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1.发明申请2-OXO-IMIDAZOPYRIDINES AS REVERSIBLE BTK INHIBITORS AND USES THEREOF 审中-公开作为可逆BTK抑制剂的2-氧代 - 咪唑并吡啶类化合物及其用途
公开(公告)号：WO2018035080A1
公开(公告)日：2018-02-22
申请号：PCT/US2017/046865
申请日：2017-08-15
Applicant: MERCK PATENT GMBH , CALDWELL, Richard D.
Inventor： CALDWELL, Richard D.
IPC: C07D471/04 , A61K31/437 , A61K31/553 , C07D519/00
Abstract: The present invention relates to imidazo pyridine compounds, and pharmaceutically acceptable compositions thereof, useful as BTK inhibitors.
Abstract translation: 本发明涉及可用作BTK抑制剂的咪唑并吡啶化合物及其药学可接受的组合物。
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公开(公告)号：WO2016057500A1
公开(公告)日：2016-04-14
申请号：PCT/US2015/054221
申请日：2015-10-06
Applicant: MERCK PATENT GMBH , GAILLARD, Pascale , SEENISAMY, Jeyaprakashnarayanan , LIU-BUJALSKI, Lesley , POTNICK, Justin , CALDWELL, Richard D. , QIU, Hui , NEAGU, Constantin , JONES, Reinaldo , WON, Annie Cho , GOUTOPOULOS, Andreas , SHERER, Brian A. , JOHNSON, Theresa L. , GARDBERG, Anna
Inventor： GAILLARD, Pascale , SEENISAMY, Jeyaprakashnarayanan , LIU-BUJALSKI, Lesley , POTNICK, Justin , CALDWELL, Richard D. , QIU, Hui , NEAGU, Constantin , JONES, Reinaldo , WON, Annie Cho , GOUTOPOULOS, Andreas , SHERER, Brian A. , JOHNSON, Theresa L. , GARDBERG, Anna
IPC: C07D471/04 , C07D519/00 , A61K31/437 , A61K31/553 , A61P29/00 , A61P37/00
CPC classification number: C07D471/04 , C07D519/00
Abstract: The present invention relates to imidazopyridine compounds of formula I, and pharmaceutically acceptable compositions thereof, useful as BTK inhibitors.
Abstract translation: 本发明涉及式I的咪唑并吡啶化合物及其药学上可接受的组合物，其可用作BTK抑制剂。
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公开(公告)号：WO2015061247A2
公开(公告)日：2015-04-30
申请号：PCT/US2014061455
申请日：2014-10-21
Applicant: MERCK PATENT GMBH , QIU HUI , CALDWELL RICHARD D , NEAGU CONSTANTIN , MOCHALKIN IGOR , LIU-BUJALSKI LESLEY , JONES REINALDO , TATE DEVON , JOHNSON THERESA L , GARDBERG ANNA
Inventor： QIU HUI , CALDWELL RICHARD D , NEAGU CONSTANTIN , MOCHALKIN IGOR , LIU-BUJALSKI LESLEY , JONES REINALDO , TATE DEVON , JOHNSON THERESA L , GARDBERG ANNA
IPC: C07D213/81
CPC classification number: C07D401/04 , A61K9/0019 , A61K9/0043 , A61K9/0048 , A61K9/0078 , A61K9/02 , A61K9/06 , A61K9/08 , A61K9/1688 , A61K9/19 , A61K9/2018 , A61K9/2059 , A61K9/2826 , A61K9/286 , A61K47/06 , A61K47/186 , C07D213/81 , C07D213/82 , C07D239/47 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/14 , C07D407/04 , C07D409/04 , C07D413/04 , C07D413/06 , C07D413/14 , C07D451/02 , C07D471/08 , C07D487/04 , C07D487/08 , C07D487/10 , C07D495/04 , C07F5/022
Abstract: The present invention relates to pyridine, pyrimidine, pyrazine, and pyridazine compounds, and pharmaceutically acceptable compositions thereof, useful as BTK inhibitors.
Abstract translation: 本发明涉及用作BTK抑制剂的吡啶，嘧啶，吡嗪和哒嗪化合物及其药学上可接受的组合物。
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公开(公告)号：WO2010051030A1
公开(公告)日：2010-05-06
申请号：PCT/US2009/005897
申请日：2009-10-30
Applicant: BIOGEN IDEC MA INC. , GUCKIAN, Kevin, M. , CALDWELL, Richard, D. , KUMARAVEL, Gnanasambandam , LEE, Wen-cherng , LIN, Edward, Yin-shiang , LIU, Xiaogao , MA, Bin , SCOTT, Daniel, M. , SHI, Zhan , ZHENG, Guo, Zhu , TAVERAS, Arthur, G. , THOMAS, Jermaine
Inventor： GUCKIAN, Kevin, M. , CALDWELL, Richard, D. , KUMARAVEL, Gnanasambandam , LEE, Wen-cherng , LIN, Edward, Yin-shiang , LIU, Xiaogao , MA, Bin , SCOTT, Daniel, M. , SHI, Zhan , ZHENG, Guo, Zhu , TAVERAS, Arthur, G. , THOMAS, Jermaine
IPC: A01N47/10 , A61K31/27 , A61K31/135
CPC classification number: A61K31/135 , A61K31/27 , C07C205/26 , C07C205/50 , C07C217/52 , C07C217/60 , C07C229/32 , C07C271/16 , C07D263/38 , C07F9/091 , C07F9/093 , C07F9/653 , C07F9/65744
Abstract: Compounds that have agonist activity at one or more of the SlP receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S lP receptors.
Abstract translation: 提供了在一种或多种S1P受体上具有激动剂活性的化合物。 这些化合物是鞘氨醇类似物，其在磷酸化之后可以作为S1P受体的激动剂。
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公开(公告)号：WO2017007987A1
公开(公告)日：2017-01-12
申请号：PCT/US2016/041438
申请日：2016-07-08
Applicant: MERCK PATENT GMBH , QIU, Hui , CALDWELL, Richard D. , LIU-BUJALSKI, Lesley
Inventor： QIU, Hui , CALDWELL, Richard D. , LIU-BUJALSKI, Lesley
IPC: C07D403/12 , C07D401/04 , C07D403/04 , C07D239/48 , C07D409/12 , C07D413/12 , C07D471/04 , C07D471/10 , C07D487/04 , A61K31/506 , A61P29/00
CPC classification number: A61K31/505 , C07D239/48 , C07D401/04 , C07D403/04 , C07D403/12 , C07D409/12 , C07D413/12 , C07D471/04 , C07D471/10 , C07D487/04
Abstract: The present invention relates to pyrimidine compounds, and pharmaceutically acceptable compositions thereof, useful as BTK inhibitors.
Abstract translation: 本发明涉及可用作BTK抑制剂的嘧啶化合物及其药学上可接受的组合物。
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Patent Agency Ranking6.发明申请PYRIDINES, PYRIMIDINES, AND PYRAZINES, AS BTK INHIBITORS AND USES THEREOF 审中-公开吡啶类，吡咯烷类和吡嗪类，作为BTK抑制剂及其用途
公开(公告)号：WO2015017502A1
公开(公告)日：2015-02-05
申请号：PCT/US2014/048810
申请日：2014-07-30
Applicant: MERCK PATENT GMBH , LIU-BUJALSKI, Lesley , NGUYEN, Ngan , QIU, Hui , JONES, Reinaldo , MOCHALKIN, Igor , CALDWELL, Richard D.
Inventor： LIU-BUJALSKI, Lesley , NGUYEN, Ngan , QIU, Hui , JONES, Reinaldo , MOCHALKIN, Igor , CALDWELL, Richard D.
IPC: C07D487/04 , A61K31/519 , A61P29/00
CPC classification number: C07D487/04 , A61K31/4985 , A61K31/519 , C07D471/04
Abstract: The present invention relates to pyridine, pyrimidine, and pyrazene compounds, and pharmaceutically acceptable compositions thereof, useful as BTK inhibitors.
Abstract translation: 本发明涉及可用作BTK抑制剂的吡啶，嘧啶和吡嗪化合物及其药学上可接受的组合物。
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公开(公告)号：WO2012109108A1
公开(公告)日：2012-08-16
申请号：PCT/US2012/023799
申请日：2012-02-03
Applicant: BIOGEN IDEC MA INC. , THOMAS, Jermaine , MI, Sha , LIN, Edward, Yin-shiang , ZHENG, Guo, Zhu , MA, Bin , CALDWELL, Richard, D. , GUCKIAN, Kevin , KUMARAVEL, Gnanasambandam
Inventor： THOMAS, Jermaine , MI, Sha , LIN, Edward, Yin-shiang , ZHENG, Guo, Zhu , MA, Bin , CALDWELL, Richard, D. , GUCKIAN, Kevin , KUMARAVEL, Gnanasambandam
IPC: A01N43/40 , A61K31/445
CPC classification number: A61K31/445 , A61K31/225 , A61K31/4545 , A61K31/4709 , A61K31/498 , A61K31/517 , A61K31/55 , A61K31/695 , A61K38/21 , A61K39/3955 , C07D211/34 , C07D211/60 , C07D211/62 , C07D215/20 , C07D401/06 , C07D405/12 , C07K16/2842
Abstract: Compounds of formula (I) or (II) can modulate the activity of SIP receptors.
Abstract translation: 式（I）或（II）的化合物可以调节SIP受体的活性。
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公开(公告)号：WO2011017561A1
公开(公告)日：2011-02-10
申请号：PCT/US2010/044607
申请日：2010-08-05
Applicant: BIOGEN IDEC MA INC. , THOMAS, Jermaine , LIU, Xiaogao , LIN, Edward, Yin-Shiang , ZHENG, Guo, Zhu , MA, Bin , CALDWELL, Richard, D. , GUCKIAN, Kevin, M. , KUMARAVEL, Gnanasambandam , TAVERAS, Arthur, G.
Inventor： THOMAS, Jermaine , LIU, Xiaogao , LIN, Edward, Yin-Shiang , ZHENG, Guo, Zhu , MA, Bin , CALDWELL, Richard, D. , GUCKIAN, Kevin, M. , KUMARAVEL, Gnanasambandam , TAVERAS, Arthur, G.
IPC: A01N43/42
CPC classification number: A61K31/695 , A61K31/085 , A61K31/11 , A61K31/137 , A61K31/165 , A61K31/18 , A61K31/185 , A61K31/197 , A61K31/198 , A61K31/216 , A61K31/222 , A61K31/223 , A61K31/235 , A61K31/277 , A61K31/337 , A61K31/397 , A61K31/40 , A61K31/401 , A61K31/404 , A61K31/41 , A61K31/428 , A61K31/445 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/517 , A61K31/662 , A61K31/683 , A61K45/06 , C07C43/247 , C07C47/575 , C07C229/14 , C07C229/22 , C07C229/46 , C07C229/48 , C07C237/08 , C07C237/52 , C07C255/54 , C07C309/14 , C07C311/51 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07D205/04 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D215/20 , C07D215/227 , C07D217/04 , C07D217/24 , C07D239/74 , C07D257/04 , C07D277/64 , C07D305/08 , C07D401/06 , C07D403/06 , C07D417/06 , C07F7/081 , C07F9/3808 , C07F9/3834 , C07F9/4006
Abstract: Compounds that have agonist activity at one or more of the SlP receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at SlP receptors.
Abstract translation: 提供了在一种或多种S1P受体上具有激动剂活性的化合物。 化合物是鞘氨醇类似物，其在磷酸化之后可以作为S1P受体的激动剂。
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公开(公告)号：WO2015061247A3
公开(公告)日：2015-04-30
申请号：PCT/US2014/061455
申请日：2014-10-21
Applicant: MERCK PATENT GMBH , QIU, Hui , CALDWELL, Richard D. , NEAGU, Constantin , MOCHALKIN, Igor , LIU-BUJALSKI, Lesley , JONES, Reinaldo , TATE, Devon , JOHNSON, Theresa L. , GARDBERG, Anna
Inventor： QIU, Hui , CALDWELL, Richard D. , NEAGU, Constantin , MOCHALKIN, Igor , LIU-BUJALSKI, Lesley , JONES, Reinaldo , TATE, Devon , JOHNSON, Theresa L. , GARDBERG, Anna
IPC: C07D403/12 , A61K31/4439 , A61K31/506 , C07D213/81 , C07D401/04 , C07D403/04 , C07D407/04 , C07D239/48 , C07D409/04 , C07D413/04 , C07D413/06 , C07D487/04 , C07D401/12
Abstract: The present invention relates to pyridine, pyrimidine, pyrazine, and pyridazine compounds, and pharmaceutically acceptable compositions thereof, useful as BTK inhibitors.
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公开(公告)号：WO2016094628A1
公开(公告)日：2016-06-16
申请号：PCT/US2015/064939
申请日：2015-12-10
Applicant: MERCK PATENT GMBH , BENDER, Andrew , LIU-BUJALSKI, Lesley , PEREIRA, Albertina , CALDWELL, Richard D. , GRENNINGLOH, Roland , XU, Daigen
Inventor： BENDER, Andrew , LIU-BUJALSKI, Lesley , PEREIRA, Albertina , CALDWELL, Richard D. , GRENNINGLOH, Roland , XU, Daigen
IPC: G01N33/53 , G01N33/58 , G01N33/574
CPC classification number: G01N33/573 , C07D495/04 , C07F5/022 , G01N33/53 , G01N33/57484 , G01N33/58 , G01N2333/912 , G01N2500/02
Abstract: The present invention relates to BTK occupancy assays.
Abstract translation: 本发明涉及BTK占用率测定。
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