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    Time, space digitally resolved quantification of luminescent targets
    3.
    发明授权
    Time, space digitally resolved quantification of luminescent targets 有权

    公开(公告)号：US10359363B2

    公开(公告)日：2019-07-23

    申请号：US15736414

    申请日：2016-06-22

    Applicant: IMEC VZW

    Inventor： Peter Peumans ,  Liesbet Lagae ,  Willem Van Roy ,  Tim Stakenborg ,  Pol Van Dorpe

    IPC: G01J3/30 ,  G01N21/64

    Abstract: A sensor device for quantifying luminescent targets. The device comprises a light source for exciting the targets, thus generating luminescence signals, and a detector for detecting these signals of the targets in a cell, resulting in a detected signal comprising a desired signal and a background signal. The detector has a spatial cell resolution and/or a time resolution that is so high that only a limited number of targets will be present in the cell when measuring at low concentration and/or that only a limited number of targets add to the cell in between two measurements. A change in the number of targets in the cell can be observed in the detected signal. The device comprises a processor configured to distinguish the desired and the background signal, and to combine the detected signals of the different cells and/or moments in time, to quantify the targets.

    Semiconductor device for detecting fluorescent particles
    4.
    发明授权
    Semiconductor device for detecting fluorescent particles 有权

    公开(公告)号：US10267733B2

    公开(公告)日：2019-04-23

    申请号：US15312116

    申请日：2015-05-22

    Applicant: IMEC VZW

    Inventor： Pol Van Dorpe ,  Liesbet Lagae ,  Peter Peumans ,  Andim Stassen ,  Philippe Helin ,  Bert Du Bois ,  Simone Severi

    IPC: G01N21/64 ,  G01N21/77

    Abstract: The present disclosure relates to semiconductor devices for detecting fluorescent particles. At least one embodiment relates to an integrated semiconductor device for detecting fluorescent tags. The device includes a first layer, a second layer, a third layer, a fourth layer, and a fifth layer. The first layer includes a detector element. The second layer includes a rejection filter. The third layer is fabricated from dielectric material. The fourth layer is an optical waveguide configured and positioned such that a top surface of the fourth layer is illuminated with an evanescent tail of excitation light guided by the optical waveguide when the fluorescent tags are present. The fifth layer includes a microfluidic channel. The optical waveguide is configured and positioned such that the microfluidic channel is illuminated with the evanescent tail. The detector element is positioned such that light from activated fluorescent tags can be received.

    Microbubble generator device, systems and method to fabricate
    5.
    发明授权
    Microbubble generator device, systems and method to fabricate 有权

    公开(公告)号：US10124338B2

    公开(公告)日：2018-11-13

    申请号：US15526922

    申请日：2015-11-19

    Applicant: IMEC VZW

    Inventor： Chengxun Liu ,  Peter Peumans ,  Liesbet Lagae ,  Bivragh Majeed

    IPC: B07C5/00 ,  B01L3/00 ,  G01N15/10 ,  G01N15/14

    Abstract: The present disclosure relates to microbubble generator devices for deflecting objects in a liquid, systems for sorting objects that utilize such devices, and methods for fabricating such devices. At least one embodiment relates to a micro-fluidic device for deflecting objects in a liquid. The device includes a substrate for providing an object-containing liquid thereon. The device also includes a microbubble generator that includes at least one microbubble generating element. The microbubble generator is located on a surface of the substrate and in direct contact with the object-containing liquid when the object-containing liquid is provided on the substrate. The at least one microbubble generating element is configured to deflect a single object in the object-containing liquid through generation of a plurality of microbubbles.

    Semiconductor Device for Detecting Fluorescent Particles
    9.
    发明申请
    Semiconductor Device for Detecting Fluorescent Particles 审中-公开

    公开(公告)号：US20170082544A1

    公开(公告)日：2017-03-23

    申请号：US15312116

    申请日：2015-05-22

    Applicant: IMEC VZW

    Inventor： Pol Van Dorpe ,  Liesbet Lagae ,  Peter Peumans ,  Andim Stassen ,  Philippe Helin ,  Bert Du Bois ,  Simone Severi

    IPC: G01N21/64

    CPC classification number: G01N21/6428 ,  G01N21/6454 ,  G01N21/648 ,  G01N21/7703 ,  G01N2201/0873

    Abstract: The present disclosure relates to semiconductor devices for detecting fluorescent particles. At least one embodiment relates to an integrated semiconductor device for detecting fluorescent tags. The device includes a first layer, a second layer, a third layer, a fourth layer, and a fifth layer. The first layer includes a detector element. The second layer includes a rejection filter. The third layer is fabricated from dielectric material. The fourth layer is an optical waveguide configured and positioned such that a top surface of the fourth layer is illuminated with an evanescent tail of excitation light guided by the optical waveguide when the fluorescent tags are present. The fifth layer includes a microfluidic channel. The optical waveguide is configured and positioned such that the microfluidic channel is illuminated with the evanescent tail. The detector element is positioned such that light from activated fluorescent tags can be received.

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