公开(公告)号：US20250052675A1

公开(公告)日：2025-02-13

申请号：US18765756

申请日：2024-07-08

Applicant: betaSENSE GmbH

Inventor： Klaus Gerwert ,  Jens Wiltfang ,  Julian Ollesch ,  Andreas Nabers ,  Jonas Schartner ,  Carsten Kötting

IPC: G01N21/3577 ,  G01N21/05 ,  G01N21/552 ,  G01N21/64 ,  G01N33/68

Abstract: Provided herein is a biosensor for conformation and secondary structure analysis, notably for the direct non-invasive qualitative secondary structure analysis of a single selected protein within a complex mixture, as e.g. a body fluid, by vibrational spectroscopic methods. For the analysis it is not required that the selected substance be isolated, concentrated, or pretreated by a special preparative procedure.

公开(公告)号：US20250020588A1

公开(公告)日：2025-01-16

申请号：US18706997

申请日：2022-11-04

Applicant: Yokogawa Electric Corporation

Inventor： Syuhei Okada

IPC: G01N21/552 ,  G01N19/04 ,  G01N21/21 ,  G01N21/3581 ,  G01N21/84

Abstract: A measurement apparatus (20) includes a controller (13) that outputs an electromagnetic wave from an electromagnetic wave output source (7) toward a sample (30) that has a first layer (31) and a second layer (32) adjacent to each other and is subjected to vibration at a predetermined vibration frequency, receives a reflected wave of the electromagnetic wave from a measurement target portion (35) at an interface between the first layer (31) and the second layer (32), calculate a frequency or an amplitude of vibration of the measurement target portion (35) based on the reflected wave, and measure an adhesive strength of the measurement target portion (35) based on the frequency or the amplitude of vibration of the measurement target portion (35) calculated based on the reflected wave.

公开(公告)号：US12196676B2

公开(公告)日：2025-01-14

申请号：US17802066

申请日：2021-02-25

Applicant: CHRYSALABS INC.

Inventor： Gabriel Mangeat ,  Benjamin De Leener ,  Jacques Michiels

IPC: G01N21/01 ,  G01N21/17 ,  G01N21/31 ,  G01N21/33 ,  G01N21/35 ,  G01N21/3554 ,  G01N21/552 ,  G01N21/62 ,  G01N21/63 ,  G01N21/85 ,  G01N33/24

Abstract: There are provided an optical probe and method for analysing a soil located in an underground area. The optical probe includes a probe head insertable into the underground area to contact the soil, the probe head including a waveguide having opposite first and second ends both optically shielded from the soil; a light source configured to generate a multiwavelength interrogating beam and optically coupled to the first end of the waveguide so that the multiwavelength interrogation beam is inputted in the waveguide to propagate towards the second end; and a detector optically coupled to the second end of the waveguide to detect said multiwavelength interrogation beam. The waveguide includes an unshielded interaction zone extending between the first and second ends providing a wavelength-dependent attenuation of the multiwavelength interrogation beam through interaction with the soil.

公开(公告)号：US12117441B2

公开(公告)日：2024-10-15

申请号：US16668005

申请日：2019-10-30

Applicant: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

Inventor： Francisco Javier Tamayo De Miguel ,  Priscila Monteiro Kosaka ,  Valerio Pini ,  Montserrat Calleja Goméz ,  Jose Jaime Ruz Martinez ,  Daniel Ramos Vega ,  Maria Ujue Gonzalez Sagardoy

IPC: G01N33/53 ,  G01N21/47 ,  G01N21/552 ,  G01N21/59 ,  G01N21/65 ,  G01N21/77 ,  G01N33/543

CPC classification number: G01N33/54346 ,  G01N21/47 ,  G01N21/554 ,  G01N21/59 ,  G01N21/658 ,  G01N21/77 ,  G01N21/7703 ,  G01N33/54373 ,  G01N2021/5903

Abstract: The present invention relates to a system for biodetection applications comprising two basic elements, a substrate with a functionalized surface and a nanoparticle, the system being capable of enhancing the plasmonic effect of the nanoparticle. The invention also relates to a biosensor incorporating such system, in addition to the method for detecting and quantifying a target analyte selected in a sample using such system. Finally, the invention relates to a device which can detect the enhanced optoplasmonic effect of the nanoparticles by means of the system of the invention or by combining the detection of such optoplasmonic effect with the analysis of the changes in the mechanical characteristics in the substrate.

公开(公告)号：US12099008B2

公开(公告)日：2024-09-24

申请号：US17644639

申请日：2021-12-16

Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

Inventor： Cyrielle Monpeurt ,  Mathieu Dupoy

IPC: G01N21/552 ,  F21V8/00

CPC classification number: G01N21/552 ,  G02B6/0058 ,  G02B6/0076

Abstract: An optical component for an attenuated total reflection multispectral imaging device, which includes a support substrate and at least two planar waveguides, and wherein the planar waveguides and the support substrate are superimposed together, with the support substrate which covers the planar waveguides; each of the planar waveguides includes at least one diffraction grating; and at least two of the planar waveguides have their diffraction gratings which have values of the average pattern distribution pitch which are distinct from each other; the support substrate includes, on one side opposite the planar waveguides, a face forming an exchange interface with a sample; and an exit face of the optical component corresponds to a lateral face of the support substrate.

公开(公告)号：US20240312568A1

公开(公告)日：2024-09-19

申请号：US18514112

申请日：2023-11-20

Applicant: PROTEIN DYNAMIC SOLUTIONS, INC.

Inventor： Belinda PASTRANA-RIOS ,  Jose Javier RODRIGUEZ-TORO

IPC: G16B40/10 ,  G01N21/25 ,  G01N21/35 ,  G01N21/552 ,  G16B15/00 ,  G16B40/00

CPC classification number: G16B40/10 ,  G01N21/255 ,  G01N21/35 ,  G16B15/00 ,  G16B40/00 ,  G01N2021/3595 ,  G01N21/552

Abstract: Characteristics of proteins, peptides, and/or CIpeptoids can be determined via two-dimensional correlation spectroscopy and/or two-dimensional co-distribution spectroscopies. Spectral data of the proteins, peptides, and/or peptoids can be obtained with respect to an applied perturbation, two-dimensional co-distribution analysis can be applied to generate an asynchronous co-distribution plot for the proteins, peptides, and/or peptoids to define the population of proteins in solution. In the two-dimensional asynchronous plot, a cross peak can be identified as correlating with an auto peak in the two-dimensional correlation synchronous plot associated with aggregation of the proteins, peptides, and/or peptoids. The two-dimensional asynchronous cross peak can be used to determine an order of a distributed presence of spectral intensities with respect to the applied perturbation. For example, for two wavenumbers v1 and v2, the value of the cross peak corresponding to the two wavenumbers can indicate a presence of spectral intensity at v1 relative to the presence of spectral intensity at v2.

公开(公告)号：US20240272084A1

公开(公告)日：2024-08-15

申请号：US18564226

申请日：2021-05-27

Applicant: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

Inventor： Sung Hoon AHN ,  Young Gyun KIM

IPC: G01N21/78 ,  G01N1/22 ,  G01N21/552 ,  G01N33/00

CPC classification number: G01N21/783 ,  G01N1/2205 ,  G01N21/552 ,  G01N33/0027

Abstract: The present disclosure relates to a color gas sensor module including an optical measurement device, a housing having an interior space therein and a gas movement passage allowing a gas to move from outside to the interior space, wherein the optical measurement device is provided in the housing and includes a light emitter that emit light and a light receiver that receives reflected light, and a gas sensor included in the housing and changing color by reacting with gas, wherein the light emitter emits light to the gas sensor, and the light receiver receives light reflected from the gas sensor.

公开(公告)号：US12061146B2

公开(公告)日：2024-08-13

申请号：US17267287

申请日：2020-10-16

Applicant: AISIN CORPORATION

Inventor： Amrita Sana ,  Giles Allison ,  Hironori Suzuki ,  Hidemi Kato ,  Masao Ando ,  Viet Cuong Le

IPC: G01N21/552 ,  H01L31/0232 ,  H01L31/108 ,  G01N21/43

CPC classification number: G01N21/553 ,  H01L31/0232 ,  H01L31/108 ,  G01N2021/434

Abstract: An electricity measuring type surface plasmon resonance sensor includes: a plasmon resonance intensifying sensor chip in which a prism and a sensor chip including an electrode, a silicon semiconductor film, and a plasmon resonance film electrode arranged in this order are arranged in an order of the prism, the electrode, the silicon semiconductor film, and the plasmon resonance film electrode; and an electric measuring apparatus which directly measures a current or voltage from the electrode and the plasmon resonance film electrode.

公开(公告)号：US20240248033A1

公开(公告)日：2024-07-25

申请号：US18417471

申请日：2024-01-19

Applicant: Academia Sinica

Inventor： Chia-Fu CHOU ,  Pei-Kuen WEI ,  Liang-Kun YU ,  Deng-Kai YANG ,  Jui-Hong WENG ,  Kuang-Li LEE ,  Shu-Cheng LO

IPC: G01N21/552 ,  B82Y15/00 ,  G01N21/19 ,  G01N21/25

CPC classification number: G01N21/554 ,  B82Y15/00 ,  G01N21/19 ,  G01N2021/258 ,  G01N2201/0633

Abstract: A surface plasmon resonance sensor is provided, which comprises: a substrate; an adaptation layer disposed on the substrate and comprising a dielectric material; and a metal layer disposed on the adaptation layer, wherein the metal layer has a grating structure comprising plural metal lines. Furthermore, a surface plasmon resonance sensing instrument comprising the same and a method for detecting an analyte using the same are also provided.

公开(公告)号：US12038379B2

公开(公告)日：2024-07-16

申请号：US17324091

申请日：2021-05-18

Applicant: Taiwan RedEye Biomedical Inc.

Inventor： Shuo-Ting Yan ,  Tsung-Jui Lin ,  Yu-Hsun Chen ,  Kuan-Wei Su

IPC: A61B5/20 ,  A61B10/00 ,  G01N21/43 ,  G01N21/552 ,  G01N33/493

CPC classification number: G01N21/552 ,  A61B10/007 ,  G01N21/43 ,  G01N33/493

Abstract: A sanitary device for the urine glucose test includes a urine container formed on an inner wall of a main body, and a measuring module with an inner space mounted at a bottom of the urine container. Within the inner space, a lens attaches to the bottom of the urine container, a rail faces a bottom surface of the lens, and a driving module moves a light unit shooting a detection beam to a measuring surface of the lens along the rail. The measuring surface contacts urine in the urine container, and reflects the detection beam out of the bottom surface into a sensor. The sensor is electrically connected to a processor. The processor determines a urine glucose level and generates a urine glucose level data instantly from an angle of incidence of the detection beam on the measuring surface and from a beam intensity signal from the sensor.