公开(公告)号：US09783507B2

公开(公告)日：2017-10-10

申请号：US15419217

申请日：2017-01-30

申请人： THERAVANCE BIOPHARMA R&D IP, LLC

发明人： Melissa Fleury ,  Anne-Marie Beausoliel ,  Adam D. Hughes ,  Daniel D. Long ,  Donna A. A. Wilton

IPC分类号： C07D295/24 ,  C07D205/04 ,  C07D267/02 ,  C07D317/10 ,  C07D249/04 ,  C07D249/10 ,  C07D231/14 ,  C07D261/18 ,  C07D263/34 ,  C07D263/38 ,  C07D271/07 ,  C07D213/81 ,  C07D239/28 ,  C07D231/20 ,  C07D275/03 ,  C07D471/04 ,  C07D403/12

CPC分类号： C07D249/04 ,  A61K31/415 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/42 ,  A61K31/421 ,  A61K31/4245 ,  A61K31/425 ,  A61K31/437 ,  A61K31/44 ,  A61K31/4985 ,  A61K31/505 ,  A61K45/06 ,  A61P9/04 ,  A61P9/12 ,  A61P13/12 ,  C07C229/34 ,  C07C271/22 ,  C07D213/81 ,  C07D231/14 ,  C07D231/18 ,  C07D231/20 ,  C07D233/70 ,  C07D233/90 ,  C07D235/08 ,  C07D237/14 ,  C07D239/28 ,  C07D239/34 ,  C07D249/10 ,  C07D249/12 ,  C07D249/18 ,  C07D261/12 ,  C07D261/18 ,  C07D263/18 ,  C07D263/34 ,  C07D263/38 ,  C07D271/07 ,  C07D275/03 ,  C07D295/10 ,  C07D309/40 ,  C07D319/06 ,  C07D401/04 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D471/04

摘要： In one aspect, the invention relates to compounds having the formula I: where R1-R6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds.

公开(公告)号：US08981094B2

公开(公告)日：2015-03-17

申请号：US12663013

申请日：2008-06-06

申请人： Jean-Pierre André Marc Bongartz ,  Joannes Theodorus Maria Linders ,  Lieven Meerpoel ,  Guy Rosalia Eugeen Van Lommen ,  Erwin Coesemans ,  Mirielle Braeken ,  Christophe Francis Robert Nestor Buyck ,  Monique Jenny Marie Berwaer ,  Katharina Antonia Germania J. M. De Waepenaert ,  Peter Walter Maria Roevens ,  Gustaaf Maria Boeckx ,  Petr Vladimirivich Davidenko

发明人： Jean-Pierre André Marc Bongartz ,  Joannes Theodorus Maria Linders ,  Lieven Meerpoel ,  Guy Rosalia Eugeen Van Lommen ,  Erwin Coesemans ,  Mirielle Braeken ,  Christophe Francis Robert Nestor Buyck ,  Monique Jenny Marie Berwaer ,  Katharina Antonia Germania J. M. De Waepenaert ,  Peter Walter Maria Roevens ,  Gustaaf Maria Boeckx ,  Petr Vladimirivich Davidenko

IPC分类号： C07D211/00 ,  C07D241/04 ,  C07D295/00 ,  C07D401/00 ,  C07D403/00 ,  C07D295/205 ,  C07D207/09 ,  C07D211/26 ,  C07D211/38 ,  C07D213/40 ,  C07D213/56 ,  C07D213/61 ,  C07D213/75 ,  C07D233/18 ,  C07D295/192 ,  C07D295/21 ,  C07D295/215 ,  C07D295/24 ,  C07D295/26 ,  C07D307/52 ,  C07D307/79 ,  C07D309/04 ,  C07D317/58 ,  C07D333/24

CPC分类号： C07D295/205 ,  C07D207/09 ,  C07D211/26 ,  C07D211/38 ,  C07D213/40 ,  C07D213/56 ,  C07D213/61 ,  C07D213/75 ,  C07D233/18 ,  C07D295/192 ,  C07D295/21 ,  C07D295/215 ,  C07D295/24 ,  C07D295/26 ,  C07D307/52 ,  C07D307/79 ,  C07D309/04 ,  C07D317/58 ,  C07D333/24

摘要： The invention relates to a DGAT inhibitor of formula (I): including any stereochemically isomeric form thereof, wherein A represents CH or N; the dotted line represents an optional bond in case A represents a carbon atom; X represents —C(═O)—; —O—C(═O)—; C(═O)—C(═O)—; —NRx—C(═O)—; —Z1—C(O)—; —Z1—NRx—C(═O)—; —C(═O)—Z1—; —NRx—C(═O)—Z1—; —S(═O)p-; —C(═S)—; —NRx—C(═S)—; —Z1—C(═S)—; —Z1—NRx—C(═S)—; —C(═S)—Z1-; —NRx—C(═S)—Z—; Y represents NRx—C(=0)-Z2—; —NRx—C(=0)-Z2—NRy—; —NRx—C(=0)-Z2—NRy—C(=0)-; —NRx—C(=0)-Z2—NRy—C(=0)-O—; —NRx—C(=0)-Z2-0-; —NRx—C(=0)-Z2-0-C(=0)-; —NRx—C(=0)-Z2—C(=0)-; —NRx—C(=0)-Z2—C(=0)-; —NRx—C(=0)-0-Z2—C(=0)-; —NRx—C(=0)-0-Z2—C(=0)-0-; —NRx—C(═O)—O—Z2—O—C(═O)—; —NRx—C(═O)—Z2—C(═O)—NRy—; —NRx—C(═O)—Z2—NRy—C(=0)-NRy—; —C(═O)—Z2—; —C(═O)—Z2—O—; —C(=0)-NRx—Z2—; —C(=0)-NRx—Z2-0-; —C(=0)-NRx—Z2—C(=0)-0-; —C(=0)-NRx—Z2-0-C(=0)-; —C(=0)-NRx—Z2—NRy—; —C(=0)-NRx—Z2—NRy—C(=0)-; —C(=0)-NRx—Z2—NRy—C(=0)-0-; R1 represents C1-12alkyl optionally substituted with cyano, C1-4alkyloxy, C1-4alkyl-oxyC1-4alkyloxy, C3-6Cycloalkyl or aryl; C2-6alkenyl; C2-6alkynyl; C3-6cycloalkyl; adamantanyl; aryl1; aryl1C1-6alkyl; Het1; or Het1C1-6alkyl; provided that when Y represents —NRX—C(═O)—Z2—; —NRx—C(=0)-Z2—NRy; —NRX—C(═O)—Z2—C(═O)—NRy—; —C(═O)—Z2—; —NRx—C(=0)-Z2—NRy—C(=0)-NRy—; —C(═O)—NRX—Z2—; —C(═O)—NRX—O—Z2—; or —C(=0)-NRx—Z2—NRy—; then R1 may also represent hydrogen; R2 represents hydrogen, C1-12alkyl, C2-6alkenyl or R3; provided that if X represents —O—C(═O)—; the R2 represents R3; and provided that (A) is excluded; a N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use as a medicine of said compounds.

公开(公告)号：US08765765B2

公开(公告)日：2014-07-01

申请号：US12600826

申请日：2008-05-15

申请人： Eva Againe Csongor ,  Norbert Antal Kirschner ,  Eva Schmidt ,  Istvan Gyertyan ,  Bela Kiss

发明人： Eva Againe Csongor ,  Norbert Antal Kirschner ,  Eva Schmidt ,  Istvan Gyertyan ,  Bela Kiss

IPC分类号： A61K31/495 ,  C07D295/096 ,  C07D295/112 ,  C07D295/24 ,  C07D295/135

CPC分类号： C07D295/135 ,  C07D295/24

摘要： The present invention relates to metabolites of(thio)-carbamoyl cyclohexane derivatives, particularly, metabolites of trans-4-{2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl}-N,N-dimethylcarbamoyl-cyclohexylamine and pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing the same and to their use in the treatment and/or prevention of a conditions which requires modulation of dopamine receptors.

摘要翻译： 本发明涉及（硫代） - 氨基甲酰基环己烷衍生物的代谢物，特别是反式-4- {2- [4-（2,3-二氯苯基） - 哌嗪-1-基] - 乙基} -N，N - 二甲基氨基甲酰基 - 环己胺及其药学上可接受的盐，用于含有该组合物的药物组合物及其在治疗和/或预防需要调节多巴胺受体的病症中的用途。

公开(公告)号：US07985594B2

公开(公告)日：2011-07-26

申请号：US12300529

申请日：2007-05-10

申请人： Robert G. Griffin ,  Kan-Nian Hu ,  Timothy M. Swager ,  Changsik Song ,  Eric Dane

发明人： Robert G. Griffin ,  Kan-Nian Hu ,  Timothy M. Swager ,  Changsik Song ,  Eric Dane

IPC分类号： G01N24/00 ,  C07D471/02 ,  C07D295/24

CPC分类号： G01R33/281 ,  C07D401/12 ,  G01N24/087 ,  G01R33/465 ,  G01R33/5601 ,  Y10T436/24

摘要： The present invention provides methods for performing dynamic nuclear polarization using biradicals with a structure of formula (I) as described herein. In general, the methods involve (a) providing a frozen sample in a magnetic field, wherein the frozen sample includes a biradical of formula (I) and an analyte with at least one spin half nucleus; (b) polarizing the at least one spin half nucleus of the analyte by irradiating the frozen sample with radiation having a frequency that excites electron spin transitions in the biradical; (c) optionally melting the sample to produce a molten sample; and (d) detecting nuclear spin transitions in the at least one spin half nucleus of the analyte in the frozen or molten sample. The present invention also provides biradicals with a structure of formula (I) with the proviso that Q1 and Q2 are different when X1 and X2 are —O—. The present invention also provides methods for making biradicals with a structure of formula (IA) as described herein.

摘要翻译： 本发明提供使用如本文所述的式（I）结构的双基进行动态核极化的方法。 通常，所述方法包括（a）在磁场中提供冷冻样品，其中所述冷冻样品包括式（I）的双基和具有至少一个自旋半核的分析物; （b）通过用具有激发双向电子自旋跃迁的频率的辐射照射冷冻样品来使分析物的至少一个自旋半核偏振; （c）任选地熔化样品以产生熔融样品; 和（d）检测冷冻或熔融样品中分析物的至少一个旋转半核中的核自旋跃迁。 本发明还提供具有式（I）结构的双基，条件是当X 1和X 2为-O-时，Q 1和Q 2不同。 本发明还提供了如本文所述制备具有式（IA）结构的双基质的方法。

公开(公告)号：US06875831B1

公开(公告)日：2005-04-05

申请号：US10019618

申请日：2000-06-26

申请人： Andreas Kramer ,  Peter Nesvadba ,  Marie-Odile Zink ,  Wiebke Wunderlich

发明人： Andreas Kramer ,  Peter Nesvadba ,  Marie-Odile Zink ,  Wiebke Wunderlich

IPC分类号： C07D241/08 ,  C07C239/20 ,  C07D211/94 ,  C07D295/24 ,  C07D401/14 ,  C07F7/18 ,  C07F9/40 ,  C08F4/00 ,  C08F4/32 ,  C08F2/00

CPC分类号： C07D295/24 ,  C07D211/94 ,  C07F7/1804 ,  C07F9/4006 ,  C08F4/00

摘要： The invention pertains to a compound of formula (I), (II) or (III) wherein R1 and R2 are independently of each other hydrogen, C1-C18alkyl, C3-C18alkenyl, C3-C18alkinyl or phenyl which are unsubstituted or substituted by NO2, halogen, amino, hydroxy, cyano, carboxy, C1-C4alkoxy, C1-C4alkylthio, C1-C4alkylamino or di(C1-C4alkyl)amino; A is a group capable of forming a stable free nitroxyl radical A*, which is bound via its oxygen atom to the carbon atom; Y is O, NR3 or CHR3—Xa, wherein Xa is O, S or NR3; R3 is hydrogen, C1-C18alkyl, C3-C18alkenyl, C3-C18alkinyl or phenyl which are unsubstituted or substituted by NO2, halogen, amino, hydroxy, cyano, carboxy, C1-C4alkoxy, C1-C4alkylthio, C1-C4alkylamino or di(C1-C4alkyl)amino; Q1 is an organic or inorganic radical, derived from a compound having at least one functional group being capable of reacting with a hydroxy group; Q2 is an organic radical derived from a mono or polyfunctional alcohol, mono or polyfunctional aminoalcohol, mono or polyfunctional amine mono or polyfunctional mercaptane, mono or polyfunctional phenol or mono or polyfunctional thiophenol; and n is a number from 1 to 20; with the proviso, that in formula (I) if n is 1, Q1 is not or if n is 2, R1 is H and R2 is —CH2—O-tert-butyl, A is not 2,2,6,6-tetramethylpiperidine or 2,2,6,6-tetramethylpiperidine-4-carboxylic acid. Further subjects of the invention are a composition comprising above compounds and at least one ethylenically unsaturated monomer, process for polymerization and the (co)polymers obtained therefrom.

摘要翻译： 本发明涉及式（I），（II）或（III）的化合物，其中R 1和R 2彼此独立地为氢，C 1 -C 18烷基，C 3 -C 18烯基，C 3 -C 18炔基或苯基，其未被取代或被NO 2 ，卤素，氨基，羟基，氰基，羧基，C 1 -C 4烷氧基，C 1 -C 4烷硫基，C 1 -C 4烷基氨基或二（C 1 -C 4烷基）氨基; A是能够形成稳定的游离硝酰基A *的基团，其通过其氧原子与碳原子结合; Y是O，NR 3或CHR 3 -Xa，其中X a是O，S或NR 3; R3是氢，C1-C18烷基，C3-C18链烯基，C3-C18链烯基或未被NO2，卤素，氨基，羟基，氰基，羧基，C1-C4烷氧基，C1-C4烷硫基，C1-C4烷基氨基或二（C1 -C 1-4烷基）氨基; Q1是具有至少一个能够与羟基反应的官能团的化合物衍生的有机或无机基团; Q2是衍生自单官能或多官能醇，单或多官能氨基醇，单官能或多官能胺单官能或多官能硫醇，单或多官能苯酚或单官能或多官能苯硫酚的有机基团; n为1〜20的数; 条件是式（I）中n为1时，如果n为2，则Q1为原子，R1为H，R2为-CH2-0-叔丁基，A为2,2,6,6-四甲基哌啶 或2,2,6,6-四甲基哌啶-4-羧酸。 本发明的其它主题是包含上述化合物和至少一种烯属不饱和单体，聚合方法和由其获得的（共）聚合物）的组合物。

公开(公告)号：US5847129A

公开(公告)日：1998-12-08

申请号：US843722

申请日：1997-04-17

申请人： Peter Harfmann ,  Stephan Astegger

发明人： Peter Harfmann ,  Stephan Astegger

IPC分类号： C02F1/32 ,  C02F1/72 ,  C07D295/24 ,  C07D295/28 ,  D01F2/00 ,  D01F13/02

CPC分类号： C07D295/24 ,  C02F1/32 ,  C02F1/722 ,  C07D295/28 ,  D01F13/02 ,  D01F2/00 ,  Y02P70/627

摘要： The invention is concerned with a process for the destruction of N-nitrosomorpholine in an aqueous solution containing N-nitrosomorpholine and a peroxidic oxidant, characterized in that said aqueous solution is exposed to ultraviolet radiation having a wavelength of substantially 254 nm.

摘要翻译： 本发明涉及在含有N-亚硝基吗啉和过氧化物氧化剂的水溶液中破坏N-亚硝基吗啉的方法，其特征在于所述水溶液暴露于波长基本为254nm的紫外线辐射。

公开(公告)号：US5567692A

公开(公告)日：1996-10-22

申请号：US443612

申请日：1995-05-18

申请人： Phaik-Eng Sum ,  Ving J. Lee ,  Raymond T. Testa

发明人： Phaik-Eng Sum ,  Ving J. Lee ,  Raymond T. Testa

IPC分类号： A61K31/65 ,  A61P31/00 ,  A61P31/04 ,  C07C20060101 ,  C07C237/26 ,  C07C239/18 ,  C07C239/20 ,  C07C255/50 ,  C07C271/22 ,  C07C323/29 ,  C07D207/06 ,  C07D207/14 ,  C07D207/16 ,  C07D207/30 ,  C07D209/02 ,  C07D211/14 ,  C07D211/56 ,  C07D213/40 ,  C07D213/74 ,  C07D221/22 ,  C07D231/12 ,  C07D231/14 ,  C07D241/04 ,  C07D241/14 ,  C07D249/02 ,  C07D249/04 ,  C07D249/08 ,  C07D265/28 ,  C07D279/04 ,  C07D295/14 ,  C07D295/15 ,  C07D295/215 ,  C07D295/24 ,  C07D307/33 ,  C07D333/20 ,  C07D333/36 ,  C07F15/00

CPC分类号： C07D213/40 ,  C07C237/26 ,  C07C239/18 ,  C07C239/20 ,  C07C271/22 ,  C07D295/15 ,  C07D295/215 ,  C07D295/24 ,  C07D333/20 ,  C07C2103/46

摘要： The invention provides a method for prevention, treatment or control of bacterial infections in warm blooded animals by administering a pharmacologically effect amount of a compound of the formula: ##STR1## wherein R, R.sup.1 and W are defined in the specification.

摘要翻译： 本发明提供了一种通过施用药理作用量的下式化合物其中R，R 1和W在说明书中定义的方法来预防，治疗或控制温血动物细菌感染的方法。

公开(公告)号：US5481036A

公开(公告)日：1996-01-02

申请号：US179195

申请日：1994-01-10

申请人： Hajime Morishima ,  Yutaka Koike ,  Masato Nakano ,  Shugo Atsuumi ,  Seiichi Tanaka ,  Kenji Matsuyama

发明人： Hajime Morishima ,  Yutaka Koike ,  Masato Nakano ,  Shugo Atsuumi ,  Seiichi Tanaka ,  Kenji Matsuyama

IPC分类号： A61K31/195 ,  A61K31/535 ,  C07C59/66 ,  C07C317/00 ,  C07C317/44 ,  C07C323/43 ,  C07D207/08 ,  C07D211/14 ,  C07D215/12 ,  C07D233/54 ,  C07D239/38 ,  C07D257/04 ,  C07D265/30 ,  C07D285/12 ,  C07D285/125 ,  C07D295/084 ,  C07D295/12 ,  C07D295/125 ,  C07D295/13 ,  C07D295/24 ,  C07D307/38 ,  C07D319/18 ,  C07D401/12 ,  C07F7/18 ,  C07C321/00

CPC分类号： C07D207/08 ,  C07C323/00 ,  C07C323/43 ,  C07C59/66 ,  C07D211/14 ,  C07D215/12 ,  C07D233/64 ,  C07D239/38 ,  C07D257/04 ,  C07D285/125 ,  C07D295/084 ,  C07D295/125 ,  C07D295/13 ,  C07D295/24 ,  C07D307/38 ,  C07D319/18 ,  C07D401/12 ,  C07F7/1856

摘要： An N-acylamino acid derivative of the formula: ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.4 and R.sup.6 is hydrogen lower alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl or a monocyclic or bicyclic heterocyclic group containing from to 4 hetero atoms; each of R.sup.3 and R.sup.5 is hydrogen or lower alkyl; A is --CH(OH)--(CH.sub.2).sub.q R.sup.7 wherein R.sup.7 is hydrogen, lower alkyl, cycloalkyl, cyloalkylalkyl, aryl, aralkyl, a monocyclic or bicyclic heterocyclic group containing from to 4 hereto atoms or --E--R.sup.10 wherein E is --S(O).sub.i -- wherein i is 0, 1 or 2, oxygen, --NR.sup.11 -- wherein R.sup.11 is hydrogen, lower alkyl, cycloalkyl, cycloalkylalkyl, aryl or aralkyl, or ##STR2## wherein each of R.sup.12 and R.sup.13 is hydrogen, lower alkyl cycloalkyl, cycloalkylalkyl, aryl or aralkyl, and R.sup.10 is hydrogen, lower alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl or a monocyclic or bicyclic heterocyclic group containing from 1 to 4 hetero atoms provided that when R.sup.10 is hydrogen, i is 0, and a is an integer of from 0 to 5; or --CH.sub.2 --CHR.sup.8 --CO--R.sup.9 wherein R.sup.8 is hydrogen, lower alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl or a monocyclic or bicyclic heterocyclic group containing from 1 to 4 hetero atoms, and R.sup.9 is hydroxyl, --OX wherein X is alkyl, aryl, lower alkoxycarbonyloxyalkyl or 1-phthalidyl, or --N(Y.sup.1) (Y.sup.2) wherein each of Y.sup.1 and Y.sup.2 is hydrogen, lower alkyl, aryl, aralkyl or cycloalkyl, or Y and.sup.1 and Y.sup.2 form together with the adjacent nitrogen atom a 5- or 6-membered heterocyclic group which may contain a further hereto atom; m is 0, 1 or 2; and n is an integer of from 1 to 5, provided that when R.sup.1 is hydrogen, m is 0; or a salt thereof, which is useful as hypotensive drugs.

摘要翻译： 下式的N-酰基氨基酸衍生物：其中R 1，R 2，R 4和R 6各自为氢低级烷基，环烷基，环烷基烷基，芳基，芳烷基或含有4个杂原子的单环或双环杂环基 原子 R 3和R 5各自为氢或低级烷基; A是-CH（OH） - （CH 2）q R 7，其中R 7是氢，低级烷基，环烷基，环烷基烷基，芳基，芳烷基，含有至4原子的单环或双环杂环基或-E-R 10，其中E是-S （O）i-其中i是0,1或2，氧，-NR 11 - ，其中R 11是氢，低级烷基，环烷基，环烷基烷基，芳基或芳烷基，或者其中R 12和R 13各自是氢， 环烷基，环烷基烷基，芳基或芳烷基，R 10为含有1至4个杂原子的氢，低级烷基，环烷基，环烷基烷基，芳基，芳烷基或单环或双环杂环基，条件是当R 10为氢时，i为0， 是从0到5的整数; 或-CH 2 -CHR 8 -CO-R 9，其中R 8是氢，低级烷基，环烷基，环烷基烷基，芳基，芳烷基或含有1至4个杂原子的单环或双环杂环基，并且R 9是羟基， ，芳基，低级烷氧基羰氧基烷基或1-苯酞基，或-N（Y1）（Y2），其中Y1和Y2各自为氢，低级烷基，芳基，芳烷基或环烷基，或Y和1和Y2与相邻的氮原子一起形成 可含有其它原子的5-或6-元杂环基; m为0,1或2; 且n为1至5的整数，条件是当R 1为氢时，m为0; 或其盐，其可用作降压药物。

公开(公告)号：US5122523A

公开(公告)日：1992-06-16

申请号：US240725

申请日：1988-09-06

申请人： Hajime Morishima ,  Yutaka Koike ,  Masato Nakano ,  Shugo Atsuumi ,  Seiichi Tanaka ,  Kenji Matsuyama

发明人： Hajime Morishima ,  Yutaka Koike ,  Masato Nakano ,  Shugo Atsuumi ,  Seiichi Tanaka ,  Kenji Matsuyama

IPC分类号： A61K31/195 ,  A61K31/535 ,  C07C59/66 ,  C07C317/00 ,  C07C317/44 ,  C07C323/43 ,  C07D207/08 ,  C07D211/14 ,  C07D215/12 ,  C07D233/54 ,  C07D239/38 ,  C07D257/04 ,  C07D265/30 ,  C07D285/12 ,  C07D285/125 ,  C07D295/084 ,  C07D295/12 ,  C07D295/125 ,  C07D295/13 ,  C07D295/24 ,  C07D307/38 ,  C07D319/18 ,  C07D401/12 ,  C07F7/18

CPC分类号： C07D207/08 ,  C07C323/00 ,  C07C323/43 ,  C07C59/66 ,  C07D211/14 ,  C07D215/12 ,  C07D233/64 ,  C07D239/38 ,  C07D257/04 ,  C07D285/125 ,  C07D295/084 ,  C07D295/125 ,  C07D295/13 ,  C07D295/24 ,  C07D307/38 ,  C07D319/18 ,  C07D401/12 ,  C07F7/1856

摘要： An N-acylamino acid derivative of the formula: ##STR1## wherein the substituents are herein defined or a salt thereof, which is useful as hypotensive drugs.

公开(公告)号：US4748241A

公开(公告)日：1988-05-31

申请号：US11526

申请日：1987-02-06

申请人： Heinz Scholten ,  Klaus Rindtorff

发明人： Heinz Scholten ,  Klaus Rindtorff

IPC分类号： C07D295/22 ,  C07D295/24

CPC分类号： C07D295/24

摘要： N-methylmorpholine-N-oxide is prepared by reacting the azeotrope of methylmorpholine and water with an aqueous solution of hydrogen peroxide. The reaction solution product is thereupon concentrated to the desired content in N-methylmorpholine-N-oxide.

摘要翻译： 通过使甲基吗啉与水的共沸物与过氧化氢水溶液反应制备N-甲基吗啉-N-氧化物。 然后将反应溶液产物浓缩至N-甲基吗啉-N-氧化物中所需的含量。