专利检索 ipc:C07D213/74 第 1 页

1.

发明公开
ARYLAMIDE DERIVATIVE HAVING ANTITUMOR ACTIVITY 审中-公开

公开(公告)号：US20240246922A1

公开(公告)日：2024-07-25

申请号：US18608369

申请日：2024-03-18

申请人： Chugai Seiyaku Kabushiki Kaisha

发明人： Yoshiaki Isshiki , Fumio Watanabe , Masaki Tomizawa , Kihito Hada , Kazuo Hattori , Kenichi Kawasaki , Ikumi Hyodo , Toshihiro Aoki

IPC分类号： C07D265/02 , C07C39/26 , C07C69/76 , C07C211/55 , C07C307/02 , C07C317/50 , C07C333/20 , C07D213/73 , C07D213/74 , C07D213/80 , C07D305/06 , C07D307/14 , C07D307/93 , C07D309/08 , C07D309/14 , C07D333/72 , C07D405/12 , C07D405/14 , C07D409/12 , C07D471/04 , C07F5/02 , C07F7/08

CPC分类号： C07D265/02 , C07C39/26 , C07C69/76 , C07C211/55 , C07C307/02 , C07C317/50 , C07C333/20 , C07D213/73 , C07D213/74 , C07D213/80 , C07D305/06 , C07D307/14 , C07D307/93 , C07D309/08 , C07D309/14 , C07D333/72 , C07D405/12 , C07D405/14 , C07D409/12 , C07D471/04 , C07F5/027 , C07F7/0812

摘要： The present disclosure provides, for example, a method of stabilizing the RAF/MEK complex in a subject, the method comprising administering to the subject an effective amount of a compound represented by the general formula below or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of the compound or salt:

wherein X1, X2, X3 and X4 are each independently —CR2═ or —N═, R2 is, for example, a halogen atom, R1 is, for example, —S(═O)2—NH—R8, R8 is, for example, a C1-6 alkyl group, R3 is, for example, a hydrogen atom, R5 is, for example, a halogen atom, R6 is, for example, a hydrogen atom, and R4 is, for example, a cyclopropyl group.

2.

发明公开
PRODRUGS OF KV7 CHANNEL OPENERS 审中-公开

公开(公告)号：US20240228434A1

公开(公告)日：2024-07-11

申请号：US18282940

申请日：2022-03-20

申请人： Xyzagen, Inc.

发明人： Christopher S. CREAN , Edward G. BROWN

IPC分类号： C07C271/28 , A61K31/216 , A61K31/44 , C07D213/74

CPC分类号： C07C271/28 , A61K31/216 , A61K31/44 , C07D213/74

摘要： Prodrugs of pharmacologically active 1,2,4-triaminobenzene derivatives of the General Formula (I); or pharmaceutically acceptable salts thereof, where the symbols R1, R2, R3, R4, R5 and R6a, R6b, and R6c and where the symbol Z are defined. Methods for the synthesis, purification, testing and use as prodrugs of pharmacologically-active agents at Kv7 ion channels are provided.

3.

发明公开
Novel 2-Pyrimidone Analogs as Potent Antiviral Agents Against Alphaviruses 审中-公开

公开(公告)号：US20240182450A1

公开(公告)日：2024-06-06

申请号：US18545749

申请日：2023-12-19

申请人： Southern Research Institute , Oregon Health and Science University

发明人： Ashish Kumar Pathak , Corinne E. Augelli-Szafran , Atefeh Garzan , Daniel Steblow , Nicole Haese

IPC分类号： C07D403/04 , C07D213/69 , C07D213/70 , C07D213/74 , C07D491/052 , C07D498/08

CPC分类号： C07D403/04 , C07D213/69 , C07D213/70 , C07D213/74 , C07D491/052 , C07D498/08

摘要： The present disclosure is concerned with 2-pyrimidone compounds that are capable of inhibiting a viral infection and methods of treating alphavirus viral infections such as, for example, chikungunya, Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), and Venezuelan equine encephalitis using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

4.

发明公开
COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING FERROPTOSIS AND TREATING EXCITOTOXIC DISORDERS 审中-公开

公开(公告)号：US20240156790A1

公开(公告)日：2024-05-16

申请号：US18518731

申请日：2023-11-24

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： Brent R. STOCKWELL , Arie ZASK , Hui TAN , Jacob D. DANIELS

IPC分类号： A61K31/4245 , A61K31/166 , A61K31/245 , A61K31/421 , A61K31/44 , A61K31/4439 , A61K31/5375 , A61P31/06 , A61P39/06 , C07C229/60 , C07C233/65 , C07D213/74 , C07D213/80 , C07D263/32 , C07D271/10 , C07D295/13 , C07D413/04 , C07D413/12

CPC分类号： A61K31/4245 , A61K31/166 , A61K31/245 , A61K31/421 , A61K31/44 , A61K31/4439 , A61K31/5375 , A61P31/06 , A61P39/06 , C07C229/60 , C07C233/65 , C07D213/74 , C07D213/80 , C07D263/32 , C07D271/10 , C07D295/13 , C07D413/04 , C07D413/12

摘要： The present disclosure provides, inter alia, a compound having the structure:

Also provided are compositions containing a pharmaceutically acceptable carrier and one or more compounds according to the present disclosure. Further provided are methods for treating or ameliorating the effects of an excitotoxic disorder in a subject, methods of modulating ferroptosis in a subject, methods of reducing reactive oxygen species (ROS) in a cell, methods for treating or ameliorating the effects of a neurodegenerative disease, methods for alleviating side effects in a subject undergoing radiotherapy and/or immunotherapy, and methods for treating or ameliorating the effects of an infection associated with ferroptosis in a subject.

5.

发明公开
MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 审中-公开

公开(公告)号：US20240132450A1

公开(公告)日：2024-04-25

申请号：US18257773

申请日：2021-12-17

申请人： ACADIA Pharmaceuticals Inc.

发明人： Martin Quibell , Tim Schulz-Utermoehl , Fraser Murray , Mark Pichowicz

IPC分类号： C07D215/08 , C07C235/22 , C07C235/24 , C07C237/40 , C07C237/42 , C07C255/54 , C07C317/32 , C07D209/12 , C07D213/56 , C07D213/64 , C07D213/74 , C07D239/34 , C07D239/42 , C07D265/30 , C07D295/135 , C07D317/58 , C07D401/12

CPC分类号： C07D215/08 , C07C235/22 , C07C235/24 , C07C237/40 , C07C237/42 , C07C255/54 , C07C317/32 , C07D209/12 , C07D213/56 , C07D213/64 , C07D213/74 , C07D239/34 , C07D239/42 , C07D265/30 , C07D295/135 , C07D317/58 , C07D401/12

摘要： Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: (I) wherein Ring A, Ring B, Ring C, R1, R2, R3, R4, R5, L, m, n, and p are as defined herein. The compounds are modulators of G-protein coupled receptor 88 (GPR88). Also disclosed are pharmaceutical compositions comprising the compounds; and the compounds for use in the treatment of diseases mediated by GPR88, including Tourette's Syndrome, Huntington's Disease (HD), Addiction, Parkinson's Disease (PD), Schizophrenia, Alzheimer's disease, and Attention Deficit Hyperactivity Disorder (ADHD).

6.

发明授权
Arylamide derivative having antitumor activity 有权

公开(公告)号：US11964950B2

公开(公告)日：2024-04-23

申请号：US17869226

申请日：2022-07-20

申请人： Chugai Seiyaku Kabushiki Kaisha

发明人： Yoshiaki Isshiki , Fumio Watanabe , Masaki Tomizawa , Kihito Hada , Kazuo Hattori , Kenichi Kawasaki , Ikumi Hyodo , Toshihiro Aoki

IPC分类号： C07D265/02 , C07C39/26 , C07C69/76 , C07C211/55 , C07C307/02 , C07C317/50 , C07C333/20 , C07D213/73 , C07D213/74 , C07D213/80 , C07D305/06 , C07D307/14 , C07D307/93 , C07D309/08 , C07D309/14 , C07D333/72 , C07D405/12 , C07D405/14 , C07D409/12 , C07D471/04 , C07F5/02 , C07F7/08

CPC分类号： C07D265/02 , C07C39/26 , C07C69/76 , C07C211/55 , C07C307/02 , C07C317/50 , C07C333/20 , C07D213/73 , C07D213/74 , C07D213/80 , C07D305/06 , C07D307/14 , C07D307/93 , C07D309/08 , C07D309/14 , C07D333/72 , C07D405/12 , C07D405/14 , C07D409/12 , C07D471/04 , C07F5/027 , C07F7/0812

摘要： The present disclosure provides, for example, a compound represented by the general formula below or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of the compound or salt:

wherein X1, X2, X3 and X4 are each independently —CR2═ or N═, R2 is, for example, a halogen atom, R1 is, for example, —S(═O)2—NH—R8, R8 is, for example, a C1-6 alkyl group, R3 is, for example, a hydrogen atom, R5 is, for example, a halogen atom, R6 is, for example, a hydrogen atom, and R4 is, for example, a cyclopropyl group. The compounds, salts or solvates provided by the present disclosure exhibit high RAF/MEK complex-stabilizing activity and can be used for the treatment or prevention of cell proliferative disorders, particularly cancers.

7.

发明公开
COMPOUNDS AND USE THEREOF FOR TREATMENT OF NEURODEGENERATIVE, DEGENERATIVE AND METABOLIC DISORDERS 审中-公开

公开(公告)号：US20240124466A1

公开(公告)日：2024-04-18

申请号：US18256995

申请日：2021-12-10

申请人： VOVA IDA THERAPEUTICS, INC. , SCRIPPS RESEARCH INSTITUTE, THE

发明人： Thomas D. BANNISTER , Corinne LASMEZAS , Minghai ZHOU , Nicole KENNEDY

IPC分类号： C07D487/04 , C07D213/34 , C07D213/61 , C07D213/74 , C07D231/12 , C07D231/56 , C07D233/64 , C07D237/30 , C07D249/08 , C07D271/06 , C07D285/08 , C07D333/18 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04 , C07D491/048 , C07D491/107 , C07D491/113 , C07D498/08

CPC分类号： C07D487/04 , C07D213/34 , C07D213/61 , C07D213/74 , C07D231/12 , C07D231/56 , C07D233/64 , C07D237/30 , C07D249/08 , C07D271/06 , C07D285/08 , C07D333/18 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04 , C07D491/048 , C07D491/107 , C07D491/113 , C07D498/08

摘要： Provided are, inter alia, compounds having a structure of Formula (X), or a pharmaceutically acceptable salt thereof composition including the same and methods of use. Ring A, L1, L2, W, R2A, R2B, and R10 are as described herein.

8.

发明公开
SYNTHESIS OF 3-NITRO-N-(2,2,2-TRIFLUOROETHYL)-4-PYRIDINAMINE 审中-公开

公开(公告)号：US20240101515A1

公开(公告)日：2024-03-28

申请号：US17754588

申请日：2020-10-29

申请人： JANSSEN SCIENCES IRELAND UNLIMITED COMPANY

发明人： Hongyu TAN , Licheng HAN

IPC分类号： C07D213/74

CPC分类号： C07D213/74

摘要： The present invention relates to a chemical synthesis route for preparing 3-nitro-N-(2,2,2-trifluoroethyl)-4-pyridinamine which compound can be used as an intermediate compound in the synthesis of RSV inhibiting imidazopyridines or imidazopyrimidines.