公开(公告)号：US09606093B2

公开(公告)日：2017-03-28

申请号：US14540410

申请日：2014-11-13

申请人： Awad Bin Saud Alquaity ,  Aamir Farooq

发明人： Awad Bin Saud Alquaity ,  Aamir Farooq

IPC分类号： G01N21/00 ,  G01N33/00 ,  G01J3/42 ,  G01N21/39 ,  G01N21/03

CPC分类号： G01N33/0027 ,  G01J3/42 ,  G01N21/031 ,  G01N21/39 ,  G01N2021/396 ,  G01N2201/0697

摘要： A system and method for cavity ring-down spectroscopy can include a pulsed quantum cascade laser, an optical ring-down cavity, a photodetector, and an oscilloscope. The system and method can produce pulse widths of less than 200 ns with bandwidths greater than 300 pm, as well as provide temporal resolution of greater than 10 μs.

公开(公告)号：US06930779B2

公开(公告)日：2005-08-16

申请号：US10286338

申请日：2002-11-01

申请人： Stephen P. McGrew

发明人： Stephen P. McGrew

IPC分类号： G01N21/21 ,  G01N21/35 ,  G01N21/39 ,  G01B9/02

CPC分类号： G01N21/21 ,  B82Y10/00 ,  B82Y20/00 ,  G01N21/3581 ,  G01N2021/396

摘要： Quantum based systems for detecting materials in a sample, including biological, chemical and physical materials are described. The systems are based on exciting the sample containing the material with a femtosecond to nanosecond probe pulse of collimated light, which is tailored to optimize detection of a given material by separating the probe pulse into component features of frequency, polarization, phase and/or amplitude. The component features are independently shaped and formed into a composite pulse selected to optimize a signature response pulse received from the material. Selection of the appropriate shapes for the component features of the pulse for a given material is accomplished by testing variations in the features on the material, assigning a fitness value to variants that tend to optimize a distinctive spectral response from the material, and using a genetic algorithm to select the combination of component features that enhances the distinctiveness of the response received over a typical background.

摘要翻译： 描述了用于检测样品中材料的基于量子的系统，包括生物，化学和物理材料。 该系统基于激发包含材料的样品，其具有飞秒至纳秒的准直光探针脉冲，其被定制以通过将探针脉冲分离成频率，极化，相位和/或幅度的分量特征来优化给定材料的检测 。 组件特征被独立地成形并形成为选择用于优化从材料接收的签名响应脉冲的复合脉冲。 通过测试材料中的特征的变化来确定对于给定材料的脉冲的组分特征的适当形状的选择，将适合度值分配给倾向于优化来自材料的特征光谱响应的变体，以及使用遗传 算法来选择增强在典型背景上接收的响应的独特性的组件特征的组合。

公开(公告)号：US11874270B1

公开(公告)日：2024-01-16

申请号：US17033596

申请日：2020-09-25

申请人： InspectIR Systems, LLC ,  University of North Texas

发明人： Guido Fridolin Verbeck, IV ,  John Redmond ,  Tim C. Wing ,  Luke Keiser

IPC分类号： G01N33/497 ,  G01N1/22 ,  G01N21/39 ,  G01N33/94 ,  G01N30/72 ,  G01N27/624

CPC分类号： G01N33/497 ,  G01N1/2247 ,  G01N21/39 ,  G01N27/624 ,  G01N30/72 ,  G01N33/948 ,  G01N33/9486 ,  G01N2021/392 ,  G01N2021/396 ,  G01N2033/4975 ,  G01N2560/00

摘要： An exemplary breath analysis system may include a sampling chamber having a molecule collector disposed therein. The molecule collector may be configured such that volatile organic compounds (VOCs) present in a breath sample introduced to the sampling chamber adhere to the molecule collector. A photodiode array configured to excite and/or heat the molecule collector to release at least a portion of the VOCs from the molecule collector to release at least the portion of the VOCs adhered to the molecule collector. An analysis device (e.g., a mass spectrometer or Terahertz (THz) spectrometer) may identify one or more target VOCs from among at least the portion of the VOCs released from the molecule collector and generate an output representative of the identified target VOC(s). The output may include information that quantitates a concentration of the target VOC(s) with respect to a source of the breath sample.

公开(公告)号：US11692935B2

公开(公告)日：2023-07-04

申请号：US17276825

申请日：2021-01-13

申请人： XI'AN UNIVERSITY OF TECHNOLOGY

发明人： Wei Shi ,  Lei Hou ,  Cheng Ma ,  Chengang Dong ,  Lei Yang ,  Jiaguang Han ,  Yanfeng Li ,  Chunmei Ouyang ,  Jianqiang Gu ,  Liguo Zhu ,  Zhaohui Zhai ,  Lianghui Du ,  Yi Zou

IPC分类号： G01N21/3581 ,  G01N21/3577 ,  G01N21/39 ,  G01N33/487 ,  G01N21/17

CPC分类号： G01N21/3581 ,  G01N21/3577 ,  G01N21/39 ,  G01N33/48721 ,  G01N2021/177 ,  G01N2021/396

摘要： Disclosed is a transient-state THz spectrometer applied to cells and biological macromolecules, including a femtosecond laser amplifier. A femtosecond laser output by the femtosecond laser amplifier is divided into two beams of pump light and probe light after passing through a beam splitter of which a transmission-reflection ratio is 7:3, the pump light is focused to irradiate a gap between electrodes of a nonlinear photoconductive antenna and emit a terahertz wave after successively passing through a half wave plate, a silver-plated reflector and a first lens, the terahertz wave forms a terahertz wave collineation after successively passing through a second lens, a slab waveguide, a third lens and an ITO film, the terahertz wave collineation and the probe light form a probe light collineation of wavefront tilt which is perpendicularly incident on a ZnTe crystal and detected and recorded by using a CCD camera.

公开(公告)号：US20170365974A1

公开(公告)日：2017-12-21

申请号：US15182841

申请日：2016-06-15

申请人： LUMINIT LLC

发明人： Russell KURTZ ,  Alkan GULSES

IPC分类号： H01S3/106 ,  H01S3/11 ,  G01N33/00 ,  G01N21/39 ,  H01S3/094 ,  H01S3/16 ,  H01S3/0941

CPC分类号： H01S3/1062 ,  G01N21/3504 ,  G01N21/359 ,  G01N21/39 ,  G01N33/004 ,  G01N33/0047 ,  G01N2021/1795 ,  G01N2021/396 ,  H01S3/061 ,  H01S3/0809 ,  H01S3/094076 ,  H01S3/0941 ,  H01S3/10061 ,  H01S3/1103 ,  H01S3/1608 ,  H01S3/1643 ,  H01S2302/00

摘要： A short-pulse, narrowband, line-selectable and tunable solid-state laser is described. The device requires a pump source, an active solid-state laser medium, an enclosing cavity, mirrors to contain the light, a method of removing the pulse from the cavity, a wavelength selection system, and a laser linewidth narrowing system. One implementation of this is an Er:YAG laser, side pumped by semiconductor lasers in the erbium absorption band near 1475 nm, with an intracavity etalon and a switchable spectral filter. To remove the pulse from the cavity, cavity dumping issues, which assures constant pulse energy and pulse length over a range of repetition rates, in this case from 100 Hz to 20 kHz. Line selection is obtained by use of wavelength filters and fine tuning with an etalon, which also acts as the linewidth narrowing system.

公开(公告)号：US20160033397A1

公开(公告)日：2016-02-04

申请号：US14884716

申请日：2015-10-15

申请人： Lawrence Livermore National Security, LLC

发明人： Tiziana C Bond ,  Garrett Cole ,  Lynford Goddard

IPC分类号： G01N21/39 ,  H01S3/105 ,  H01S3/1055 ,  H01S3/08

CPC分类号： G01N21/39 ,  G01N21/774 ,  G01N2021/396 ,  G01N2021/399 ,  G01N2201/06113 ,  G01N2201/068 ,  H01S3/08059 ,  H01S3/1053 ,  H01S3/1055 ,  H01S5/0028 ,  H01S5/10 ,  H01S5/18366 ,  H01S5/18369 ,  H01S2302/00

摘要： Configurations for in-situ gas detection are provided, and include miniaturized photonic devices, low-optical-loss, guided-wave structures and state-selective adsorption coatings. High quality factor semiconductor resonators have been demonstrated in different configurations, such as micro-disks, micro-rings, micro-toroids, and photonic crystals with the properties of very narrow NIR transmission bands and sensitivity up to 10−9 (change in complex refractive index). The devices are therefore highly sensitive to changes in optical properties to the device parameters and can be tunable to the absorption of the chemical species of interest. Appropriate coatings applied to the device enhance state-specific molecular detection.

摘要翻译： 提供原位气体检测的结构，包括小型光子器件，低光损耗，导波结构和状态选择性吸附涂层。 已经在不同的配置中证明了高品质因子半导体谐振器，例如微盘，微环，微环形圈和具有非常窄的NIR透射带的性质的光子晶体和高达10-9的灵敏度（复折射率的变化 指数）。 因此，器件对于器件参数的光学性质的变化非常敏感，并且可以调节为感兴趣的化学物质的吸收。 施加到装置上的合适的涂层增强状态特异性分子检测。

公开(公告)号：US11788956B2

公开(公告)日：2023-10-17

申请号：US17603524

申请日：2019-09-30

申请人： Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences

发明人： Hua Li ,  Ziping Li ,  Wenjian Wan ,  Juncheng Cao

IPC分类号： G01N21/3581 ,  G01N21/01 ,  H01S5/042 ,  H01S5/34 ,  G01N21/39

CPC分类号： G01N21/3581 ,  G01N21/01 ,  H01S5/042 ,  H01S5/3402 ,  G01N2021/0112 ,  G01N2021/396 ,  G01N2201/06113

摘要： The present application provides a terahertz spectrum measurement system and a method for analyzing a terahertz spectrum of a substance, wherein the terahertz spectrum measurement system comprises: two terahertz quantum cascade lasers with their emission ports arranged oppositely; and a vacuum hood arranged between the emission ports of two terahertz quantum cascade lasers. The terahertz spectrum measurement system and the method for analyzing a terahertz spectrum of a substance realize a separate terahertz dual frequency comb while retaining the advantages of the on-chip dual frequency comb system, which solves the problem that the on-chip dual frequency comb cannot directly measure the terahertz spectra of substances.

公开(公告)号：US20160274023A1

公开(公告)日：2016-09-22

申请号：US14660670

申请日：2015-03-17

申请人： Daniel L. Carpenter

发明人： Daniel L. Carpenter

IPC分类号： G01N21/39 ,  G01N33/49

CPC分类号： G01N21/39 ,  G01N33/492 ,  G01N2021/396

摘要： A quantum cascading laser system for analyzing pathogenic microorganisms, where the quantum cascading laser system comprises a tunable laser unit, a beam splitter, lens, sample chamber, optical detector, data acquisition system, reference detector, and lock-in amplifier, where a computer controls the system and conducts the data analysis from the data produced from the quantum cascading laser system against a set of data derived from known pathogenic mircoorganisms to identify the pathogenic organisms in the original sample.

摘要翻译： 用于分析致病微生物的量子级联激光系统，其中量子级联激光系统包括可调谐激光器单元，分束器，透镜，样品室，光学检测器，数据采集系统，参考检测器和锁定放大器，其中计算机 控制系统并从量子级联激光系统产生的数据对来自已知致病微生物的一组数据进行数据分析，以鉴定原始样品中的致病生物体。

公开(公告)号：US09377399B2

公开(公告)日：2016-06-28

申请号：US13674839

申请日：2012-11-12

申请人： Lawrence Livermore National Security, LLC

发明人： Tiziana C Bond ,  Garrett Cole ,  Lynford Goddard

IPC分类号： G01N21/39 ,  H01S5/10 ,  H01S3/08 ,  H01S3/105 ,  H01S3/1055 ,  G01N21/77 ,  H01S5/183 ,  H01S5/00

CPC分类号： G01N21/39 ,  G01N21/774 ,  G01N2021/396 ,  G01N2021/399 ,  G01N2201/06113 ,  G01N2201/068 ,  H01S3/08059 ,  H01S3/1053 ,  H01S3/1055 ,  H01S5/0028 ,  H01S5/10 ,  H01S5/18366 ,  H01S5/18369 ,  H01S2302/00

摘要： Configurations for in-situ gas detection are provided, and include miniaturized photonic devices, low-optical-loss, guided-wave structures and state-selective adsorption coatings. High quality factor semiconductor resonators have been demonstrated in different configurations, such as micro-disks, micro-rings, micro-toroids, and photonic crystals with the properties of very narrow NIR transmission bands and sensitivity up to 10−9 (change in complex refractive index). The devices are therefore highly sensitive to changes in optical properties to the device parameters and can be tunable to the absorption of the chemical species of interest. Appropriate coatings applied to the device enhance state-specific molecular detection.

摘要翻译： 提供原位气体检测的结构，包括小型光子器件，低光损耗，导波结构和状态选择性吸附涂层。 已经在不同的配置中证明了高品质因子半导体谐振器，例如微盘，微环，微环形圈和具有非常窄的NIR透射带的性质的光子晶体和高达10-9的灵敏度（复折射率的变化 指数）。 因此，器件对于器件参数的光学性质的变化非常敏感，并且可以调节为感兴趣的化学物质的吸收。 施加到装置上的合适的涂层增强状态特异性分子检测。

公开(公告)号：US09347878B2

公开(公告)日：2016-05-24

申请号：US14422924

申请日：2013-08-09

申请人： THE SCIENCE AND TECHNOLOGY FACILITIES COUNCIL

发明人： Damien Weidmann ,  Richard Brownsword

IPC分类号： G01N21/00 ,  G01N21/39 ,  G01J3/42 ,  G01N21/3504

CPC分类号： G01N21/39 ,  G01J3/42 ,  G01J2003/423 ,  G01N21/3504 ,  G01N2021/396 ,  G01N2201/022 ,  G01N2201/06113

摘要： Method and apparatus for external cavity laser absorption spectroscopy There is disclosed an apparatus, and corresponding methods, for determining one or more characteristics of a sample in an absorption cell using laser absorption spectroscopy. For example, the characteristic may be concentration of a species in the sample. The apparatus comprises an external cavity semiconductor laser comprising a semiconductor gain medium within an optical resonator. The absorption cell is located within the optical resonator of the external cavity semiconductor laser so as to be optically coupled with the gain medium. A controller is arranged to provide a varied injection current to the semiconductor gain medium. A photodetector is arranged to detect laser light output by the external cavity semiconductor laser. An analyzer is arranged to determine one or more characteristics of the sample from behavior of the detected laser light output as a function of the varied injection current.

摘要翻译： 用于外腔激光吸收光谱的方法和装置公开了一种用于使用激光吸收光谱法确定吸收单元中的样品的一个或多个特性的装置和相应的方法。 例如，特征可以是样品中物种的浓度。 该装置包括在光谐振器内包括半导体增益介质的外腔半导体激光器。 吸收单元位于外腔半导体激光器的光学谐振器内，以便与增益介质光耦合。 控制器被布置成向半导体增益介质提供变化的注入电流。 光检测器被布置成检测由外腔半导体激光器输出的激光。 分析器被布置成根据检测到的激光输出的行为来确定样品的一个或多个特性作为改变的注入电流的函数。