公开(公告)号：US20240363323A1

公开(公告)日：2024-10-31

申请号：US18309565

申请日：2023-04-28

申请人： KARSA OY

发明人： Aleksei SHCHERBININ ,  Jyri MIKKILÄ ,  Verner HEMMILÄ ,  Hans-Jurg JOST

IPC分类号： H01J49/04 ,  H01J49/00

CPC分类号： H01J49/049 ,  H01J49/0031

摘要： The present disclosure concerns a desorption device including a mesh structure forming a mesh filter the mesh being formed by back-bone material being coated by gas adsorbing and/or absorbing absorbent. The present disclosure concerns also a desorption device hosting device to hold such desorption device in sampling, and a system as well as a chemical analysis method using such desorption devices in the sampling of a sample being analyzed.

公开(公告)号：US20240359153A1

公开(公告)日：2024-10-31

申请号：US18763537

申请日：2024-07-03

申请人： MLS ACQ, INC. D/B/A MAX ANALYTICAL TECHNOLOGIES

发明人： Martin L. Spartz

IPC分类号： B01J15/00 ,  G01N21/3504 ,  G01N27/416 ,  G01N27/622 ,  G01N30/02 ,  G01N30/06 ,  H01J49/04

CPC分类号： B01J15/005 ,  G01N21/3504 ,  G01N27/622 ,  G01N30/06 ,  H01J49/0422 ,  G01N27/4162 ,  G01N2030/025

摘要： A gas analysis system and method with a spectrometer, such as a Fourier transform infrared spectrometer, utilizing a reactor, such as a catalytic reactor, for providing reference spectra.

公开(公告)号：US20240355686A1

公开(公告)日：2024-10-24

申请号：US18759691

申请日：2024-06-28

申请人： Daniel Pierce RADIN

发明人： Daniel Pierce RADIN

IPC分类号： H01L21/66 ,  G01N21/94 ,  G01N21/95 ,  H01J49/00 ,  H01J49/04 ,  H01J49/10

CPC分类号： H01L22/12 ,  G01N21/94 ,  G01N21/9501 ,  H01J49/0036 ,  H01J49/0422 ,  H01J49/105

摘要： Disclosed herein are compositions and methods employing AMPA Receptor (AMPR) antagonist compounds to treat AMPAR positive cancers in mammalian subjects. In certain detailed embodiments the AMPAR antagonist is a Perampanel compound, effective to mediate potent oncolytic effects to prevent or reduce the severity or recurrence of a variety of cancer forms, including central nervous system (CNS) cancers.

公开(公告)号：US12125691B2

公开(公告)日：2024-10-22

申请号：US18208116

申请日：2023-06-09

申请人： Purdue Research Foundation

发明人： Robert Graham Cooks ,  Alan Keith Jarmusch ,  Valentina Pirro

IPC分类号： H01J49/04 ,  A61B5/00 ,  A61B5/145 ,  A61B10/02 ,  A61F13/38 ,  G01N30/72 ,  H01J49/16 ,  G01N1/02

CPC分类号： H01J49/0459 ,  A61B5/14503 ,  A61B5/7282 ,  A61B10/02 ,  A61F13/38 ,  G01N30/72 ,  H01J49/0409 ,  H01J49/165 ,  G01N2001/028

摘要： The invention generally relates to systems and methods for sample analysis using swabs. In certain aspects, the invention provides systems that include a probe having a conductive proximal portion coupled to a porous material at a distal portion of the probe that is configured to retain a portion of a sample that has contacted the porous material, and a mass spectrometer having an inlet. The system is configured such that the porous material at a distal portion of the probe is aligned over the inlet of the mass spectrometer.

公开(公告)号：US20240347328A1

公开(公告)日：2024-10-17

申请号：US18294930

申请日：2022-03-25

申请人： SHIMADZU CORPORATION

发明人： Kazutaka MITSUI ,  Hidenori TAKAHASHI ,  Yuta MIYAZAKI

IPC分类号： H01J49/00 ,  H01J49/04

CPC分类号： H01J49/0031 ,  H01J49/005 ,  H01J49/0422

摘要： The method of operating a mass spectrometer includes: introducing precursor ions into a reaction chamber; generating radicals by generating plasma by supplying source gas and radio-frequency power to a radical generation chamber for a predetermined period by transmitting a predetermined control signal to a source gas supply part and a radio-frequency power supply part; generating product ions by introducing the radicals into the reaction chamber; measuring an intensity of light having a wavelength band including a wavelength of light emitted from the plasma inside the radical generation chamber; and determining and notifying an abnormality of the mass spectrometer on a basis of a fact that the intensity of the light exceeds a predetermined abnormality determination threshold value during a period other than the predetermined period.

公开(公告)号：US20240345044A1

公开(公告)日：2024-10-17

申请号：US18294348

申请日：2022-08-04

申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

发明人： David Cox ,  Chang Liu

IPC分类号： G01N30/72 ,  G01N30/02 ,  G01N30/06 ,  H01J49/04

CPC分类号： G01N30/724 ,  G01N30/02 ,  G01N30/06 ,  H01J49/0454 ,  G01N2030/027

摘要： Disclosed are methods for separating target and non-target analytes in a sample. The methods can utilize an acoustic droplet ejector (ADE) and an open port interface (OPI) to achieve liquid chromatography (LC)-like separation for an analytical instrument such as, for example, a mass spectrometer.

公开(公告)号：US20240344938A1

公开(公告)日：2024-10-17

申请号：US18431570

申请日：2024-02-02

申请人： UT-Battelle, LLC

发明人： Vilmos Kertesz ,  Gary J. Van Berkel

IPC分类号： G01N1/24 ,  G01N1/02 ,  G01N1/10 ,  H01J49/04 ,  H01J49/16

CPC分类号： G01N1/24 ,  G01N1/10 ,  H01J49/0418 ,  H01J49/0463 ,  H01J49/164 ,  G01N2001/028

摘要： A system for sampling a sample material includes a device for directing sample into a capture probe. The device for supplying sample material to the probe can be a device for radiating energy to the surface to eject sample from the sample material. A probe includes an outer probe housing having an open end. A liquid supply conduit has an outlet positioned to deliver liquid to the open end. An exhaust conduit removes liquid from the open end of the housing. The liquid supply conduit can be connectable to a liquid supply for delivering liquid at a first volumetric flow rate to the open end of the housing. A liquid exhaust system can be in fluid connection with the liquid exhaust conduit for removing liquid from the liquid exhaust conduit at a second volumetric flow rate, which exceeds the first volumetric flow rate such that gas with sample is withdrawn with the liquid. The probe can produce a vortex of liquid in the liquid exhaust conduit. A method for sampling a surface and a sampling probe system are also disclosed.

公开(公告)号：US12100580B1

公开(公告)日：2024-09-24

申请号：US18406459

申请日：2024-01-08

申请人： Chris Salvino ,  Andrew Dummer

发明人： Chris Salvino ,  Andrew Dummer

IPC分类号： H01J49/04 ,  H01J49/00 ,  H01J49/20

CPC分类号： H01J49/0022 ,  H01J49/0086 ,  H01J49/0422 ,  H01J49/049 ,  H01J49/20

摘要： Disclosed is a He-3 detector arrangement that generally comprises a mass spectrometer that has an intake funnel configured to receive (sniff out) He-3 through an intake port directly from an open environment. The intake funnel is configured to direct the He-3 into the mass spectrometer. The arrangement further comprises a heating element configured to liberate the He-3 from regolith via heat. A mobile carrier is configured to position the intake port the regolith to obtain samples of the He-3.

公开(公告)号：US20240310327A1

公开(公告)日：2024-09-19

申请号：US18274947

申请日：2022-02-04

申请人： OSAKA UNIVERSITY

发明人： Michisato TOYODA ,  Toshinobu HONDO ,  Hiroshi NAKAYAMA

IPC分类号： G01N27/62 ,  G01N30/02 ,  H01J49/04 ,  H01J49/14 ,  H01J49/26

CPC分类号： G01N27/62 ,  H01J49/0468 ,  H01J49/0495 ,  H01J49/14 ,  H01J49/26 ,  G01N30/02

摘要： Provided is a technique to carry out mass spectrometry of a wide variety of subject compounds to be analyzed, each of which is extracted in a supercritical fluid. A mass spectrometer (1) includes: a supercritical fluid introduction section (3) for introducing and releasing, to vacuum, a supercritical fluid in which a subject compound for mass spectrometry is contained (extracted); an ionization section (4) that ionizes the subject compound which is extracted in the supercritical fluid, the ionization being carried out in the vacuum by a molecular reaction involving proton transfer; and a mass measurement section (5) that measures a mass of the subject compound which has been ionized.

公开(公告)号：US12087566B2

公开(公告)日：2024-09-10

申请号：US18227417

申请日：2023-07-28

申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

发明人： Livia Schiavinato Eberlin ,  Thomas Milner ,  Jialing Zhang ,  John Lin ,  John Rector ,  Nitesh Katta ,  Aydin Zahedivash

IPC分类号： H01J49/04 ,  A61B10/00 ,  B01L3/00 ,  G01N30/72 ,  G01N33/487 ,  G01N33/574 ,  G01N33/68 ,  H01J49/00 ,  B01L3/02 ,  G01N1/02 ,  G01N1/40

CPC分类号： H01J49/0431 ,  A61B10/0045 ,  B01L3/502 ,  G01N30/72 ,  G01N33/487 ,  G01N33/574 ,  G01N33/6848 ,  H01J49/0031 ,  H01J49/04 ,  B01L3/0293 ,  B01L2200/0605 ,  B01L2400/0655 ,  G01N1/02 ,  G01N2001/028 ,  G01N2001/4061 ,  G01N2560/00

摘要： Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.