
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公开(公告)号：US20040137017A1
公开(公告)日：2004-07-15
申请号：US10611398
申请日：2003-06-30
申请人： Chiron S.p.A.
IPC分类号： A61K039/38 , C07H021/04 , C12N001/21 , C07K014/28 , C12N015/09 , A61K039/00 , C12N001/20 , A61K039/106 , C12N015/00 , C12N015/63 , C12N015/70 , C12N015/74 , C07K001/00 , C07K014/00 , C07K017/00
CPC分类号： C07K14/28 , A61K38/00 , A61K39/00 , C07K14/245 , C07K2319/00 , C12N2799/026 , Y02A50/472
摘要： An immunogenic detoxified protein comprising the amino acid sequence of subunit A of a cholera toxin (CT-A) or a fragment thereof or the amino acid sequence of subunit A of an Escherichia coli heat labile toxin (LT-A) or a fragment thereof wherein the amino acids at, or in positions corresponding to Ser-63 and Arg-192 are replaced with another amino acid. The immunogenic detoxified protein is useful as vaccine for Vibrio cholerae or an enterotoxigenic strain of Escherichia coli and is produced by recombinant DNA means by site-directed mutagenesis.
摘要翻译： 包含霍乱毒素（CT-A）或其片段的亚基A的氨基酸序列或大肠杆菌热不稳定毒素（LT-A）或其片段的亚基A的氨基酸序列的免疫原性解毒蛋白，其中 对应于Ser-63和Arg-192的位置或位置的氨基酸被另外的氨基酸替代。 免疫原性解毒蛋白质可用作霍乱弧菌或大肠杆菌肠毒素菌株的疫苗，并通过重组DNA方法通过定点诱变产生。
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公开(公告)号：US20040101536A1
公开(公告)日：2004-05-27
申请号：US10703886
申请日：2003-11-07
申请人： Chiron S.P.A.
发明人： Giuseppe Teti , Luciano Polonelli
IPC分类号： A61K039/02 , C07K014/315
CPC分类号： C40B40/02 , A01K2217/05 , A61K39/00 , C07K14/315 , C07K16/4233 , C12N15/1037
摘要： The invention relates to peptide, oligopeptide or polypeptide compounds that are capable of eliciting a protective immune response against the capsular polysaccharide of group B Streptococcus (GBS), particularly type III GBS. Such compounds are useful in the development of vaccines that are effective against diseases caused by these pathogens.
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