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    FABRICATION OF CONDUCTIVE PATHWAYS, MICROCIRCUITS AND MICROSTRUCTURES IN MICROFLUIDIC NETWORKS
    91.
    发明申请
    FABRICATION OF CONDUCTIVE PATHWAYS, MICROCIRCUITS AND MICROSTRUCTURES IN MICROFLUIDIC NETWORKS 审中-公开
    微流控网络中导电路径，微型计算机和微结构的制造

    公开(公告)号：WO2007061448A3

    公开(公告)日：2008-08-28

    申请号：PCT/US2006019787

    申请日：2006-05-18

    Applicant: HARVARD COLLEGE ,  BRUZEWICZ DEREK A ,  BONCHEVA-BETTEX MILA ,  WHITESIDES GEORGE M ,  SIEGEL ADAM ,  WEIBEL DOUGLAS B ,  SHEVKOPLYAS SERGEY ,  MARTINEZ ANDRES

    Inventor： BRUZEWICZ DEREK A ,  BONCHEVA-BETTEX MILA ,  WHITESIDES GEORGE M ,  SIEGEL ADAM ,  WEIBEL DOUGLAS B ,  SHEVKOPLYAS SERGEY ,  MARTINEZ ANDRES

    IPC: H05K3/10 ,  B01F13/00 ,  B01L3/00 ,  B29C39/12

    CPC classification number: H05K3/101 ,  B01L3/5027 ,  B01L3/502707 ,  B01L2200/12 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0874 ,  B01L2400/0415 ,  B33Y80/00 ,  H05K1/0272 ,  H05K1/032 ,  H05K3/389 ,  H05K2201/0162 ,  H05K2201/0305 ,  H05K2203/128 ,  Y10T29/49117

    Abstract: Disclosed herein are a variety of microfluidic devices and solid, typically electrically conductive devices that can be formed using such devices as molds. In certain embodiments, the devices that are formed comprise conductive pathways formed by solidifying a liquid metal present in one or more microfluidic channels (such devices hereinafter referred to as "microsolidic" devices). In certain such devices, in which electrical connections can be formed and/or reformed between regions in a microfluidic structure; in some cases, the devices/circuits formed may be flexible and/or involve flexible electrical components. In certain embodiments, the solid metal wires/conductive pathways formed in microfluidic channel(s) may remain contained within the microfluidic structure. In certain such embodiments, the conductive pathways formed may be located in proximity to other microfluidic channel(s) of the structure that carry flowing fluid, such that the conductive pathway can create energy (e.g. electromagnetic and/or thermal energy) that interacts withy and/or affects the flowing fluid and/or a component contained therein or carried thereby. In other embodiments, a microsolidic structure may be removed from a microfluidic mold to form a stand-alone structure. In certain embodiments, the solid metal structures formed may interact with light energy incident upon a structure or may be used to fabricate a light-weight electrode. Another aspect of the invention relates to the formation of self-assembled structures that may comprise these electrically conductive pathways/connections.

    Abstract translation: 本文公开了各种微流体装置和可以使用诸如模具的装置形成的固体，通常导电的装置。 在某些实施方案中，形成的装置包括通过固化存在于一个或多个微流体通道（这种装置在下文中称为“微溶体”装置）中的液态金属形成的导电通路。 在某些这样的装置中，其中可以在微流体结构的区域之间形成和/或重组电连接; 在一些情况下，所形成的器件/电路可能是柔性的和/或涉及柔性电气部件。 在某些实施方案中，在微流体通道中形成的固体金属线/导电路径可以保持在微流体结构内。 在某些这样的实施例中，所形成的导电路径可以位于结构的其它微流体通道附近，其携带流动的流体，使得导电路径可以产生与...相互作用的能量（例如电磁和/或热能） /或影响流动的流体和/或其中所含的或由其携带的部件。 在其它实施方案中，微溶体结构可以从微流体模具中移除以形成独立结构。 在某些实施方案中，形成的固体金属结构可与入射到结构上的光能相互作用，或者可用于制造轻质电极。 本发明的另一方面涉及可以包括这些导电路径/连接的自组装结构的形成。

    DEVICE FOR STUDYING CELLS OF THIXOTROPIC MATERIAL AND METHOD OF MANUFACURE THEREOF
    92.
    发明申请
    DEVICE FOR STUDYING CELLS OF THIXOTROPIC MATERIAL AND METHOD OF MANUFACURE THEREOF 审中-公开
    用于研究双相材料的细胞的装置及其制造方法

    公开(公告)号：WO2008078326A3

    公开(公告)日：2008-08-14

    申请号：PCT/IL2007001607

    申请日：2007-12-25

    Applicant: SENG ENTPR LTD ,  DEUTSCH MORDECHAI ,  DEUTSCH ASSAF

    Inventor： DEUTSCH MORDECHAI ,  DEUTSCH ASSAF

    IPC: B01L3/00

    CPC classification number: B01L3/5085 ,  B01L2200/12 ,  B01L2300/0809 ,  B01L2300/0829 ,  B01L2300/0887 ,  B01L2300/0893

    Abstract: Provided in some embodiments are novel planar well-bearing components made of a thixotropic material, the components having a relatively homogeneous thickness, and on which a surface is located an array of wells, where the bottoms of the individual wells of a component being relatively coplanar, each well of a size and shape suitable for retaining a cell therein. Provided in some embodiments are novel methods for producing a planar well-bearing component useful for holding and studying living cells including impressing a well-array into a surface of a thixotropic material.

    Abstract translation: 在一些实施例中提供了由触变材料制成的新颖的平面承载部件，所述部件具有相对均匀的厚度，并且其上的表面位于孔阵列上，其中部件的各个孔的底部相对共面 每个孔的尺寸和形状适合于在其中保留电池。 在一些实施方案中提供了用于生产用于保持和研究活细胞的平面有益部件的新颖方法，包括将阵列施加到触变材料的表面中。

    MULTI-WELL IMPROVED PLATE
    93.
    发明申请
    MULTI-WELL IMPROVED PLATE 审中-公开
    多层改良板

    公开(公告)号：WO2008093109A1

    公开(公告)日：2008-08-07

    申请号：PCT/GB2008/000352

    申请日：2008-02-04

    Applicant: ADVANCED BIOTECHNOLOGIES LIMITED ,  COULLING, Jeffrey, Leonard ,  MAY, Simon

    Inventor： COULLING, Jeffrey, Leonard ,  MAY, Simon

    IPC: B01L3/00

    CPC classification number: B01L3/50851 ,  B01L2200/12 ,  B01L2300/0829

    Abstract: A thin walled multi-well plate for PCR use comprising: (i) a deck and skirt portion said deck and skirt portion having an outer surface and an inner surface; (ii) a plurality of wells for holding chemical reactants, each well comprising a well wall having an inner surface and an outer surface; wherein the deck and skirt portion and the plurality of wells are of integral construction and formed from the same plastics material, and wherein the deck and skirt portion has a mean thickness from 1.5mm ± 10% to 3mm ± 10%.

    Abstract translation: 一种用于PCR用途的薄壁多孔板，包括：（i）甲板和裙部，所述甲板和裙部具有外表面和内表面; （ii）用于保持化学反应物的多个孔，每个孔包括具有内表面和外表面的井壁; 其中所述甲板和裙部以及所述多个井具有一体构造，并且由相同的塑料材料形成，并且其中所述甲板和裙部的平均厚度为1.5mm±10％至3mm±10％。

    MICROFLUIDIC DEVICE
    94.
    发明申请
    MICROFLUIDIC DEVICE 审中-公开
    微流体装置

    公开(公告)号：WO2008087405A1

    公开(公告)日：2008-07-24

    申请号：PCT/GB2008/000143

    申请日：2008-01-16

    Applicant: LAB 901 LIMITED ,  BARLOW, David ,  THOMPSON, David ,  MACNAMARA, Ken ,  POLWART, Stuart

    Inventor： BARLOW, David ,  THOMPSON, David ,  MACNAMARA, Ken ,  POLWART, Stuart

    IPC: B01L3/00

    CPC classification number: B32B27/06 ,  B01L3/502707 ,  B01L3/502738 ,  B01L2200/12 ,  B01L2300/0645 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/0638 ,  B32B27/32 ,  B32B2307/7265 ,  B32B2323/04 ,  B32B2323/10

    Abstract: The present invention relates to a microfluidic device, comprising a laminate of first and second films, one or each film including an integrally thermoformed structure such that the films together define an enclosed volume (19) for fluid containment therebetween, characterised in that each film itself comprises a laminate of a relatively higher softening temperature thermoplastic polymeric material (14,17) and with respect thereto, a relatively lower melt temperature thermoplastic polymeric material (15,16), the respective relatively low melt temperature thermoplastic polymeric materials of each film being melted together to attach the said first and second films together. The invention further relates to a method of manufacturing the microfluidic device.

    Abstract translation: 本发明涉及一种微流体装置，其包括第一和第二膜的层压体，一个或每个膜包括整体热成型结构，使得膜一起限定用于其间流体容纳的封闭容积（19），其特征在于每个膜本身 包括相对较高的软化温度的热塑性聚合物材料（14,17）和相对于其相对较低的熔融温度的热塑性聚合物材料（15,16）的层压材料，每个膜的相应的相对较低的熔融温度的热塑性聚合材料被熔化 一起将所述第一和第二膜连接在一起。 本发明还涉及一种制造微流体装置的方法。

    A THREE-WAFER CHANNEL STRUCTURE FOR A FLUID ANALYZER
    100.
    发明申请
    A THREE-WAFER CHANNEL STRUCTURE FOR A FLUID ANALYZER 审中-公开
    流体分析仪的三通道通道结构

    公开(公告)号：WO2008005588A2

    公开(公告)日：2008-01-10

    申请号：PCT/US2007062068

    申请日：2007-02-13

    Applicant: HONEYWELL INT INC ,  BONNE ULRICH ,  HIGASHI ROBERT

    Inventor： BONNE ULRICH ,  HIGASHI ROBERT

    CPC classification number: G01N30/6095 ,  B01L3/5027 ,  B01L2200/027 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/1827 ,  G01N1/40 ,  G01N1/405 ,  G01N25/18 ,  G01N30/6026

    Abstract: A three-wafer channel or column structure for a fluid analyzer. The structure may have a support member, membrane, or support wafer containing heaters and interactive elements. The membrane may have a channel of one wafer facing the interactive element side and a space of another wafer facing the other side. The membrane may have perforations to equalize the pressures on both sides of the membrane. A detector in the membrane may have exposure to both the channel and space for good sensitivity, as the sample may be on both sides of the membrane. The wafers may be bonded with a thin film of non-flowing viscous material. Capillaries may be attached to an inlet and outlet of the channel and be parallel to an elongated dimension of the channel.

    Abstract translation: 用于流体分析仪的三晶片通道或柱结构。 该结构可以具有包含加热器和交互元件的支撑构件，膜或支撑晶片。 膜可以具有面向交互元件侧的一个晶片的通道和面向另一侧的另一个晶片的空间。 膜可以具有穿孔以均衡膜两侧的压力。 膜中的检测器可以暴露于通道和空间两者以获得良好的灵敏度，因为样品可以在膜的两侧。 晶片可以用非流动的粘性材料的薄膜粘合。 毛细管可以连接到通道的入口和出口并且平行于通道的细长尺寸。

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