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公开(公告)号：US20240343682A1
公开(公告)日：2024-10-17
申请号：US18755058
申请日：2024-06-26
申请人： City of Hope
发明人： Linda H. Malkas , David Horne , Robert J. Hickey , Long Gu
IPC分类号： C07C233/76 , A61K31/167 , A61K31/4409 , A61K31/4418 , A61K31/4725 , A61K33/243 , A61P35/00 , A61P35/02 , C07C237/22 , C07D213/68 , C07D217/26 , C07D401/12
CPC分类号： C07C233/76 , A61K31/167 , A61K31/4409 , A61K31/4418 , A61K31/4725 , A61K33/243 , A61P35/00 , A61P35/02 , C07C237/22 , C07D213/68 , C07D217/26 , C07D401/12
摘要： Described herein, inter alia, are compositions of PCNA modulators and methods for treating or preventing cancer.
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公开(公告)号：US12054447B2
公开(公告)日：2024-08-06
申请号：US17730948
申请日：2022-04-27
申请人： City of Hope
发明人： Linda H. Malkas , David Horne , Robert J. Hickey , Long Gu
IPC分类号： C07C233/76 , A61K31/167 , A61K31/4409 , A61K31/4418 , A61K31/4725 , A61K33/243 , A61P35/00 , A61P35/02 , C07C237/22 , C07D213/68 , C07D217/26 , C07D401/12
CPC分类号： C07C233/76 , A61K31/167 , A61K31/4409 , A61K31/4418 , A61K31/4725 , A61K33/243 , A61P35/00 , A61P35/02 , C07C237/22 , C07D213/68 , C07D217/26 , C07D401/12 , A61K33/24 , A61K2300/00 , A61K31/4725 , A61K2300/00 , A61K31/4418 , A61K2300/00
摘要： Described herein, inter alia, are compositions of PCNA modulators and methods for treating or preventing cancer.
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公开(公告)号：US11872226B2
公开(公告)日：2024-01-16
申请号：US17310512
申请日：2020-02-07
申请人： MEDIBIOFARMA, S.L.
发明人： Julio Castro Palomino Laria , Juan Camacho Gómez , Rodolfo Rodríguez Iglesias , Irene Velilla Martínez
IPC分类号： A61K31/505 , A61K31/195 , A61K31/277 , A61K31/341 , A61K31/381 , A61K31/415 , A61K31/4418 , C07C233/76 , C07C255/59 , C07D213/56 , C07D231/12 , C07D239/26 , C07D307/58 , C07D333/24
CPC分类号： A61K31/505 , A61K31/195 , A61K31/277 , A61K31/341 , A61K31/381 , A61K31/415 , A61K31/4418 , C07C233/76 , C07C255/59 , C07D213/56 , C07D231/12 , C07D239/26 , C07D307/58 , C07D333/24
摘要： The present invention relates to novel, optionally substituted, N-benzyl-2-phenoxybenzamide derivatives of formula (I), as modulators of EP4 and/or EP2 receptors of prostaglandin E2 (PGE2), to processes for their preparation, to pharmaceutical compositions comprising said compounds and to said compound for use in the treatment of pathological conditions, disorders or diseases that can improve by modulation of EP4 and/or EP2 receptors of prostaglandin E2 (PGE2) such as cancer disease, pain, inflammation, neurodegenerative diseases and kidney diseases.
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公开(公告)号：US20220395512A1
公开(公告)日：2022-12-15
申请号：US17663716
申请日：2022-05-17
申请人： TMEM16A Limited
发明人： Stephen Collingwood , Clive Mccarthy , Jonathan David Hargrave , Duncan Alexander Hay , Thomas Beauregard Schofield , Sarah Ellam , Craig Stephen Buxton , Matthew Habgood , Peter Neville Ingram , Chun Yan Ma , Spencer Charles Robert Napier , Abdul Kadar Shaikh , Matthew Raymond Smith , Christopher Charles Stimson , Edward Richard Walker
IPC分类号： A61K31/5377 , A61K31/167 , A61K31/351 , A61K31/4025 , A61K31/4045 , A61K31/416 , A61K31/44 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/498 , A61K45/06 , C07C233/76 , C07D209/18 , C07D213/81 , C07D231/56 , C07D309/14 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： Compounds of general formula (I): wherein R1, R2, R3, R4, R5a, R5b X1, X2, Z and Y are as defined herein are positive modulators of the calcium-activated chloride channel (CaCC), TMEM16A. The compounds are useful for treating diseases and conditions affected by modulation of TMEM16A, particularly respiratory diseases and conditions.
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5.发明申请公开(公告)号：US20220117962A1
公开(公告)日：2022-04-21
申请号：US17310512
申请日：2020-02-07
申请人： MEDIBIOFARMA, S.L.
发明人： Julio Castro Palomino Laria , Juan Camacho Gómez , Rodolfo Rodríguez Iglesias , Irene Velilla Martínez
IPC分类号： A61K31/505 , C07D213/56 , C07C233/76 , C07D239/26 , C07D333/24 , C07D231/12 , C07D307/58 , C07C255/59 , A61K31/4418 , A61K31/195 , A61K31/381 , A61K31/415 , A61K31/341 , A61K31/277
摘要： The present invention relates to novel, optionally substituted, N-benzyl-2-phenoxybenzamide derivatives of formula (I), as modulators of EP4 and/or EP2 receptors of prostaglandin E2 (PGE2), to processes for their preparation, to pharmaceutical compositions comprising said compounds and to said compound for use in the treatment of pathological conditions, disorders or diseases that can improve by modulation of EP4 and/or EP2 receptors of prostaglandin E2 (PGE2) such as cancer disease, pain, inflammation, neurodegenerative diseases and kidney diseases.
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公开(公告)号：US10550070B2
公开(公告)日：2020-02-04
申请号：US15760959
申请日：2016-09-16
申请人： City of Hope
发明人： Linda H. Malkas , David Horne , Robert J. Hickey , Long Gu
IPC分类号： C07C233/76 , A61K33/24 , A61K31/167 , A61P35/00 , A61P35/02 , C07D213/68 , A61K31/4409
摘要： Described herein, inter alia, are compositions of PCNA modulators and methods for treating or preventing cancer.
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公开(公告)号：US10407383B2
公开(公告)日：2019-09-10
申请号：US15114646
申请日：2015-02-03
申请人： BASF SE
IPC分类号： C07C237/52 , A01N37/10 , A01N37/18 , A01N37/46 , A01N43/20 , A01N43/40 , A01N43/54 , C07C63/70 , C07C69/78 , C07C233/65 , C07C233/66 , C07C233/76 , C07D213/40 , C07D213/75 , C07D239/26 , C07D239/42 , C07D239/48 , C07D331/04
摘要： The present invention relates to cyclopent(adi)ene compounds of formula I wherein the variables are as defined in the claims and description. The compounds are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds.
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公开(公告)号：US20180339960A1
公开(公告)日：2018-11-29
申请号：US15760959
申请日：2016-09-16
申请人： City of Hope
发明人： Linda H. Malkas , David Horne , Robert J. Hickey , Long Gu
IPC分类号： C07C233/76 , A61K33/24 , A61K31/167 , A61P35/00 , A61P35/02 , C07D213/68 , A61K31/4409
CPC分类号： C07C233/76 , A61K31/167 , A61K31/4409 , A61K31/4418 , A61K31/4725 , A61K33/24 , A61P35/00 , A61P35/02 , C07C237/22 , C07D213/68 , C07D217/26 , C07D401/12 , A61K2300/00
摘要： Described herein, inter alia, are compositions of PCNA modulators and methods for treating or preventing cancer.
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9.发明授权公开(公告)号：US09808003B2
公开(公告)日：2017-11-07
申请号：US14785470
申请日：2014-04-16
申请人： Syngenta Limited
发明人： Alaric James Avery , John Benjamin Taylor , Russell Colin Viner , Jeffery Steven Wailes , Ian Stuart Cloudsdale , John Kenneth Dickson, Jr. , Ian Henry Aspinall , Janice Black , Emma Briggs , Shuji Hachisu , Simon Hardy
IPC分类号： A01N37/18 , A01N37/40 , A01N43/00 , C07C233/00 , C07C235/46 , C07D213/81 , C07D213/82 , C07D215/48 , C07D237/24 , C07D239/52 , C07D241/24 , C07D307/68 , C07D333/38 , C07D401/12 , C07D401/14 , A01N43/40 , C07D231/14 , C07D231/56 , C07D233/90 , C07D239/28 , C07D471/04 , C07C233/76 , C07D207/46 , C07D277/56 , A01N25/32 , A01N43/08 , A01N43/10 , A01N43/16 , A01N43/38 , A01N43/42 , A01N43/52 , A01N43/54 , A01N43/56 , A01N43/58 , A01N43/60 , A01N43/76 , A01N43/78 , A01N43/80 , A01N43/82 , A01N47/06 , C07C233/31 , C07C233/32 , C07C235/60 , C07C233/61
CPC分类号： A01N37/18 , A01N25/32 , A01N37/40 , A01N43/08 , A01N43/10 , A01N43/16 , A01N43/38 , A01N43/40 , A01N43/42 , A01N43/52 , A01N43/54 , A01N43/56 , A01N43/58 , A01N43/60 , A01N43/76 , A01N43/78 , A01N43/80 , A01N43/82 , A01N47/06 , C07C233/31 , C07C233/32 , C07C233/61 , C07C233/76 , C07C235/46 , C07C235/60 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D207/46 , C07D213/81 , C07D213/82 , C07D215/48 , C07D231/14 , C07D231/56 , C07D233/90 , C07D237/24 , C07D239/28 , C07D239/52 , C07D241/24 , C07D277/56 , C07D307/68 , C07D333/38 , C07D401/12 , C07D401/14 , C07D471/04
摘要： The present invention relates to a compound of formula (I): wherein the substituents are as defined herein, and wherein the compound of formula (I) is optionally present as an agrochemically acceptable salt thereof. These compounds are thought to be suitable for use as herbicides. The invention therefore also relates to a method of controlling weeds, especially grassy monocotyledonous weeds, in crops of useful plants, comprising applying a compound of formula (I), or a herbicidal composition comprising such a compound, to the plants or to the locus thereof.
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10.发明授权公开(公告)号：US09802936B2
公开(公告)日：2017-10-31
申请号：US11869474
申请日：2007-10-09
IPC分类号： C07D487/04 , C07C233/31 , C07C233/76 , C07C235/46 , C07C235/48 , C07C235/50 , C07C235/54 , C07C237/32 , C07C271/20 , C07C275/24 , C07C311/20 , C07D207/14 , C07D211/56 , C07D211/58 , C07D309/14 , C07D317/54 , C07D319/18 , C07D321/08 , C07D335/02 , C07F9/36 , C07K14/705 , C07K14/72 , C12Q1/68
CPC分类号： C07D487/04 , C07C233/31 , C07C233/76 , C07C235/46 , C07C235/48 , C07C235/50 , C07C235/54 , C07C237/32 , C07C271/20 , C07C275/24 , C07C311/20 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D207/14 , C07D211/56 , C07D211/58 , C07D309/14 , C07D317/54 , C07D319/18 , C07D321/08 , C07D335/02 , C07F9/36 , C07K14/70567 , C07K14/721 , C12Q1/6897
摘要： This invention relates to a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene. The ligands comprise a class of ketones.
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