公开(公告)号：US20240280535A1

公开(公告)日：2024-08-22

申请号：US18569809

申请日：2022-06-13

申请人： President and Fellows of Harvard College

发明人： Donhee Ham ,  Woo-Bin Jung ,  Han Sae Jung ,  Jun Wang ,  Young-Ha Hwang ,  Henry Julian Hinton ,  Jeffrey T. Abbott ,  Hongkun Park

IPC分类号： G01N27/416 ,  G01N27/27 ,  G01N27/30

CPC分类号： G01N27/4167 ,  G01N27/27 ,  G01N27/302

摘要： Devices and methods for controlling the local pH of solutions (e.g., for parallelized polymer synthesis) are generally described. These may offer several advantages, including the ability to control pH using a plurality of pixels, and/or the ability to sense the pH associated with each pixel, according to certain embodiments. In some embodiments, such devices are used to selectively synthesize polymer sequences (e.g., DNA sequences) associated with each pixel. The pixels can, in some embodiments, comprise electrodes that can apply an electrical potential or current to a solution comprising an electrically sensitive pH modifier. In some cases, reaction of the electrically sensitive pH modifier may cause a change in pH. The pixels may comprise circuit components that can operate in multiple modes (e.g. as potentiostats, galvanostats, or open-circuit potential sensors capable of sensing local pH).

公开(公告)号：US12050197B2

公开(公告)日：2024-07-30

申请号：US17650941

申请日：2022-02-14

申请人： LIFE TECHNOLOGIES CORPORATION

发明人： Melville Davey ,  Simon Cawley ,  Alan Williams

IPC分类号： G01N27/414 ,  G16B30/00 ,  G16B30/10 ,  G16B30/20 ,  G01N27/27

CPC分类号： G01N27/4145 ,  G16B30/00 ,  G16B30/10 ,  G16B30/20 ,  G01N27/27

摘要： A method for nucleic acid sequencing includes receiving a plurality of signals indicative of a parameter measured for a plurality of defined spaces, at least some of the defined spaces including one or more sample nucleic acids, the signals being responsive to a plurality of nucleotide flows introducing nucleotides to the defined spaces; determining, for at least some of the defined spaces, whether the defined space includes a sample nucleic acid; processing, for at least some of the defined spaces determined to include a sample nucleic acid, the received signals to improve a quality of the received signals; and predicting a plurality of nucleotide sequences corresponding to respective sample nucleic acids for the defined spaces based on the processed signals and the nucleotide flows.

公开(公告)号：US12038405B2

公开(公告)日：2024-07-16

申请号：US18324346

申请日：2023-05-26

申请人： LIFE TECHNOLOGIES CORPORATION

发明人： Mark Milgrew ,  Jonathan Rothberg ,  James Bustillo

IPC分类号： G01N27/414 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N27/27

CPC分类号： G01N27/4145 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N27/27 ,  G01N27/414 ,  Y10T29/49002

摘要： Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.

公开(公告)号：US20240158828A1

公开(公告)日：2024-05-16

申请号：US18423077

申请日：2024-01-25

申请人： Avails Medical, Inc.

发明人： Oren S. KNOPFMACHER ,  Meike HERGET ,  Michael D. LAUFER ,  August ESTABROOK

IPC分类号： C12Q1/18 ,  C12Q1/00 ,  C12Q1/02 ,  C12Q1/04 ,  G01N27/27 ,  G01N27/327 ,  G01N33/50

CPC分类号： C12Q1/18 ,  C12Q1/006 ,  C12Q1/025 ,  C12Q1/04 ,  G01N27/27 ,  G01N27/3273 ,  G01N27/3275 ,  G01N33/5011 ,  B01L3/502715 ,  G01N27/3272

摘要： Various devices, systems and methods for detecting infectious agents or determining a susceptibility of an infectious agent to an anti-infective are described herein. One example method comprises introducing a fluid sample to a surface; exposing the surface to a solution; sampling the solution after exposing the solution to the surface; and detecting a change in an electrical characteristic of a sensing device exposed to the solution sampled corresponding to a presence of the infectious agent in the fluid sample.

公开(公告)号：US20240125735A1

公开(公告)日：2024-04-18

申请号：US18275477

申请日：2021-12-08

申请人： HITACHI HIGH-TECH CORPORATION

发明人： Miki FURUYA ,  Emiko USHIKU

IPC分类号： G01N27/416 ,  G01N21/78 ,  G01N27/27 ,  G01N27/333

CPC分类号： G01N27/4163 ,  G01N21/78 ,  G01N27/27 ,  G01N27/333

摘要： The present invention is provided with an electrolyte measurement unit 11, a second measurement unit for performing measurement of a different measurement item to the electrolyte measurement unit 11, a sampling mechanism 5 for dispensing a sample to the electrolyte measurement unit 11 or the second measurement unit, and a control unit 13 for controlling the operation of respective devices. When the sample is dispensed to the second measurement unit by the sampling mechanism 5 or measurement of the sample is performed by the second measurement unit, the control unit 13 measures the potential in a state in which ion-selective electrodes 104, 105, and 106 are filled with an internal standard liquid, and determines, on the basis of measured data, whether or not there is an abnormality in the electrolyte measurement unit 11. An electrolyte analysis device capable of sensing an unstable state at an early stage, and a method for determining an abnormality in an electrolyte concentration measurement unit, are thereby provided.

公开(公告)号：US20230333039A1

公开(公告)日：2023-10-19

申请号：US17876871

申请日：2022-07-29

申请人： Board of Regents, The University of Texas System

发明人： Arjang Hassibi ,  Arun Manickam ,  Rituraj Singh

IPC分类号： G01N27/27 ,  C12Q1/6874 ,  G01N27/327

CPC分类号： G01N27/27 ,  C12Q1/6874 ,  G01N27/3276

摘要： A method and device for performing DNA sequencing and extracting structural information from unknown nucleic acid strands. The device includes a microwell structure, where identical DNA strands are immobilized within the microwell structure on a surface of a micro-bead, an active electrode or a porous polymer. The device further includes a CMOS-integrated semiconductor integrated circuit, where the CMOS-integrated semiconductor integrated circuit includes metal layers on a silicon substrate, where the metal layers form an active electrode biosensor. In addition, a sensing electrode is formed by creating openings in a passivation layer of the CMOS-integrated semiconductor integrated circuit to hold a single bead, on which the DNA strands are immobilized.

公开(公告)号：US11782008B2

公开(公告)日：2023-10-10

申请号：US16942707

申请日：2020-07-29

申请人： Endress+Hauser Conducta GmbH+Co. KG

发明人： Erik Hennings ,  Dagmar Kaschuba ,  Marco Bezzon

IPC分类号： G01N27/27 ,  G01N27/416

CPC分类号： G01N27/27 ,  G01N27/4163 ,  G01N27/4167

摘要： Disclosed is an apparatus for determining a process variable of a medium in a containment, comprising first and second oscillatory elements, first and second driving/receiving units, and electronics. The first driving/receiving unit is embodied to excite the first oscillatory element using a first electrical excitation signal to execute mechanical oscillations, and to receive the mechanical oscillations of the first oscillatory element and to convert such into a first electrical, received signal, wherein the second driving/receiving unit is embodied to excite the second oscillatory element by means of a second electrical excitation signal to execute mechanical oscillations, and to receive the mechanical oscillations of the second oscillatory element and to convert such into a second electrical, received signal, and wherein the electronics is embodied to determine the process variable from the first received signal and/or the second received signal.

公开(公告)号：US20230314366A1

公开(公告)日：2023-10-05

申请号：US18187049

申请日：2023-03-21

申请人： NGK INSULATORS, LTD.

发明人： Yuichiro KONDO ,  Osamu NAKASONE ,  Yusuke WATANABE

IPC分类号： G01N27/41 ,  G01M15/10 ,  G01N27/409 ,  G01N27/27

CPC分类号： G01N27/41 ,  G01M15/102 ,  G01N27/409 ,  G01N27/27

摘要： A sub adjustment pump cell pumps out oxygen from a measurement gas introduced into a sub adjustment chamber to the extent that H2O and CO2 contained in the measurement gas are not decomposed, a first pump cell pumps out oxygen from a first chamber so that substantially all of H2O and CO2 contained in the measurement gas introduced from the sub adjustment chamber into the first chamber are decomposed, concentrations of H2O and CO2 are identified from a pump-in current when H2 and CO generated by decomposition are oxidized in the second chamber and the third chamber, and a concentration of oxygen contained in the measurement gas is identified based on a magnitude of a current flowing between a sub adjustment inner electrode and an outer electrode at the time when the sub adjustment pump cell pumps out oxygen from the sub adjustment chamber.

公开(公告)号：US11719664B2

公开(公告)日：2023-08-08

申请号：US16552120

申请日：2019-08-27

申请人： Korea Advanced Institute of Science and Technology

发明人： Yeon Sik Jung ,  Hyeuk Jin Han ,  Seunghee Cho ,  Gyurac Lee

IPC分类号： G01N27/27 ,  H01L29/41 ,  G01N21/65 ,  H01J37/26

CPC分类号： G01N27/27 ,  G01N21/658 ,  H01L29/413 ,  H01J37/26

摘要： A multimodal sensor of high sensitivity and high selectivity using multifunctional three-dimensional nanostructure having electric and optical sensing ability and a method thereof are provided. The method includes forming multi-layered nanowires including a multifunctional material, transferring the nanowires to a plurality of layers onto a target substrate to form the three-dimensional nanostructure, heat-treating the three-dimensional nanostructure, and forming electrode layers at the three-dimensional nanostructure.

公开(公告)号：US20230243774A1

公开(公告)日：2023-08-03

申请号：US17928586

申请日：2021-04-21

申请人： SHARP KABUSHIKI KAISHA

发明人： FUMITOSHI YASUO ,  KENICHI KITOH ,  TOMOKO TERANISHI ,  CHIHIRO TACHINO

IPC分类号： G01N27/27 ,  G01N27/414

CPC分类号： G01N27/27 ,  G01N27/4148

摘要： A cell signal measurement electrode plate includes a first transistor including a gate terminal connected to a first selection line and a source terminal connected to a second selection line, a second transistor including a gate terminal connected to a drain terminal of the first transistor, a source terminal connected to an electrode, and a drain terminal connected to a common wiring line, and a first capacitor including one capacitance electrode connected to the drain terminal of the first transistor and another capacitance electrode connected to a capacitance element potential fixing wiring line.