公开(公告)号：WO2009071483A1

公开(公告)日：2009-06-11

申请号：PCT/EP2008/066288

申请日：2008-11-27

Applicant: VIA PHARMACEUTICALS, INC. ,  BOLIN, David Robert ,  CAI, Jianping ,  GOODNOW, Robert, Alan Jr.

Inventor： BOLIN, David Robert ,  CAI, Jianping ,  GOODNOW, Robert, Alan Jr.

IPC: C07D231/56 ,  C07D401/12 ,  A61P3/06 ,  A61K31/416

CPC classification number: C07D231/56 ,  C07D401/12

Abstract: Provided herein are compounds of the Formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.

Abstract translation: 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如肥胖症，II型糖尿病和代谢综合征。

公开(公告)号：WO2008141976A1

公开(公告)日：2008-11-27

申请号：PCT/EP2008/055843

申请日：2008-05-13

Applicant: F. HOFFMANN-LA ROCHE AG ,  BOLIN, David Robert ,  CHEUNG, Adrian Wai-Hing ,  FIROOZNIA, Fariborz ,  HAMILTON, Matthew Michael ,  MCDERMOTT, Lee Apostle ,  QIAN, Yimin ,  TAN, Jenny ,  YUN, Weiya

Inventor： BOLIN, David Robert ,  CHEUNG, Adrian Wai-Hing ,  FIROOZNIA, Fariborz ,  HAMILTON, Matthew Michael ,  MCDERMOTT, Lee Apostle ,  QIAN, Yimin ,  TAN, Jenny ,  YUN, Weiya

IPC: C07D231/14 ,  C07D263/34 ,  C07D277/56 ,  C07D307/68 ,  C07D401/12 ,  C07D401/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  A61K31/422 ,  A61K31/427 ,  A61K31/4178 ,  A61K31/4192 ,  A61K31/4427

CPC classification number: C07D263/34 ,  C07D231/14 ,  C07D277/56 ,  C07D307/68 ,  C07D401/12 ,  C07D401/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14

Abstract: Provided herein are compounds of the formula (I) as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.

Abstract translation: 本文提供式（I）化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如肥胖症，II型糖尿病和代谢综合征。

公开(公告)号：WO2008003612A3

公开(公告)日：2008-01-10

申请号：PCT/EP2007/056351

申请日：2007-06-26

Applicant: F. HOFFMANN-LA ROCHE AG ,  BOLIN, David Robert ,  KHAN, Wajiha ,  MICHEL, Hanspeter

Inventor： BOLIN, David Robert ,  KHAN, Wajiha ,  MICHEL, Hanspeter

IPC: C07K14/575 ,  A61P11/08 ,  A61K38/22

Abstract: A VPAC-2 receptor agonist of the formula [X-(SEQ ID NO: 2)-Y] for treating pulmonary obstructive disorders, e.g. COPD, administered, e.g. by inhalation.

公开(公告)号：WO2008003612A2

公开(公告)日：2008-01-10

申请号：PCT/EP2007056351

申请日：2007-06-26

Applicant: HOFFMANN LA ROCHE ,  BOLIN DAVID ROBERT ,  KHAN WAJIHA ,  MICHEL HANSPETER

Inventor： BOLIN DAVID ROBERT ,  KHAN WAJIHA ,  MICHEL HANSPETER

IPC: C07K14/575 ,  A61K38/22 ,  A61P11/08

CPC classification number: C07K14/57563

Abstract: A VPAC-2 receptor agonist of the formula [X-(SEQ ID NO: 2)-Y] for treating pulmonary obstructive disorders, e.g. COPD, administered, e.g. by inhalation.

Abstract translation: 用于治疗肺阻塞性疾病的式[X-（SEQ ID NO：2）-Y]的VPAC-2受体激动剂，例如。 COPD， 通过吸入。

公开(公告)号：WO2006082010A1

公开(公告)日：2006-08-10

申请号：PCT/EP2006/000786

申请日：2006-01-30

Applicant: F.HOFFMANN-LA ROCHE AG ,  BOLIN, David, Robert ,  MICHOUD, Christophe

Inventor： BOLIN, David, Robert ,  MICHOUD, Christophe

IPC: C07C243/36 ,  C07C243/38 ,  C07C255/53 ,  C07C317/22 ,  C07C321/28 ,  C07D307/68 ,  C07D309/08 ,  C07D333/38 ,  C07D335/02 ,  A61K31/165 ,  A61K31/166 ,  A61K31/277 ,  A61K31/341 ,  A61K31/351 ,  A61K31/381

CPC classification number: C07D335/02 ,  C07C259/08 ,  C07C259/10 ,  C07C317/22 ,  C07C323/18 ,  C07C323/60 ,  C07C2601/08 ,  C07C2601/14 ,  C07D307/68 ,  C07D309/08 ,  C07D333/38

Abstract: Provided herein are compounds of the formula (I), as well as pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 2´ , R 3 , R 4 , R 5 and X are as defined in the specification and claims. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.

Abstract translation: 本文提供式（I）化合物及其药学上可接受的盐，其中R 1，R 2，R 2， R 3，R 4，R 5和X如说明书和权利要求中所定义。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如肥胖症，II型糖尿病和代谢综合征。

公开(公告)号：WO2005040150A3

公开(公告)日：2005-05-06

申请号：PCT/EP2004/011206

申请日：2004-10-07

Applicant: F. HOFFMANN-LA ROCHE AG ,  BOLIN, David, Robert ,  CHEN, Shaoqing ,  MISCHKE, Steven, Gregory ,  QIAN, Yimin

Inventor： BOLIN, David, Robert ,  CHEN, Shaoqing ,  MISCHKE, Steven, Gregory ,  QIAN, Yimin

IPC: C07D401/04

Abstract: Compounds of formula (I) are provided, wherein R 1 and R 2 are as designated in the specification. The compounds have utility for the treatment of type 2 diabetes mellitus.

公开(公告)号：WO2011067266A1

公开(公告)日：2011-06-09

申请号：PCT/EP2010/068590

申请日：2010-12-01

Applicant: F. HOFFMANN-LA ROCHE AG ,  BOLIN, David Robert ,  HAYDEN, Stuart ,  QIAN, Yimin ,  THAKKAR, Kshitij Chhabilbhai

Inventor： BOLIN, David Robert ,  HAYDEN, Stuart ,  QIAN, Yimin ,  THAKKAR, Kshitij Chhabilbhai

IPC: C07C229/14 ,  C07C233/47 ,  C07C233/48 ,  C07C233/51 ,  C07C233/63 ,  C07C233/83 ,  C07C235/12 ,  C07C271/22 ,  C07C311/06 ,  C07C311/14 ,  C07C311/19 ,  C07D207/16 ,  C07D207/28 ,  C07D211/60 ,  C07D213/81

CPC classification number: C07C233/47 ,  C07C229/14 ,  C07C233/48 ,  C07C233/51 ,  C07C233/63 ,  C07C233/83 ,  C07C235/12 ,  C07C271/22 ,  C07C311/06 ,  C07C311/14 ,  C07C311/19 ,  C07C2601/02 ,  C07C2601/04 ,  C07D207/16 ,  C07D207/28 ,  C07D211/60 ,  C07D213/81 ,  C07D213/82 ,  C07D233/90 ,  C07D275/02 ,  C07D277/56 ,  C07D279/02 ,  C07D295/215 ,  C07D307/24 ,  C07D417/06

Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.

Abstract translation: 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗代谢疾病和病症，例如II型糖尿病。

公开(公告)号：WO2011067174A1

公开(公告)日：2011-06-09

申请号：PCT/EP2010/068279

申请日：2010-11-26

Applicant: F. HOFFMANN-LA ROCHE AG ,  BOLIN, David, Robert ,  HAMILTON, Matthew, Michael

Inventor： BOLIN, David, Robert ,  HAMILTON, Matthew, Michael

IPC: A61P3/10 ,  C07C233/25 ,  C07C233/47 ,  C07C233/60 ,  A61K31/095 ,  A61K31/194 ,  A61K31/195 ,  A61K31/401 ,  C07C311/08 ,  C07C311/09 ,  C07D207/08 ,  C07D207/16

CPC classification number: C07C233/25 ,  A61K31/095 ,  A61K31/194 ,  A61K31/195 ,  A61K31/401 ,  C07C233/47 ,  C07C233/60 ,  C07C311/08 ,  C07C311/09 ,  C07C2601/08 ,  C07D207/08 ,  C07D207/16

Abstract: Provided herein are compounds of the formula (I), as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.

Abstract translation: 本文提供式（I）化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗代谢疾病和病症，例如II型糖尿病。

公开(公告)号：WO2011057993A1

公开(公告)日：2011-05-19

申请号：PCT/EP2010/067070

申请日：2010-11-09

Applicant: F. HOFFMANN-LA ROCHE AG ,  BOLIN, David, Robert ,  HAYDEN, Stuart ,  QIAN, Yimin

Inventor： BOLIN, David, Robert ,  HAYDEN, Stuart ,  QIAN, Yimin

IPC: C07D231/56 ,  A61K31/416

CPC classification number: C07D231/56

Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.

Abstract translation: 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗代谢疾病和病症，例如II型糖尿病。

公开(公告)号：WO2010065310A1

公开(公告)日：2010-06-10

申请号：PCT/US2009/064971

申请日：2009-11-18

Applicant: VIA PHARMACEUTICALS, INC ,  BOLIN, David, Robert ,  HAYDEN, Stuart ,  QIAN, Yimi ,  YUN, Weiya

Inventor： BOLIN, David, Robert ,  HAYDEN, Stuart ,  QIAN, Yimi ,  YUN, Weiya

IPC: C07D405/00 ,  C07D409/00

CPC classification number: C07D409/12 ,  C07D209/42 ,  C07D307/85 ,  C07D333/70 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/14 ,  C07D417/12

Abstract: Provided herein are compounds of the following formula (I), as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.

Abstract translation: 本文提供了下式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如肥胖症，II型糖尿病和代谢综合征。