公开(公告)号：US12115139B2

公开(公告)日：2024-10-15

申请号：US15998013

申请日：2018-08-15

申请人： Todd Alan Weinfield

发明人： Todd Alan Weinfield

IPC分类号： A61K31/14 ,  A61K9/00 ,  A61K31/095 ,  A61K31/155 ,  A61K31/17 ,  A61K31/45 ,  A61P31/10

CPC分类号： A61K31/14 ,  A61K9/0014 ,  A61K31/095 ,  A61K31/155 ,  A61K31/17 ,  A61K31/45 ,  A61P31/10 ,  A61K2300/00

摘要： A method of treating nail infections by using keratolytic, quaternary ammonium chloride, biguanide compounds and water heated above nail temperature.

公开(公告)号：US20240115570A1

公开(公告)日：2024-04-11

申请号：US18263733

申请日：2021-02-02

申请人： NeSA LLC ,  NEZU LIFE SCIENCE CO., LTD.

发明人： Takeshi NISHINO ,  Teruo KUSANO

IPC分类号： A61K31/519 ,  A61K31/095 ,  A61K31/122 ,  A61K31/355 ,  A61K31/375 ,  A61K31/426 ,  A61K31/444 ,  A61P31/12

CPC分类号： A61K31/519 ,  A61K31/095 ,  A61K31/122 ,  A61K31/355 ,  A61K31/375 ,  A61K31/426 ,  A61K31/444 ,  A61P31/12

摘要： An antiviral agent contains a xanthine oxidase inhibitor in combination with an active oxygen scavenger. A method for producing an antiviral agent includes combining a xanthine oxidase inhibitor-with an active oxygen scavenger. A method for treating a viral infectious disease, includes administering to a subject in need thereof a xanthine oxidase inhibitor in combination with an active oxygen scavenger.

公开(公告)号：US11896698B2

公开(公告)日：2024-02-13

申请号：US15763920

申请日：2016-09-30

申请人： RB HEALTH (US) LLC

发明人： Jessica Wilson ,  Sarah Frances de Szalay ,  Elizabeth Bruning ,  Rui Yang

IPC分类号： A61K8/44 ,  A61K8/34 ,  A61K8/365 ,  A61K8/46 ,  A61Q17/00 ,  A61Q19/10 ,  A61K8/45 ,  A61K8/20 ,  A61K31/095 ,  A61K8/86 ,  A61Q19/00 ,  A61K8/39 ,  A61K31/19 ,  A61K31/765 ,  A61K8/04 ,  A61K31/785 ,  A61K31/047 ,  A61K45/06 ,  A61K8/42

CPC分类号： A61K8/442 ,  A61K8/046 ,  A61K8/20 ,  A61K8/345 ,  A61K8/365 ,  A61K8/39 ,  A61K8/42 ,  A61K8/44 ,  A61K8/45 ,  A61K8/463 ,  A61K8/86 ,  A61K31/047 ,  A61K31/095 ,  A61K31/19 ,  A61K31/765 ,  A61K31/785 ,  A61K45/06 ,  A61Q17/005 ,  A61Q19/005 ,  A61Q19/10 ,  A61K2800/75 ,  A61K31/047 ,  A61K2300/00 ,  A61K31/19 ,  A61K2300/00 ,  A61K31/095 ,  A61K2300/00 ,  A61K31/765 ,  A61K2300/00 ,  A61K31/785 ,  A61K2300/00

摘要： A personal wash composition which provides an effective antimicrobial benefit against fungi, gram positive and gram negative bacteria, which composition comprises: a) from 0.1% to 10 wt % betaine surfactant, b) from 0.1% to 5.0 wt % lactic acid, c) from 0.1% to 20 wt % polyhydric C2-C6 alcohol, d) from 0% to 10 wt % alkyl polyethoxy carboxylate of the formula RO(CH2CH2O)kCH2COO−M+ wherein R is a C8-C22 alkyl, k is an integer from 0 to 20, and M is a soluble salt-forming cation, e) from 0% to 10 wt % alkyl polyethoxy amides of the formula RO(CH2CH2O)kCH2CONH2 wherein R is a C8-C22 alkyl, k is an integer from 0 to 20, f) >8 wt % alkyl ether sulphate, g) water, h) a pH of 3.8-4.5, i) 10-20 wt % total surfactant, j) from 0.1 to 10 wt % metal salt.

公开(公告)号：US20230321036A1

公开(公告)日：2023-10-12

申请号：US18009102

申请日：2021-06-10

申请人： Trustees of Tufts College

发明人： Qiaobing Xu ,  Yamin Li

IPC分类号： A61K31/4025 ,  A61K31/357 ,  A61K31/7048 ,  A61K31/095 ,  A61K9/14 ,  A61K47/28 ,  A61K31/69 ,  A61K47/68

CPC分类号： A61K31/4025 ,  A61K9/14 ,  A61K31/095 ,  A61K31/357 ,  A61K31/69 ,  A61K31/7048 ,  A61K47/28 ,  A61K47/6809

摘要： Disclosed are lipidoid compounds as well as lipidoid nanoparticles comprising such compounds.

公开(公告)号：US11779551B1

公开(公告)日：2023-10-10

申请号：US18049468

申请日：2022-10-25

申请人： Kathleen S. Rein ,  Yuan Liu

发明人： Kathleen S. Rein ,  Yuan Liu

IPC分类号： A61K31/095 ,  A61P31/00 ,  A61K31/375 ,  A61K31/145

CPC分类号： A61K31/095 ,  A61K31/145 ,  A61K31/375 ,  A61P31/00

摘要： The subject invention provides compounds as antitoxins for mitigating the toxic effects of algal toxins, e.g., brevetoxins. These compounds are mercaptan based compounds and derivatives that react rapidly with such toxins, e.g., brevetoxins and can be used to treat poisoning in a subject caused by such toxins. The subject invention also provides compositions comprising the mercaptan based compounds and derivatives for use to mitigate the toxic effects of brevetoxins. Further provided are methods of using the mercaptan based compounds and derivatives and compositions for treating and/or preventing brevetoxin poisoning in a subject such a human and marine animal.

公开(公告)号：US11712423B2

公开(公告)日：2023-08-01

申请号：US17222089

申请日：2021-04-05

申请人： Nicholas L. Abbott ,  Christopher J. Murphy

发明人： Nicholas L. Abbott ,  Christopher J. Murphy

IPC分类号： A61K38/17 ,  A61K47/42 ,  A61K9/70 ,  A61K48/00 ,  A61K9/00 ,  A61K45/06 ,  A61K31/00 ,  A61K31/095 ,  A61K31/375 ,  A61K31/66 ,  A61K31/70 ,  A61K31/7088 ,  A61K31/726 ,  A61K38/02 ,  A61K38/05

CPC分类号： A61K9/70 ,  A61K9/006 ,  A61K9/0014 ,  A61K9/0034 ,  A61K9/0043 ,  A61K9/0048 ,  A61K31/00 ,  A61K31/095 ,  A61K31/375 ,  A61K31/66 ,  A61K31/70 ,  A61K31/7088 ,  A61K31/726 ,  A61K38/02 ,  A61K38/05 ,  A61K38/1735 ,  A61K45/06 ,  A61K47/42 ,  A61K48/0075

摘要： The present invention relates to methods and compositions for modifying mucous membranes. In particular, the present invention relates to treating diseases associated with mucous membranes by changing the intrinsic chemical composition and/or physical features of a target mucous membrane.

公开(公告)号：US11679125B1

公开(公告)日：2023-06-20

申请号：US18067605

申请日：2022-12-16

申请人： EXELA PHARMA SCIENCES, LLC

发明人： John Maloney ,  Aruna Koganti ,  Phanesh Koneru

IPC分类号： A61K33/08 ,  A61K33/06 ,  A23L33/16 ,  A61K31/191 ,  A61K9/00 ,  A61K31/405 ,  A61K31/095 ,  A23L33/175 ,  A61K31/198 ,  A61K31/4172 ,  A61K31/401 ,  A61K33/28 ,  A61K33/241 ,  A61K33/36 ,  A61K33/00 ,  A61K47/02 ,  A61J1/14

CPC分类号： A61K33/06 ,  A23L33/16 ,  A23L33/175 ,  A61K9/0029 ,  A61K31/095 ,  A61K31/191 ,  A61K31/198 ,  A61K31/401 ,  A61K31/405 ,  A61K31/4172 ,  A61K33/00 ,  A61K33/241 ,  A61K33/28 ,  A61K33/36 ,  A61K47/02 ,  A23V2002/00 ,  A61J1/1412

摘要： The subject matter described herein is directed to stable L-cysteine compositions for injection, comprising: L-cysteine or a pharmaceutically acceptable salt thereof and/or hydrate thereof in an amount from about 10 mg/mL to about 100 mg/mL; Aluminum in an amount from about 1.0 parts per billion (ppb) to about 250 ppb; cystine in an amount from about 0.01 wt % to about 2 wt % relative to L-cysteine; pyruvic acid in an amount from about 0.01 wt % to about 2 wt % relative to L-cysteine; a pharmaceutically acceptable carrier, comprising water; headspace O2 that is less than 1.0%; dissolved oxygen present in the carrier in an amount from about 0.01 parts per million (ppm) to about 1 ppm, wherein the composition is enclosed in a single-use container having a volume of from 10 mL to 100 mL. Also described are compositions for a total parenteral nutrition regimen and methods for their use.

公开(公告)号：US20230172885A1

公开(公告)日：2023-06-08

申请号：US17924661

申请日：2021-05-11

申请人： The Regents of the University of California

发明人： John Vincent Fahy ,  Irina Gitlin ,  Wilfred Raymond

IPC分类号： A61K31/198 ,  A61P11/00 ,  A61P29/00 ,  A61K45/06 ,  A61P31/14 ,  A61K31/185 ,  A61K31/145 ,  A61K31/661 ,  A61K31/381 ,  A61K38/06 ,  A61K31/194 ,  A61K31/095

CPC分类号： A61K31/198 ,  A61P11/00 ,  A61P29/00 ,  A61K45/06 ,  A61P31/14 ,  A61K31/185 ,  A61K31/145 ,  A61K31/661 ,  A61K31/381 ,  A61K38/063 ,  A61K31/194 ,  A61K31/095

摘要： Provided herein, inter alia, are methods and compositions including thiol-containing compounds for treating coronavirus infection.

公开(公告)号：US11654186B2

公开(公告)日：2023-05-23

申请号：US16701644

申请日：2019-12-03

申请人： NUTRAMAX LABORATORIES, INC.

发明人： Brian Cornblatt ,  Grace Cornblatt ,  Anton Bzhelyansky ,  Robert Henderson

IPC分类号： A61K31/716 ,  A61K31/095 ,  A61K36/064 ,  A61K36/31 ,  A61K36/07 ,  A61K38/47 ,  A23L33/105 ,  A61K31/375 ,  A61K31/7028 ,  A61K33/06 ,  A61K9/14 ,  A61P3/06 ,  A61K31/26 ,  A61K45/06 ,  A61K9/00 ,  A61K9/28 ,  A61K31/194 ,  A61K47/42 ,  A61K31/19 ,  A61K36/28 ,  A61K36/06 ,  A61K31/357

CPC分类号： A61K38/47 ,  A23L33/105 ,  A61K9/0053 ,  A61K9/14 ,  A61K9/28 ,  A61K31/19 ,  A61K31/194 ,  A61K31/26 ,  A61K31/357 ,  A61K31/375 ,  A61K31/7028 ,  A61K31/716 ,  A61K33/06 ,  A61K36/06 ,  A61K36/07 ,  A61K36/28 ,  A61K36/31 ,  A61K45/06 ,  A61K47/42 ,  A61P3/06 ,  C12Y302/01147 ,  A23V2002/00 ,  A61K2300/00 ,  A61K38/47 ,  A61K2300/00 ,  A61K31/375 ,  A61K2300/00 ,  A61K31/26 ,  A61K2300/00 ,  A61K36/28 ,  A61K2300/00 ,  A61K36/06 ,  A61K2300/00 ,  A61K36/07 ,  A61K2300/00

摘要： The present disclosure relates to the synergistic combination of a sulforaphane precursor, an enzyme capable of converting the sulforaphane precursor to sulforaphane, a cofactor of the enzyme, and a glucan. The present disclosure also relates to the synergistic combination of sulforaphane or a derivative thereof and a glucan. The present disclosure also relates to the synergistic combination of a broccoli extract or powder and a glucan. The glucan may be a β-glucan. The glucan may be provided in a mushroom extract or powder selected from one or more of a maitake, a shiitake, or a reishi mushroom. Compositions and methods relating to these combinations are described.

公开(公告)号：US20230139771A1

公开(公告)日：2023-05-04

申请号：US17912660

申请日：2021-02-04

申请人： Wellington Silva

发明人： Wellington Silva

IPC分类号： A61K31/07 ,  A61K31/375 ,  A61K31/355 ,  A61K31/095 ,  A61K33/34 ,  A61K33/30 ,  A61K33/32 ,  A61K31/122 ,  A61K31/352 ,  A61K31/714 ,  A61K38/06 ,  A61K31/198 ,  A61K31/185 ,  A61K31/16 ,  A61K31/01 ,  A61K31/05

摘要： The present invention patent application relates essentially to an additive, the function of which is to enhance immunity, prevent various diseases and increase detoxification of the organism. The additive is composed of: 60 mcg of vitamin A; 4.5 mg of vitamin C; 1 mg of vitamin E; 3.4 mcg of selenium; 0.5 mg of copper; 0.7 mg of zinc; 0.23 mg of manganese; 3 mg of coenzyme Q10; 5 mg of pycnogenol; 0.13 mg of vitamin B2; 1.6 mg of vitamin B3; 0.13 mg of vitamin B6; 24 mcg of folic acid; 0.24 mcg of vitamin B12; 2 mg of glutathione; 100 mg of leucine; 20 mg of isoleucine; 20 mg of valine; 50 mg of glycine; 50 mg of taurine; 300 mg of glutamine; 60 mg of acetylcysteine; 50 mg of cysteine; 100 mg of methionine; 0.5 mg of vitamin B5; 2 mg of lycopene; and 4 mg of resveratrol.