公开(公告)号：US12195608B2

公开(公告)日：2025-01-14

申请号：US17394962

申请日：2021-08-05

Applicant: TOPPAN INC. ,  THE UNIVERSITY OF TOKYO

Inventor： Nao Nishijima ,  Shuji Fujisawa

IPC: C08L1/02 ,  C08B37/00 ,  C08B37/08 ,  C08F2/16 ,  C08F2/22 ,  C08F2/44 ,  C08F12/36 ,  C08J3/12 ,  C08L5/08

Abstract: What is provided is a method for producing a composite-particle composition including a first step of obtaining a dispersion liquid of fine fibers; a second step of coating a surface of liquid droplets of a polymerizable monomer or a polymer with the fine fibers in the dispersion liquid to stabilize the liquid droplets as an emulsion; a third step of polymerizing the liquid droplets of the polymerizable monomer or the polymer to obtain composite particles including the polymer coated with the fine fibers; and a fourth step of adsorbing a compound that forms an ionic bond in a pair with an ionic functional group of the fine fibers onto the fine fibers in the surface of the composite particles.

公开(公告)号：US20250011585A1

公开(公告)日：2025-01-09

申请号：US18733235

申请日：2024-06-04

Applicant: Board of Regents, The University of Texas System

Inventor： Sylvia Lucia Natividad-Diaz ,  Britanny L. Stark

IPC: C08L5/08 ,  C08B37/08

Abstract: An engineered material includes methacrylated hyaluronic acid conjugated with 3-thiophene acetic acid or with poly(3-thiophene) acetic acid. Preparation can include Fischer esterification of methacrylated hyaluronic acid with 3-thiophene acetic acid or with poly(3-thiophene) acetic acid in the presence of an acid activator to produce methacrylated hyaluronic acid conjugated with 3-thiopheneacetic acid or with poly(3-thiophene) acetic acid. Precursor preparation can include doping the 3-thiophene acetic acid or poly(3-thiophene) acetic acid with iodine for example to influence conductivity.

公开(公告)号：US12186397B2

公开(公告)日：2025-01-07

申请号：US16173769

申请日：2018-10-29

Applicant: National Cheng Kung University

Inventor： Lynn L. H. Huang

IPC: A61K47/34 ,  A61K38/18 ,  A61K38/19 ,  A61K38/30 ,  A61L24/00 ,  A61L24/08 ,  A61L24/10 ,  A61L27/20 ,  A61L27/22 ,  A61L27/24 ,  A61L27/38 ,  A61L27/44 ,  A61L27/52 ,  A61L27/54 ,  C08B11/02 ,  C08B11/12 ,  C08B15/00 ,  C08B15/10 ,  C08B37/00 ,  C08B37/08 ,  C08G12/46 ,  C08H1/00 ,  C08H1/06 ,  C08L5/08 ,  C08L89/06 ,  C09J105/08 ,  C12N5/00 ,  C08G69/10 ,  C08L77/04

Abstract: A cell tissue gel, comprising one or more matrix molecules cross-linked with a cross-linking agent, and a quenching agent bound to a reactive group of the cross-linking agent, wherein the quenching agent contains a moiety that is capable of reacting with the reactive group of the cross-linking agent and the one or more matrix molecules contain one or more functional groups that are capable of cross-linking with the reactive group, the amount of the reactive group of the cross-linking agent being equal to or less than a total amount including the amount of the one or more functional groups and the amount of the moiety.

公开(公告)号：US12162961B2

公开(公告)日：2024-12-10

申请号：US17082370

申请日：2020-10-28

Applicant: COMMISSARIAT À L'ENERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES

Inventor： Olivier Raccurt ,  Aurélien Auger

IPC: C08B37/08 ,  G01N21/78 ,  H01M10/0525 ,  H01M10/48

Abstract: A material that can be used for detecting at least one alkaline element in cationic form chosen from polymers or inorganic materials, the material being functionalised by at least one group, referred to as group A, comprising one or more aromatic rings, the or all or a portion of the aromatic rings comprising at least one imine substituent and the or all or a portion of the aromatic rings comprising at least one atom carrying a free doublet within the or all or a portion of the rings and/or at least one other substituent different from an imine substituent comprising at least one atom carrying a free doublet.

公开(公告)号：US12071489B2

公开(公告)日：2024-08-27

申请号：US17318845

申请日：2021-05-12

Applicant: CORNELL UNIVERSITY

Inventor： Dan Luo ,  Dong Wang

IPC: C08B37/00 ,  B01D11/02 ,  C08B37/08 ,  C08J3/09

CPC classification number: C08B37/0003 ,  B01D11/0288 ,  C08B37/003 ,  C08J3/09 ,  C08J2367/04

Abstract: Crosslinked nucleotide polymers. A crosslinked nucleotide polymer may be formed by reaction of a biomass comprising DNA and/or RNA with one or more crosslinker(s). A crosslinked nucleotide polymers may be formed by a crosslinking reaction including an aza-Michael addition reaction. Crosslinked nucleotide polymers may be present in various forms and compositions and form various articles of manufacture. Crosslinked nucleotide polymers may be used in therapeutic methods, coating methods, and cell-free protein production methods.

公开(公告)号：US20240199822A1

公开(公告)日：2024-06-20

申请号：US18590007

申请日：2024-02-28

Applicant: Galderma Holding SA

Inventor： Johan OLSSON ,  Craig Steven HARRIS

IPC: C08J3/075 ,  A61K8/04 ,  A61K8/73 ,  A61K9/00 ,  A61Q19/00 ,  C07C209/62 ,  C07C213/00 ,  C07C269/06 ,  C07F7/08 ,  C08B37/00 ,  C08B37/08 ,  C08J3/24 ,  C08J7/14 ,  C08K5/09 ,  C08L5/00 ,  C08L5/08

CPC classification number: C08J3/075 ,  A61K8/042 ,  A61K8/73 ,  A61K8/735 ,  A61K9/0019 ,  A61Q19/00 ,  C07C209/62 ,  C07C213/00 ,  C07C269/06 ,  C07F7/083 ,  C08B37/0063 ,  C08B37/0069 ,  C08B37/0072 ,  C08J3/24 ,  C08J7/14 ,  C08K5/09 ,  C08L5/00 ,  C08L5/08 ,  C07C2603/18 ,  C08J2305/00 ,  C08J2305/08

Abstract: A method of preparing a hydrogel product including crosslinked glycosaminoglycan molecules, said method including: i) providing a glycosaminoglycan crosslinked by amide bonds, wherein the crosslinked glycosaminoglycans include residual amine groups; and ii) acylating residual amine groups of the crosslinked glycosaminoglycans provided in i) to form acylated crosslinked glycosaminoglycans.

公开(公告)号：US20240182651A1

公开(公告)日：2024-06-06

申请号：US18168938

申请日：2023-02-14

Applicant: Win Coat Corporation

Inventor： Ta-Jo LIU ,  Hsiu-Feng YEH ,  Shin-Yi YIN ,  Yi-Jyun LIAO ,  Ying-Hua HSU

IPC: C08J3/075 ,  C08B37/08 ,  C08J3/28

CPC classification number: C08J3/075 ,  C08B37/0072 ,  C08J3/28 ,  C08J2305/08 ,  C08J2367/07

Abstract: Provided is a hydrogel composition, which comprises a modified HA, PEGDA and water; wherein, based on a total weight of the hydrogel composition, a content of the modified HA is 1 wt % to 7 wt % and a content of PEGDA is 43 wt % to 49 wt %; the modified HA is obtained by modifying HA with methacrylic anhydride; an average molecular weight of PEGDA is 1 kDa to 10 kDa. The hydrogel composition of the present invention has good compatibility of raw materials, which does not cause HA precipitation, and a hydrogel material produced therefrom simultaneously has good mechanical properties, good swell capability and good biocompatibility, such that the hydrogel material can be applied in many fields.

公开(公告)号：US20240132630A1

公开(公告)日：2024-04-25

申请号：US18480242

申请日：2023-10-03

Applicant: Navidea Biopharmaceuticals, Inc.

Inventor： Jeffrey Scott Arnold ,  David A. Ralph

IPC: C08B37/02 ,  A61K31/717 ,  A61K31/721 ,  A61K31/722 ,  A61K31/728 ,  C08B37/00 ,  C08B37/08

CPC classification number: C08B37/0021 ,  A61K31/717 ,  A61K31/721 ,  A61K31/722 ,  A61K31/728 ,  C08B37/003 ,  C08B37/0072 ,  C08B37/0087

Abstract: Provided are methods of attaching a mannose-binding C-type lectin receptor targeting moiety to a polymeric carbohydrate backbone using an amide linkage. The amide linkage may be found between a leash, such as an amine terminated leash, and the mannose-binding C-type lectin receptor targeting moieties. The compounds and compositions disclosed utilizing the amide linkage provide for highly stable compounds with a significant reduction in loss of mannose-binding C-type lectin receptor targeting moieties from the polymeric carbohydrate backbone.

公开(公告)号：US20240124656A1

公开(公告)日：2024-04-18

申请号：US18474363

申请日：2023-09-26

Applicant: POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION

Inventor： Hyung Joon Cha ,  Jae Yun Lee ,  Jin Young Yun ,  Hyun Tack Woo

IPC: C08H1/00 ,  C07K14/435 ,  C08B37/08

CPC classification number: C08H1/00 ,  C07K14/43504 ,  C08B37/0072

Abstract: The present disclosure relates to a conductive hydrogel including a mussel adhesive protein, a liquid metal, and hyaluronic acid and a preparation method thereof.

公开(公告)号：US20240101720A1

公开(公告)日：2024-03-28

申请号：US18372969

申请日：2023-09-26

Applicant: UCHICAGO ARGONNE, LLC

Inventor： Meltem Urgun Demirtas ,  Chaoyi Ba

IPC: C08B37/08 ,  B29C39/00 ,  C08J5/18

CPC classification number: C08B37/003 ,  B29C39/003 ,  C08J5/18 ,  B29K2005/00 ,  C08J2305/08

Abstract: A method of forming a plastic component can includes treating a polysaccharide source with an acid solution under conditions sufficient to extract the starch from the polysaccharide source, wherein the polysaccharide precipitates in the acid solution; separating the precipitate from the acid solution; drying the separated precipitate; admixing the dried precipitate with water to form a slurry; and casting or molding the slurry to form the plastic component.