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    METHODS FOR IMPROVED PRODUCTION OF VITAMINS D2 AND D3
    1.
    发明申请
    METHODS FOR IMPROVED PRODUCTION OF VITAMINS D2 AND D3 审中-公开

    公开(公告)号：US20170369436A1

    公开(公告)日：2017-12-28

    申请号：US15537391

    申请日：2015-12-18

    申请人： NUCELIS LLC

    发明人： Laszlo TREIBER

    IPC分类号： C07C401/00 ,  A23L33/155 ,  C07J9/00 ,  C07C2602/24 ,  C07C2601/14

    CPC分类号： C07C401/00 ,  A23L33/155 ,  A23V2250/7104 ,  A23V2250/7106 ,  C07C2601/14 ,  C07C2602/24 ,  C07J9/00

    摘要： It is an object of the present invention to provide methods for producing vitamin D that gives improved yields and reduced side product contamination. In various aspects, these methods provide for production of vitamin-D2 using ergosterol as provitamin D2 or a dihydroxy derivative thereof as a starting material, or production of vitamin-D3 using 7-dehydrocholesterol as provitamin D3 or a dihydroxy derivative thereof as the starting material. The methods described herein comprise irradiating the starting material in a solution including an organic or inorganic base with light in the wavelength range 245-360 nanometers (nm) to obtain a product containing pre-vitamin-D2 or pre-vitamin-D3, and heating the product to convert the resulting pre-vitamin-D2 or pre-vitamin-D3 to vitamin D2 or vitamin D3. In various embodiments, these methods further comprise recovering vitamin D2 or vitamin D3 from this reaction as a purified product.

    METHODS OF EXTRACTING FAT SOLUBLE VITAMINS
    5.
    发明申请
    METHODS OF EXTRACTING FAT SOLUBLE VITAMINS 审中-公开
    提取脂溶性维生素的方法

    公开(公告)号：US20140033805A1

    公开(公告)日：2014-02-06

    申请号：US13940938

    申请日：2013-07-12

    申请人： Waters Technologies Corporation

    发明人： Tarang Nema ,  Evelyn Mei Ling Goh

    IPC分类号： G01N1/28

    CPC分类号： G01N1/28 ,  A23L33/155 ,  A23V2002/00 ,  G01N33/02 ,  G01N2001/4061 ,  A23V2250/702 ,  A23V2250/7104 ,  A23V2250/7106 ,  A23V2250/712 ,  A23V2250/7142 ,  A23V2250/7144 ,  A23V2300/14

    摘要： The present invention provides novel, simple and reliable methods for extraction of fat soluble vitamins (FSVs) from a sample matrix obtained from food products (e.g., vitamin-enriched foods and fortified food matrices) or biological samples. In certain aspects, the invention provides solid phase extraction (SPE) methods. In certain embodiments, the invention relates to two-step elution methods, which provide excellent recovery of all fat-soluble vitamins from complicated food matrices (such as, vitamin-enriched foods and fortified food products) or biological samples in a simultaneous manner. In certain embodiments, the invention uses OASIS® materials as sorbent beds for separating and/or extracting FSVs from the sample matrix.

    摘要翻译： 本发明提供从从食品（例如富含维生素的食品和强化食品基质）或生物样品获得的样品基质中提取脂溶性维生素（FSV）的新型，简单和可靠的方法。 在某些方面，本发明提供固相萃取（SPE）方法。 在某些实施方案中，本发明涉及两步洗脱方法，其以复合食物基质（例如富含维生素的食物和强化食品）或生物样品以同时方式提供所有脂溶性维生素的极好的回收。 在某些实施方案中，本发明使用OASIS®材料作为用于从样品基质分离和/或提取FSV的吸附剂床。

    Treatment and Prevention of Diabetes and Obesity
    9.
    发明申请
    Treatment and Prevention of Diabetes and Obesity 审中-公开

    公开(公告)号：US20180042287A1

    公开(公告)日：2018-02-15

    申请号：US15674876

    申请日：2017-08-11

    申请人： Summit Innovation Labs, LLC

    发明人： Haile Mehansho

    IPC分类号： A23L33/00 ,  A23L33/19 ,  A23L33/17 ,  A23L33/185 ,  A23L33/15 ,  A23L33/16

    CPC分类号： A23L33/40 ,  A23L33/00 ,  A23L33/105 ,  A23L33/12 ,  A23L33/15 ,  A23L33/16 ,  A23L33/17 ,  A23L33/185 ,  A23L33/19 ,  A23V2002/00 ,  A23V2200/328 ,  A23V2250/161 ,  A23V2250/1882 ,  A23V2250/2112 ,  A23V2250/21168 ,  A23V2250/21172 ,  A23V2250/708 ,  A23V2250/71 ,  A23V2250/7104 ,  A23V2250/7106

    摘要： The invention encompasses compositions and methods for effectively treating and/or preventing diabetes and/or obesity. This is accomplished by totally addressing the multiple mechanisms that lead to such conditions. The invention includes compositions comprising a combination of agents that effectively suppress, regulate or interfere with the various biochemical processes and mechanisms that lead to diabetes and obesity. The inventive compositions used for administration to human and other mammalian subjects comprise (1) at least one agent capable of modulating expression and/or activity of one or more of peroxisome activated protein receptor gamma (PPAR-γ), CAAT/enhancer binding protein-α (C/EBPα) and Sterol Regulatory Element-Binding Protein (SREBP-1); (2) at least one agent capable of activating Wnt/β-catenin pathway; (3) at least one agent capable of activating the adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; (4) at least one agent that inhibits the activity of pro-oxidants including reactive nitrogen species and reactive oxygen species (ROS); (5) at least one agent that suppresses one or more of inflammatory mediators including interleukins IL-1α, IL-1β, IL-6, NF-κB, TNF-α, matrix metalloproteinases (MMPs) and prostaglandin E2 (PGE2); (6) at least one agent capable of enhancing glucose transporter (GLUT4) and/or inhibiting glucose transporter GLUT2; (7) at least one agent that induces the expression of and/or activates adiponectin and (8) at least one agent that induces the expression of and/or activates sirtuin (SIRT1). The active agents for use herein are natural materials such as phytonutrients, vitamins and minerals. Compositions with combinations of such natural agents have the ability to prevent, reduce or treat diabetes and obesity by (a) clearing glucose and fatty acids from blood, (b) reducing the number of adipose cells and fat storage, (c) interfering with fat, glucose, and cholesterol biosynthesis, and (d) promoting fat and glucose oxidation.Since the present compositions are aimed toward normalizing metabolism and energy expenditure and managing oxidative stress and inflammation, they are also beneficial in relation to physical activity, in particular performance, endurance, fatigue and recovery during intensive and continuous exercise/exertion.